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Cholinergic Sites in Skeletal Muscle

  • Richard R. Almon
  • Stanley H. Appel
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 11)

Abstract

The physiological properties of mammalian skeletal muscle vary considerably as a function of innervation. Developmentally, the resting membrane potential, the cell surface distribution of acetyl-choline sensitivity and the characteristics of the action potential all change (1, 2, 25). Experimental denervation causes the muscles to revert to a state similar to the one observed prior to innervation ontogenetically. In recent years considerable effort has been directed towards the correlation of molecular properties of the membrane with denervation induced changes in physiological properties of the muscle (3, 5, 8–11, 15–17, 19, 21, 22). This approach, is pertinent to the understanding of both the molecular mechanisms of these physiological phenomena, and their significance to the innervation process.

Keywords

Power Function Muscle Preparation Denervated Muscle Innervate Muscle Unsaturable Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Richard R. Almon
    • 1
    • 2
  • Stanley H. Appel
    • 1
    • 2
  1. 1.Department of BiologyUniversity of CaliforniaLa JollaUSA
  2. 2.Division of NeurologyDuke University Medical CenterDurhamUSA

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