Avian RNA Tumor Viruses

  • Hidesaburo Hanafusa
Part of the Cancer book series (C, volume 2)


Avian RNA tumor viruses are a group with certain characteristics that can be defined by both pathogenic and molecular criteria. Other designations which have been used for RNA tumor virus include leukovirus, oncornavirus (oncogenic RNA), Rous virus, retravirus (reverse transcriptase positive virus), rnadna virus (RNA → DNA virus), and type C Virus. Historically, the viruses have been isolated from birds with certain diseases and so have been named after these diseases. The following viruses are considered to belong to the avian RNA tumor virus group.


Rous Sarcoma VIrus Helper Virus Avian Myeloblastosis Virus Avian Leukosis Virus Chick Embryo Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. August, J. T., Bolognesi, D. P., Fleissner, E., Gilden, R. V., and Nowinski, R. C., 1973, A proposed nomenclature for virion proteins of oncogenic RNA viruses, Virology 60: 595–601.Google Scholar
  2. Bader, J. P., 1964, The role of deoxyribonucleic acid in the synthesis of Rous sarcoma virus, Virology 22: 462–468.PubMedGoogle Scholar
  3. Bader, J. P., 1965, The DNA requirement of Rous sarcoma and Rous-associated viruses, Virology 26: 253–261.PubMedGoogle Scholar
  4. Bader, J. P., 1972a, Metabolic requirements for infection by Rous sarcoma virus. IV. Virus reproduction and cellular transformation without cellular division, Virology 48: 494–501.PubMedGoogle Scholar
  5. Bader, J. P., 1972b, Temperature-dependent transformation of cells infected with a mutant of Bryan Rous sarcoma virus, J. Virol. 10: 267–276.PubMedGoogle Scholar
  6. Balduzzi, P., and Morgan, H. R., 1970, Mechanism of oncogenic transformation by Rous sarcoma virus. I. Intracellular inactivation of cell-transforming ability of Rous sarcoma virus by 5-bromodeoxyuridine and light, J. Virol. 5: 470–477.PubMedGoogle Scholar
  7. Balk, S. D., Whitfield, J. F., Youdale, T., and Braun, A. C., 1973, Role of calcium, serum, plasma, and folic acid in the control of proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts, Proc. Natl. Acad. Sci. 70: 675–679.PubMedGoogle Scholar
  8. Baltimore, D., 1970, RNA-dependent DNA polymerase in virions of RNA tumor viruses, Nature (Gond.) 226: 1209–1211.Google Scholar
  9. Baltimore, D., and Smoler, D., 1971, Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses, Proc. Natl. Acad. Sci. 68: 1507–1511.PubMedGoogle Scholar
  10. Baluda, M. A., 1962, Properties of cells infected with avian myeloblastosis virus, Cold Spring Harbor Symp. Quant. Biol. 27: 415–425.PubMedGoogle Scholar
  11. Baluda, M. A., 1972, Widespread presence, in chickens, of DNA complementary to the RNA genome of avian leukosis viruses, Proc. Natl. Acad. Sci. 69: 576–580.PubMedGoogle Scholar
  12. Bang, F. B., and Haley, R., 1958, The appearance and disappearance of antibodies to Rous virus in normal chickens, J. Natl. Cancer Inst. 20: 329–338.PubMedGoogle Scholar
  13. Beard, J. W., 1956. Virus of avian myeloblastic leukosis, Poultry Sci. 35: 203–223.Google Scholar
  14. Beard, J. W., 1963, Avian virus growths and their etiologic agents, Advan. Cancer Res. 7: 1–127.Google Scholar
  15. Begg, A. M., 1929, A filtrable fibrosarcoma of the fowl, Brit. J. Exp. Pathol. 10: 322.Google Scholar
  16. Biggs, P. M., Milne, B. S., Graf, T., and Bauer, H., 1973, Oncogenicity of non-transforming mutants of avian sarcoma viruses, J. Gen. Virol. 18: 399–403.PubMedGoogle Scholar
  17. Biquard, J. M., and Vigier, P., 1970, Isolement et etude d’un mutant conditionnel du virus de Rous a capacite transformante thermosensible, Compt. Rend. Acad. Sci. Paris D271: 2430–2433.Google Scholar
  18. Biquard, J. M., and Vigier, P., 1972, Agglutination parla concanavaline A des fibroblastes d’embryon de poule transforme par le virus de Rous (SR-RSV) et un mutant thermosensible de ce virus, Compt. Rend. Acad. Sci. Paris D274: 144–147.Google Scholar
  19. Boettiger, D., and Temin, H. M., 1970, Light inactivation of focus formation by chicken embryo fibroblasts infected with avian sarcoma virus in the presence of 5-bromodeoxyuridine, Nature (Lond.) 228: 622–624.Google Scholar
  20. Bolognesi, D. P., Bauer, H., Gelderblom, H., and Hüper, G., 1972a, Polypeptides of avian RNA tumor viruses. IV. Components of the viral envelope Virology 47: 551–566.PubMedGoogle Scholar
  21. Bolognesi, D. P., Gelderblom, H., Bauer, H., Mölling, K., and Hüper, G., 19726, Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core, Virology 47: 567–578.Google Scholar
  22. Burger, M. M., and Martin, G. S., 1972, Agglutination of cells transformed by Rous sarcoma virus by wheat germ agglutinin and concanavalin A, Nature New Biol. 237: 9–12.PubMedGoogle Scholar
  23. Burk, D., Sprince, H., Spangeler, J. M., Rabat, E. A., Furth, J., and Claude, A., 1941, The metabolism of chicken tumors, J. Natl. Cancer Inst. 2: 201–240.Google Scholar
  24. Burmester, B. R., 1971, Viruses of the leukosis/sarcoma group, in: Poultry Diseases and World Economy ( R. F. Gordon and B. M. Freeman, eds.), pp. 135–152, British Poultry Science, Edinburgh.Google Scholar
