Advertisement

Polypeptides: Vascular Actions as Modified by Prostaglandins

  • P. Y.-K. Wong
  • J. C. McGiff
  • A. Terragno
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)

Abstract

The general conclusion that prostaglandins are primarily local or tissue hormones (1), which exert their effects at or near sites of synthesis, has particular significance for the vasculature. Thus, the capacity of blood vessels to synthesize prostaglandins intramurally (2) enables these local hormones to influence vascular tone and reactivity directly by affecting the vasoconstrictor actions of angiotensin and catechol amines (3) and by modulating the release of norepinephrine from adrenergic nerves (4). The proposal that prostaglandins participate in the regulation of vascular reactivity is supported by the following observations: 1) enhanced vascular reactivity to pressor stimuli occurs in organs with low basal rates of prostaglandin synthesis and after inhibition of prostaglandin synthesis in organs with high biosynthetic capacity (5); and 2) exogenous PGE2 reversibly inhibits the vasoconstrictor activity of pressor stimuli (6).

Keywords

Vascular Reactivity Prostaglandin Synthesis Vascular Action Prostaglandin Synthetase Pressor Stimulus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Vane, J.R.: Brit. J. Pharmacol. 35:209–242, 1969.Google Scholar
  2. 2.
    Terragno, D.A., Crowshaw, K., Terragno, N.A. and McGiff, J.C.: Circ. Res. 36 and (suppl I):I-76, 1975.Google Scholar
  3. 2a.
    Terragno, D.A., Crowshaw, K., Terragno, N.A. and McGiff, J.C.: Circ. Res. and 37 (suppl I):I-80, 1975.Google Scholar
  4. 3.
    McGiff, J.C., Crowshaw, K., Terragno, N.A. and Lonigro, A.J.: Nature (Lond) 227:1255–1257, 1970.CrossRefGoogle Scholar
  5. 4.
    Hedqvist, P.: Acta. Physiol. Scand. (suppl) 345:1–40, 1970.Google Scholar
  6. 5.
    Aiken, J.W. and Vane, J.R.: J. Pharmacol. Exp. Ther. 184:678–687, 1973.PubMedGoogle Scholar
  7. 6.
    Lonigro, A.J., Terragno, N.A., Malik, K.U. and McGiff, J.C.: Prostaglandins 3:595–606, 1973.PubMedCrossRefGoogle Scholar
  8. 7.
    Terragno, N.A., Terragno, D.A., Pacholczyk, D. and McGiff, J.C.: Nature (Lond) 249:57–58, 1974.CrossRefGoogle Scholar
  9. 8.
    Lonigro, A.J., Itskovitz, H.D., Crowshaw, K. and McGiff, J.C.: Circ. Res. 32:712–717, 1973.PubMedGoogle Scholar
  10. 9.
    McGiff, J.C., Crowshaw, K., Terragno, N.A., Malik, K.U. and Lonigro, A. J.: Clin. Sci. 42:223–233, 1972.PubMedGoogle Scholar
  11. 10.
    McGiff, J.C., Crowshaw, K., Terragno, N.A. and Lonigro, A.J.: Circ. Res. 26 I-121–1970Google Scholar
  12. 10a.
    McGiff, J.C., Crowshaw, K., Terragno, N.A. and Lonigro, A.J.: Circ. Res. 27(suppl I):I-130, 1970.Google Scholar
  13. 11.
    McGiff, J.C., Terragno, N.A., Malik, K.U. and Lonigro, A.J.: Circ. Res. 31:36–43, 1972.PubMedGoogle Scholar
  14. 12.
    Vane, J.R. and McGiff, J.C.: Circ. Res. 36 I-68 and 1975.Google Scholar
  15. 12a.
    Vane, J.R. and McGiff, J.C.: Circ. Res. 37 (suppl I): I-75, 1975.Google Scholar
  16. 13.
    McGiff, J.C. and Itskovitz, H.D.: Circ. Res. 33:479–488, 1973.PubMedGoogle Scholar
  17. 14.
    Hamberg, M., Svensson, J. and Samuelsson, B.: Proc. Nat. Acad. Sci. (Wash.) 71:3824–3828, 1974.CrossRefGoogle Scholar
  18. 15.
    Mellander, S. and Johansson, B.: Pharmacol. Rev. 20:117–196, 1968.PubMedGoogle Scholar
  19. 16.
    Ledingham, J.M. and Cohen, R.D.: Lancet 2:979–981, 1963.PubMedCrossRefGoogle Scholar
  20. 17.
    Christ, E.J. and Van Dorp, D.A.: Advances in the Biosciences, International Conference on Prostaglandins, Vol 9, edited by Bergstrom, S., Pergamon Press, New York, 1972, pp. 35–38.Google Scholar
  21. 18.
