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Endothelial Proliferation Factor

  • B. Haber
  • R. L. Suddith
  • H. T. Hutchison
  • P. J. Kelly
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 11)

Abstract

The viability of the brain is predicated upon its blood supply. Nowhere is the process of vascularization of the brain more dramatically visualized than in the expansion of the capillary bed within and around tumors of the CNS (6). Recent evidence suggests that this endothelial proliferation (or neovascularization as it is often called) is mediated by a soluble factor (12) released by the growing tumor cells as proposed earlier by Algire (1). The new vessels are recruited by the tumor from the already existent host vasculature in the region of the tumor (1, 26).

Keywords

Nerve Growth Factor Conditioned Medium Endothelial Proliferation Half Maximal Response Thymidine Label Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    ALGIRE, G. H. and CHALKLEY, H. W., J. Nat. Cancer Inst. 6 (1945) 73.Google Scholar
  2. 2.
    CAVALLO, T., SADE, R., FOLKMAN, J. and COTRAN, R. S., J. Cell. Biol. 54 (1972) 408.PubMedCrossRefGoogle Scholar
  3. 3.
    CAVALLO, T., SADE, R., FOLKMAN, J. and COTRAN, R. S., Am. J. Pathol. 70 (1973) 345.PubMedGoogle Scholar
  4. 4.
    CHALKEY, H. W., Comments on ALGIRE, G. H. and LEGALLAIS, F. Y., Special Publications. N. Y. Acad. Sci. 4 (1948) 164.Google Scholar
  5. 5.
    EHRMANN, R. L. and KNOTH, M., J. Nat. Canc. Inst. 41 (1968) 1329.Google Scholar
  6. 6.
    FEIGEN, I., ALLEN, L. B. and LIPKIN, L., Cancer 11 (1958) 264.CrossRefGoogle Scholar
  7. 7.
    FOLKMAN, J., MERLER, E. and ABERNATHY, C, J. Exp. Med. 133 (1971) 275.PubMedCrossRefGoogle Scholar
  8. 8.
    FOLKMAN, J., Adv. in Cancer Res. 19 (1974) 331.CrossRefGoogle Scholar
  9. 9.
    GIMBRONE, M. A., LEAPMAN, S. B., COTRAN, R. S. and FOLKMAN, J., J. Exp. Med. 136 (1972) 261.PubMedCrossRefGoogle Scholar
  10. 10.
    GIMBRONE, M. A., LEAPMAN, S. B., COTRAN, R. S. and FOLKMAN, J., J. Nat. Canc. Inst. 50 (1973) 219.Google Scholar
  11. 11.
    GIMBRONE, M. A., COTRAN, R. S. and FOLKMAN, J., J. Cell. Biol. 60 (1974) 673.PubMedCrossRefGoogle Scholar
  12. 12.
    GREENBLATT, M. and SHUBI, K. P., J. Nat. Canc. Inst. 41 (1968) 111.Google Scholar
  13. 13.
    JAFFE, E. A., NACHMAN, R. L., BECKER, C. G. and MINICK, C. R., J. Clin. Invest. 52 (1973) 2745.PubMedCrossRefGoogle Scholar
  14. 14.
    KELLY, P. J., SUDDITH, R. L., HUTCHISON, H. T., WERRBACH, K. and HABER, B., J. Neurosurgery (1976) in press.Google Scholar
  15. 15.
    LONGO, A. and PENHOET, E., Proc. Nat. Acad. Sci. USA 71 (1974) 2347.PubMedCrossRefGoogle Scholar
  16. 16.
    OGER, J., ARNASON, B. G. W., PANTAZIS, N., LEHRICH, J. and YOUNG, M., Proc. Nat. Acad. Sci. USA 71 (1974) 1554.PubMedCrossRefGoogle Scholar
  17. 17.
    REYNOLDS, P. and PEREZ-POLO, J. R., Neuroscience Letters (1975) in press.Google Scholar
  18. 18.
    SHINE, H. D., Master’s Thesis. Univ. of Texas, Austin (1975).Google Scholar
  19. 19.
    STOBO, J. D., ROSENTHAL, A. and PAUL, W. D., J. Immunol. 108 (1972) 1.PubMedGoogle Scholar
  20. 20.
    SUDDITH, R. L., KELLY, P. J., HUTCHISON, H. T. and HABER, B., Fed. Proc. 34 (1975) 731.Google Scholar
  21. 21.
    SUDDITH, R. L., KELLY, P. J., HUTCHISON, H. T., MURRAY, E. A. and HABER, B., Science 190 (1975) 682.PubMedCrossRefGoogle Scholar
  22. 22.
    TANNOCK, I. F., Br. J. Cancer 22 (1968) 258.PubMedCrossRefGoogle Scholar
  23. 23.
    TANNOCK, I. F., Cancer Res. 30 (1970) 2470.PubMedGoogle Scholar
  24. 24.
    TUAN, D., SMITH, S., FOLKMAN, J. and MERLER, F., Biochem. 12 (1973) 159.Google Scholar
  25. 25.
    THURMAN, G. B., SILVER, B. B., HOOPER, J. A., GIOVANELLA, B. C. and GOLDSTEIN, A. L., Proceedings of the 1st International Workshop on Nude Mice, Gustav Fischer Verlag, Stuttgart (1974).Google Scholar
  26. 26.
    WARREN, B. A. and SHUBIK, P., Lab Invest. 15 (1966) 464.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • B. Haber
    • 1
    • 2
    • 3
  • R. L. Suddith
    • 1
    • 2
    • 3
  • H. T. Hutchison
    • 1
    • 2
    • 3
  • P. J. Kelly
    • 1
    • 2
    • 3
  1. 1.Division of NeurobiologyThe Marine Biomedical InstituteUSA
  2. 2.Department of NeurologyUniversity of Texas Medical BranchGalvestonUSA
  3. 3.Department of Human Biological Chemistry and GeneticsUniversity of Texas Medical BranchGalvestonUSA

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