Papilloma-Myxoma Viruses

  • Yohei Ito
Part of the Cancer book series (C, volume 2)


The two groups of viruses to be discussed in this chapter are apparently dissimilar, although they do share DNA as their essential component. The papilloma viruses belong to the papovavirus group and are included in the medium-sized DNA viruses, while myxoma virus and its allied agents belong to the larger DNA viruses of the pox group. Nevertheless, an acceptable basis for bringing them together may derive from the fact that they both are literally the most “classical” tumor viruses (Shope, 1932, 1933). Two viruses representing these groups, Shope papilloma and myxoma, have played a very important role in setting the stage for the earliest identification of tumor viruses in mammalian species; they were first reported by the pioneering investigator in the field, Richard Shope. The other feature common to them is that the tumors they induce are benign in the sense that the tumor cells rarely metastasize to remote tissues and organs. In many cases, even spontaneous regression is not uncommon. However, myxoma virus as an infectious agent can be lethal to the host.


Human Papilloma Virus Vaccinia Virus Nucleic Acid Extract Myxoma Virus Domestic Rabbit 
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  1. Andrewes, C. H., and Horstman, D. M., 1949, The susceptibility of virus to ethyl ether, J. Gen. Microbiol. 3: 290.PubMedGoogle Scholar
  2. Avery, O. T., Macleod, C. M., and Mccarty, M., 1944, Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a deoxyribonucleic acid fraction isolated from Pneumococcus III, J. Exp. Med. 79: 137.PubMedCrossRefGoogle Scholar
  3. Beard, J. W., 1948a, Review: Purified animal viruses, J. Immunol. 58: 49.Google Scholar
  4. Beard, J. W., 1948b The chemical, physical and morphological properties of animal viruses, Physiol. Rev. 28: 349.Google Scholar
  5. Beard, J. W., Bryan, W. R., and Wyckoff, R. W. G., 1939, Isolation of the rabbit papilloma virus protein, J. Infect. Dis. 65: 43.CrossRefGoogle Scholar
  6. Berry, G. P., and Dedrick, H. M., 1936a, A method for changing the virus of rabbit fibroma (Shope) into that of infectious myxomatosis (Sanarelli), J. Bacteriol. 31: 50.Google Scholar
  7. Berry, G. P., and Dedrick, H. M., 1936b, Further observations on the transformation of the virus of rabbit fibroma (Shope) into that of infectious myxomatosis (Sanarelli), J. Bateriol. 32: 356.Google Scholar
  8. Black, P. H., Hartley, J. W., Rowe, W. P., and Huebner, R. J., 1963, Transformation of bovine tissue culture cells by bovine papilloma virus, Nature (Lond.) 199: 1016.CrossRefGoogle Scholar
  9. Breedis, C., Berwick, L., and Anderson, T. F., 1962, Fractionation of Shope papilloma virus in cesium chloride density gradients, Virology 17: 84.PubMedCrossRefGoogle Scholar
  10. Bryan, W. R., and Beard, J. W., Correlation of frequency of positive inoculations with inoculation period and concentration of purified papilloma protein, J. Infect. Dis. 66: 245.Google Scholar
  11. Chambers, V. C., and Ito, Y., 1964, Morphology of Shope papilloma virus associated with nucleic acid-induced tumors of cottontail rabbits, Virology 23: 434.PubMedCrossRefGoogle Scholar
  12. Chambers, V. C., Ito, Y., and Evans, C. A., 1966, Technique for visualizing papovaviruses in tumors and in tissue cultures, J. Bacteriol. 91: 2090.PubMedGoogle Scholar