  25. Burmester, B. R., Prickett, C. O., and Belding, T. C., 1946, A filtrable agent producing lymphoid tumours and osteopetrosis in chickens, Cancer Res. 6: 189–196.PubMedGoogle Scholar
  26. Burmester, B. R., Fontes, A. K., Waters, N. F., Bryan, W. R., and Groupé, V., 1960, The response of several inbred lines of white leghorns to inoculation with the viruses of strain RPL12 visceral lymphomatosis-erythroblastosis and of Rous sarcoma, Poultry Sci. 39: 199–215.Google Scholar
  27. Bussell, R. H., and Robinson, W. S., 1973, Membrane proteins of uninfected and Rous sarcoma virus-transformed avian cells, J. Virol. 12: 320–327.PubMedGoogle Scholar
  28. Canaani, E., and Duesberg, P., 1972, Role of subunits of 60–70S avian tumor virus ribonucleic acid in its template activity for the viral deoxyribonucleic acid polymerase, J. Virol. 10: 23–31.PubMedGoogle Scholar
  29. Canaant, E., Helm, K. V. D., and Duesberg, P., 1973, Evidence for 30–40S RNA as precursor of the 60–70S RNA of Rous sarcoma virus, Proc. Natl. Acad. Sci. 70: 401–405.Google Scholar
  30. Chen, J. H., and Hanafusa, H., 1973, Detection of a protein of avian leukoviruses in uninfected chick cells by radioimmunoassay, J. Virol. 13: 340–346.Google Scholar
  31. Cheung, K. S., Smith, R. E., Stone, M. P., and Joklik, W. K., 1972, Comparison of immature (rapid harvest) and mature Rous sarcoma virus particles, Virology 50: 851–864.PubMedGoogle Scholar
  32. Coffin, J. M., and Temin, H. M., 1972, Hybridization of Rous sarcoma virus DNA polymerase product and RNA from chicken and rat cells infected with Rous sarcoma virus, J. Virol 9: 766–775.PubMedGoogle Scholar
  33. Colby, C., and Rubin, H., 1969, Growth and nucleic acid synthesis in normal cells and cells infected with Rous sarcoma virus, J. Natl. Cancer Inst. 43: 437–444.PubMedGoogle Scholar
  34. CooK, M. K., 1969, Cultivation of a filtrable agent associated with Marek’s disease, J. Natl. Cancer Inst. 43: 203–212.Google Scholar
  35. Crittenden, L. B., and Smith, E. J., 1973, Genetic control of spontaneous RAV-0 production, in: Possible Episomes in Eukaryotes ( L. Silvestri, ed.), North-Holland, Amsterdam.Google Scholar
  36. Crittenden, L. B., Stone, H. A., Reamer, R. H., and Okazaki, W., 1967, Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses, J. Virol. 1: 898–904.PubMedGoogle Scholar
  37. Dales, S., and Hanafusa, H., 1972, Penetration and intracellular release of the genomes of avian RNA tumor viruses, Virology 50: 440–458.PubMedGoogle Scholar
  38. Darcel, C. le Q., 1973, Tumor Viruses of the Fowl, Monograph No. 8, Canadian Department of Agriculture, Ottawa.Google Scholar
  39. de Thé, G., Becker, C., and Beard, J. W., 1964, Virus of avian myeloblastosis (BAI strain A). XXV. Ultracytochemical study of virus and myeloblast phosphatase activity, J. Natl. Cancer Inst. 32: 201–237.Google Scholar
  40. Dougherty, R. M., and Distefano, H. S., 1966, Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos, Virology 29: 586–595.PubMedGoogle Scholar
  41. Duesberg, P. H., 1968, Physical properties of Rous sarcoma virus RNA, Proc. Natl. Acad. Sci. 60: 1511–1518.PubMedGoogle Scholar
  42. Duesberg, P. H., and Vogt, P. K., 1970, Differences between the ribonucleic acids of transforming and non-transforming avian tumor viruses, Proc. Natl. Acad. Sci. 67: 1673–1680.PubMedGoogle Scholar
  43. Duesberg, P. H., and Vogt, P. K., 1973, RNA species obtained from clonal lines of avian sarcoma and from avian leukosis virus, Virology 54: 207–219.PubMedGoogle Scholar
  44. Duff, R. G., and Vogt, P. K., 1969, Characteristics of two new avian tumor virus subgroups, Virology 39: 18–30.PubMedGoogle Scholar
  45. Engelbreth-Holm, J., and Rothe-Meyer, A., 1935, On the connection between erythroblastosis (haemocytoblastosis), myelosis and sarcoma in chicken. Acta Pathol. Microbiol. Scand. 12: 352–365.Google Scholar
  46. Erikson, E., and Erikson, R. L., 1970, Isolation of amino acid acceptor RNA from purified avian myeloblastosis virus, J. Mol. Biol. 52: 387–390.PubMedGoogle Scholar
  47. Fan, H., and Baltimore, D., 1973, RNA metabolism of murine leukemia virus, J. Mol. Biol. 80: 93–117.PubMedGoogle Scholar
  48. Fenner, F., Mcauslan, B. R., Mims, C. A., Sambrook, J., and White, D. O., 1974, The Biology of Animal Viruses, 2nd ed., Academic Press, New York.Google Scholar
  49. Fields, B. N., and Joklik, W. K., 1969, Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus, Virology 37: 335–342.PubMedGoogle Scholar
  50. Fleissner, E., 1971, Chromatographic separation and antigenic analysis of proteins of oncornaviruses. I. Avian leukosis-sarcoma viruses, J. Virol. 8: 778–785.PubMedGoogle Scholar
  51. Foulds, L., 1934, The growth and spread of six filterable tumours of the fowl, transmitted by grafts, Imperial Cancer Research Fund, I Ith Scientific Report, pp. 15–25.Google Scholar
  52. Friis, R. R., 1972, Abortive infection of Japanese quail cells with avian sarcoma viruses, Virology 50: 701–712.PubMedGoogle Scholar
  53. Friis, R. R., Toyoshima, K., and Vogt, P. K., 1971, Conditional lethal mutants of avian sarcoma viruses. I. Physiology of ts 75 and ts 149, Virology 43: 375–389.PubMedGoogle Scholar
