Malignant Transformation by Herpesviruses

  • Fred Rapp
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 5)


Determination of the etiology of human neoplasia has presented a formidable challenge. Since Ellerman and Bang (1908) and subsequently Rous (1911) demonstrated early in this century that a transmissible agent could cause leukemia and sarcoma of chickens, scientists have engaged in a frustrating quest for comparable human viruses. In the past decade, demonstration that DNA containing papovaviruses can lytically infect some cells and can both transform cells in culture and produce tumors in experimental animals (Butel, Tevethia and Melnick, 1972) has initiated investigation of multipotential viruses indigenous to human populations.


Herpes Simplex Virus Thymidine Kinase Virus Antigen Burkitt Lymphoma Human Herpesvirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adam, E., R. H. Kaufman, J. L. Melnick, A. H. Levy, and W. E. Rawls. 1972. Am. J. Epidemiol. 96:427–442.PubMedGoogle Scholar
  2. Adldinger, H.K., and B. W. Calnek. 1973. J. Nat. Cancer Inst. 50: 1287–1298.Google Scholar
  3. Albrecht, T., and F. Rapp. 1973. Virology, in press.Google Scholar
  4. Aurelian, L., B. Schumann, R. L. Marcus, and H. J. Davis. 1973. Science 181:161–164.PubMedCrossRefGoogle Scholar
  5. Aurelian, L., J. D. Strandberg, L. V. Meléndez, and L. A. Johnson. 1971. Science 174:704–707.PubMedCrossRefGoogle Scholar
  6. Benjamin, T. L. 1972. Current Topics in Microbiology and Immunology 59:107–133.PubMedCrossRefGoogle Scholar
  7. Butel, J. S., S. S. Tevethia, and J. L. Melnick. 1972. Adv. in Cancer Res. 15:1–55.CrossRefGoogle Scholar
  8. Collard, W., H. Thornton, and M. Green. 1973. Nature New Biol. 243:264–266.PubMedGoogle Scholar
  9. Collard, W., H. Thornton, M. Mizell, and M. Green. 1973. Science 181:448–449.PubMedCrossRefGoogle Scholar
  10. Darai, G., and K. Munk. 1973. Nature New Biol. 241:268–269.PubMedCrossRefGoogle Scholar
  11. Doller, E., R. Duff, and F. Rapp. 1973. Intervirology, in press.Google Scholar
  12. Duff, R., E. Doller, and F. Rapp. 1973. Science 180:79–81.PubMedCrossRefGoogle Scholar
  13. Duff, R., and F. Rapp. 1971. J. Virol. 8:469–477.PubMedGoogle Scholar
  14. Duff, R., and F. Rapp. 1973. J. Virol., in press.Google Scholar
  15. Ellerman, V., and O. Bang. 1908. Centralbl. f.Bakt., Abt. I (Orig.) 46:595–609.Google Scholar
  16. Frenkel, N., B. Roizman, E. Cassai, and A. Nahmias. 1972. Proc. Nat. Acad. Sei. U.S.A. 69:3784–3789.CrossRefGoogle Scholar
  17. Glaser, R., R. G. Duff, and F. Rapp. 1972. Cancer Res. 32:2803–2806.PubMedGoogle Scholar
  18. Glaser, R., and M. Nonoyama. 1973. Science 179:492–493.PubMedCrossRefGoogle Scholar
  19. Glaser, R., M. Nonoyama, B. Decker, and F. Rapp. 1973. Virology, in press.Google Scholar
  20. Glaser, R., and F. Rapp. 1972. J. Virol. 10:288–296.PubMedGoogle Scholar
  21. Granoff, A. 1972. Fed. Proc. 31:1626–1633.PubMedGoogle Scholar
  22. Hausen, H. zur, V. Diehl, H. Wolf, H. Schulte-Holthausen, and U. Schneider. 1972. Nature New Biol. 237:189–190.Google Scholar
  23. Hausen, H. zur, H. Schulte-Holthausen, G. Klein, W. Henle, G. Henle, P. Clifford, and L. Santesson. 1970. Nature 228:1056–1058.PubMedCrossRefGoogle Scholar
