Advertisement

Smooth Muscle pp 673-687 | Cite as

Analysis of Bulk-Diffusion-Limited Exchange of Ions in Smooth Muscle Preparations

  • A. W. Jones

Abstract

Smooth muscle cells are embedded in a matrix of extracellular connective tissue and intervening water. In many preparations, this can account for half or more of the tissue volume. Therefore, studies which attempt to define isotope kinetics of smooth muscle per se have the added difficulty of determining the modifications imposed by movement of tracer through the extracellular space. There is also the related problem of defining flux components whose exchange with the external solution may be entirely limited by diffusion through the extracellular matrix. These problems are not unique to smooth muscle research, as evidenced by earlier approaches to diffusion—skeletal muscle ion exchange properties (Harris and Burn, 1949; Keynes, 1954).

Keywords

Smooth Muscle Bulk Diffusion Plane Sheet Kinetic Component Taenia Coli 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bagby, R. M., Young, A. M., Dotson, R. S., Fisher, B. A., and McKinnon, K. 1971. Contraction of single smooth muscle cells from Bufo marinus stomach. Nature, 234:351–352.PubMedCrossRefGoogle Scholar
  2. Brading, A. F. 1967. A constant flow apparatus for measuring radioactive ion effluxes from guinea-pig taenia coli. J. Physiol., 192:15–16P.Google Scholar
  3. Brading, A. F. and Jones, A. W. 1969. Distribution and kinetics of CoEDTA in smooth muscle and its use as an extracellular marker. J. Physiol., 200:387–401.PubMedGoogle Scholar
  4. Casteels, R. 1969. Calculation of the membrane potential in smooth muscle cells of the guinea-pig’s taenia coli by the Goldman equation. J. Physiol, 205:193–208.PubMedGoogle Scholar
  5. Crank, J. 1956.The Mathematics of Diffusion. Oxford University Press, London.Google Scholar
  6. Dick, D. A. T. and Lea, E. J. A. 1964. Na fluxes in single toad oocytes with special reference to the effect of external and internal Na concentration on Na efflux. J. Physiol, 174:55–90.PubMedGoogle Scholar
  7. Frazer, A., Secunda, S. K., and Mendels, J. 1972. A method for the determination of sodium, potassium, magnesium, and lithium concentrations in erythrocytes.Clin. Chim. Acta, 36:499–509.PubMedCrossRefGoogle Scholar
  8. Goodford, P. J. 1965. The loss of radioactive 45Calcium from the smooth muscle of the guinea-pig taenia coli.J. Physiol, 776:180–190.Google Scholar
  9. Goodford, P. J. 1970. Ion movements in smooth muscle. In: Membranes and Ion Transport, Vol. 2, Chapter 2. Ed. by Bittar, E. E. Wiley, New York.Google Scholar
  10. Haid, A. 1952. Statistical Theory with Engineering Applications. Wiley, New York.Google Scholar
  11. Harris, E. J. and Burn, G. P. 1949. The transfer of sodium and potassium ions between muscle and surrounding medium. Trans. Faraday Soc., 45:508–528.CrossRefGoogle Scholar
  12. Huxley, A. F. 1960. Appendix 2 to chapter by Solomon, A. K. In: Mineral Metabolism, Vol. 1, Part A, pp. 163–166. Ed. by Comar, C. L. and Bronner, F. Academic Press, New York.Google Scholar
  13. Jones, A. W. 1970a. Factors affecting sodium exchange and distribution in rabbit myometrium. Physiol Chem. Phys., 2:79–95.Google Scholar
  14. Jones, A. W. 1970b. Effects of progesterone treatment on potassium accumulation and permeation in rabbit myometrium. Physiol Chem. Phys., 2:151–167.Google Scholar
  15. Jones, A. W. and Karreman, G. 1969. Ion exchange properties of the canine carotid artery. Biophys. J., 9:884–909.PubMedCrossRefGoogle Scholar
  16. Jones, A. W. and Swain, M. L. 1972. Chemical and kinetic analysis of sodium distribution in canine lingual artery. Am. J. Physiol., 223:1110–1118.PubMedGoogle Scholar
  17. Jones, A. W., Somlyo, A. P., and Somlyo, A. V. 1973. Potassium accumulation in smooth muscle and associated ultrastructural changes. J. Physiol, 232:247–273.PubMedGoogle Scholar
  18. Keynes, R. D. 1954. The ionic fluxes in frog muscle. Proc. R. Soc. B, 742:359–382.CrossRefGoogle Scholar
  19. Llaurado, J. G. 1969. Digital computer simulation as an aid to the study of arterial wall Na kinetics. J. Appl. Physiol, 27:544–550.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • A. W. Jones
    • 1
  1. 1.Department of PhysiologyUniversity of Missouri School of MedicineColumbiaUSA

Personalised recommendations