  54. Fujinami, A., and Inamoto, K., 1914, Ueber Geschwülste bei japanischen Haushühnern insbesondere über einen transplantablen Tumor, Z. Krebsforsch. 14: 94.Google Scholar
  55. Goldié, A., 1970, Radio-induced mutants of the Schmidt-Ruppin strain of Rous sarcoma virus, Virology 40: 1022–1029.Google Scholar
  56. Graf, T., 1972, A plaque assay for avian RNA tumor viruses, Virology 50: 567–578.PubMedGoogle Scholar
  57. Graf, T., Bauer, H., Gelderblom, H., and Bolognesi, D. P., 1971, Studies on the reproductive and cell-converting abilities of avian sarcoma viruses, Virology 43: 427–441.PubMedGoogle Scholar
  58. Gross, L., 1970, Oncogenic Viruses, 2nd ed., Pergamon Press, New York.Google Scholar
  59. Haguenau, F., and Beard, J. W., 1962, The avian sarcoma-leukosis complex: Its biology and ultrastructure, in: Tumors Induced by Viruses: Ultrastructural Studies ( A. J. Dalton and F. Haguenau, eds.), pp. 1–59, Academic Press, New York.Google Scholar
  60. Hakomori, S., Saito, T., and Vogt, P. K., 1971, Transformation by Rous sarcoma virus: Effects on cellular glycolipids, Virology 44: 609–621.PubMedGoogle Scholar
  61. Halpern, M. S., Wade, E., Rucker, E., Baxter-Gabbard, K. L., Levine, A. S., and Friis, R. R., 1973, A study of the relationship of reticuloendotheliosis virus to the avian leukosis-sarcoma complex of viruses, Virology 53: 287–299.PubMedGoogle Scholar
  62. Hanafusa, H., 1965, Analysis of the defectiveness of Rous sarcoma virus. III. Determining influence of a new helper virus on the host range and susceptibility to interference of RSV, Virology 25: 248–255.PubMedGoogle Scholar
  63. Hanafusa, H., 1969a, Replication of oncogenic viruses in virus-induced tumor cells—Their persistence and interaction with other viruses, Advan. Cancer Res. 12: 137–165.Google Scholar
  64. Hanafusa, H., 19696, Rapid transformation of cells by Rous sarcoma virus, Proc. Natl. Acad. Sci. 63: 318–325.Google Scholar
  65. Hanafusa, H., 1970, Virus production by Rous sarcoma cells, Curr. Top. Microbiol. Immunol. 51: 114–123.PubMedGoogle Scholar
  66. Hanafusa, H., and Hanafusa, T., 1966a, Analysis of defectiveness of Rous sarcoma virus. IV. Kinetics of RSV production, Virology 28: 369–378.PubMedGoogle Scholar
  67. Hanafusa, H., and Hanafusa, T., 1966b, Determining factor in the capacity of Rous sarcoma virus to induce tumors in mammals, Proc. Natl. Acad. Sci. 55: 532–538.Google Scholar
  68. Hanafusa, H., and Hanafusa, T., 1968, Further studies on RSV production from transformed cells, Virology 34: 630–636.PubMedGoogle Scholar
  69. Hanafusa, H., and Hanafusa, T., 1971, Noninfectious RSV deficient in DNA polymerase, Virology 43: 313–316.PubMedGoogle Scholar
  70. Hanafusa, H., Hanafusa, T., and Rubin, H., 1963, The defectiveness of Rous sarcoma virus, Proc. Natl. Acad. Sci. 49: 572–580.PubMedGoogle Scholar
  71. Hanafusa, H., Hanafusa, T., and Rubin, H., 1964, Analysis of the defectiveness of Rous sarcoma virus. II Specification of RSV antigenicity by helper virus, Proc. Natl. Acad. Sci. 51: 41–48.PubMedGoogle Scholar
  72. Hanafusa, H., Miyamoto, T., and Hanafusa, T., 1970a, A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus, Proc. Natl. Acad. Sci. 66: 314–321.PubMedGoogle Scholar
  73. Hanafusa, H., Hanafusa, T., and Miyamoto, T., 1970b, Avian leukosis-sarcoma viruses: Complementation and rescue, in: The Biology of Oncogenic Viruses (Second Lepetit Colloquium, L. G. Silvestri, ed.), pp. 170–175, North-Holland, Amsterdam.Google Scholar
  74. Hanafusa, H., Aoki, T., Kawai, S., Miyamoto, T., and Wilsnack, R. E., 1973, Presence of antigen common to avian tumor viral envelope antigen in normal chick embryo cells, Virology 56: 22–32.PubMedGoogle Scholar
  75. Hanafusa, T., and Hanafusa, H., 1967, Interaction among avian tumor viruses giving enhanced infectivity, Proc. Natl. Acad. Sci. 58: 818–825.PubMedGoogle Scholar
  76. Hanafusa, T., and Hanafusa, H., 1973, Isolation of leukosis-type virus from pheasant embryo cells: Possible presence of viral genes in cells, Virology 51: 247–251.PubMedGoogle Scholar
  77. Hanafusa, T., Miyamoto, T., and Hanafusa, H., 1970a, A type of chick embryo cell that fails to support formation of infectious RSV, Virology 40: 55–64.PubMedGoogle Scholar
  78. Hanafusa, T., Hanafusa, H., and Miyamoto, T., 1970b, Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses, Proc. Natl. Acad. Sci. 67: 1797–1803.PubMedGoogle Scholar
  79. Hanafusa, T., Hanafusa, H., Miyamoto, T., and Fleissner, E., 1972, Existence and expression of tumor virus genes in chick embryo cells, Virology 47: 475–482.PubMedGoogle Scholar
  80. Harel, J., Harel, L., Goldé, A., and Vigier, P., 1966, Homologie entre génome du virus du sarcome de Rous (RSV) et génome cellulaire, Compt. Rend. Acad. Sci. Paris 263: 745.Google Scholar
  81. Hatanaka, M., and Hanafusa, H., 1970, Analysis of a functional change in membrane in the process of cell transformation by Rous sarcoma virus; alteration in the characteristics of sugar transport, Virology 41: 647–652.PubMedGoogle Scholar
  82. Hatanaka, M., Kakefuda, T., Gilden, R. V., and Callan, E. A. O., 1971, Cytoplasmic DNA synthesis induced by RNA tumor viruses, Proc. Natl. Acad. Sci. 68: 1844–1847.PubMedGoogle Scholar
