Liquid Crystalline Behavior of Biologically Important Lipids Polyunsaturated Cholesterol Esters and Phospholipids

  • D. M. Small
  • C. Loomis
  • M. Janiak
  • G. G. Shipley


Lipids are biologically important molecules. They give structure to plasma membranes and intracellular organelles, provide a source of metabolic energy and play a role in many essential biological processes such as transmission of information across membranes, transmission of nerve impulses, antigen-antibody reactions and thrombogenesis. Lipids have also been implicated in pathological processes, for instance the lipid storage diseases (1) gallstones and (2) atherosclerosis (3).


Cholesterol Ester Smectic Phase Isotropic Liquid Lamellar Liquid Crystal Cholesteric Phase 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    “Lipid Storage Diseases” (J. Bernsohn and H.J. Grossman eds.) Academic Press, New York and London, (1971).Google Scholar
  2. 2.
    Small, D.M., Advances in Internal Medicine, 16, 243–264(1970).Google Scholar
  3. 3.
    “Atherosclerosis” (R.J.Jones ed.) Springer-Verlag, New York, Heidelberg, Berlin, (1970).Google Scholar
  4. 4.
    Small, D.M., J.Am. Oil Chem. Soc., 45, 108–119(1968).CrossRefGoogle Scholar
  5. 5.
    Luzzati, V., In “Biological Membranes” (D. Chapman, ed.), Academic Press, New York and London, pp.71–123(1968).Google Scholar
  6. 6.
    Chapman, D. and Wallach, D.F.H., In “Biological Membranes” (D. Chapman, ed.), Academic Press, New York and London, pp.125–202(1968).Google Scholar
  7. 7.
    Small, D.M., In “Surface Chemistry of Biological Systems” (M. Blank, ed.) Plenum Press, New York, pp.55–83(1970).Google Scholar
  8. 8.
    Phillips, M.C., In “Progress in Surface and Membrane Science” (J.F. Danielli, M.D. Rosenberg and D. Cadenhead, eds.)Academic Press, New York and London, 5, 139–221(1972).Google Scholar
  9. 9.
    Shipley, G.G., In “Biological Membranes” (D. Chapman and D.F.H. Wallach, eds.) Academic Press, New York and London, 2, 1–89(1973)Google Scholar
  10. 10.
    Bourges, M., Small, D.M. and Dervichian, D.G., Biochim. Biophys. Acta, 137, 157–167(1967).Google Scholar
  11. 11.
    Lecuyer, H. and Dervichian, D.G., J. Mol. Biol. 45, 39(1969).Google Scholar
  12. 12.
    Friedel, G., Ann. Physique, 18, 273–274(1922).Google Scholar
  13. 13.
    Shipley, G.G., Halks, M. and Small, D.M., (unpublished results)Google Scholar
  14. 14.
    Davis, G.J., Porter, R.S., Steiner, J.W. and Small, D. M., Molec, Crystals and Liq. Crystals, 10, 331–336(1970).CrossRefGoogle Scholar
  15. 15.
    Small, D.M., Bourges, M., and Dervichian, D.G., Biochim. Biophys. Acta, 125, 563–580(1966).Google Scholar
  16. 16.
    Wuthier, R.E., J. Lipid Res., 7, 544–550(1966).Google Scholar
  17. 17.
    Small, D.M., J. Lipid Res., 8, 551–557(1967).Google Scholar
  18. 18.
    Elliot, A., J. Sci. Instrum., 42, 312–316(1965).CrossRefGoogle Scholar
  19. 19.
    Franks, A., Br. J. Appl. Phys., 9, 349–352(1958).CrossRefGoogle Scholar
  20. 20.
    Rosevear, F.B., J. Amer.Oil Chem. Soc, 31, 628–329(1954).CrossRefGoogle Scholar
  21. 21.
    Shipley, G.G., Atkinson, D. and Scanu, A.M., J. Supramol. Struc, 1, 98–103(1972).CrossRefGoogle Scholar
  22. 22.
    Skipski, V.P., In “Blood Lipids and Lipoproteins: Quantitation, Composition, and Metabolism” (G.J. Nelson, ed.), Wiley-Inter-Science, Toronto, pp.471–583 (1972).Google Scholar
  23. 23.
    Small, D.M., Bourges, M., and Dervichian, D.G., Nature, 211, 816–818(1966).CrossRefGoogle Scholar
  24. 24.
    Adam, N.K., “The Physics and Chemistry of Surfaces”, Oxford Univ. Press, London, (1941).Google Scholar
  25. 25.
    Kwong, C.N., Heikkila, R.E., and Cornwell, D.G., J. Lipid Res. 12, 31(1971).Google Scholar
  26. 26.
    Ladbrooke, B.D., Williams, R.M., and Chapman, D., Biochim. Biophys. Acta, 150, 333(1968).CrossRefGoogle Scholar
  27. 27.
    Shipley, G.G., Avecilla, L. and Small, D.M., unpublished observations.Google Scholar
  28. 28.
    Rand, R. P., and Luzzati, V., Biophys. J., 8, 125(1968).CrossRefGoogle Scholar
  29. 29.
    Luzzati, V., Gulik-Krzywicki, T., Tardieu, A., Nature, 218, 1031–1034(1968).CrossRefGoogle Scholar
  30. 30.
    Tardieu, A., Luzzati, V., and Reman, F.C., J. Mol. Biol., 75, 711–733(1973).Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • D. M. Small
    • 1
  • C. Loomis
    • 1
  • M. Janiak
    • 1
  • G. G. Shipley
    • 1
  1. 1.Biophysics Section, Department of MedicineBoston University School of MedicineBostonUSA

Personalised recommendations