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The Changing Role of Surgery in the Treatment of Cancer

  • Bernard Fisher
Part of the Cancer book series (C, volume 6)

Abstract

When consideration is given to recent advances and progress made in the treatment of cancer, little attention is directed toward those changes taking place that are probably as profound and as far reaching in consequence as are any in our time. To many—particularly those in other disciplines—the surgical approach to cancer is deemed anachronistic in concept. While categorically such may be true, the leading edge of that specialty is attempting to redefine the basis for cancer surgery so that it is in keeping with present understanding of tumor biology.

Keywords

Breast Cancer Primary Tumor Cancer Surgery Thoracic Duct Radical Mastectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alexander, P., 1972, Tumor immunology in perspective, in: Frontiers of Radiation Therapy and Oncology (J. M. Vaeth, ed.), pp. 213–222, Karger, New York.Google Scholar
  2. Alexander, P., and Hall, J. G., 1970, The role of immunoblasts in host resistance and immunotherapy of primary sarcomata, Adv. Cancer Res. 13:1.PubMedCrossRefGoogle Scholar
  3. Ashworth, R. T., 1869, A case of cancer in which cells similar to those in the tumours were seen in the blood after death, Aust. Med. J. 14:146.Google Scholar
  4. Barski, G., and Youn, J. K., 1969, Evolution of cell-mediated immunity in mice bearing an antigenic tumor: Influence of tumor growth and surgical removal, J. Natl. Cancer Inst. 43:111.PubMedGoogle Scholar
  5. Bartels, F., 1909, Das Lymphgefässystem, Gustav Fischer, Jena.Google Scholar
  6. Bosner, G. M., 1945, Microscopical study of evolution of mouse mammary cancer—Effect of milk factor and comparison with human disease, J. Pathol. Bacteriol. 57:413.CrossRefGoogle Scholar
  7. Burnet, F. M., 1967, Immunological aspects of malignant disease, Lancet 1:1171.PubMedCrossRefGoogle Scholar
  8. Cheatle, G. L., and Cutler, M., 1931, Tumours of the BreastTheir Pathology, Symptoms and Diagnosis and Treatment, Lippincott, Philadelphia.Google Scholar
  9. Currie, G. A., and Basham, C., 1972, Serum mediated inhibition of the immunological reactions of the patient to his own tumour: A possible role for circulating antigen, Br. J. Cancer 26:427.PubMedCrossRefGoogle Scholar
  10. Delarue, N. C., 1960, The free cancer cell, Can. Med. Assoc. J. 82:1175.PubMedGoogle Scholar
  11. Dewys, W. D., 1972, Studies correlating the growth rate of a tumor and its metastases and providing evidence for tumor related systemic growth retarding factors, Cancer Res. 32:374.PubMedGoogle Scholar
  12. Donovan, A. J., 1967, The effect of surgery on reticuloendothelial function, Arch. Surg. (Chicago) 94:247.CrossRefGoogle Scholar
  13. Everson, T. C., and Cole, W. H., 1966, Spontaneous Regression of Cancer, Saunders, Philadelphia.Google Scholar
  14. Fisher, B., and Fisher, E. R., 1965, The biology of metastasis, in: Current Concepts in Surgery (J. H. Davis, ed.), pp. 321–351, McGraw-Hill, New York.Google Scholar
  15. Fisher, B., and Fisher, E. R., 1966a, Transmigration of lymph nodes by tumor cells, Science 152:1397.PubMedCrossRefGoogle Scholar
  16. Fisher, B., and Fisher, E. R., 1966b, Interrelationship of hematogenous and lymphatic tumor cell dissemination, Surg. Gynecol. Obstet. 122:791.PubMedGoogle Scholar
  17. Fisher, B., and Fisher, E. R., 1967a, The barrier function of the lymph node to tumor cells and erythrocytes. I. Normal nodes, Cancer 20:1907.PubMedCrossRefGoogle Scholar
