Receptors Mediating Cell Aggregation in Dictyostelium Discoideum

  • Gunther Gerisch
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 11)


Several hours after the end of the growth phase, single cells of Dictyostelium discoideum aggregate into a multicellular organism. Cell differentiation during the interphase between growth and aggregation is expressed in cell surface changes which include the following markers: 1) an increase in the number of cyclic-AMP binding sites which are believed to act as receptors mediating chemotaxis and other developmental functions of extracellular cyclic-AMP (13, 14, 18); 2) a fast increase in the activity of cyclic-AMP phosphodiesterase (19). This enzyme is involved in the control of the cyclic AMP released from, and diffusing between, the interacting cells in an aggregation field (17); 3) the appearance of antigenic sites (“contact sites A”) related to cell adhesion (2).


Contact Site Antigenic Site Cell Surface Change Crude Membrane Preparation Aggregation Field 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Gunther Gerisch
    • 1
  1. 1.Biozentrum der Universität BaselBaselSwitzerland

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