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Genetics of RNA Tumor Viruses

  • Peter K. Vogt
Part of the Comprehensive Virology book series (CV, volume 9)

Abstract

The genetic analysis of RNA tumor viruses has two main objectives: (1) to provide an understanding of virus replication and (2) to explain virus-induced transformation of the host cell. Virus replication results from a complex interaction of viral and cellular genomes. Viral genetics, however, considers only the virus side of this interaction; the numerous and specific cellular functions which are required for the synthesis of infectious virus will have to be defined by a genetic analysis of the host cell. In virus-induced transformation, viral genetic information presumably interferes with the genetic regulatory apparatus of the host cell, and here again it is important to realize that focusing on the viral information will reveal only part of a very complex interaction between two organisms. Despite these obvious limitations, the viral genome is at the moment that partner in this interaction which is more amenable to experimental study and offers realistic opportunities for an increase of our insight into virus replication and cellular transformation.

Keywords

Murine Leukemia Virus Rous Sarcoma Virus Helper Virus Nonpermissive Temperature Avian Myeloblastosis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aaronson, S. A., 1973, Biologic characterization of mammalian cells transformed by a primate sarcoma virus, Virology 52: 562.PubMedCrossRefGoogle Scholar
  2. Aaronson, S. A., and Rowe, W. P., 1970, Nonproducer clones of murine sarcoma virus transformed BALB/3T3 cells, Virology 42: 9.PubMedCrossRefGoogle Scholar
  3. Aaronson, S. A., and Stephenson, J. R., 1973, Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells, Proc. Natl. Acad. Sci. USA 70: 2055.PubMedCrossRefGoogle Scholar
  4. Aaronson, S. A., and Weaver, C. A., 1971, Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells, J. Gen. Virol. 13: 245.PubMedCrossRefGoogle Scholar
  5. Aaronson, S. A., Jainchill, J. L., and Todaro, G. J., 1970, Murine sarcoma virus transformation of BALB/3T3 cells: Lack of dependence on murine leukemia virus, Proc. Natl. Acad. Sci. USA 66: 1236.PubMedCrossRefGoogle Scholar
  6. Aaronson, S. A., Bassin, R. H., and Weaver, C., 1972, Comparison of murine sarcoma viruses in nonproducer and S+L--transformed cells, J. Virol. 9: 701.PubMedGoogle Scholar
  7. Aaronson, S. A., Stephenson, J. R., Hino, S., and Tronick, S. R., 1975, Differential expression of helper viral structural polypeptides in cells transformed by clonal isolates of wolly monkey sarcoma virus, J. Virol. 16: 1117.PubMedGoogle Scholar
  8. Abelson, H. T., and Rabstein, L. S., 1970, Lymphosarcoma: Virus-induced thymic-independent disease in mice, Cancer Res. 30: 2213.PubMedGoogle Scholar
  9. Ambros, V. R., Chen, L. B., and Buchanan, J. M., 1975, Surface ruffles as markers for studies of cell transformation by Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 72: 3144.PubMedCrossRefGoogle Scholar
  10. Anderson, W. B., Johnson, G. S., and Pastan, I., 1973a, Transformation of chick-embryo fibroblasts by wild-type and temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity, Proc. Natl. Acad. Sci. USA 70: 1055.PubMedCrossRefGoogle Scholar
  11. Anderson, W. B., Lovelace, E., and Pastan, I., 1973b, Adenylate cyclase activity is decreased in chick embryo fibroblasts transformed by wild-type and temperature sensitive Schmidt-Ruppin Rous sarcoma virus, Biochem. Biophys. Res. Commun. 52: 1293.PubMedCrossRefGoogle Scholar
  12. Bader, A. V., 1973, Role of mitochondria in the production of RNA-containing tumor viruses, J. Virol. 11: 314.PubMedGoogle Scholar
  13. Bader, J. P., 1972, Temperature-dependent transformation of cells infected with a mutant of Bryan Rous sarcoma virus, J. Virol. 10: 267.PubMedGoogle Scholar
  14. Bader, J. P., Ray, D. A., and Brown, N. R., 1974, Accumulation of water during transformation of cells by an avian sarcoma virus, Cell 3: 307.PubMedCrossRefGoogle Scholar
