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Negative Skin Sensitization Test with KRS-5

  • Richard P. Oertel
  • Elvin A. Newmann

Abstract

KRS-5 (42 mole % T1Br + 58 mole % T1I) is known as a useful optical material for infrared transmission. References to it in the spectroscopy literature are usually accompanied by warnings that it is highly toxic. The toxicology literature, however, discusses only the adverse systemic effects of T1 compounds, effects that are seen when T1 is administered orally or subcutaneously or when it is absorbed through the skin from solution.l, 2 No information is directly applicable to the situation most commonly encountered in the spectroscopy laboratory, where human skin comes into direct contact with the smooth face of a large single crystal of KRS-5. This situation arises during routine handling of the crystals and when living skin is being studied by reflection techniques. There seems very little likelihood that such exposures could result in the absorption of enough T1 to provoke any systemic response, since the water solubility of KRS-5 is only 0.2 mg/ml water at 20°C.3

Keywords

Test Animal Adverse Systemic Effect Infrared Transmission Large Single Crystal Reflection Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    H. E. Stokinger, in Industrial Hygiene and Toxicology, F. A. Patty, Ed. (Interacience, New York, 1963), Vol. II, 2nd ed., p. 1138.Google Scholar
  2. 2.
    I. V. Sanotskii, Toksikol. Novykh Prom. Khim. Veshchestv No. 2, 94 (1961); Chem. Abstr. 97, 15450i (1962).Google Scholar
  3. 3.
    J. Tadayon, in Laboratory Methods in Infrared Spectroscopy, R. G. J. Miller, Ed. ( Heyden and Son, Ltd., London, 1965 ), p. 72.Google Scholar
  4. 4.
    E. V. Buehler, Arch. Dermatol. 91, 171 (1965).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • Richard P. Oertel
    • 1
  • Elvin A. Newmann
    • 1
  1. 1.The Procter and Gamble CompanyMiami Valley LaboratoriesCincinnatiUSA

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