Use of Pseudotypes of Vesicular Stomatitis Virus to Study Cellular Resistance to Murine Rna Tumor Viruses
Pseudotypes of vesicular stomatitis virus (VSV) genomes coated by the surface envelope from an N-tropic or a B-tropic tumor virus grow equally well in cells homozygous for either the Fv-1 n or Fv-1 p alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step following attachment and penetration.
KeywordsChinese Hamster Ovary Cell Chinese Hamster Ovary Vesicular Stomatitis Virus Murine Cell Cellular Resistance
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