Generation of Prostaglandin and Thromboxane-Like Substances by Large Airways and Lung Parenchyma

  • R. J. Gryglewski
  • A. Dembińska-Kieć
  • L. Grodzińska
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 13)


Anggard and Samuelsson (1965) were the first researchers to study the biosynthesis of prostaglandins in lungs. They found that the low speed supernatant (900 × g) of a homogenate of guinea pig lungs incubated with arachidonic acid converted 10% of the substrate to more polar products than arachidonic acid. These products were identified as PGF, PGE2 and their metabolites. Guinea pig lung homogenates were used by Vane (1971) in his work that lead to the discovery of the anti-prosta-glandin synthetase activity of aspirin like drugs. In rat lung homogenates dihomo-γ-linolenic acid is mainly converted to PGD1, similarily as prostaglandin endoper-oxides PGH1 and PGH2 are chiefly metabolized to PGD1 and PGD2, respectively (Nugteren and Hazelhof, 1973). Further studies on metabolism of radioactive arachidonic acid by whole homogenates of guinea pig lungs brought to unexpected results (Hamberg and Samuelsson, 1974). The formation of PGF2 and PGE2, both in 2–3% yield was confirmed.


Lung Parenchyma Airway Smooth Muscle Rabbit Aorta Prostaglandin Endoperoxide Aortic Strip 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. J. Gryglewski
    • 1
  • A. Dembińska-Kieć
    • 1
  • L. Grodzińska
    • 1
  1. 1.Department of PharmacologyCopernicus Academy of Medicine in CracowCracowPoland

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