  18. Fisher, B., and Fisher, E. R., 1967b, The barrier function of the lymph node to tumor cells and erythrocytes. II. Effect of X-ray, inflammation, sensitization and tumor growth, Cancer 20:1914.PubMedCrossRefGoogle Scholar
  19. Fisher, B., and Fisher, E. R., 1968, Role of the lymphatic system in dissemination of tumor, in: Lymph and the Lymphatic System, pp. 324–347, Charles C Thomas, Springfield, Ill.Google Scholar
  20. Fisher, B., Saffer, E. A., and Fisher, E. R., 1972, Studies concerning the regional lymph node in cancer. III. Response of regional lymph node cells from breast and colon cancer patients to PHA stimulation, Cancer 30:1202.PubMedCrossRefGoogle Scholar
  21. Fisher, B., Saffer, E. A., and Fisher, E. R., 1974a, Studies concerning the regional lymph node in cancer. IV. Tumor inhibition by regional lymph node cells, Cancer 33:631.PubMedCrossRefGoogle Scholar
  22. Fisher, B., Wolmark, N., and Coyle, J., 1974b, Effect of Corynebacterium parvum on cytotoxicity of regional and non-regional lymph node cells from animal with tumors present and removed, J. Natl. Cancer Inst 53:1793.PubMedGoogle Scholar
  23. Fisher, B., Saffer, E., and Fisher, E. R., 1974c, Studies concerning the regional lymph node in cancer. VII. Thymidine uptake by cells from nodes of breast cancer patients relative to axillary location and histopathologic discriminants, Cancer Res. 34:1668.PubMedGoogle Scholar
  24. Fisher, B., Slack, N., Katrych, D. L., and Wolmark, N., 1975a, Ten year follow-up of breast cancer patients in a cooperative clinical trial evaluating surgical adjuvant chemotherapy, Surg. Gynecol. Obstet. 140:528.PubMedGoogle Scholar
  25. Fisher, B., Carbone, P., Economou, S. G., Frelick, R., Glass, A., Lerner, H., Redmond, C., Zelen, M., Katrych, D. L., Wolmark, N., Band, P., Fisher, E. R., and other cooperating investigators, 1975b, 1-Phenylalanine mustard (l-PAM) in the management of primary breast cancer: A report of early findings, N. Engl. J. Med., 292:117.PubMedCrossRefGoogle Scholar
  26. Fisher, B., Wolmark, N., Coyle, J., and Saffer, E. A., 1976, Effect of a growing tumor and its removal on the cytotoxicity of macrophages from cultured bone marrow cells, Cancer Res. 36:2302.PubMedGoogle Scholar
  27. Fisher, E. R., and Fisher, B., 1974, Some theoretical and practical considerations of metastases, Contemp. Surg. 4:85.Google Scholar
  28. Fisher, E. R., and Turnbull, R. B., Jr., 1955, Cytologic demonstration and significance of tumor cells in the mesenteric venous blood in patients with colorectal carcinoma, Surg. Gynecol. Obstet. 100:102.PubMedGoogle Scholar
  29. Fisher, E. R., Saffer, E. A., and Fisher, B., 1973, Studies concerning the regional lymph node in cancer. VI. Correlation of lymphocyte transformation of regional node cells and some histopathologic discriminants, Cancer 32:104.PubMedCrossRefGoogle Scholar
  30. Foote, F. W., and Stewart, F. W., 1945, Comparative studies of cancerous versus noncancerous breasts, Ann. Surg. 121:5.Google Scholar
  31. Frindel, E., Malaise, E. P., Alpen, E., and Tubiana, M., 1967, Kinetics of Cell. proliferation of an experimental tumor, Cancer Res. 27:1122.PubMedGoogle Scholar
  32. Gallager, H. S., and Martin, J. E., 1969, The study of mammary carcinoma by mammography and whole organ sectioning, Cancer 23:855.PubMedCrossRefGoogle Scholar
  33. Gershon, R. D., and Carter, R. L., 1969, Factors controlling concomitant immunity in tumor bearing hamsters: Effect of prior splenectomy and tumor removal, J. Natl. Cancer Inst. 43:533.PubMedGoogle Scholar
  34. Graham, J. B., and Graham, R. M., 1955, Antibodies elicited by cancer in patients, Cancer 8:409.PubMedCrossRefGoogle Scholar
  35. Gray, H. J., 1939, Relation of the lymphatic vessels to the spread of cancer, Br. J. Surg. 26:462.CrossRefGoogle Scholar
