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Replication and Transformation by Papovaviruses

  • George Khoury
  • Norman P. Salzman
Part of the Cancer book series (C, volume 2)

Abstract

The principal members of the papova group are polyoma virus (Stewart et al., 1957), simian virus 40 (SV40), which is a vacuolating virus of monkeys (Sweet and Hilleman, 1960), and the papilloma viruses (Melnick, 1962). The name for this group of viruses is derived from the first two letters of the names of each of the viruses that were first included in the group, papilloma, polyoma, vacuolating virus (Melnick, 1962). The viruses are 40–57 nm in diameter and, as determined by negative staining, the outer shell has symmetry of the T = 7 icosahedral surface lattice and is composed of 72 morphological subunits (Finch and Klug, 1965; Anderer et al., 1967). The viruses contain no lipids and therefore are resistant to ether. Polyoma and SV40 do not share common antigens, and presently there is no evidence for the existence of homology betweeen their DNAs. The papovaviruses are capable of initiating a lytic cycle of replication or a latent infection. For the papilloma viruses it is difficult to obtain a suitable cell line in which the lytic cycle can be studied; therefore, studies that we will discuss concerning viral replication will deal exclusively with SV40 and polyoma.

Keywords

Simian Virus Lytic Cycle Replicative Intermediate Polyoma Virus Hybrid Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • George Khoury
    • 1
  • Norman P. Salzman
    • 1
  1. 1.Laboratory of Biology of Viruses, National Institutes of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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