Use of Pseudotypes of Vesicular Stomatitis Virus to Study Cellular Resistance to Murine Rna Tumor Viruses

  • Alice S. Huang
  • Peter Besmer
  • David Baltimore
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 5)


Pseudotypes of vesicular stomatitis virus (VSV) genomes coated by the surface envelope from an N-tropic or a B-tropic tumor virus grow equally well in cells homozygous for either the Fv-1 n or Fv-1 p alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step following attachment and penetration.


Chinese Hamster Ovary Cell Chinese Hamster Ovary Vesicular Stomatitis Virus Murine Cell Cellular Resistance 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Alice S. Huang
    • 1
    • 2
  • Peter Besmer
    • 1
    • 2
  • David Baltimore
    • 1
    • 2
  1. 1.Department of Microbiology and Molecular GeneticsHarvard Medical SchoolBostonUSA
  2. 2.Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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