RNA Oncogenic Virus-Associated Antigens

And Host Immune Response to Them
  • Tadao Aoki
  • Louis R. Sibal
Part of the Cancer book series (C, volume 4)


The rapid development of analytical techniques has revealed the complexity of antigens associated with type B and type C RNA viruses. These antigens may be broadly categorized as either viral, cellular, or soluble (Aoki, 1973) (Table 1). Based on the morphological structure of viruses, which consists of an inner nucleoid and an outer shell surrounded by an envelope acquired during budding of the virus from the surface of infected cells (deHarven, 1968), viral antigens can additionally be divided into viral envelope antigens (VEAs) and intraviral antigens. Cell surface antigens (CSAs) induced by viruses and by malignant transformation (mutation of the cellular genome) possess several type specificities (Klein, 1969; Old and Boyse, 1965). To date, while viral antigens have been found intracellularly, no viral-genome-induced cellular antigens have been demonstrated there. Several groups of soluble antigens corresponding to the above specificities have been detected in the circulation and in the kidneys of virus-infected animals (see below).


Murine Leukemia Virus Immunoelectron Microscopy Soluble Antigen Woolly Monkey Endogenous Virus 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Tadao Aoki
    • 1
  • Louis R. Sibal
    • 1
  1. 1.Viral Oncology Area, Division of Cancer Cause and PreventionNational Cancer Institute, NIHBethesdaUSA

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