Recording of Extracellular Electrical Activity
Much of smooth muscle electrophysiology, especially of the gastrointestinal tract, involves the recording of extracellular potentials rather than transmembrane potentials. This has been necessitated in large part by the technical difficulties inherent in intracellular recording from such small, mechanically active cells, especially when recording is attempted in vivo. The relative ease of extracellular recording can be offset, however, by the configurational complexity of the resultant tracings. This can be attributed, in part, to the patterns of extracellular current flow associated with changes in membrane potential of a core conductor. Many of the properties of core conductors are exhibited by smooth muscle cells and by some smooth muscle tissues.
KeywordsCurrent Flow Recording Electrode Lead Wire Silver Wire Smooth Muscle Tissue
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