    Hollander, W., Kramsch, D.M., Franzblau, C., Paddock, J. and Colombo, M.A.: Circ. Res. 34 I-131 1974 andGoogle Scholar
  22. 18a.
    Hollander, W., Kramsch, D.M., Franzblau, C., Paddock, J. and Colombo, M.A.: Circ. Res. 35 (suppl I): I-141, 1974.Google Scholar
  23. 19.
    Gould, A.B., Skeggs, L.T., Jr. and Kahn, J.R.: J. Exp. Med. 119:389–399, 1964.PubMedCrossRefGoogle Scholar
  24. 20.
    Burnstock, G., Gannon, B. and Iwayama, T.: Cire. Res. 26 II-5 1970 andGoogle Scholar
  25. 20a.
    Burnstock, G., Gannon, B. and Iwayama, T.: Cire. Res. 27 (suppl II):–II-23, 1970.Google Scholar
  26. 21.
    Zusman, R.M., Spector, D., Caldwell, B.V., Speroff, L., Schneider, G. and Mulrow, P.J.: J. Clin. Invest. 52:1093–1098, 1973.PubMedCrossRefGoogle Scholar
  27. 22.
    Hamberg, M.: FEBS Letter 5: 127–130, 1969.CrossRefGoogle Scholar
  28. 23.
    Malik, K.U. and McGiff, J.C.: Circ. Res. 36:599–609, 1975.PubMedGoogle Scholar
  29. 24.
    Tobian, L.: Fed. Proc. 33:138–142, 1974.PubMedGoogle Scholar
  30. 25.
    Armstrong, J.M., Blackwell, G.J., Flower, R.J., McGiff, J.C., Mullane, K.M. and Vane, J.R.: Nature 260:582–586, 1976.PubMedCrossRefGoogle Scholar
  31. 26.
    Hamberg, M. and Samuelsson, B.: Proc. Nat. Acad. Sci. 71: 3400–3404, 1974.PubMedCrossRefGoogle Scholar
  32. 27.
    Blackwell, G.J., Flower, R.J. and Vane, J.R.: Biochim. Biophys. Acta 398:178–190, 1975.PubMedGoogle Scholar
  33. 28.
    Needleman, P., Minkes, M. and Raz, A.: Science 193:163–165, 1976.PubMedCrossRefGoogle Scholar
  34. 29.
    McGiff, J.C., Itskovitz, H.D., Terragno, A. and Wong, P.Y-K: Fed. Proc. 35:175–180, 1976.PubMedGoogle Scholar
  35. 30.
    Bobbin, R.P. and Guth, P.S.: J. Pharmacol. Exp. Ther. 160: 11–21, 1968.Google Scholar
  36. 31.
    Messina, E.J., Weiner, R. and Kaley, G.: Circ. Res. 37:430–437, 1975.PubMedGoogle Scholar
  37. 32.
    Hong, S.L. and Levine, L.: J. Biol. Chem. (In Press)Google Scholar
  38. 33.
    Nakano, J., Anggard, E. and Samuelsson, B.: Eur. J. Biochem. 11:386, 1969.PubMedCrossRefGoogle Scholar
  39. 34.
    Leslie, C.A. and Levine, L.: Biochem. Biophys. Res. Com. 52:717–724, 1973.PubMedCrossRefGoogle Scholar
  40. 35.
    Lee, S.C. and Levine, L.: J. Biol. Chem. 250:4549, 1975.PubMedGoogle Scholar
  41. 36.
    Pace-Asciak, C. and Nashat, M.: Biochim. Biophys. Acta 388: 243, 1975.PubMedGoogle Scholar
  42. 37.
    Chan, J.A., Nagasawa, M., Takeguchi, C. and Sih, C.J.: Biochemistry 14:2987, 1975.PubMedCrossRefGoogle Scholar
  43. 38.
    Baraké, J., Park, W.K. and Regoli, D.: Can. J. Physiol. Pharmacol. 53:345–353, 1974.Google Scholar
  44. 39.
    Clyman, R.I., Sandler, J.A., Manganiello, V.C. and Vaughan, M.: J. Clin. Invest. 55: 1020–1025, 1975.PubMedCrossRefGoogle Scholar
  45. 40.
    Dunham, E.W., Haddox, M.K. and Goldberg, N.D.: Proc. Nat. Acad. Sci., U.S.A. 71 :815–819, 1974.CrossRefGoogle Scholar
  46. 41.
    Amer, M.S., Gomoll, A.W., Perach, J.L., Ferguson, H.C. and McKinney, G.R.: Proc. Nat. Acad. Sci., U.S.A. 21:4930–4934, 1974.CrossRefGoogle Scholar
  47. 42.
    Clyman, R.I., Blacksin, A.S., Manganiello, V.C. and Vaughan, M.: Proc. Nat. Acad. Sci., U.S.A. 72:3883–3887, 1975.CrossRefGoogle Scholar
  48. 43.
    Kuehl, F.A., Jr., Circilo, V.J., Ham, E.A. and Humes, J.L.: Advances in the Biosciences, International Conference on Prostaglandins, Vol 9, edited by Bergstrom, S. and Bernhard, S., Pergamon Press, Vieweg, Braunschweig, 1973, pp. 155–172.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • P. Y.-K. Wong
    • 1
  • J. C. McGiff
    • 1
  • A. Terragno
    • 1
  1. 1.Departments of Pharmacology and MedicineUniversity of TennesseeMemphisUSA

Personalised recommendations