Human Acute Leukemia: Increasing Evidence for Involvement of Type-C Rna Tumor Viruses

  • Robert C. Gallo
  • Robert E. Gallagher
  • Hrishikes Mondal
  • David H. Gillespie
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 5)


Type-C RNA tumor viruses have been associated with the development of leukemia/lymphoma in birds, rodents, cats, and subhuman primates. In man, however, morphologically identifiable virus particles have not been definitively identified in cells from patients with these diseases despite extensive searches by skilled electron microscopists. In recent years remarkable progress has been made in the biochemical and immunological characterization of RNA tumor viruses, and by these more sensitive parameters, “foot-prints” of RNA tumor viruses were first identified in human leukemic cells (Gallo, Yang, and Ting, 1970). The viral “footprints” so far identified consist of the two essential replicative components of RNA tumor viruses, intact 70S (or subunit 35S) virus-specific RNA (Baxt, Hehlman, and Spiegelman, 1972; Gallo et al., in press; Gallagher et al., in press) and virus-related RNA-directed DNA polymerase (reverse transcriptase) (Sarngadharan et al., 1972; Todaro and Gallo, 1973; Gallagher et al., submitted for publication).


Acute Myelogenous Leukemia Microsomal Fraction Human Leukemic Cell Avian Myeloblastosis Virus Murine Sarcoma Virus 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Robert C. Gallo
    • 1
  • Robert E. Gallagher
    • 1
  • Hrishikes Mondal
    • 1
  • David H. Gillespie
    • 1
  1. 1.Laboratory of Tumor Cell BiologyNational Cancer Institute, U.S. National Institutes of HealthUSA

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