Specific Binding and Ability of Vasoactive Intestinal Octacosa-Peptide (VIP) to Activate Adenylate Cyclase in Isolated Pancreatic Acinar Cells from the Guinea Pig

  • Jean Christophe
  • Patrick Robberecht
  • Thomas P. Conlon
  • Jerry D. Gardner
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 11)


This is probably the first instance in which the specific binding of a gastrointestinal hormone to a digestive cell other than the hepatocyte has been studied. The vasoactive intestinal octacosa-peptide (VIP) was recently isolated from porcine upper small intestine (19) and its amino acid sequence has been determined (4, 12).


Specific Binding Adenylate Cyclase Acinar Cell Adenylate Cyclase Activity Pancreatic Acinar Cell 
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  1. 1.
    AMSTERDAM, A. and JAMIESON, J. D., J. Cell Biol. 63 (1974) 1037, 1057.PubMedCrossRefGoogle Scholar
  2. 2.
    BATAILLE, D., FREYCHET, P. and ROSSELIN, G., Endocrinology 95 (1974) 713.PubMedCrossRefGoogle Scholar
  3. 3.
    BIRNBAUMER, L. and POHL, S. L., J. Biol. Chem. 248 (1973) 2056.PubMedGoogle Scholar
  4. 4.
    BODANSZKY, M., KLAUSNER, Y. S. and SAID, S. I., Proc. Nat. Acad. Sci. USA 70 (1973) 382.PubMedCrossRefGoogle Scholar
  5. 5.
    DE MEYTS, P., ROTH, J., NEVILLE, D. M., GAVIN, J. R. and LESNIAK, M. A., Biochem. Biophys. Res. Commun. 55 (1973) 154.PubMedCrossRefGoogle Scholar
  6. 6.
    DESBUQUOIS, B., LAUDAT, M. H. and LAUDAT, P., Biochem. Biophys. Res. Commun. 53 (1973) 1187.CrossRefGoogle Scholar
  7. 7.
    DESBUQUOIS, B., Eur. J. Biochem, 46 (1974) 439.PubMedCrossRefGoogle Scholar
  8. 8.
    DESCHODT-LANCKMAN, M., ROBBERECHT, P., DE NEEF, P., LABRIE, F. and CHRISTOPHE, J., Gastroenterology 68 (1975) 318.PubMedGoogle Scholar
  9. 9.
    FRANDSEN, E. K. and MOODY, A. J., Horm. Metab. Res. 5 (1973) 196.CrossRefGoogle Scholar
  10. 10.
    HUNTER, W. M., and GREENWOOD, F. C, Nature 194 (1972) 495.CrossRefGoogle Scholar
  11. 11.
    MAROIS, C., NORISSET, J. and DUNNIGAN, J. , Rev. Can. Biol. 31 (1972) 253.PubMedGoogle Scholar
  12. 12.
    MUTT, V. and SAID, S. I., Eur. J. Biochem. 42 (1974) 581.PubMedCrossRefGoogle Scholar
  13. 13.
    ROBBERECHT, P., DESCHODT-LANCKMAN, M., DE NEEF, P., BORGEAT, P. and CHRISTOPHE, J., FEBS Letters 43 (1974) 139.PubMedCrossRefGoogle Scholar
  14. 14.
    RODBELL, M., BIRNBAUMER, L. and POHL, S. L., J. Biol. Chem. 245 (1970) 718.PubMedGoogle Scholar
  15. 15.
    RODBELL, M., KRANS, H. M. J., POHL, S. L. and BIRNBAUMER, L., J. Biol. Chem. 246 (1971) 1861.PubMedGoogle Scholar
  16. 16.
    RODBELL, M., LIN, M. C. and SALOMON, Y., J. Biol. Chem. 249 (1974) 59.PubMedGoogle Scholar
  17. 17.
    ROTH, J., Metabolism 22 (1973) 1059.PubMedCrossRefGoogle Scholar
  18. 18.
    RUTTEN, W. J., DE PONT, J. J. H. H. M. and BONTING, S. L., Biochim. Biophys. Acta 274 (1972) 201.PubMedCrossRefGoogle Scholar
  19. 19.
    SAID, S. I, and MUTT, V., Eur. J. Biochem. 28 (1972) 199.PubMedCrossRefGoogle Scholar
  20. 20.
    SALOMON, Y., LONDOS, C. and RODBELL, M., Anal. Biochem. 58 (1974) 541.PubMedCrossRefGoogle Scholar
  21. 21.
    SCHWARTZ, C. J., KIMBERG, D. V., SHEERIN, H. E., FIELD, M. and SAID, S. I. (1975) in press.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Jean Christophe
    • 1
  • Patrick Robberecht
    • 1
  • Thomas P. Conlon
    • 1
  • Jerry D. Gardner
    • 1
  1. 1.Section on Gastroenterology, Digestive Diseases BranchNational Institute of Arthritis, Metabolism, and Digestive DiseasesBethesdaUSA

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