  15. Balduzzi, P. C., 1976, Cooperative transformation studies with temperature sensitive mutants of Rous sarcoma virus, J. Virol. 18: 332.PubMedGoogle Scholar
  16. Balduzzi, P., and Morgan, H. R., 1970, Mechanism of oncogenic transformation by Rous sarcoma virus. I. Intracellular inactivation of cell-transforming ability of Rous sarcoma virus by 5-bromodeoxyuridine and light, J. Virol. 5: 470.PubMedGoogle Scholar
  17. Balduzzi, P. C., and Murphy, H., 1975, Plaque assay of avian sarcoma viruses using casein, J. Virol. 16: 707.PubMedGoogle Scholar
  18. Ball, J. K., Harvey, D., and McCarter, J. A., 1973a, Evidence for naturally occurring murine sarcoma virus, Nature (London) 241: 272.CrossRefGoogle Scholar
  19. Ball, J. K., McCarter, J. A., and Sunderland, S. M., 1973b, Evidence for helper independent murine sarcoma virus. I. Segregation of replication-defective and transformation-defective viruses, Virology 56: 268.PubMedCrossRefGoogle Scholar
  20. Baltimore, D., 1970, Viral RNA-dependent DNA polymerase, Nature (London) 226: 1209.CrossRefGoogle Scholar
  21. Baltimore, D., 1975, Tumor viruses: 1974, Cold Spring Harbor Symp. Quant. Biol. 39: 1187.PubMedCrossRefGoogle Scholar
  22. Baluda, M. A., and Goetz, I. E., 1961, Morphological conversion of cell cultures by avian myeloblastosis virus, Virology 15: 185.PubMedCrossRefGoogle Scholar
  23. Baluda, M. A., Shoyab, M., Markham, P. D., Evans, R. M., and Drohan, W. N., 1975, Base sequence complexity of 35 S avian myeloblastosis virus RNA determined by molecular hybridization kinetics, Cold Spring Harbor Symp. Quant. Biol. 39: 869.PubMedCrossRefGoogle Scholar
  24. Bassin, R. H., Tuttle, N., and Fischinger, P. J., 1970, Isolation of murine sarcoma virus-transformed mouse cells which are negative for leukemia virus from agar suspension cultures, Int. J. Cancer 6: 95.PubMedCrossRefGoogle Scholar
  25. Bassin, R. H., Phillips, L. A., Kramer, M. J., Haapala, D. K., Peebles, P. T., Nomura, S., and Fischinger, P. J., 197la, Transformation of mouse 3T3 cells by murine sarcoma virus: Release of virus-like particles in the absence of replicating murine leukemia helper virus, Proc. Natl. Acad. Sci. USA 68: 1520.Google Scholar
  26. Bassin, R. H., Tuttle, N., and Fischinger, P. J., 1971b, Rapid cell culture assay technique for murine leukaemia viruses, Nature (London) 229: 564.CrossRefGoogle Scholar
  27. Bassin, R. H., Duran-Troise, G., Gerwin, B. I., Gisselbrecht, S., and Rein, A., 1975, Murine sarcoma virus pseudotypes acquire a determinant specifying N or B tropism from leukaemia virus during rescue, Nature (London) 256: 223.Google Scholar
  28. Bauer, H., Kurth, R., Rohrschneider, L., Pauli, G., Friis, R. R., and Gelderblom, H., 1975, The role of cell surface changes in RNA tumor virus-transformed cells, Cold Spring Harbor Symp. Quant. Biol. 39: 1181.PubMedCrossRefGoogle Scholar
  29. Beaudreau, G. S., Becker, C., Bonar, R. A., Wallbank, A. M., Beard, D., and Beard, J. W., 1960, Virus of avian myeloblastosis. XIV. Neoplastic response of normal chicken bone marrow treated with the virus in tissue culture, J. Natl. Cancer Inst. 24: 395.PubMedGoogle Scholar
  30. Beemon, K., Duesberg, P., and Vogt, P., 1974, Evidence for crossing-over between avian tumor viruses based on analysis of viral RNAs, Proc. Natl. Acad. Sci. USA 71: 4254.PubMedCrossRefGoogle Scholar
  31. Beemon, K. L., Faras, A. J., Haase, A. T., Duesberg, P. H., and Maisel, J. E., 1976, Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses, J. Virol. 17: 525.PubMedGoogle Scholar
  32. Bellamy, A. R., Gillies, S. C., and Harvey, J. D., 1974, Molecular weight of two oncornavirus genomes: Derivation from particle molecular weights and RNA content, J. Virol. 14: 1388.PubMedGoogle Scholar
  33. Bender, W., and Davidson, N., 1976, Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules, Cell 7: 595.PubMedCrossRefGoogle Scholar
