Studies of SV40 DNA Replication

  • George C. Fareed
  • Norman P. Salzman
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 5)


The genome of Simian Virus 40 (SV40) is a covalently closed duplex DNA molecule of 3.6 x 106 daltons. We have been concerned with defining the mechanism by which SV40 DNA is replicated during the permissive infection. The small size of SV40 DNA and its replicative intermediates has permitted both the biophysical and biochemical studies which we shall summarize in this communication.


Genome Length Template Strand Primary Initiation Daughter Strand Alkaline Sucrose Gradient 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • George C. Fareed
    • 1
    • 2
  • Norman P. Salzman
    • 2
  1. 1.Department of Biological ChemistryHarvard Medical SchoolBostonUSA
  2. 2.Laboratory of Biology of Viruses, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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