Evidence for a Macromolecular Effector of Cell Differentiation in Dictyostelium Discoideum Amoebae

  • Michel Darmon
  • Claudette Klein
  • Philipe Brachet
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 11)


Upon depletion of their food supply, myxamoebae undertake their developmental program, the first stage of which is marked by the aggregation of cells toward central collection points. Aggregation follows a period of starvation called interphase, during which cells differentiate into aggregation-competent amoebae(7): they attain an elongated morphology, move chemotactically toward their neighboring cells (4), and form specific cell-cell contacts (6) which appear to require membrane components (contact sites A) present specifically on starved cells (3). Movement of amoebae is directed by an acrasin (4), cAMP (2, 14), which starved cells rhythmically release into the media (18) . The response of cells to the chemotactic signal appears to involve surface cAMP-binding receptors (15) which probably function in the stimulation of cAMP synthesis and emission (17, 19, 20).


Cell Aggregation Dictyostelium Discoideum Phosphodiesterase Activity Chemotactic Signal cAMP Synthesis 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Michel Darmon
    • 1
  • Claudette Klein
    • 1
  • Philipe Brachet
    • 1
  1. 1.Unité de Différenciation Cellulaire Département de Biologie MoléculaireInstitut PasteurParisFrance

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