  34. Benveniste, R. E., and Scolnick, E. M., 1973, RNA in mammalian sarcoma virus transformed nonproducer cells homologous to murine leukemia virus RNA, Virology 51: 370.PubMedCrossRefGoogle Scholar
  35. Benveniste, R. E., and Todaro, G. J., 1973, Homology between type-C viruses of various species as determined by molecular hybridization, Proc. Natl. Acad. Sci. USA 70: 3316.PubMedCrossRefGoogle Scholar
  36. Benveniste, R. E., and Todaro, G. J., 1974a, Evolution of type C viral genes. I. Nucleic acid from baboon type C virus as a measure of divergence among primate species, Proc. Natl. Acad. Sci. USA 71: 4513.PubMedCrossRefGoogle Scholar
  37. Benveniste, R. E., and Todaro, G. J., 1974b, Evolution of C-type viral genes: Inheritance of exogenously acquired viral genes, Nature (London) 252: 456.CrossRefGoogle Scholar
  38. Benveniste, R. E., and Todaro, G. J., 1975, Evolution of type C viral genes: Preservation of ancestral murine type C viral sequences in pig cellular DNA, Proc. Natl. Acad. Sci. USA 72: 4090.PubMedCrossRefGoogle Scholar
  39. Benveniste, R. E., Lieber, M. M., and Todaro, G. J., 1974, A distinct class of inducible murine type-C viruses that replicates in the rabbit SIRC cell-line, Proc. Natl. Acad. Sci. USA 71: 602.PubMedCrossRefGoogle Scholar
  40. Bernstein, A., MacCormick, R., and Martin, G. S., 1976, Transformation-defective mutants of avian sarcoma viruses: The genetic relationship between conditional and non-conditional mutants, Virology 70: 206.PubMedCrossRefGoogle Scholar
  41. Biggs, P. M., Milne, B. S., Graf, T., and Bauer, H., 1973, Oncogenicity of non-transforming mutants of avian sarcoma viruses, J. Gen. Virol. 18: 399.PubMedCrossRefGoogle Scholar
  42. Bilello, J. A., Strand, M., and August, J. T., 1974, Murine sarcoma virus gene expression: Transformants which express viral envelope glycoprotein in the absence of the major internal protein and infectious particles, Proc. Natl. Acad. Sci. USA 71: 3234.PubMedCrossRefGoogle Scholar
  43. Billeter, M. A., Parson, J. T., and Coffin, J. M., 1974, The nucleotide sequence complexity of avian tumor virus RNA, Proc. Natl. Acad. Sci. USA 71: 3560.PubMedCrossRefGoogle Scholar
  44. Biquard, J.-M., 1973, Agglutinability of Rous cells by concanavalin A: Study with a temperature-sensitive RSV mutant and inhibitors of macromolecular synthesis, Intervirology 1: 220.PubMedCrossRefGoogle Scholar
  45. Biquard, J.-M., and Vigier, P., 1971, Isolement ét etude d’un mutant conditionnel du virus de Rous à capacité transformante thermosensible, C. R. Acad. Sci. Paris 271 (D): 2430.Google Scholar
  46. Biquard, J.-M., and Vigier, P., 1972, Characteristics of a conditional mutant of Rous sarcoma virus defective in ability to transform cells at high temperature, Virology 47: 444.PubMedCrossRefGoogle Scholar
  47. Bishop, J. M., and Varmus, H., 1975, Molecular biology of RNA tumor viruses, in: Cancer, Vol. 2 ( F. F. Becker, ed.), pp. 3–48, Plenum Publishing Corporation, New York.Google Scholar
  48. Bishop, J. M., Levinson, W. E., Quintrell, N., Sullivan, D., Fanshier, L., and Jackson, J., 1970a, The low molecular weight RNAs of Rous sarcoma virus. I. The 4S RNA, Virology 42: 182.PubMedCrossRefGoogle Scholar
  49. Bishop, J. M., Levinson, W. E., Sullivan, D., Fanshier, L., Quintrell, N., and Jackson, J., 1970b, The low molecular weight RNAs of Rous sarcoma virus. II. The 7 S RNA, Virology 42: 927.PubMedCrossRefGoogle Scholar
  50. Blair, D. G., Mason, W. S., Hunter, E., and Vogt, P. K., 1976, Temperature-sensitive mutants of avian sarcoma viruses: Genetic recombination between multiple or coordinate mutants and avian leukosis viruses, Virology 75: 48.PubMedCrossRefGoogle Scholar
  51. Boettiger, D., 1974, Virogenic nontransformed cells isolated following infection of normal rat kidney cells with B77 strain Rous sarcoma virus, Cell 3: 71.PubMedCrossRefGoogle Scholar
  52. Boettiger, D., 1975, Activation and repression of virus expression in mammalian cells infected by Rous sarcoma virus, Cold Spring Harbor Symp. Quant. Biol. 39: 1169.PubMedCrossRefGoogle Scholar