  83. Hayward, W. S., and Hanafusa, H., 1973, Detection of avian tumor virus RNA in uninfected chick embryo cells, J. Virol 11: 157–167.PubMedGoogle Scholar
  84. Hill, M., and Hillova, H., 1972, Virus recovery in chicken cells tested with Rous sarcoma cell DNA, Nature New Biol. 237: 35–39.PubMedGoogle Scholar
  85. Hirst, G. K., 1962, Genetic recombination with Newcastle disease virus, poliovirus, and influenza, Cold Harbor Symp. Quant. Biol. 27: 303–309.Google Scholar
  86. Huebner, R. J., Armstrong, D., Okuyan, M., Sarma, P. S., and Turner, H. C., 1964, Specific complement-fixing viral antigens in hamster and guinea pig tumors induced by the Schmidt—Ruppin strain of avian sarcoma, Proc. Natl. Acad. Sci. 51: 742–750.PubMedGoogle Scholar
  87. Hung, P. P., 1973, Rescue of chemically inactivated Rous sarcoma virus transforming activity by avian leukosis virus, Virology 53: 463–467.PubMedGoogle Scholar
  88. Hung, P. P., Robinson, H. L., and Robinson, W. S., 1971, Isolation and characterization of proteins from Rous sarcoma virus, Virology 43: 251–266.PubMedGoogle Scholar
  89. Ishimoto, N., Temin, H. M., and Strominger, J. L., 1966, Studies on carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts, J. Biol. Chem. 241: 2052–2057.PubMedGoogle Scholar
  90. Ishizaki, R., and Shimizu, T., 1970, Heterogeneity of strain R avian erythroblastosis virus, Cancer Res. 30: 2827–2831.PubMedGoogle Scholar
  91. Ishizaki, R., and Vogt, P. K., 1966, Immunological relationships among envelope antigens of avian tumor viruses, Virology 30: 375–387.PubMedGoogle Scholar
  92. Ishizaki, R., Langlois, A. J., Chabot, J., and Beard, J. W., 1971, Component of strain MC29 avian leukosis virus with the property of defectiveness, J. Virol. 8: 821–827.PubMedGoogle Scholar
  93. Ivanov, X., Mladenov, Z., Nedyalkov, S., Todorov, T. G. and Yakimov, M., 1964, Experimental investigations into avian leucoses. V. Transmission, haematology and morphology of avian myelocytomatosis, Bull. Inst. Pathol. Comp. Anim. 10: 5–38.Google Scholar
  94. Jonsson, N., and Sjogren, H. 0., 1965, Further studies on specific transplantation antigens in Rous sarcoma of mice, J. Exp. Med. 122: 403–421.PubMedGoogle Scholar
  95. Kabat, E. A., 1939, A polysaccharide in tumors due to a virus of leucosis and sarcoma of flows, J. Biol. Chem. 130: 143–147.Google Scholar
  96. Kang, C. Y., and Temin, H. M., 1972, Endogenous RNA—directed DNA polymerase activity in uninfected chicken embryos, Proc. Natl. Acad. Sci. 69: 1550–1554.Google Scholar
  97. Kang, C. Y., and Temin, H. M., 1973, Lack of sequence homology among RNAs of avian leukosis—sarcoma viruses, reticuloendotheliosis viruses, and chicken endogenous RNA—directed DNA polymerase activity, J. Virol. 12: 1314–1324.PubMedGoogle Scholar
  98. Kapeller, M., and Doljanski, F., 1972, Agglutination of normal and Rous sarcoma virus—transformed chick embryo cells by concanavalin A and wheat germ agglutinin, Nature New Biol. 235: 184–185.PubMedGoogle Scholar
  99. Kawat, S., and Hanafusa, H., 1971, The effects of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant, Virology 46: 470–479.Google Scholar
  100. Kawai, S., and Hanafusa, H., 1972a, Plaque assay for some strains of avian leukosis virus, Virology 48: 126–135.PubMedGoogle Scholar
  101. Kawai, S., and Hanafusa, H., 1972b, Genetic recombination with avian tumor virus, Virology 49: 37–44.PubMedGoogle Scholar
  102. Kawai, S., and Hanafusa, H., 1973, Isolation of defective mutant of avian sarcoma virus, Proc. Natl. Acad. Sci. 70: 3493–3497.PubMedGoogle Scholar
  103. Kawai, S., Metroka, C. E., and Hanafusa, H., 1972, Complementation of functions required for cell transformation by double infection with RSV mutants, Virology 49: 302–304.PubMedGoogle Scholar
  104. Kurth. R., and Bauer, H., 1972, Common tumor-specific surface antigens on cells of different species transformed by avian RNA tumor viruses, Virology 49: 145–159.Google Scholar
  105. Lai, M. M. C., and Duesberg, P. H., 1972, Adenylic acid—rich sequence in RNAs of Rous sarcoma virus and Rauscher mouse leukaemia virus, Nature (Land.) 235: 383–386.Google Scholar
  106. Langlois, A. J., and Beard, J. W., 1967, Converted-cell focus formation in culture by strain MC29 avian leukosis virus, Proc. Soc. Exp. Biol. Med. 126: 718–722.Google Scholar
  107. Leong, J., Garapin, A., Jackson, N., Fanshier, L., Levinson, W., and Bishop, J. M., 1972, Virus-specific ribonucleic acid in cells producing Rous sarcoma virus: Detection and characterization, J. Virol. 9: 891–902.PubMedGoogle Scholar
  108. Linial, M., and Mason, W. S., 1973, Characterization of two conditional early mutants of Rous sarcoma virus, Virology 53: 258–273.PubMedGoogle Scholar
  109. Livingston, D. M., Parks, W. P., Scolnick, E. M., and Ross, J., 1972, Affinity chromatography of avian type C viral reverse transcriptase: Studies with Rous sarcoma virus transformed rat cells, Virology 50: 388–395.PubMedGoogle Scholar
  110. Lowy, D. R., Rowe, W. P., Teich, N., and Harti,Ey, J. W., 1971, Murine leukemia virus: High frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine, Science 174: 155–156.PubMedGoogle Scholar