  24. Henle, G., W. Henle, G. Klein, P. Gunven, P. Clifford, R. H. Morrow, and J. L. Ziegler. 1971. J. Nat. Cancer Inst. 46:861–871.PubMedGoogle Scholar
  25. Hinze, H. C, and D. L. Wegner. 1973. Cancer Res. 33:1434–1435.PubMedGoogle Scholar
  26. Hollinshead, A. C., and G. Tarro. 1973. Science 179:698–700.PubMedCrossRefGoogle Scholar
  27. Hsiung, G. D., C. K. Y. Fong, and P. A. Gross. 1973. Cancer Res. 33:1436–1442.PubMedGoogle Scholar
  28. Josey, W. E., A. J. Nahmias, and Z. M. Naib. 1968. Am. J. Obstet. Gynecol. 101:718–729.Google Scholar
  29. Kieff, E., B. Hoyer, S. Bachenheimer, and B. Roizman. 1972. J. Virol. 9:738–745.PubMedGoogle Scholar
  30. Klein, G. 1973. The Epstein-Barr virus (EBV). In A. S. Kaplan [Editor], The Herpesviruses. Academic Press, New York.Google Scholar
  31. Klein, G., G. Pearson, A. Rabson, D. V. Ablashi, L. Falk, L. Wolfe, F. Deinhardt, and H. Rabin. 1973. Int. J. Cancer, in press.Google Scholar
  32. Kutinova, L., V. Vonka, and J. Broucek, 1973. J. Nat. Cancer Inst. 50:759–766.PubMedGoogle Scholar
  33. Laufs, R., and B. Fleckenstein. 1972. Med. Microbiol. Immunol. 158:135–146.PubMedCrossRefGoogle Scholar
  34. Ludwig, H. 0., N. Biswal, and M. Benyesh-Melnick. 1972. Virology 49:95–101.PubMedCrossRefGoogle Scholar
  35. Martin, G. S. 1970. Nature 227:1021–1023.PubMedCrossRefGoogle Scholar
  36. Meléndez, L. V., R. D. Hunt, M. D. Daniel, C. E. O. Fraser, H. H. Barahona, N. W. King, and F. G. Garcia. 1972. Fed. Proc. 31: 1643–1650.PubMedGoogle Scholar
  37. Miller, G., and M. Lipman. 1973. Proc. Nat. Acad. Sei. U.S.A. 70:190–194.CrossRefGoogle Scholar
  38. Munyon, W., E. Kraiselburd, D. Davis, and J. Mann. 1971. J. Virol. 7:813–820.PubMedGoogle Scholar
  39. Munyon, W. Personal communication.Google Scholar
  40. Nonoyama, M., and J. S. Pagano. 1971. Nature New Biol. 233:103–106.PubMedGoogle Scholar
  41. Purchase, H. G. 1972. Fed. Proc. 31:1634–1638.PubMedGoogle Scholar
  42. Rapp, F. 1973. J. Nat. Cancer Inst. 50:825–832.PubMedGoogle Scholar
  43. Rapp, F. Unpublished observations.Google Scholar
  44. Rapp, F., R. Conner, R. Glaser, and R. Duff. 1972. J. Virol. 9: 1059–1063.PubMedGoogle Scholar
  45. Rapp, F., J. H. Li, and M. Jerkofsky. 1973. Virology, in press.Google Scholar
  46. Rawls, W. E., K. Iwamoto, E. Adam, J. L. Melnick, and G. H. Green. 1970. Lancet 2:1142.PubMedCrossRefGoogle Scholar
  47. Rawls, W. E., W. A. F. Tompkins, and J. L. Melnick. 1969. Amer. J. Epidemiol. 89:547–554.Google Scholar
  48. Reedman, B. M., and G. Klein. 1973. Int« J. Cancer 11:499–520.PubMedCrossRefGoogle Scholar
  49. Rous, P. 1911. J. Exp. Med. 13:397–411.PubMedCrossRefGoogle Scholar
  50. Sabin, A. B., and G. Tarro. 1973. Proc« Nat. Acad. Sei* U.S.A., in press.Google Scholar
  51. St. Jeor, S., and F. Rapp. 1973a. J. Virol. 11:986–990.Google Scholar
  52. St. Jeor S. C, and F. Rapp. 1973b. Science, in press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Fred Rapp
    • 1
  1. 1.Department of Microbiology, College of Medicine, Milton S. Hershey Medical CenterThe Pennsylvania State UniversityHersheyUSA

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