  53. Boettiger, D., and Temin, H. M., 1970, Light inactivation of focus formation by chicken embryo fibroblasts infected with avian sarcoma virus in the presence of 5bromodeoxyuridine, Nature (London) 228: 622.CrossRefGoogle Scholar
  54. Boettiger, D., Love, D. N., and Weiss, R. A., 1975, Virus envelope markers in mammalian tropism of avian RNA tumor viruses, J. Virol. 15: 108.PubMedGoogle Scholar
  55. Bolognesi, D. P., 1974, Structural components of RNA tumor virus, in: Advances in Virus Research, Vol. 19 ( M. Lauffer, F. Bang, K. Maramorosch, and K. Smith, eds.), pp. 315–360, Academic Press, New York.CrossRefGoogle Scholar
  56. Bolognesi, D. P., Bauer, H., Gelderblom, H., and Gudrun, H., 1972, Polypeptides of avian RNA tumor virus. IV. Components of the viral envelope, Virology 47: 551.PubMedCrossRefGoogle Scholar
  57. Bonar, R. A., Sverak, L., Bolognesi, D. P., Langlois, A. J., Beard, D., and Beard, J. W., 1967, Ribonucleic acid components of BAI strain A (myeloblastosis) avian tumor virus, Cancer Res. 27: 1138.PubMedGoogle Scholar
  58. Bookout, J. B., and Sigel, M. M., 1975, Characterization of a conditional mutant of Rous sarcoma virus with alterations in early and late functions of cell transformation, Virology 67: 474.PubMedCrossRefGoogle Scholar
  59. Bryant, M. L., and Klement, V., 1976, Clonal heterogeneity of wild mouse leukemia viruses: Host range and antigenicity, Virology 73: 532.PubMedCrossRefGoogle Scholar
  60. Burger, M. M., and Martin, G. S., 1972, Agglutination of cells transformed by Rous sarcoma virus by wheat germ agglutinin and concanavalin A, Nature (London) New Biol. 237: 9.Google Scholar
  61. Bussell, R. H., and Robinson, W. S., 1973, Membrane proteins of uninfected and Rous sarcoma virus-transformed avian cells, J. Virol. 12: 320.PubMedGoogle Scholar
  62. Butterworth, B. E., 1973, A comparison of virus-specific polypeptides of encephalomyocarditis virus, human rhinovirus-IA, and poliovirus, Virology 56: 439.PubMedCrossRefGoogle Scholar
  63. Butterworth, B. E., and Rueckert, R. R., 1972, Kinetics of synthesis and cleavage of encephalomyocarditis virus-specific proteins, Virology 50: 535.PubMedCrossRefGoogle Scholar
  64. Callahan, R., Lieber, M. M., and Todaro, G. J., 1975, Nucleic acid homology of murine xenotropic type C viruses, J. Virol. 15: 1378.PubMedGoogle Scholar
  65. Canaani, E., and Duesberg, P., 1972, Role of subunits of 60 to 70 S avian tumor virus ribonucleic acid in its template activity for the viral deoxyribonucleic acid polymerase, J. Virol. 10: 23.PubMedGoogle Scholar
  66. Canaani, E., Helm, K. V. D., and Duesberg, P., 1973, Evidence for 30–40 S RNA as precursor of the 60–70 S RNA of Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 70: 401.PubMedCrossRefGoogle Scholar
  67. Carchman, R. A., Johnson, G. S., Pastan, I., and Scolnick, E. M., 1974, Studies on the levels of cyclic AMP in cells transformed by wild-type and temperature-sensitive Kirsten sarcoma virus, Cell 1: 59.CrossRefGoogle Scholar
  68. Chan, E. W., Schiop-Stansly, P. E., and O’Connor, T. E., 1974, Rescue of cell-transforming virus from a non-virus-producing bovine cell culture transformed by feline sarcoma virus, J. Natl. Cancer Inst. 52: 469.PubMedGoogle Scholar
  69. Chen, L. B., and Buchanan, J. M., 1975, Plasminogen-independent fibrinolysis by proteases produced by transformed chick embryo fibroblasts, Proc. Natl. Acad. Sci. USA 72: 1132.PubMedCrossRefGoogle Scholar
  70. Chen, Y. C., and Vogt, P. K., 1977, Endogenous leukosis viruses in the avian family Phasianidae. Virology 76: 740.CrossRefGoogle Scholar
  71. Chen, Y. C., Hayman, M. J., and Vogt, P. K., 1977, Properties of mammalian cells transformed by temperature sensitive mutants of avian sarcoma virus, in preparation.Google Scholar
  72. Cheung, K.-S., Smith, R. E., Stone, M. P., and Joklik, W. K., 1972, Comparison of immature (rapid harvest) and mature Rous sarcoma virus particles, Virology 50: 851.PubMedCrossRefGoogle Scholar
