Evidence for a Gradient of Adhesive Specificity in the Developing Chick Retina
The evidence summarized in the preceding chapter by Glaser et al. shows that cell-cell receptors occur on developing brain cells. As might be expected from such a complex tissue, there appears to be a multitude of receptor specificities and these have both spatially and temporally different distributions. Recent success in extracting elements of these recognition systems has raised the hope of answering one of the basic questions about cell recognition by characterizing a receptor at the molecular level. Another major question, perhaps even more difficult to answer, concerns the functional role of cell-cell receptors during embryonic development. Work in this field proceeds on the assumption that such receptors play an essential role in the formation of tissues from cells, and while this is a reasonable guess, direct evidence showing cell-cell receptor involvement in tissue morphogenesis is lacking. Consequently experiments have been initiated to examine the relationship between patterns of cell-cell adhesion and normal cellular patterns which occur during the development of the brain.
KeywordsOptic Tectum Neural Retina Probe Cell Adhesive Specificity Chick Retina
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