Smooth Muscle pp 391-401 | Cite as

The Peristaltic Reflex

  • H. W. Kosterlitz
  • A. J. Watt


Bayliss and Starling (1899) showed that local stimulation of the intestine causes inhibition below the point of stimulation and excitation above it; a wave of contraction of the circular muscle coat travels in an aboral direction. They concluded from their experiments that the extrinsic innervation is not essential for the described reflex responses which are controlled by the intrinsic nerve plexuses.


Longitudinal Muscle Circular Muscle Organ Bath Peristaltic Activity Longitudinal Contraction 
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  1. Bayliss, W. M. and Starling, E. H. 1899. The movements and innervation of the small intestine. J. Physiol (Lond.) 24:99–143.Google Scholar
  2. Brownlee, G. and Harry, J. 1963. Some pharmacological properties of the circular and longitudinal muscle strips from the guinea-pig isolated ileum. Br. J. Pharmacol., 21:544–554.Google Scholar
  3. Bülbring, E. and Crema, A. 1958. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br. J. Pharmacol., 15:444–457.Google Scholar
  4. Bülbring, E. and Crema, A. 1959. The release of 5-hydroxytryptaine in relation to pressure exerted on the intestinal mucosa. J. Physiol. (Lond.), 146:18–28.Google Scholar
  5. Bülbring, E. and Lin, R. C. Y. 1958. The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J. Physiol. (Lond.), 140:381–407.Google Scholar
  6. Bülbring, E., Crema, A., and Saxby, O. B. 1958a. A method for recording peristalsis in isolated intestine. Br. J. Pharmacol., 13:440–443.Google Scholar
  7. Bülbring, E., Lin, R. C. Y., and Schofield, G. 1958b. An investigation of the peristaltic reflex in relation to anatomical observations. Quart. J. Exp. Physiol, 43:23–31.Google Scholar
  8. Burnstock, G., Campbell, G., and Rand, M. J. 1966. The inhibitory innervation of the taenia of the guineapig caecum. J. Physiol. (Lond.), 182:504–526.Google Scholar
  9. Burnstock, G., Campbell, G., Satchell, D., and Smythe, A. 1970. Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br. J. Pharmacol., 40:668–688.PubMedCrossRefGoogle Scholar
  10. Crema, A., Frigo, G. M., and Lecchini, S. 1970. A pharmacological analysis of the peristaltic reflex in the isolated colon of the guinea-pig or cat. Br. J. Pharmacol., 39:334–345.PubMedCrossRefGoogle Scholar
  11. Diament, M. L., Kosterlitz, H. W., and McKenzie, J. 1961. Role of the mucous membrane in the peristaltic reflex in the isolated ileum of the guinea-pig. Nature. (Lond.), 190:1205–1206.CrossRefGoogle Scholar
  12. Erspamer, V. 1966. Peripheral physiological and pharmacological actions of indolealkylamines. In: 5-Hydroxytryptamine and related indolealkylamines, Handbook of Experimental Pharmacology, Vol. 19, pp. 245–359. Ed. by Erspamer, V., Springer Verlag, Berlin.CrossRefGoogle Scholar
  13. Feldberg, W. and Lin, R. C. Y. 1949. The action of local anaesthetics and D-tubocurarine on the isolated intestine of the rabbit and guinea-pig. Br. J. Pharmacol., 4:33–44.Google Scholar
  14. Frigo, G. M. and Lecchini, S. 1970. An improved method for studying the peristaltic reflex in the isolated colon. Br. J. Pharmacol, 39:346–356.PubMedCrossRefGoogle Scholar
  15. Ginzel, K. H. 1959. Are mucosal nerve fibres essential for the peristaltic reflex? Nature (Lond.), 184:1235–1236.CrossRefGoogle Scholar
  16. Gregory, J. E. and Bentley, G. A. 1968. The peristaltic reflex in the isolated guinea-pig ileum during drug- induced spasm of the longitudinal muscle. Aust. J. Exp. Biol med. Sci., 46:1–16.PubMedCrossRefGoogle Scholar
  17. Harry, J. 1963. The action of drugs on the circular muscle strip from the guinea-pig isolated ileum. Br. J. Pharmacol, 20:399–417.Google Scholar
  18. Holman, M. E. and Hughes, J. R. 1965. An inhibitory component of the response to distension of the rat ileum. Nature. (Lond.), 207:641–642.CrossRefGoogle Scholar
  19. Hukuhara, T., Nakayama, S., and Nanba, R. 1960. The effects of 5-HT upon the intestinal motility, especially with respect to the intestinal mucosal intrinsic reflex. Jap. J. Physiol, 70:420–426.CrossRefGoogle Scholar
