α-Melanotropin Receptors: Non-Identical Hormonal Message Sequences (Active Sites) Triggering Receptors in Melanocytes, Adipoctytes and CNS Cells

  • Alex Eberle
  • Robert Schwyzer
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 11)


α-Melanotropin (α-melanocyte-stimulating hormone, α-MSH), a pituitary tridecapeptide, exhibits strong effects on a variety of tissues. The best known is certainly the dramatic impact on the color change of cold-blooded vertebrates where α-MSH causes darkening of the skin by dispersion of the melanophore pigment granules. a-MSH seems also to control—at least partially—the pigmentation of mammals and men (35). Only a small number of extrapigmentary effects of α-melanotropin will be mentioned here as e.g. the lipolytic activity in rabbit adipose tissue (7, 45), the effects on learning and the central nervous system (11, 13, 46, 47, 58), and the activity on sebum secretion in the rat (49, 60).


Lipolytic Response Sebum Secretion Squalus Acanthias Tetrapeptide Sequence National Biomedical Research Foundation 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Alex Eberle
    • 1
  • Robert Schwyzer
    • 1
  1. 1.Institute of Molecular Biology and BiophysicsSwiss Federal Institute of Technology (ETH)ZürichSwitzerland

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