Smooth Muscle pp 339-345 | Cite as

Stimulation with High Potassium

  • G. B. Weiss


In the normal sequence of physiological events leading from excitation to contraction in smooth muscle, a depolarizing stimulus initiates a series of steps that eventually result in a contractile response. Experimentally, a dissociation between events related to excitation and those occurring subsequent to this is of value in order to study and to characterize the component cellular reactions in an unambiguous fashion. Development and use of high potassium solutions has been one of the more valuable approaches to these problems.


Smooth Muscle Contractile Response High Potassium Stimulatory Agent Intestinal Smooth Muscle 
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  1. Bianchi, C. P. 1969. Introduction: statement of the problem. Fed. Proc., 28:1624–1627.PubMedGoogle Scholar
  2. Brecht, K. and Gebert, G. 1971. The effect of potassium on vascular smooth muscle. In: Proc. Symp.Physiol. Pharmacol. Vase. Neuroeffector Systems, Interlaken 1969, pp. 312–322, S. Karger, Basel.Google Scholar
  3. Burnstock, G. and Prosser, C. L. 1960. Conduction in smooth muscles: comparative electrical properties.Am. J. Physiol., 799:553–559.Google Scholar
  4. Burnstock, G. and Straub, R. W. 1958. A method for studying the effects of ions and drugs on the resting and action potentials in smooth muscle with external electrodes. J. Physiol, 140:156–167.PubMedGoogle Scholar
  5. Casteels, R and Kuriyama, H. 1966. Membrane potential and ion content in the smooth muscle of the guinea-pig’s taenia coli at different external potassium concentrations. J. Physiol. (Lond.), 184:120–130.Google Scholar
  6. Daniel, E. E. 1963. On roles of calcium, strontium and barium in contraction and excitability of rat uterine muscle. Arch. Intern. Pharmacodyn., 74(5):298–349.Google Scholar
  7. Daniel, E. E. 1965. Attempted synthesis of data regarding divalent ions in muscle function. In: Muscle, pp. 295–313. Ed. by Paul, W. M. Daniel, E. E. Kay, C. M., and Monckton, G., Pergamon, London.Google Scholar
  8. Devine, C. E., Somlyo, A. V., and Somlyo, A. P. 1972. Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscles.J. Cell Biol, 52:690–718.PubMedCrossRefGoogle Scholar
  9. Durbin, R. P. and Jenkinson, D. H. 1961. The calcium dependence of tension development in depolarized smooth muscle.J. Physiol (Lond.), 757:90–96.Google Scholar
  10. Edman, K. A. P. and Schild, H. O. 1962. The need for calcium in the contractile responses induced by acetylcholine and potassium in the rat uterus. J. Physiol (Lond.), 161:424–441.Google Scholar
  11. Evans, D. H. L., Schild, H. O., and Thesleff, S. 1958. Effects of drugs on depolarized plain muscle.J.Physiol (Lond.), 745:474–485.Google Scholar
  12. Gabella, G. 1971. Caveolae intracellulares and sarcoplasmic reticulum in smooth muscle. J. Cell Sci.,8601–609.PubMedGoogle Scholar
  13. Goodford, P. J. 1966. An interaction between potassium and sodium in the smooth muscle of the guinea-pig taenia coli. J. Physiol (Lond.), 186:11–26.Google Scholar
  14. Goodford, P. J. 1967. The calcium content of the smooth muscle of the guinea-pig taenia coli. J. Physiol (Lond.), 792:145–157.Google Scholar
  15. Goodman, F. R. and Weiss, G. B. 1971a. Dissociation by lanthanum of smooth muscle responses to potassium and acetylcholine.Am. J. Physiol, 220:159–166Google Scholar
  16. Goodman, F. R. and Weiss, G. B. 1971b. Effects of lanthanum on 45Ca movements and on contractions induced by norepinephrine, histamine and potassium in vascular smooth muscle. J. Pharmacol Exp. Ther., 777:415–425.Google Scholar
  17. Goodman, F. R., Weiss, G. B., Weinberg, M. N., and Pomarantz, S. D. 1972. Effects of added or substituted potassium ion on 45Ca movements in rabbit aortic smooth muscle. Circ. Res., 31672–681.Google Scholar
  18. Hagiwara, S. and Takahashi, K. 1967. Surface density of calcium ions and calcium spikes in the barnacle muscle fiber membrane. J. Gen. Physiol., 50:583–601.PubMedCrossRefGoogle Scholar