  20. Hukuhara, T., Neya, T., and Tsuchiya, K. 1969. The efl’ect of the intrinsic mucosal reflex upon the propagation of intestinal contractions. Jap. J. Physiol, 19:824–833.CrossRefGoogle Scholar
  21. Koelle, G. B., Koelle, E. S., and Friedenwald, J. S. 1950. The eff’ect of inhibition of specific and nonspecific Cholinesterase on motility of the isolated ileum. J. Pharmac. Exp. Ther., 100:180–191.Google Scholar
  22. Kosteritz, H. W. 1967. Intrinsic intestinal reflexes. Am. J. Dig. Dis. N. S., 12:245–254.CrossRefGoogle Scholar
  23. Kosterlitz, H. W. 1968. Intrinsic and extrinsic nervous control of motiHty of the stomach and the intestines. In: Handbook of Physiology, Alimentary Canal, Vol. 4, pp. 2147–2171. Ed. by Code, C. F., American Physiological Society, Washington, D.C.Google Scholar
  24. Kosterlitz, H. W. and Lees, G. M. 1964. Pharmacological analysis of intrinsic intestinal reflexes. Pharmacol Rev., 16:301–339.PubMedGoogle Scholar
  25. Kosterlitz, H. W. and Robinson, J. A. 1957. Inhibition of the peristaltic reflex of the isolated guinea-pig ileum. J. Physiol (Lond.), 136:249–262.Google Scholar
  26. Kosterlitz, H. W. and Robinson, J. A. 1959. Reflex contractions of the longitudinal muscle coat of the isolated guinea-pig ileum. J. Physiol (Lond.), 146:369–319.Google Scholar
  27. Kosterlitz, H. W. and Watt, A. J. 1963. Reflex contractions of the longitudinal muscle of the isolated guinea-pig ileum, resistant to the inhibitory actions of morphine and hyoscine. J. Physiol (Lond.), 169:115–116P.Google Scholar
  28. Kosterlitz, H. W., Pirie, V. W., and Robinson, J. A. 1956. The mechanism of the peristaltic reflex in the isolated guinea-pig ileum. J. Physiol. (Lond.), 133:681–694.Google Scholar
  29. Kosterlitz, H. W., Lydon, R. J., and Watt, A. J. 1970. The effects of adrenaline, noradrenaline and isoprenaline on inhibitory α- and β-adrenoreceptors in the longitudinal muscle of the guinea-pig ileum. Br. J. Pharmacol., 39:398–413.PubMedCrossRefGoogle Scholar
  30. Kottegoda, S. R. 1969. An analysis of possible nervous mechanisms involved in the peristaltic reflex. J. Physiol. (Lond.), 200:687–712.Google Scholar
  31. McDougal, M. D. and West, G. B. 1954. The inhibition of the peristaltic reflex by sympathomimetic amines. Brit. J. Pharmacol., 9:131–137.PubMedGoogle Scholar
  32. Paton, W. D. M. 1957. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br. J. Pharmacol., 12:119–127.Google Scholar
  33. Paton, W. D. M. and Vane, J. R. 1963. An analysis of the responses of the isolated stomach to electrical stimulation and drugs. J. Physiol. (Lond.), 165:10–46.Google Scholar
  34. Paton, W. D. M. and Zaimis, E. J. 1949. The pharmacological actions of polymethylene bistrimethyl-ammonium salts. Br. J. Pharmacol., 4:381–400.Google Scholar
  35. Planelles, J. 1925. Mutterkornstudien. 1. Über das Zusammenwirken von Ergotamin und Adrenalin am Meerschweinchendarm. Namyn-Schmiedebergs Arch. Exp. Path. Pharmak., 105:38–48.CrossRefGoogle Scholar
  36. Schaumann, O., Jochum, K., and Schmidt, H. 1953. Analgetika und Darmmotorik. II. Zum Mechanismus der Peristaltik. Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak., 279:302–309.Google Scholar
  37. Sperelakis, N. and Prosser, C. L. 1959. Mechanical and electrical activity in intestinal smooth muscle. Am. J. Physiol, 196:850–856.PubMedGoogle Scholar
  38. Trendelenburg, P. 1917. Physiologische und pharmakologische Versuche über die Dünndarmperistaltik. Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak., 81:55–129.CrossRefGoogle Scholar
  39. Watt, A. J. 1966. Inhibitory mechanisms in guinea-pig isolated ileum. Ph.D. Thesis, University of Aberdeen.Google Scholar
  40. Wood, J. D., and Perkins, W. E. 1970. Mechanical interaction between longitudinal and circular axes of the small intestine. Am. J. Physiol, 218:762–768.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • H. W. Kosterlitz
    • 1
    • 2
  • A. J. Watt
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of AberdeenAberdeenScotland
  2. 2.Department of PhysiologyUniversity of ManchesterManchesterEngland

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