  36. Haagensen, C. D., 1933, An exhibit of important books, papers, and memorabilia illustrating the evolution of the knowledge of cancer, Am. J. Cancer 18:42.Google Scholar
  37. Halsted, W. S., 1890/1891, The treatment of wounds with especial reference to the value of the blood clot in the management of dead spaces, Johns Hopkins Hosp. Rep. 2:255.Google Scholar
  38. Halsted, W. S., 1907, The results of radical operations for the cure of carcinoma of breast, Ann. Surg. 46:1.PubMedCrossRefGoogle Scholar
  39. Handley, W. S., 1922, Cancer of the Breast and Its Operative Treatment, A. Murray, London.Google Scholar
  40. Hayward, O. S., 1965a, The history of oncology. I. Early oncology and the literature of discovery, Surgery 58:460.PubMedGoogle Scholar
  41. Hayward, O. S., 1965b, The history of oncology. II. The society for investigating cancer, London, Surgery 58:586.PubMedGoogle Scholar
  42. Hayward, O. S., 1965c, The history of oncology. III. America and the cancer lectures of Nathan Smith, Surgery 58:745.Google Scholar
  43. Hellström, I., Hellström, K. E., and Sjögren, H. O., 1970, Serum mediated inhibition of cellular immunity to methylcholanthrene-induced murine sarcomas, Cell. Immunol. 1:18.PubMedCrossRefGoogle Scholar
  44. Heppner, G. H., 1972, In vitro studies on cell-mediated immunity following surgery in mice sensitized to syngeneic mammary tumors, Int. J. Cancer 9:119.PubMedCrossRefGoogle Scholar
  45. Hughes, L. E., and McKay, W. D., 1965, Suppression of the tubercular response in malignant disease, Br. Med. J. 2:1346.PubMedCrossRefGoogle Scholar
  46. Humphrey, L. J., Wingard, D. W., and Lang, R., 1969, The effect of surgery and anesthesia on the immunologic responsiveness of the rat, Surgery 65:946.PubMedGoogle Scholar
  47. Humphrey, L. J., Frederickson, E. L., and Amerson, J. R., 1970, Effect of anesthesia and amputation on tumor and general immunity of the mouse, J. Surg. Res. 10:265.PubMedCrossRefGoogle Scholar
  48. Israel, L., Mugica, J., and Chahinian, P., 1973, Prognosis of early bronchogenic carcinoma: Survival curves of 451 patients after resection of lung cancer in relation to the results of the preoperative tuberculin skin test, Biomedicine 19:68.PubMedGoogle Scholar
  49. Kramer, W. M., and Rush, B. F., 1973, Mammary duct proliferation in the elderly—A histopathologic study, Cancer 31:130.PubMedCrossRefGoogle Scholar
  50. Laird, A. K., 1964, Dynamics of tumor growth, Br. J. Cancer 18:490.CrossRefGoogle Scholar
  51. LeDran, H. F., 1757, Mémoires avec un précis de plusieurs observations sur le cancer, Mem. Acad. R. Chic. 3:1.Google Scholar
  52. Long, L., Jonasson, O., Roberts, S., McGrath, R., McGrew, E., and Cole, W. H., 1960, Cancer cells in the blood; results of simplified isolation technique, AMA Arch. Surg. 80:910.PubMedCrossRefGoogle Scholar
  53. McCredie, J. A., Inch, W. R., Kruuv, J., and Watson, T. A., 1965, The rate of tumor growth in animals, Growth 29:331.Google Scholar
  54. Mikulska, A. B., Smith, C., and Alexander, P., 1966, Evidence for an immunological reaction of the host directed against its own actively growing primary tumor, J. Natl. Cancer Inst. 36:29.PubMedGoogle Scholar
  55. Morgagni, G. G., 1769, The Seats and Causes of Diseases Investigated by Anatomy, Miller and Cadell, London (translated by B. Alexander, reprinted by Hafner, 1960, for New York Academy of Medicine).Google Scholar
  56. Nicholson, G. W., 1921, Carcinoma of breast, Br. J. Surg. 8:527.CrossRefGoogle Scholar
  57. Odili, J. L., and Taylor, G., 1971, Transience of immune responses to tumour antigens in man, Br. Med. J. 4:584.PubMedCrossRefGoogle Scholar