  111. Ludford, C. G., Purchase, H. G., and Cox, H. W., 1972, Duck infectious anemia virus associated with Plasmodium lophurae, Exp. Parasitol. 31: 29–38.PubMedGoogle Scholar
  112. Machala, O., Donner, L., and Svoboda, J., 1970, A full expression of the genome of Rous sarcoma virus in heterokaryons formed after fusion of virogenic mammalian cells and chicken fibroblasts, J. Gen. Virol. 8: 219–229.PubMedGoogle Scholar
  113. Macpherson, I., 1970, The characteristics of animal cells transformed in vitro, Advan. Cancer Res. 13: 169–215.Google Scholar
  114. Macpherson, I., and Montagnier, L., 1964, Agar suspension culture for the selective assay of cells transformed by polyoma virus, Virology 23: 291–294.PubMedGoogle Scholar
  115. Manaker, R. A., and Groupé, V., 1956, Discrete foci of altered chick embryo cells associated with Rous sarcoma virus in tissue culture, Virology 2: 838–840.PubMedGoogle Scholar
  116. Markham, P. D., and Baluda, M. A., 1973, The integrated state of oncornavirus DNA in normal chicken cells and in cells transformed by avian myeloblastosis virus, J. Virol. 12: 721–732.PubMedGoogle Scholar
  117. Martin, G. S., 1970, Rous sarcoma virus: A function required for the maintenance of the transformed state, Nature (Lond.) 227: 1021–1023.Google Scholar
  118. Martin, G. S., and Duesberg, P. H., 1972, The a subunit in the RNA of transforming avian tumor viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in non-transforming variants, Virology 47. 494–497.PubMedGoogle Scholar
  119. Martin, G. S., Venuta, S., Weber, M., and Rubin, H., 1971, Temperature-dependent alterations in sugar transport in cells infected by a temperature-sensitive mutant of Rous sarcoma virus, Proc. Natl. Acad. Sci. 68: 2739–2741.PubMedGoogle Scholar
  120. Miyamoto, K., and Gilden, R. V., 1971, Electron microscopic studies of tumor viruses. I. Entry of murine leukemia virus into mouse embryo fibroblasts, J. Virol. 7: 395–406.PubMedGoogle Scholar
  121. Mizutani, S., and Temin, H. M., 1973, Lack of serological relationship among DNA polymerases of avian leukosis—sarcoma viruses, reticuloendotheliosis viruses, and chicken cells, J. Virol. 12: 440–448.PubMedGoogle Scholar
  122. Mölling, K., Bolognesi, D. P., Bauer, H., Busen, W., Plassmann, H. W., and Hausen, P., 1971, Association of viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA—DNA hybrids, Nature New Biol. 234: 240–243.PubMedGoogle Scholar
  123. MoscoviCl, C., 1967, A quantitative assay for avian myeloblastosis virus, Proc. Soc. Exp. Biol. Med. 125: 1213–1215.Google Scholar
  124. Moscovici, C., and Vogt, P., 1968, Effects of genetic cellular resistance on cell transformation and virus replication in chicken hematopoietic cell cultures infected with avian myeloblastosis virus (BAI-A), Virology 35: 487–497.PubMedGoogle Scholar
  125. Moscovici, C., and Zanetti, M., 1970, Studies of single foci of hematopoietic cells transformed by avian myeloblastosis virus, Virology 42: 61–67.PubMedGoogle Scholar
  126. Neiman, P. E., 1972, Rous sarcoma virus nucleotide sequence in cellular DNA: Measurement by RNA-DNA hybridization, Science 178: 750–752.PubMedGoogle Scholar
  127. Otten, J., Bader, J., Johnson, G. S., and Pastan, I., 1972, A mutation in a Rous sarcoma virus gene that controls adenosine 3’,5’-monophosphate levels and transformation, J. Biol. Chem. 247: 1632–1633.PubMedGoogle Scholar
  128. Parson, J. T., Coffin, J. M., Haroz, R. K., Bromley, P. A., and Weissmann, C., 1973, Quantitative determination and location of newly synthesized virus-specific ribonucleic acid in chicken cells infected with Rous sarcoma virus, J. Virol. 11: 761–774.Google Scholar
  129. Payne, L. N., and Biggs, P. M., 1964, Differences between highly inbred lines of chickens in the response to Rous sarcoma virus of the chorioallantoic membrane and of embryonic cells in tissue culture, Virology 24: 610–616.PubMedGoogle Scholar
  130. Payne, L. N., and Chubb, R. C., 1968, Studies on the nature and genetic control of an antigen in normal chick embryos which reacts in the COFAL test, J. Gen. Virol. 3: 379–391.PubMedGoogle Scholar
  131. Peterson, D. A., Baxter-Gabbard, K. L., and Levine, A. S., 1972, Avian reticuloendotheliosis (strain T). V. DNA-polymerase, Virology 47: 251–254.PubMedGoogle Scholar
  132. Piraino, F., 1967, The mechanism of genetic resistance of chick embryo cells to infection by Rous sarcoma virus—Bryan strain (BS-RSV), Virology 32: 700–707.PubMedGoogle Scholar
  133. Pontén, J., 1963, Chromosome analysis of three virus-associated chicken tumors: Rous sarcoma, erythroleukemia, and RPL12 lymphoid tumor, J. Natl. Cancer Inst. 30: 897–921.PubMedGoogle Scholar
  134. Purchase, H. G., Ludford, C., Nazarian, K., and Cox, H. W., 1973, A new group of oncogenic viruses: Reticuloendotheliosis, chick syncytial, duck infectious anemia, and spleen necrosis viruses, J. Natl. Cancer Inst. 51: 489–499.PubMedGoogle Scholar
  135. Quigley, J. P., Rifkin, D. B., and Reich, E., 1971, Phospholipid composition of Rous sarcoma virus, host cell membranes and other enveloped RNA viruses, Virology 46: 106–116.PubMedGoogle Scholar
