The major advantage in using preparations from the large intestine for the examination of the pharmacology of autonomic neuromuscular transmission is that different types of nerve, which can be stimulated separately (or almost so), affect a single piece of tissue. Three classes of efferent nerves, each releasing a different transmitter, can be activated. The substances released are noradrenaline, from adrenergic nerves, acetylcholine, from cholinergic nerves, and an unidentified inhibitory transmitter, from enteric inhibitory nerves. There is evidence that some noncholinergic excitatory nerves may affect the muscle of the large intestine, but such nerves will not be considered here.
KeywordsLarge Intestine Small Mammal Distal Colon Longitudinal Muscle Myenteric Plexus
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