The Role of Plasmids in Crown-Gall Formation by A.Tumefaciens

  • J. Schell
Part of the NATO Advanced Study Institutes Series book series (NSSA, volume 3)


The gram-negative bacterium Agrobacterium tumefaciens induces crown-gall tumours in many, mostly dicotyledonous, plants. Once the tumour induction has taken place, the autonomous proliferation of the tumour cells becomes independent of the bacteria since no bacteria can be detected intracellularly in plant cells that are being transformed or in the cells of sterile crown-gall tumours grown in vitro (1). These facts led Braun (2) to introduce the concept of a Tumor Inducing Principle (TIP) that would be transferred from the bacteria to the plant cell thus producing the neoplasmic transformation.


Agrobacterium Strain Phage Particle Large Plasmid Temperate Phage Caesium Chloride 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • J. Schell
    • 1
  1. 1.Laboratorium voor GenetikaR.U.GGentBelgium

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