  136. Reamer. R. H., and Okazaki, W., 1971, Evidence for the defectiveness of the Harris strain of Rous sarcoma virus, J. Natl. Cancer Inst. 44: 763–767.Google Scholar
  137. Rifkin, D. B., and Compans, R. W., 1971, Identification of the spike proteins of Rous sarcoma virus, Virology 46: 485–489.PubMedGoogle Scholar
  138. Robinson, H. L., 1967, Isolation of non-infectious particles containing Rous sarcoma virus RNA from the medium of Rous sarcoma virus-transformed nonproducer cells, Proc. Natl. Acad. Sci. 57: 1655–1662.PubMedGoogle Scholar
  139. Robinson, W. S., and Robinson, H. L., 1971, DNA polymerase in defective Rous sarcoma virus, Virology 44: 456–462.Google Scholar
  140. Robinson, W. S., Pitkanen, A., and Rubin, H., 1965, The nucleic acid of the Bryan strain of Rous sarcoma virus: Purification of the virus and isolation of the nucleic acid, Proc. Natl. Acad. Sci. 54: 137–144.PubMedGoogle Scholar
  141. Rosenthal, P. N., Robinson, H. L., Robinson, W. S., Hanafusa, T., and Hanafusa, H., 1971, DNA in uninfected and virus-infected cells complementary to avian tumor virus RNA, Proc. Natl. Acad. Sci. 68: 2336–2340.PubMedGoogle Scholar
  142. Rous, P., 1911, A sarcoma of the fowl transmissible by an agent separable from the tumor cells, J. Exp. Med. 13: 397–411.PubMedGoogle Scholar
  143. Rubin, H., 1955, Quantitative relations between causative virus and cell in the Rous no. 1. chicken sarcoma, Virology 1: 445–473.PubMedGoogle Scholar
  144. Rubin, H., 1960a, A virus in chick embryos which induces resistance in vitro to infection with Rous sarcoma virus, Proc. Natl. Acad. Sci. 46: 1105–1119.PubMedGoogle Scholar
  145. Rubin, H., 1960b, An analysis of the assay of Rous sarcoma cells in vitro by the infective center technique, Virology 10: 29–49.PubMedGoogle Scholar
  146. Rubin, H., 1960c, The suppression of morphological alterations in cells infected with Rous sarcoma virus, Virology 12: 14–31.PubMedGoogle Scholar
  147. Rubin, H., 1962, The immunological basis for non-infective Rous sarcomas, Cold Spring Harbor Symp. Quant. Biol. 27: 441–452.PubMedGoogle Scholar
  148. Rubin, H., 1965, Genetic control of cellular susceptibility to pseudotypes of Rous sarcoma virus, Virology 26: 270–276.PubMedGoogle Scholar
  149. Rubin, H., 1966, The inhibition of chick embryo cell growth by medium obtained from cultures of Rous sarcoma cells, Exp. Cell Res. 41: 149–161.PubMedGoogle Scholar
  150. Rubin, H., and Temin, H. M., 1959, A radiological study of cell-virus interaction in the Rous sarcoma, Virology 7: 75–91.PubMedGoogle Scholar
  151. Rubin, H., and Vogt, P. K., 1962, An avian leukosis virus associated with stocks of Rous sarcoma virus, Virology 17: 184–194.PubMedGoogle Scholar
  152. Rubin, H., Cornelius, A., and Fanshier, L., 1961, The pattern of congenital transmission of an avian leukosis virus, Proc. Natl. Acad. Sci. 47: 1058–1069.PubMedGoogle Scholar
  153. Rubin, H., Fanshier, L., Cornelius, A., and Hughes, W. F., 1962, Tolerance and immunity to chickens after congenital and contact infection with an avian leukosis virus, Virology 17: 143–156.PubMedGoogle Scholar
  154. Sarma, P. S., Turner, H. C., and Huebner, R. J., 1964, An avian leukosis group-specific complement fixation reaction: Application for the detection and assay of non-cytopathogenic leukosis viruses, Virology 23: 313–321.PubMedGoogle Scholar
  155. Scheele, C. M., and Hanafusa, H., 1971, Proteins of helper-dependent RSV, Virology 45: 401–410.PubMedGoogle Scholar
  156. Scheele, C. M., and Hanafusa, H., 1972, Electrophoretic analysis of the RNA of avian tumor viruses, Virology 50: 753–764.PubMedGoogle Scholar
  157. Siegert, W., Konings, R. N. H., Bauer, H., and Hofschneider, P. H., 1972, Translation of avian myeloblastosis virus RNA in a cell-free lysate of Escherichia coli, Proc. Natl. Acad. Sci. 69: 888–891.PubMedGoogle Scholar
  158. Simkovic, D., 1972, Characteristics of tumors induced in mammals, especially rodents, by viruses of the avian leukosis sarcoma group, Advan. Virus Res. 17: 95–127.Google Scholar
  159. Steck, F. T., and Rubin, H., 1965, The mechanism of interference between an avian leukosis virus and Rous sarcoma virus. II. Early steps of infection by RSV of cells under conditions of interference, Virology 29: 642–653.Google Scholar
  160. Steck, T. L., Kaufman, S., and Bader, J. P., 1968, Glycolysis in chick embryo cell cultures transformed by Rous sarcoma virus, Cancer Res. 28: 1611–1619.PubMedGoogle Scholar
  161. Stephenson, J. R., and Aaronson, S. A., 1972, A genetic locus for inducibility of C-type virus in Balb/c cells: The effect of a nonlinked regulatory gene on detection of virus after chemical activation, Proc. Natl. Acad. Sci. 69: 2798–2801.PubMedGoogle Scholar
  162. Stephenson, J. R., Wilsnack, R. E., and Aaronson, S. A., 1973, Radioimmunoassay for avian C-type virus group specific antigen: Detection in normal and virus transformed cells, J. Virol. 11: 893–899.PubMedGoogle Scholar
  163. Suni, J., Vaheri, A., and Ruoslahti, E., 1973, Radioimmunoassay of avian RNA tumor virus group-specific antigen, Intervirology 1:119–126.PubMedGoogle Scholar
