Studies of SV40 DNA Replication
The genome of Simian Virus 40 (SV40) is a covalently closed duplex DNA molecule of 3.6 x 106 daltons. We have been concerned with defining the mechanism by which SV40 DNA is replicated during the permissive infection. The small size of SV40 DNA and its replicative intermediates has permitted both the biophysical and biochemical studies which we shall summarize in this communication.
KeywordsGenome Length Template Strand Primary Initiation Daughter Strand Alkaline Sucrose Gradient
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