Abstract
Several hours after the end of the growth phase, single cells of Dictyostelium discoideum aggregate into a multicellular organism. Cell differentiation during the interphase between growth and aggregation is expressed in cell surface changes which include the following markers: 1) an increase in the number of cyclic-AMP binding sites which are believed to act as receptors mediating chemotaxis and other developmental functions of extracellular cyclic-AMP (13, 14, 18); 2) a fast increase in the activity of cyclic-AMP phosphodiesterase (19). This enzyme is involved in the control of the cyclic AMP released from, and diffusing between, the interacting cells in an aggregation field (17); 3) the appearance of antigenic sites (“contact sites A”) related to cell adhesion (2).
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Gerisch, G. (1976). Receptors Mediating Cell Aggregation in Dictyostelium Discoideum . In: Bradshaw, R.A., Frazier, W.A., Merrell, R.C., Gottlieb, D.I., Hogue-Angeletti, R.A. (eds) Surface Membrane Receptors. NATO Advanced Study Institutes Series, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2772-1_5
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DOI: https://doi.org/10.1007/978-1-4684-2772-1_5
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