  164. Svoboda, J., 1964, Malignant interaction of Rous virus with mammalian cells in vivo and in vitro, Natl. Cancer Inst. Monogr. 17: 277–292.Google Scholar
  165. Svoboda, J., and Hlozanek, I., 1970, Role of cell association in virus infection and virus rescue, Advan. Cancer Res. 13: 217–269.Google Scholar
  166. Taylor, H. W., and Olson, L. D., 1972, Spectrum of infectivity and transmission of the T-virus, Avian Dis. 16: 330–335.PubMedGoogle Scholar
  167. Temin, H. M., 1960, The control of cellular morphology in embryonic cells infected with Rous sarcoma virus in vitro, Virology 10: 182–197.PubMedGoogle Scholar
  168. Temin, H. M., 1963, The effect of actinomycin D on growth of Rous sarcoma virus in vitro, Virology 20: 577–582.PubMedGoogle Scholar
  169. Temin, H. M., 1964a, The participation of DNA in Rous sarcoma virus production, Virology 23: 486–494.PubMedGoogle Scholar
  170. Temin, H. M., 19646, The nature of the provirus of Rous sarcoma, Natl. Cancer Inst. Monogr. 17: 557–570.Google Scholar
  171. Temin, H. M., 1965, The mechanism of carcinogenesis by avian sarcoma viruses. I. Cell multiplication and differentiation, J. Natl. Cancer Inst. 35: 679–693.PubMedGoogle Scholar
  172. Temin, H. M., 1968, Studies on carcinogenesis by avian sarcoma viruses. VIII. Glycolysis and cell multiplication, Int. J. Cancer 3: 273–282.PubMedGoogle Scholar
  173. Temin, H. M., 1971, Mechanism of cell transformation by RNA tumor viruses, Ann. Rev. Microbiol. 25: 609–648.Google Scholar
  174. Temin, H. M., 1973, The cellular and molecular biology of RNA tumor viruses, especially avian leukosis-sarcoma viruses, and their relatives, Advan. Cancer Res. 19: 47–104.Google Scholar
  175. Temin, H. M., and Baltimore, D., 1972, RNA-directed DNA synthesis and RNA tumor viruses, Advan. Virus Res. 17: 129–186.Google Scholar
  176. Temin, H. M., and Mizutani, S., 1970, RNA-dependent DNA polymerase in virions of Rous sarcoma virus, Nature (Lond.) 226: 1211–1213.Google Scholar
  177. Temin, H. M., and Rubin, H., 1958, Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture, Virology 6: 669–688.PubMedGoogle Scholar
  178. Temin, H. M., and Rubin, H., 1959, A kinetic study of infection of chick embryo cells in vitro by Rous sarcoma virus, Virology 8: 209–222.PubMedGoogle Scholar
  179. Temin, H. M., Pierson, R. W., JR., and Dulak, N. C., 1972, The role of serum in the control of multiplication of avian and mammalian cells in culture, in: Growth, Nutrition, and Metabolism of Cells in Culture, Vol. 1 ( G. H. Rothblat and V. J. Cristofalo, eds.), pp. 49–81, Academic Press, New York.Google Scholar
  180. Theilen, G. H., Zeigel, R. F., and Twiehaus, M. J., 1966, Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail, J. Natl. Cancer Inst. 37: 731–743.PubMedGoogle Scholar
  181. Thurzo, V., Smida, J., Smidova-Kovarova, V., and Simkovic, D., 1963, Some properties of the fowl virus tumor B77, Acta Unio Int. Contra Cancrum 19: 304–305.PubMedGoogle Scholar
  182. Tooze, J. (ed.), 1973, The molecular biology of tumor viruses, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.Google Scholar
  183. Toyoshima, K., and Vogt, P. K., 1969a, Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions, Virology 38: 414–426.PubMedGoogle Scholar
  184. Toyoshima, K., and Vogt, P. K., 19696, Temperature sensitive mutants of an avian sarcoma virus, Virology 39: 930–931.Google Scholar
  185. Toyoshima, K., Frits, R. R., and Vogt, P. K., 1970, The reproductive and cell-transforming capacities of avian sarcoma virus B77: Inactivation with UV light, Virology 42: 163–170.PubMedGoogle Scholar
  186. Trager, W., 1959, A new virus of ducks interfering with development of malaria parasite (Plasmodium lophurae), Proc. Soc. Exp. Biol. Med. 101: 578–582.PubMedGoogle Scholar
  187. Unkeless, J. C., Tobia, A., Ossowski, L., Quigley, J. P., Rifkin, D. B., and Reich, E., 1973a, An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses, J. Exp. Med. 137: 85–111.Google Scholar
  188. Unkeless, J. C., Dang, K., Kellerman, G. M., and Reich, E., 19736, Fibrinolysis associated with oncogenic transformation: Partial purification and characterization of the cell factor—a plasminogen activator, J. Biol. Chem. 249: 4295–4305.Google Scholar
  189. Varmus, H. E., Levinson, W. E., and Bishop, J. M., 1971, Extent of transcription by the RNA dependent DNA polymerase of Rous sarcoma virus, Nature New Biol. 233: 19–21.PubMedGoogle Scholar
  190. Varmus, H. E., Weiss, R. A., Friis, R. R., Levinson, W., and Bishop, J. M., 1972, Detection of avian tumor virus–specific nucleotide sequences in avian cell DNA, Proc. Natl. Acad. Sci. 69: 20–24.PubMedGoogle Scholar
  191. Varmus, H. E., Bishop, J. M., and Vogt, P. K., 1973a, Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus, J. Mol. Biol. 73: 613–626.Google Scholar
  192. Varmus, H. E., Vogt, P. K., and Bishop, J. M., 19736, Integration of Rous sarcoma virus–specific DNA following infection of permissive and non-permissive hosts, Proc. Natl. Acad. Sci. 70: 3067–3071.Google Scholar