  73. Chi, Y. Y., and Bassel, A. R., 1975, Electron microscopy of viral RNA: Avian tumor virus RNA, Virology 64: 217.PubMedCrossRefGoogle Scholar
  74. Clarke, B. J., Axelrad, A. A., Shreeve, M. M., and McLeod, D. L., 1975, Erythroid colony induction without erythropoietin by Friend leukemia virus, in vitro, Proc. Natl. Acad. Sci. USA 72: 3556.PubMedCrossRefGoogle Scholar
  75. Coffin, J. M., and Billeter, M. A., 1976, A physical map of the Rous sarcoma virus genome, J. Mol. Biol. 100: 293.PubMedCrossRefGoogle Scholar
  76. Cooper, G. M., and Temin, H. M., 1974, Infectious Rous sarcoma virus and reticuloendotheliosis virus DNAs, J. Virol. 14: 1132.PubMedGoogle Scholar
  77. Cooper, G. M., and Temin, H. M., 1975, Infectious DNA from cells infected with Rous sarcoma virus, reticuloendotheliosis virus or Rous-associated virus-O, Cold Spring Harbor Symp. Quant. Biol. 39: 1027.PubMedCrossRefGoogle Scholar
  78. Cooper, P. D., and Wyke, J. A., 1975, The genome of RNA tumor viruses: A functional requirement for a polyploid structure? Cold Spring Harbor Symp. Quant. Biol. 39: 997.PubMedCrossRefGoogle Scholar
  79. Courington, D., and Vogt, P. K., 1967, Electron microscopy of chick fibroblasts infected by defective Rous sarcoma virus and its helper, J. Virol. 1: 400.PubMedGoogle Scholar
  80. Crittenden, L. B., 1968, Observations on the nature of a genetic cellular resistance to avian tumor viruses, J. Natl. Cancer Inst. 41: 145.PubMedGoogle Scholar
  81. Crittenden, L. B., 1975, Two levels of genetic resistance to lymphoid leukosis, Avian Dis. 19: 281.PubMedCrossRefGoogle Scholar
  82. Crittenden, L. B., and Motta, J. V., 1975, The role of tvb locus in genetic resistance to RSV (RAV-O), Virology 67: 327.PubMedCrossRefGoogle Scholar
  83. Crittenden, L. B., Okazaki, W., and Reamer, R., 1963, Genetic resistance to Rous sarcoma virus in embryo cell cultures and embryos, Virology 20: 541.PubMedCrossRefGoogle Scholar
  84. Crittenden, L. B., Okazaki, W., and Reamer, R. H., 1964, Genetic control of responses to Rous sarcoma and strain RPLI2 viruses in the cells, embryos, and chickens of two inbred lines, Natl. Cancer Inst. Monogr. 17: 161.Google Scholar
  85. Crittenden, L. B., Stone, H. A., Reamer, R. H., and Okazaki, W., 1967, Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses, J. Virol. 1: 898.PubMedGoogle Scholar
  86. Crittenden, L. B., Wendel, E. J., and Motta, J. V., 1973, Interaction of genes controlling resistance to RSV (RAV-O), Virology 52: 373.PubMedCrossRefGoogle Scholar
  87. Dahlberg, J. E., Sawyer, R. C., Taylor, J. M., Faras, A. J., Levinson, W. E., Goodman, H. M., and Bishop, J. M., 1974, Transcription of DNA from the 70 S RNA of Rous sarcoma virus. I. Identification of a specific 4 S RNA which serves as primer, J. Virol. 13: 1126.PubMedGoogle Scholar
  88. Dahlberg, J. E., Harada, F., and Sawyer, R. C., 1975, Structure and properties of an RNA primer for initiation of Rous sarcoma virus DNA synthesis in vitro, Cold Spring Harbor Symp. Quant. Biol. 39: 925.PubMedCrossRefGoogle Scholar
  89. Dales, S., and Hanafusa, H., with the assistance of Huima, T., 1972, Penetration and intracellular release of the genomes of avian RNA tumor viruses, Virology 50: 440.Google Scholar
  90. Dalton, A. J., 1962, Micromorphology of murine tumor viruses and of affected cells, Fed. Proc. 21: 936.PubMedGoogle Scholar
  91. Dawson, P. J., Tacke, R. B., and Fieldsteel, A. H., 1968, Relationship between Friend virus and an associated lymphatic leukaemia virus, Br . J. Cancer 22: 569.PubMedCrossRefGoogle Scholar
  92. Declève, A., Niwa, O., Gelmann, E., and Kaplan, H. S., 1975, Replication kinetics of N- and B-tropic murine leukemia viruses on permissive and nonpermissive cells in vitro, Virology 65: 320.PubMedCrossRefGoogle Scholar
  93. De Giuli, C., Kawai, S., Dales, S., and Hanafusa, H., 1975, Absence of surface projections on some noninfectious forms of RSV, Virology 66: 253.PubMedCrossRefGoogle Scholar