  13. Chaproniere, D. M., 1956, The effect of myxoma virus on cultures of rabbit tissues, Virology 2: 599.PubMedCrossRefGoogle Scholar
  14. Clemmessen, J., 1939, The influence of roentgen radiation on immunity to Shope fibroma virus, Am. J. Cancer 35: 378.Google Scholar
  15. Crawford, L. V., 1964, A study of Shope papilloma virus DNA, J. Mol. Biol. 8: 489.PubMedCrossRefGoogle Scholar
  16. Crawford, L. V., 1965, A study of human papilloma virus DNA, J. Mol. Biol. 13: 362.PubMedCrossRefGoogle Scholar
  17. Crawford, L. V., and Crawford, E. M., 1963, A comparative study of polyoma and papilloma viruses, Virology 21: 258.PubMedCrossRefGoogle Scholar
  18. Crawford, L. V., Follett, E. A. C., and Crawford, E. M., 1966, An electron microscopic study of DNA from three tumor viruses, J. Micros. 5: 597.Google Scholar
  19. Duran-Reynals, F., 1940, Production of degenerative inflammatory or neoplastic effects in the newborn rabbit by the Shope fibroma virus, Yale J. Biol. Med. 13: 99.PubMedGoogle Scholar
  20. Duran-Reynals, L., 1945, Immunological factors that influence the neoplastic effects of the rabbit fibroma virus, Cancer Res. 5: 25.Google Scholar
  21. Evans, C. A., 1963, Immunological studies of the Shope papilloma-carcinoma complex of rabbits, Acta Unio. Int. Contra. Cancrum 19: 110.Google Scholar
  22. Evans, C. A., Weiser, R. S., and Ito, Y., 1962a, Antiviral and antitumor immunologic mechanism operative in the Shope papilloma-carcinoma system, Cold Spring Harbor Symp. Quant. Biol. 27: 722.CrossRefGoogle Scholar
  23. Evans, C. A., Gorman, L. R., Ito, Y., and Weiser, R. S., 1962b, Antitumor immunity in the Shope papilloma-carcinoma complex of rabbits. I. Papilloma regression induced by homologous and autologous tissue vaccines, J. Natl. Cancer Inst. 29: 277.Google Scholar
  24. Fenner, F., and Mcintyre, G. A., 1956, Infectivity titrations of myxoma virus in the rabbit and the developing chick embryo, J. Hyg. (Carob.) 54: 246.CrossRefGoogle Scholar
  25. Gross, L., 1966, Oncogenic Viruses, p. 23, Pergamon Press, New York.Google Scholar
  26. Hoffstadt, R. E., and Pilcher, K. S., 1938, The use of chorioallantoic membrane of the developing chick embryo as a medium in the study of virus myxomatosum, J. Bacteriol. 35: 353.PubMedGoogle Scholar
  27. Holowczak, J. A., and Joklik, W. K., 1967, Studies on the proteins of vaccinia virus. I. Structural proteins of virions and cores, Virology 33: 717.PubMedCrossRefGoogle Scholar
  28. Howatson, A. F., and Crawford, L. V., 1963, Direct-counting of the capsomers in polyoma and papilloma viruses, Virology 21: 1.PubMedCrossRefGoogle Scholar
  29. Hurst, E. W., 1939, The effect of cortisone and of 6-mercaptopurine on the Shope fibroma, J. Pathol. Bacteriol. 87: 29.CrossRefGoogle Scholar
  30. Ishimoto, A., and Ito, Y., 1969, Specific surface antigen in Shope papilloma cells, Virology 39: 595.PubMedCrossRefGoogle Scholar
  31. Ito, Y., 1960, A tumor-producing factor extracted by phenol from papillomatous tissue (Shope) of cottontail rabbits, Virology 12: 596.PubMedCrossRefGoogle Scholar
  32. Ito, Y., 1961, Heat-resistance of the tumorigenic nucleic acid of Shope papillontatosis, Proc. Natl. Acad. Sci. 47: 1897.PubMedCrossRefGoogle Scholar