  19. Hinke, J. A. M. 1965. Calcium requirements for noradrenahne and high potassium ion contraction in arterial smooth muscle. In: Muscle, pp. 269–284. Ed. by Paul, W. M., Daniel, E. E., Kay, C. M., and Monckton, G. Pergamon, London.Google Scholar
  20. Hodgkin, A. L. and Horowicz, P. 1960. Potassium contractures in single muscle fibres. J. Physiol. (Lond.), 755:386–403.Google Scholar
  21. Hudgins, P. M. and Weiss, G. B. 1968. Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium. J. Pharmacol. Exp. Ther., 759:91–97.Google Scholar
  22. Hurwitz, L., Battle, P., and Weiss, G. B. 1962. Action of the calcium antagonists cocaine and ethanol on contraction and potassium efflux of smooth muscle. J. Gen. Physiol, 45:315–332.CrossRefGoogle Scholar
  23. Hurwitz, L., Joiner, P. D., and Von Hägen, S. 1967a. Mechanical responses of intestinal smooth muscle in a calcium-free medium. Proc. Soc. Exp. Biol. Med., 725:518–522.Google Scholar
  24. Hurwitz, L., Von Hägen, S., and Joiner, P. D. 1967b. Acetylcholine and calcium on membrane permeability and contraction of intestinal smooth muscle. J. Gen. Physiol, 50:1157–1172.PubMedCrossRefGoogle Scholar
  25. Hurwitz, L., Joiner, P. D., and Von Hägen, S. 1967c. Calcium pools utilized for contraction in smooth muscle. Am. J. Physiol, 213:1299–1304.PubMedGoogle Scholar
  26. Krejci, I. and Daniel, E. E. 1970. Effects of altered external calcium concentrations on fluxes of calcium 45 in rat myometrium. Am. J. Physiol, 279:263–269.Google Scholar
  27. Kuriyama, H. 1970. Effects of ions and drugs on the electrical activity of smooth muscle. In: Smooth Muscle, pp. 366–395. Ed. by Bülbring, E., Brading, A. F., Jones, A. W., and Tomita, T. Williams and Wilkins, Baltimore, Maryland.Google Scholar
  28. Laszlo, D., Eckstein, D. M., Lewin, R., and Stern, K. G. 1952. Biological studies on stable and radioactive rare earth compounds. I. On the distribution of lanthanum in the mammalian organism. J. Nat.Cancer Inst., 75:559–571.Google Scholar
  29. Somlyo, A. V. and Somlyo, A. P. 1971. Strontium accumulation by sarcoplasmic reticulum and mitochondria in vascular smooth muscle. Science, 174 955–958.PubMedCrossRefGoogle Scholar
  30. Sperelakis, N. 1962. Ca45and Sr89movements with contraction of depolarized smooth muscle. Am.J.Physiol,Google Scholar
  31. Urakawa, N. and Holland, W. C. 1964. Ca++uptake and tissue calcium in K-induced phasic and tonic contraction in taenia coli. Am. J. Physiol, 207:873–876.PubMedGoogle Scholar
  32. Van Breemen, C. 1969. Blockade of membrane calcium fluxes by lanthanum in relation to vascular smooth muscle contractility. Arch. Int. Physiol Biochim., 77:710–716.PubMedCrossRefGoogle Scholar
  33. Van Breemen, C. and Daniel, E. E. 1966. The influence of high potassium depolarization and acetylcholine on calcium exchange in rat uterus. J. Gen. Physiol, 49:1299–1317.PubMedCrossRefGoogle Scholar
  34. Van Breemen, C., Farinas, B. R., Gerba, P., and McNaughton, E. D. 1972. Excitation-contraction coupling in rabbit aorta studied by the lanthanum method for measuring cellular calcium influx. Circ. Res., 50:44–54.CrossRefGoogle Scholar
  35. Weiss, G. B. 1972. Alterations in 45Ca distribution and movements in ileal longitudinal smooth muscle. Agents Actions, 2:246–256.PubMedCrossRefGoogle Scholar
  36. Weiss, G. B. and Goodman, F. R. 1969. Effects of lanthanum on contraction, calcium distribution and Ca45movements in intestinal smooth muscle.J. Pharmacol Exp. Ther., 769:46–55.Google Scholar
  37. Weiss, G. B. and Hurwitz, L. 1963. Physiological evidence for multiple calcium sites in smooth muscle. J. Gen. Physiol, 47:173–187.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • G. B. Weiss
    • 1
  1. 1.Department of PharmacologyUniversity of Texas Southwestern Medical SchoolDallasUSA

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