Immunobiology of Chemically Induced Tumors

  • Michael R. Price
  • Robert W. Baldwin
Part of the Cancer book series (C, volume 4)


A prerequisite to the analysis of cellular and humoral immune responses to neoantigens associated with chemically induced tumors is that their occurrence and specificity must be adequately defined. This has been achieved with a number of experimental tumor models, and, as indicated in a previous volume of this series, a major conclusion is that transformation by chemical carcinogens frequently results in the expression of neoantigens which function to promote tumor rejection reactions, although this is by no means a universal feature of chemical neoplasia (Baldwin and Price, Vol. 1, Chap. 12). Tumor-associated rejection antigens are, however, almost uniformly characterized by a high degree of specificity so that immunity to transplanted tumors in syngeneic hosts is directed only against cells of the immunizing tumor. There have proved to be very few exceptions to this, and individually specific neoantigens have even been demonstrated on cells transformed in vitro by chemical carcinogens (see Baldwin and Price, Vol. 1, Chap. 12, for further discussion of this point). One disparity recently observed has been with murine bladder tumors induced with 3-methylcholanthrene (MCA). With these, cross-reactivity was demonstrated by in vitro lymphocytotoxicity assays, although in tumor rejection tests individually distinct neoantigens were revealed (Taranger et al, 1972; Wahl et al., 1974).


Spleen Cell Tumor Immunity Tumor Rejection Peritoneal Exudate Cell Embryonic Antigen 


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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Michael R. Price
    • 1
  • Robert W. Baldwin
    • 1
  1. 1.Cancer Research Campaign LaboratoriesUniversity of NottinghamNottinghamEngland

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