  94. Delius, H., Duesberg, P. H., and Mangel, W. F., 1975, Electron microscope measurements of Rous sarcoma virus RNA, Cold Spring Harbor Symp. Quant. Biol. 39: 835.PubMedCrossRefGoogle Scholar
  95. Dinowitz, M., 1975, Inhibition of Rous sarcoma virus by a-amanitin: Possible role of cell DNA-dependent RNA polymerase form II, Virology 66: 1.PubMedCrossRefGoogle Scholar
  96. Dougherty, R. M., and Di Stephano, H. S., 1965, Virus particles associated with “nonproducer” Rous sarcoma cells, Virology 27: 351.PubMedCrossRefGoogle Scholar
  97. Dougherty, R. M., and Rasmussen, R., 1964, Properties of a strain of Rous sarcoma virus that infects mammals, Natl. Cancer Inst. Monogr. 17: 337.Google Scholar
  98. Duesberg, P. H., 1968, Physical properties of Rous sarcoma virus RNA, Proc. Natl. Acad. Sci. USA 60: 1511.PubMedCrossRefGoogle Scholar
  99. Duesberg, P. H., and Vogt, P. K., 1970, Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses, Proc. Natl. Acad. Sci. USA 67: 1673.PubMedCrossRefGoogle Scholar
  100. Duesberg, P. H., and Vogt, P. K., 1973a, RNA species obtained from clonal lines of avian sarcoma and avian leukosis virus, Virology 54: 207.PubMedCrossRefGoogle Scholar
  101. Duesberg, P. H., and Vogt, P. K., 1973b, Gel electrophoresis of avian leukosis and sarcoma viral RNA in formamide: Comparison with other viral and cellular RNA species, J. Virol. 12: 594.PubMedGoogle Scholar
  102. Duesberg, P. H., Martin, G. S., and Vogt, P. K., 1970, Glycoprotein components of avian and murine RNA tumor viruses, Virology 41: 631.PubMedCrossRefGoogle Scholar
  103. Duesberg, P. H., Kawai, S., Wang, L.-H., Vogt, P. K., Murphy, H. M., and Hanafusa, H., 1975a, RNA of replication-defective strains of Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 72: 1569.PubMedCrossRefGoogle Scholar
  104. Duesberg, P., Vogt, P. K., Beemon, K., and Lai, M., 1975b, Avian RNA tumor viruses: Mechanism of recombination and complexity of the genome, Cold Spring Harbor Symp. Quant. Biol. 39: 847.PubMedCrossRefGoogle Scholar
  105. Duesberg, P. H., Wang, L. H., Mellon, P., Mason, W. S., and Vogt, P. K., 1976, Towards a complete genetic map of Rous sarcoma virus, in: Animal Virology ( D. Baltimore, A. S. Huang, and C. F. Fox, eds.), pp. 107–123, Academic Press, New York.Google Scholar
  106. Duff, R. G., and Vogt, P. K., 1969, Characteristics of two new avian tumor virus subgroups, Virology 39: 18.PubMedCrossRefGoogle Scholar
  107. Dulbecco, R., 1973, Cell transformation by viruses and the role of viruses in cancer: The eleventh Marjory Stephenson memorial lecture, J. Gen. Microbiol. 79: 7.PubMedGoogle Scholar
  108. Eckner, R. J., 1973, Helper-dependent properties of Friend spleen focus-forming virus: Effect of the Fv-1 gene on the late stages in virus synthesis, J. Virol. 12: 523.PubMedGoogle Scholar
  109. Eckner, R. J., and Steeves, R. A., 1971, Defective Friend spleen focus-forming virus: Pseudotype neutralization by helper-specific antisera, Nature (London) New Biol. 229: 241.Google Scholar
  110. Eckner, R. J., and Steeves, R. A., 1972, A classification of the murine leukemia viruses: Neutralization of pseudotypes of Friend spleen focus-forming virus by type-specific murine antisera, J. Exp. Med. 136: 832.PubMedCrossRefGoogle Scholar
  111. Eiden, J. J., Quade, K., and Nichols, J. L., 1976, Interaction of tryptophan transfer RNA with Rous sarcoma virus 35 S RNA, Nature (London) 259: 245.Google Scholar
  112. Eisenman, R., Vogt, V. M., and Diggelmann, H., 1975, Synthesis of avian RNA tumor virus structural proteins, Cold Spring Harbor Symp. Quant. Biol. 39: 1067.PubMedCrossRefGoogle Scholar
  113. Erikson, E., and Erikson, R. L., 1970, Isolation of amino acid acceptor RNA from purified avian myeloblastosis virus, J. Mol. Biol. 52: 387.PubMedCrossRefGoogle Scholar
  114. Erikson, E., and Erikson, R. L., 1971, Association of 4S ribonucleic acid with oncornavirus ribonucleic acids, J. Virol. 8: 254.PubMedGoogle Scholar
