Studies on Non-Transforming Host Range Mutants of Polyoma Virus
Two kinds of conditional lethal mutants of polyoma virus have been isolated and partially characterized. The most widely studied are the temperature-sensitive mutants which comprise at least four distinct groups based on complementation and other physiological tests. The second kind of mutant to be isolated is of the host range type; these mutants are selected to grow on polyoma-transformed mouse cells but not on normal mouse cells. Table 1 gives the selected properties of these two general classes of mutants. Progress in the characterization of temperature-sensitive and host range mutants has recently been reviewed (Benjamin, 1972).
KeywordsWild Type Virus Polyoma Virus Permissive Function Avian Sarcoma Virus Cell Surface Change
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