  33. Ito, Y., 1963, Studies on subviral tumorigenesis: Carcinoma derived from nucleic acid—induced papillomas of rabbit skin, Acta Unio. Int. Contra. Cancrum. 19: 280.PubMedGoogle Scholar
  34. Ito, Y., 1970a, Induction of papillomas in rabbits with nucleic acid extracts from V X 7 carcinomas, Brit. J. Cancer 26: 16.Google Scholar
  35. Ito, Y., 1970b, “Masking” and “unmasking” of Shope papilloma virus—coded functions in transformed rabbit cells, in: Defectiveness, Rescue and Stimulation on Oncogenic Viruses, Centre National de la Recherche Scientifique, Paris.Google Scholar
  36. Ito, Y., and Evans, C. A., 1961, Induction of tumors in domestic rabbits with nucleic acid preparations from partially purified Shope papilloma virus and from extracts of the papillomas of domestic and cotton tail rabitts, J. Exp. Med. 114: 485.PubMedCrossRefGoogle Scholar
  37. Joklik, W. K., 1962, Some properties of poxvirus DNA, J. Mol. Biol. 5: 265.CrossRefGoogle Scholar
  38. Joklik, W. K., 1966, The poxviruses, Bacteriol. Rev. 30: 33.PubMedGoogle Scholar
  39. Kahler, H., and, Lloyd, B. J., 1952, Electron microscopic study of the Shope Papilloma virus, J. Natl. Cancer Inst. 12: 1167.PubMedGoogle Scholar
  40. Kass, S. J., and Knight, C. A., 1965., Purification and chemical analysis of Shope papilloma virus, Virology 27: 273.PubMedCrossRefGoogle Scholar
  41. Kato, S., and Cutting, W., 1959, A study of the inclusion bodies of rabbit myoxma fibroma virus and a consideration of the relationship between all pox virus inclusion bodies, Stanford Med. Bull. 17: 34.PubMedGoogle Scholar
  42. Kato, S., Takahashi, M., Miyamoto, H., and Kamahora, J., 1963, Shope fibroma and rabbit myoxma viruses. I. Autoradiographic and cytoimmunological study on “B” type inclusions, Biken J. 6: 127.PubMedGoogle Scholar
  43. Kato, S., Ono, K., Miyamoto, H., and Mantani, M., 1966, Virus-host interaction in rabbit fibrosarcoma produced by Shope fibroma virus, Biken J. 9: 51.Google Scholar
  44. Kato, S., Miyamoto, H., Ono, K., Tsuru, K., Mantani, M., and Tanigaki, T., 1967, Virus-host cell interaction in cellular proliferation induced by poxvirus, in: Second International Symposium for Cellular Chemistry, Pergamon Press, New York.Google Scholar
  45. Kidd, J. G., 1938, The course of virus-induced rabbit papillomas as determined by virus, cells and host, J. Exp. Med. 67: 551.PubMedCrossRefGoogle Scholar
  46. Kilham, L., 1957, Transformation of fibroma into myxoma virus in tissue culture, Proc. Soc. Exp. Biol. Med. 95: 59.PubMedGoogle Scholar
  47. Kilham, L., 1959, Relation of thermoresistance among fibroma and myxoma viruses, Virology 9: 486.PubMedCrossRefGoogle Scholar
  48. Kleinschmidt, A. K., Kass, S. J., and Knight, C. A., Cyclic DNA of Shope papilloma virus, J. Mol, Biol. 13: 749.Google Scholar
  49. Klug, A., and Finch, J. T., 1965, Structure of viruses of the papilloma polyoma type. I. Human wart virus, J. Mol. Biol. 11: 403.PubMedCrossRefGoogle Scholar
  50. Knight, C. A., 1950, Amino acids of Shope papilloma virus, Proc. Soc. Exp. Biol. Med. 75: 843.PubMedGoogle Scholar
  51. Kreider, J. W., 1963, Studies on the mechanism responsible for the spontaneous regression of the Shope rabbit papilloma, Cancer Res. 23: 1593.PubMedGoogle Scholar
  52. Lloyd, B. J., Jr., and Kahler, H., 1955, Electron microscopy of rabbit fibroma, J. Natl. Cancer Inst. 15: 991.PubMedGoogle Scholar