  115. Erikson, E., Erikson, R. L., Henry, B., and Pace, N. R., 1973, Comparison of oligonucleotides produced by RNase TI digestion of 7 S RNA from avian and murine oncornaviruses and from uninfected cells, Virology 53: 40.PubMedCrossRefGoogle Scholar
  116. Erikson, R. L., 1969, Studies on the RNA from avian myeloblastosis virus, Virology 37: 124.PubMedCrossRefGoogle Scholar
  117. Evans, R. M., Shoyab, M., and Baluda, M. A., 1975, Studies on characterization of the integration sites of avian RNA tumor virus-specific DNA, Cold Spring Harbor Symp. Quant. Biol. 39: 1005.PubMedCrossRefGoogle Scholar
  118. Fan, H., and Baltimore, D., 1973, RNA metabolism of murine leukemia virus: Detection of virus-specific RNA sequences in infected and uninfected cells and identification of virus-specific messenger RNA, J. Mol. Biol. 80: 93.PubMedCrossRefGoogle Scholar
  119. Fan, H., and Paskind, M., 1974, Measurement of the sequence complexity of cloned Moloney murine leukemia virus 60 to 70 S RNA: Evidence for a haploid genome, J. Virol. 14: 421.PubMedGoogle Scholar
  120. Faras, A. J., 1975, The methionyl transfer RNAs of Rous sarcoma virus, Virology 63: 583.PubMedCrossRefGoogle Scholar
  121. Faras, A. J., Garapin, A. C., Levinson, W. E., Bishop, J. M., and Goodman, H. M., 1973, Characterization of the low-molecular-weight RNAs associated with the 70 S RNA of Rous sarcoma virus, J. Virol. 12: 334.PubMedGoogle Scholar
  122. Faras, A. J., Dahlberg, J. E., Sawyer, R. C., Harada, F., Taylor, J. M., Levinson, W. E., Bishop, J. M., and Goodman, H. M., 1974, Transcription of DNA from the 70 S RNA of Rous sarcoma virus. II. Structure of a 4 S RNA primer, J. Virol. 13: 1134.PubMedGoogle Scholar
  123. Fields, B. N., and Joklik, W. K., 1969, Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus, Virology 37: 335.PubMedCrossRefGoogle Scholar
  124. Fieldsteel, A. H., Kurahara, C., and Dawson, P. J., 1969, Moloney leukaemia virus as a helper in retrieving Friend virus from a non-infectious reticulum cell sarcoma, Nature (London) 223: 1274.CrossRefGoogle Scholar
  125. Fieldsteel, A. H., Dawson, P. J., and Kurahara, C., 1971, In vivo and in vitro recovery of defective Friend virus by various leukemia viruses, Int. J. Cancer 8: 304.Google Scholar
  126. Fischinger, P. J., Peebles, P. T., Nomura, S., and Haapala, D. K., 1973, Isolation of an RD-114-like oncornavirus from a cat cell line, J. Virol 11: 978.PubMedGoogle Scholar
  127. Fischinger, P. J., Nomura, S., and Bolognesi, D. P., 1975, A novel murine oncornavirus with dual eco-and xenotropic properties, Proc. Natl. Acad. Sci. USA 72: 5150.PubMedCrossRefGoogle Scholar
  128. Fiszman, M. Y., and Fuchs, P., 1975, Temperature-sensitive expression of differentiation in transformed myoblasts, Nature (London) 254: 429.CrossRefGoogle Scholar
  129. Friesen, B., and Rubin, H., 1961, Some physiochemical and immunological properties of an avian leukosis virus (RIF), Virology 15: 387.CrossRefGoogle Scholar
  130. Friis, R. R., 1971, Inactivation of avian sarcoma viruses with UV light: A difference between helper-dependent and helper-independent strains, Virology 43: 521.PubMedCrossRefGoogle Scholar
  131. Friis, R. R., and Hunter, E., 1973, A temperature-sensitive mutant of Rous sarcoma virus that is defective for replication, Virology 53: 479.PubMedCrossRefGoogle Scholar
  132. Friis, R. R., Toyoshima, K., and Vogt, P. K., 1971, Conditional lethal mutants of avian sarcoma viruses. I. Physiology of ts75 and ís149, Virology 43: 375.PubMedCrossRefGoogle Scholar
  133. Friis, R. R., Mason, W. S., Chen, Y. C., and Halpern, M. S., 1975, A replication defective mutant of Rous sarcoma virus which fails to make a functional reverse transcriptase, Virology 64: 49.PubMedCrossRefGoogle Scholar
  134. Fujita, D. J., Chen, Y. C., Friis, R. R., and Vogt, P. K., 1974, RNA tumor viruses of pheasants: Characterization of avian leukosis subgroups F and G, Virology 60: 558.PubMedCrossRefGoogle Scholar
  135. Furuichi, Y., Shatkin, A. J., Stavnezer, E., and Bishop, J. M., 1975, Blocked, methylated 5’-terminal sequence in avian sarcoma RNA, Nature (London) 257: 618.CrossRefGoogle Scholar
