Studies on Non-Transforming Host Range Mutants of Polyoma Virus

  • Thomas L. Benjamin
  • Leonard Norkin
  • Emanuel Goldman
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 5)


Two kinds of conditional lethal mutants of polyoma virus have been isolated and partially characterized. The most widely studied are the temperature-sensitive mutants which comprise at least four distinct groups based on complementation and other physiological tests. The second kind of mutant to be isolated is of the host range type; these mutants are selected to grow on polyoma-transformed mouse cells but not on normal mouse cells. Table 1 gives the selected properties of these two general classes of mutants. Progress in the characterization of temperature-sensitive and host range mutants has recently been reviewed (Benjamin, 1972).


Wild Type Virus Polyoma Virus Permissive Function Avian Sarcoma Virus Cell Surface Change 
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Copyright information

© Springer Science+Business Media New York 1975

Authors and Affiliations

  • Thomas L. Benjamin
    • 1
  • Leonard Norkin
    • 2
  • Emanuel Goldman
    • 3
  1. 1.Department of PathologyHarvard Medical SchoolUSA
  2. 2.Department of MicrobiologyUniversity of MassachusettsUSA
  3. 3.Department of PathologyHarvard Medical SchoolBostonUSA

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