Abstract
Investigations in a variety of systems have shown that dissociated single cells will, under appropriate conditions, aggregate and, if maintained in culture, will morphologically differentiate to resemble the original organ or tissue (23, 33, 34). It can further be shown that in mixed aggregates of cells prepared from different organs (for example, neural retina and liver) there occurs cell segregation such that cells originally derived from the same organ attached to each other and separate from the cells derived from a different organ. The simplest explanation for this observation is that cells have a preferential or higher affinity for homologous cells, and if free to move within the aggregate, will rearrange so as to be adjacent to homologous rather than hetero-logous cells. This simple view is probably an oversimplification, because not only do cells migrate to be adjacent to homologous cells, but they also take up characteristic positions within the aggregate which cannot be explained simply by differential affinities (33).
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ARTZT, K. and BENNETT, D., Nature 256 (1975) 545.
ARTZT, K., BENNETT, D. and JACOB, F., Proc. Nat. Acad. Sci.USA 71 (1974) 811.
BALSANO, J. and LILIEN, J., Proc. Nat. Acad. Sci. USA 71 (1974) 727.
BARBERA, A. J., MARCHASI, R. B. and ROTH, S., Proc. Nat. Acad. Sci. USA 70 (1973) 2482.
BOCCHINI, V. and ANGELETTI, P. U., Proc. Nat. Acad. Sci. USA 64 (1969) 787.
BUC-CARON, M., GACHELIN, G., HOFNUNG, M., and JACOB, F., Proc. Nat. Acad. Sci. USA 71 (1974) 1730.
CAULDWELL, C. G., HENKART, P. and HUMPHREYS, T., Biochemistry 12 (1973) 3051.
CHIPOWSKY, S., LEE, Y. C. and ROSEMAN, S., Proc. Nat. Acad. Sci. USA 70 (1973) 2309.
CHIPOWSKY, S., SCHNAAR, R. and ROSEMAN, S., Fed. Proc. 34 (1975) 614.
CRICK, F. H. C. and LAWRENCE, P. A., Science 184 (1975) 340.
DE LONG, G. R. and SIDMAN, R. L., Developmental Biol. 22 (1970) 584.
FRAZIER, W. A., HOGUE-ANGELETTI, R. A., SHERMAN, R. and BRADSHAW, R. A., Biochemistry 12 (1973) 3281.
GARBER, B. B. and MOSCONA, A. A., Developmental Biol. 27 (1972) 235.
GOTTLIEB, D. I., MERRELL, R. and GLASER, L., Proc. Nat. Acad. Sci. USA 71 (1974) 1800.
GOTTLIEB, D. I. and GLASER, L., Biochem. Biophys. Res. Comm. 63 (1975) 815.
HAMBURGER, V. and HAMILTON, H. L., J. Morphology 88 (1951) 49.
HAUSMAN, R. E. and MOSCONA, A. A., Proc. Nat. Acad. Sci. USA 70 (1973) 3111.
HAUSMAN, R. E. and MOSCONA, A. A., Proc. Nat. Acad. Sci. USA 72 (1975) 916.
MARTIN, G. R., Cell 5 (1975) 229.
MERRELL, R. and GLASER, L., Proc. Nat. Acad. Sci. USA 70 (1973) 2794.
MERRELL, R., GOTTLIEB, D. I. and GLASER, L., Topics in Neurobiology,Vol. 2 (S. Barondes ed.) Plenum Press, New York (1976) in press.
MERRELL, R., PULLIAM, M. W., RANDONO, L., BOYD, L. F., BRADSHAW, R. A. and GLASER, L., Proc. Nat. Acad. Sci. USA 72 (1975) 4270.
MOSCONA, A. A., Cells and Tissues in Culture (F. N. Willmer ed.) Academic Press, New York, Vol. 1 (1965) 197.
ORR, C. W. and ROSEMAN, S., J. Membrane Biol. 1 (1968) 110.
ROSEMAN, S., Chem. Phys. Lipids 5 (1970) 270.
ROSEN, S. D., KAFKA, J. A., SIMPSON, D. L. and BARONDES, S. H., Proc. Nat. Acad. Sci. USA 70 (1973) 2554.
ROSEN, S, D., SIMPSON, D. L., ROSE, J. E. and BARONDES, S. H. Nature 252 (1974) 128, 149.
ROTH, S. and WESTON, J. A., Proc. Nat. Acad. Sci. USA 58 (1967) 974.
ROTH, S., Developmental Biol. 18 (1968) 602.
ROTH, S., McGUIRE, E. J. and ROSEMAN, S., J. Cell Biol. 51 (1971) 525.
ROTH, S. and WHITE, D., Proc. Nat. Acad. Sci. USA 69 (1972) 485.
SCHUBERT, D., HEINEMANN, S., CARLISLE, W., TARIKAS, H., KIMES, B., PATRICK, J., STEINBACH, J. H., CULP, W. and BRANDT, B. L., Nature 249 (1974) 224.
STEINBERG, M. S., Science 141 (1963) 401.
TOWNES, P. S. and HOLTFRETER, J., J. Expt. Zool. 128 (1955) 53.
WALTHER, B. T., OHNAN, R. and ROSEMAN, S., Proc. Nat. Acad. Sci. USA 70 (1973) 1569.
WEINBAUM, C. and BURGER, M. M., Nature 244 (1973) 510.
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Glaser, L., Merrell, R., Gottlieb, D.I., Littman, D., Pulliam, M.W., Bradshaw, R.A. (1976). Neuronal Cell Adhesion. In: Bradshaw, R.A., Frazier, W.A., Merrell, R.C., Gottlieb, D.I., Hogue-Angeletti, R.A. (eds) Surface Membrane Receptors. NATO Advanced Study Institutes Series, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2772-1_9
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