  53. Lush, D., 1937, The virus of infectious myxomatosis of rabbits on the chorioallantoic membrane of the developing egg, Austral. J. Exp. Biol. Med. Sci. 15: 131.CrossRefGoogle Scholar
  54. Morrison, J. M., Keir, H. M., Subak-Sharpe, H., and Crawford, L. V., 1967, Nearest neighbor base sequence analysis of the deoxyribonucleic acids of a further three mammalian viruses: Simian virus 40, human papilloma virus and adenovirus type 2, J. Gen. Virol. 1: 101.PubMedCrossRefGoogle Scholar
  55. Noyes, W. F., 1965, Studies on the human wart virus. II. Changes in primary human cell cultures, Virology 25: 358.PubMedCrossRefGoogle Scholar
  56. Noyes, W. F., and Mellors, R. C., 1957, Fluorescent antibody detection of the antigens of the Shope papilloma virus in papillomas of the wild and domestic rabbit, J. Exp. Med. 106: 555.PubMedCrossRefGoogle Scholar
  57. Orth, G., Vielle, F., and Changeux, J. P., 1967, On the arginase of the Shope papillomas, Virology 31: 729.PubMedCrossRefGoogle Scholar
  58. Osato, T., and Ito, Y., 1967, In vitro cultivation and immunofluorescent studies of transplantable carcinoma V x 2 and V x 7, J. Exp. Med. 126: 881.PubMedCrossRefGoogle Scholar
  59. Osato, T., and Ito, Y., 1968, Immunofluorescence studies of Shope papilloma virus in cottontail rabbit kidney tissue cultures, Proc. Soc. Exp. Biol. Med. 128: 1025.Google Scholar
  60. Passen, S., and Schultz, R. B., 1965, Use of papilloma virus-induced arginase as a biochemical marker in vitro, Virology 26: 122.PubMedCrossRefGoogle Scholar
  61. Potz, L., 1957, Elektronenmikroskopische Untersuchungen der Kaninchenhaut bei infectktioser Myxmatose, Beitr. Pathol. Anat. 118: 1.PubMedGoogle Scholar
  62. Rodriguez-Burgos, A., Chordi, A., Diaz, R., and Tormo, J., 1966, Immunoelectrophoretic analysis of vaccinia virus, Virology 30: 569.PubMedCrossRefGoogle Scholar
  63. Rogers, S., 1959, Induction of arginase in rabbit epithelium by the Shope papilloma virus, Nature (Lunl.) 183: 1815.CrossRefGoogle Scholar
  64. Rous, P., and Beard, J. W., 1935, The progression to carcinoma of virus-induced rabbit papillomas (Shope), J. Exp. Med. 63: 523.CrossRefGoogle Scholar
  65. Rous, P., and Friedewald, W. F., 1944, The effect of chemical carcinogens on virus-induced rabbit papillomas, J. Exp. Med. 79: 511.PubMedCrossRefGoogle Scholar
  66. Sarov, I., and Becker, Y., 1967, Studies on vaccinia virus DNA, Virology 33: 112.CrossRefGoogle Scholar
  67. Satoh, P. S., and Ito, Y., 1968, Ornithine transcarbamoylase in Shope papilloma, Virology 35: 335.PubMedCrossRefGoogle Scholar
  68. Satoh, P. S., Yoshida, T. O., and Ito, Y., 1967, Studies on the arginase activity of Shope papilloma: Possible presence of isozymes, Virology 33: 354.PubMedCrossRefGoogle Scholar
  69. Schwerdt, P. R., and Schwerdt, C. E., 1962, A plaque assay for myxoma virus infectivity, Proc. Soc. Exp. Biol. Med. 109: 717.PubMedGoogle Scholar
  70. Shiratori, O., Osato, T., and Ito, Y., 1969, “Induction” of viral antigen in established cell line (SP-8) derived from Shope virus—induced cutaneous papilloma of rabbits, Proc. Soc. Exp. Biol. Med. 130:115.PubMedGoogle Scholar
  71. Shope, R. E., 1932, A transmissible tumor-like condition in rabbits, J. Exp. Med. 56: 793.PubMedCrossRefGoogle Scholar