  193. Vecchio, G., Tsuchida, N., Shanmugam, G., and Green, M., 1973, Virus specific messenger RNA and nascent polypeptides in polyribosomes of cells replicating murine sarcoma–leukemia viruses, Proc. Natl. Acad. Sci. 70: 2064–2068.PubMedGoogle Scholar
  194. Vigier, P., 1970a, Effect of agar, calf embryo extract, and polyanions on production of foci of transformed cells by Rous sarcoma virus, Virology 40: 179–192.PubMedGoogle Scholar
  195. Vigier, P., 19706, RNA oncogenic viruses: Structure, replication, and oncogenicity, Prog. Med. Virol. 12: 240–283.Google Scholar
  196. Vigier, P., and Goldé, A., 1964, Effects of actinomycin D and of mitomycin Con the development of Rous sarcoma virus, Virology 23: 511–519.PubMedGoogle Scholar
  197. Vigier, P., and Svoboda, J., 1965, Etude, en culture, de la production du virus de Rous par contact entre les cellules du sarcome XC du rat et les cellules d’embryon de poule, Compt. Rend. Acad. Sci. Paris 261: 4278–4281.Google Scholar
  198. Vogt, P. K., 1965a, Avian tumor viruses, Advan. Virus Res. 11: 293–385.Google Scholar
  199. Vogt, P. K., 19656, A heterogeneity of Rous sarcoma virus revealed by selectively resistant chick embryo cells, Virology 25: 237–247.Google Scholar
  200. Vogt, P. K., 1967a, Phenotypic mixing in the avian tumor virus group, Virology 32: 708–717.PubMedGoogle Scholar
  201. Vogt, P. K., 19676, DEAE-dextran enhancement of cellular transformation induced by avian sarcoma viruses, Virology 33: 175–177.Google Scholar
  202. Vogt, P. K., 1967c, Virus-directed host responses in the avian leukosis and sarcoma complex, in: Perspectives in Virology, Vol. V ( M. Pollard, ed.), pp. 199–228, Academic Press, New York.Google Scholar
  203. Vogt, P. K., 1969, Focus assay of Rous sarcoma virus, in: Fundamental Techniques in Virology ( K. Habel and N. P. Salzman, eds.), pp. 198–211, Academic Press, New York.Google Scholar
  204. Vogt, P. K., 197la, Spontaneous segregation of non-transforming viruses from cloned sarcoma viruses, Virology 46: 939–946.Google Scholar
  205. Vogt, P. K., 1971 b, Genetically stable reassortment of markers during mixed infection with avian tumor viruses, Virology 46: 947–952.Google Scholar
  206. Vogt, P. K., and Friis, R. R., 1971, An avian leukosis virus related to RSV(0): Properties and evidence for helper activity, Virology 43: 223–234.PubMedGoogle Scholar
  207. Vogt, P. K., and Ishizaki, R., 1965, Reciprocal patterns of genetic resistance to avian tumor viruses in two lines of chickens, Virology 26: 664–672.PubMedGoogle Scholar
  208. Vogt, P. K., and Ishizaki, R., 1966, Patterns of viral interference in the avian leukosis and sarcoma complex, Virology 30: 368–374.PubMedGoogle Scholar
  209. Vogt, P. K., and Rubin, H., 1963, Studies on the assay and multiplication of avian myeloblastosis virus, Virology 19: 92–104.PubMedGoogle Scholar
  210. Vogt, V. M., and Eisenman, R., 1973, Identification of a large polypeptide precursor of avian oncornavirus proteins, Proc. Natl. Acad. Sci. 70: 1734–1738.PubMedGoogle Scholar
  211. Warren, L., Critchley, D., and Macpherson, I., 1972, Surface glycoproteins and glycolipids of chicken embryo cells transformed by a temperature-sensitive mutant of Rous sarcoma virus, Nature (Lond.) 235: 275–277.Google Scholar
  212. Weiss, R. A., 1969, The host range of Bryan strain Rous sarcoma virus synthesized in the absence of helper virus, J. Gen. Virol. 5: 511–528.Google Scholar
  213. Weiss, R. A., and Payne, L. N., 1971, The heritable nature of the factor in chicken cells which acts as a helper virus for Rous sarcoma virus, Virology 45: 508–515.PubMedGoogle Scholar
  214. Weiss, R. A., Friis, R. R., Katz, E., and Vogt, P. K., 1971, Induction of avian tumor viruses in normal cells by physical and chemical carcinogens, Virology 46: 920–938.PubMedGoogle Scholar
  215. Weiss, R. A., Mason, W. S., and Vogt, P. K., 1973, Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses, Virology 52: 535–552.PubMedGoogle Scholar
  216. Weissbach, A., Bolden, A., Muller, R., Hanafusa, H., and Hanafusa, T., 1972, Deoxyribonucleic acid polymerase activities in normal and leukovirus-infected chicken embryo cells, J. Virol. 10: 321–327.PubMedGoogle Scholar
  217. Wickus, G. G., and Robbins, P. W., 1973, Plasma membrane proteins of normal and Rous sarcoma virus—transformed chick embryo fibroblasts, Nature New Biol. 245: 65–67.PubMedGoogle Scholar
  218. Wyke, J. A., 1973, Complementation of transforming functions by temperature-sensitive mutants of avian sarcoma virus, Virology 54: 28–36.PubMedGoogle Scholar
  219. Wyke, J. A., and Linial, M., 1973, Temperature-sensitive avian sarcoma viruses: A physiological comparison of twenty mutants, Virology 53: 152–161.PubMedGoogle Scholar
  220. Zavada, J., 1972, VSV pseudotype particles with the coat of avian myeloblastosis virus, Nature New Biol. 240: 122–124.PubMedGoogle Scholar
  221. zeigel, R. F., theilen, G. H., and twiehaus, M. J., 1966, Electron microscopic observations on RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail, J. Natl. Cancer Inst. 37: 709–729.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Hidesaburo Hanafusa
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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