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A New NMR Microtechnique

  • Louis V. Haynes
  • Charles D. Sazavsky

Abstract

Proton nuclear magnetic resonance spectroscopy has proven to be an invaluable aid to the organic chemist for identifying unknown compounds. However, the method suffers from relatively poor sensitivity. This limitation is particularly aggravating to researchers involved with natural product isolation and small scale synthetic work. The amount of sample available is frequently less than the 3–5 mg which are normally required to obtain a reasonably good spectrum with a standard 5 mm sample tube. Furthermore, if the sample is purified by gas chromatography, the time required to collect a sufficieptly large sample can run into several hours, or even days. The need for a routine method of handling these microsamples has prompted us to explore sensitivity enhancement methods in our NMR service laboratory.

Keywords

Nuclear Magnetic Resonance Capillary Tube Outer Tube Radioactive Contamination Deuterated Chloroform 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Louis V. Haynes
    • 1
  • Charles D. Sazavsky
    • 1
  1. 1.Miami Valley LaboratoriesProcter & Gamble CompanyCincinnatiUSA

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