Clinical Effects of the Prostaglandins on the Respiratory System
The prostaglandins were first isolated from the lungs by Bergström and his coworkers more than 14 years ago (1). It is now established that in animal studies all prostaglandins have powerful effects on both respiratory smooth muscle and on pulmonary vascular smooth muscle and that the lungs have an important function in their metabolic degradation, since some 90–95% of infused E and F prostaglandins are removed predominantly by the enzyme 15-prostaglandin dehydrogenase (15-PGDH) on a single passage through the pulmonary circulation. It is of interest that the A prostaglandins, which have a similar but less potent effect than the E prostaglandins, are less readily degraded by 15-PGDH in the lungs of experimental animals. Similar results have been obtained with prostaglandin F2α (PGF2α) man and it is suggested that degradation occurs in the pulmonary endothelial cells (2,3).
KeywordsAirway Resistance Bronchodilator Effect Flufenamic Acid Disodium Cromoglycate Pulmonary Endothelial Cell
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