  72. Shope, R. E., 1933, Infectious papillomatosis of rabbits; with a note on the histopathology, J. Exp. Med. 58: 607.PubMedCrossRefGoogle Scholar
  73. Shope, R. E., 1936, Infectious fibroma of rabbits. IV. The infection with virus myxomatosum of rabbits recovered from fibroma, J. Exp. Med. 63: 43.PubMedCrossRefGoogle Scholar
  74. Shope, R. E., 1962, Are animal tumor viruses always virus-like? (review), J. Gen. Physiol, 45: Suppl. 143.PubMedCrossRefGoogle Scholar
  75. Subak-Sharpe, H., Burk, R. R., Crawford, L. V., Morrison, J. M., Hay, J., and Keir, H. M., 1966, An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbor base sequences, Cold Spring Harbor Symp. Quant. Biol. 31: 737.PubMedCrossRefGoogle Scholar
  76. Syverton, J. T., 1952, The pathogenesis of the rabbit papilloma-to-carcinoma sequence, Ann. N. Y. Acad. Sci. 54: 1126.PubMedCrossRefGoogle Scholar
  77. Syverton, J. T., and Berry, G. P., 1935, Carcinoma in the cottontail rabbit following spontaneous virus papilloma (Shope), Proc. Soc. Exp. Biol. Med. 33: 399.Google Scholar
  78. Thomas, M., Boiron, M., Tanzer, J., Levy, J. P., and Bernard, J., 1964, In vitro transformation of mice cells by bovine papilloma virus, Nature (Lond.) 202: 709.CrossRefGoogle Scholar
  79. Verna, J. E., and Eylar, O. R., 1962, Rabbit fibroma virus plaque assay and in vitro studies, Virology 16: 266.CrossRefGoogle Scholar
  80. Vinograd, J., Leowitz, J., Radloff, R., Watson, R,, and Laipis, P., 1965, The twisted circular form of polyoma viral DNA, Proc. Natl. Acad. Sci. 53: 1104.PubMedCrossRefGoogle Scholar
  81. Watson, J. D., and Littlefield, J. W., 1960, Some properties of DNA from Shope papilloma virus, J. Mol. Biol. 2: 161.CrossRefGoogle Scholar
  82. Westwood, J. C. N., Harris, W. J., Zwartouw, H. T., Titmuss, D. H. J., and Appleyard, G., 1964 Studies on the structure of vaccinia virus, J. Gen. Microbiol. 34: 67.PubMedGoogle Scholar
  83. Williams, M. G., Howatson, A. F., and Almeida, J. D., 1961, Morphological characterization of the viruses of human common wart (Verruca vulgaris), Nature (Lond.), 189: 895.CrossRefGoogle Scholar
  84. Williams, R. C., Kass, S. J., and Knight, C. A., 1960, Structure of Shope papilloma virus particles, Virology 12: 48.PubMedCrossRefGoogle Scholar
  85. Winocour, E., 1965, Attempts to detect an integrated polyoma genome by nucleic acid hybridization. II. Complementarity between polyoma virus DNA and mouse synthetic RNA, Virology 27: 520.PubMedCrossRefGoogle Scholar
  86. Woodroofe, G. M., and Fenner, F., 1962, Serological relationship within the poxgroup: An antigen common to all members of the group, Virology 16: 334.PubMedCrossRefGoogle Scholar
  87. Woodroofe, G. M., and Fenner, F., 1965, Viruses of the myxoma—fibroma subgroup of the poxviruses. I. Plaque production in cultured cells, plaque-reduction tests and cross—protection tests in rabbits, Austral. J. Exp. Biol. Med. Sci. 43: 123.CrossRefGoogle Scholar
  88. Yoshida, T. O., and Ito, Y., 1968, Immunofluorescent study on early virus—cell interaction in Shope papilloma in vitro system, Proc. Soc. Exp. Biol. Med. 128: 587.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Yohei Ito
    • 1
  1. 1.Department of Microbiology, Faculty of MedicineUniversity of KyotoKyotoJapan

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