  58. Park, S. K., Brody, J. I., Wallace, H. A., and Blakemore, W. S., 1971, Immunosuppressive effect of surgery, Lancet 1:53.PubMedCrossRefGoogle Scholar
  59. Patey, D. H., 1967, A review of 146 cases of carcinoma of the breast operated on between 1930 and 1943, Br. J. Cancer 21:260.PubMedCrossRefGoogle Scholar
  60. Pilch, Y. H., and Riggins, R. S., 1966, Antibodies to spontaneous and MC-induced tumors in inbred mice, Cancer Res. 26:871.PubMedGoogle Scholar
  61. Pool, E. H., and Dunlop, R. R., 1934, Cancer cells in bloodstream, Am. J. Cancer 21:99.Google Scholar
  62. Riddle, P. R., 1967, Distributed immune reactions following surgery, Br. J. Surg. 54:882.PubMedCrossRefGoogle Scholar
  63. Ritchie, A. C., and Webster, D. R., 1961, Tumor cells in the blood, in: Proceedings of the Fourth Canadian Cancer Conference, Academic Press, New York.Google Scholar
  64. Roberts, S., Jonasson, O., Long, L., McGrew, E. A., McGrath, R., and Cole, W. H., 1962, Relationship of cancer cells in the circulating blood to operation, Cancer 15:232.PubMedCrossRefGoogle Scholar
  65. Saba, T. M., 1970, Mechanism mediating reticuloendothelial system depression after surgery, Proc. Soc. Exp. Biol. Med. 133:1132.PubMedGoogle Scholar
  66. Saba, T. M., and DiLuzio, 1969, Surgical stress and reticuloendothelial function, Surgery 65:802.PubMedGoogle Scholar
  67. Schabel, F. M., Jr., 1969, The use of tumor growth kinetics in planning “curative” chemotherapy of advanced solid tumors, Cancer Res. 29:2384.PubMedGoogle Scholar
  68. Schabel, F. M., Jr., 1975, Concepts for systemic treatment of micrometastases, Cancer 35:15.PubMedCrossRefGoogle Scholar
  69. Scovill, W. A., and Saba, T. M., 1973, Humoral recognition deficiency in the etiology of reticuloendothelial depression induced by surgery, Ann. Surg. 178:59.PubMedCrossRefGoogle Scholar
  70. Simpson-Herren, L., Sanford, A. H., and Holmquist, J. P., 1974, Cell. population kinetics of transplanted and metastatic Lewis lung carcinoma, Cell. Tissue Kinet. 7:349.PubMedGoogle Scholar
  71. Skipper, H. E., 1974, Combination Therapy, p. 1, Booklet 13, Southern Research Institute, Birmingham, Ala., December 23, 1974.Google Scholar
  72. Slack, N. H., Bross, E. J., Nemoto, T., and Fisher, B., 1973, Experience with bilateral primary carcinoma of the breast in a cooperative study, Surg. Gynecol. Obstet. 136:433.PubMedGoogle Scholar
  73. Stjernswärd, J., 1968, Immune status of the primary host toward its own methylcholanthrene induced sarcomas, J. Natl. Cancer Inst. 40:13.PubMedGoogle Scholar
  74. Urban, J. A., 1967, Bilaterality of cancer of the breast: Biopsy of the opposite breast, Cancer 20:1867.PubMedCrossRefGoogle Scholar
  75. Urban, J. A., 1969, Biopsy of the “normal” breast in treating breast cancer, Surg. Clin. N. Am. 49:291.PubMedGoogle Scholar
  76. Valsalva, A. M., 1704, Deaure Humana Troatatus, C. Pisarii, Bononrae.Google Scholar
  77. Virchow, R., 1863, Cellular Pathology, Lippincott, Philadelphia.Google Scholar
  78. Ward, G. R., 1913, The blood in cancer with bone metastases, Lancet 1:676.CrossRefGoogle Scholar
  79. Watkins, S. M., 1973, The effects of surgery on lymphocyte transformation in patients with cancer, Clin. Exp. Immunol. 14:69.PubMedGoogle Scholar
  80. Whitney, R. B., Levy, J. G., and Smith, A. G., 1974, Influence of tumor size and surgical resection on cell mediated immunity in mice, J. Natl. Cancer Inst. 53: 111.PubMedGoogle Scholar
  81. Willis, R. A., 1953, Pathology of Tumors, 2nd ed., Butterworth, London.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Bernard Fisher
    • 1
  1. 1.University of Pittsburgh School of MedicinePittsburghUSA

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