  136. Gahmberg, C. G., and Hakomori, S.-I., 1973, Altered growth behavior of malignant cells associated with changes in externally labeled glycoprotein and glycolipid, Proc. Natl. Acad. Sci. USA 70: 3329.PubMedCrossRefGoogle Scholar
  137. Gazdar, A. F., Russell, E., Sarma, P. S., Sarin, P. S., Hall, W., and Chopra, H. C., 1973, Properties of noninfectious and transforming viruses released by Murine sarcoma virus-induced hamster tumor cells, J. Virol. 12: 931.PubMedGoogle Scholar
  138. Gazzolo, L., Moscovici, M. G., and Moscovici, C., 1974, Replication of avian sarcoma viruses in chicken macrophages, Virology 58: 514.PubMedCrossRefGoogle Scholar
  139. Gazzolo, L., Moscovici, M. G., Moscovici, C., and Vogt, P. K., 1975, Susceptibility and resistance of chicken macrophages to avian RNA tumor viruses, Virology 67: 553.PubMedCrossRefGoogle Scholar
  140. Gianni, A. M., and Weinberg, R. A., 1975, Partially single-stranded form of free Moloney viral DNA, Nature (London) 255: 646.CrossRefGoogle Scholar
  141. Gianni, A. M., Smotkin, D., and Weinberg, R. A., 1975, Murine leukemia virus: Detection of unintegrated double-stranded DNA forms of the provirus, Proc. Natl. Acad. Sci. USA 72: 447.PubMedCrossRefGoogle Scholar
  142. Gianni, A. M., Hutton, J. R., Smotkin, D., and Weinberg, R. A., 1976, Proviral DNA of Moloney leukemia virus: Purification and visualization, Science 191: 569.PubMedCrossRefGoogle Scholar
  143. Gielkens, A. L. J., Salden, M. H. L., and Bloemendal, H., 1974, Virus-specific messenger RNA on free and membrane-bound polyribosomes from cells infected with Rauscher leukemia virus, Proc. Natl. Acad. Sci. USA 71: 1093.PubMedCrossRefGoogle Scholar
  144. Gielkens, A. L. J., Van Zaane, D., Bloemers, H. P. J., and Bloemendal, H., 1976, Synthesis of Rauscher murine leukemia virus-specific polypeptides in vitro, Proc. Natl. Acad. Sci. USA 73: 356.PubMedCrossRefGoogle Scholar
  145. Goldé, A., 1970, Radio-induced mutants of the Schmidt-Ruppin strain of Rous sarcoma virus, Virology 40: 1022.PubMedCrossRefGoogle Scholar
  146. Goldé, A., and Latarjet, R., 1966, Dissociation, par irradiation, des fonctions oncogène et infectieuse du virus de Rous, souche de Schmidt-Ruppin, C. R. Acad. Sci Paris 262 (D): 420.Google Scholar
  147. Graf, T., 1972, A plaque assay for avian RNA tumor viruses, Virology 50: 567.PubMedCrossRefGoogle Scholar
  148. Graf, T., and Bauer, H., 1970, Studies on the relative target size of various functions in the genome of avian tumor viruses, in: “Defectivité, Démasquage et Stimulation des Virus Oncogènes, pp. 87–92, Editions du Centre National de la Recherche Scientifique, Paris.Google Scholar
  149. Graf, T., and Friis, R. R., 1973, Differential expression of transformation in rat and chicken cells infected with an avian sarcoma virus is mutant, Virology 56: 369.PubMedCrossRefGoogle Scholar
  150. Graf, T., Bauer, H., Gelderblom, H., and Bolognesi, D. P., 1971, Studies on the reproductive and cell-converting abilities of avian sarcoma viruses, Virology 43: 427.PubMedCrossRefGoogle Scholar
  151. Granboulan, N., Huppert, J., and Lacour, F., 1966, Examen au microscope electronique du RNA du virus de la myeloblastose aviaire, J. Mol. Biol. 16: 571.PubMedCrossRefGoogle Scholar
  152. Grandgenett, D. P., Gerard, G. F., and Green, M., 1973, A single subunit from avian myeloblastosis virus with both RNA-directed DNA polymerase and ribonuclease H activity, Proc. Natl. Acad. Sci. USA 70: 230.PubMedCrossRefGoogle Scholar
  153. Greenberger, J. S., Anderson, G. R., and Aaronson, S. A., 1974a, Transformation-defective virus mutants in a class of morphologic revertants of sarcoma virus transformed nonproducer cells, Cell 2: 279.PubMedCrossRefGoogle Scholar
  154. Greenberger, J. S., Stephenson, J. R., Aoki, T., and Aaronson, S. A., 1974b, Cell-surface antigens of murine sarcoma-virus-transformed nonproducer cells: Further evidence for lack of transplantation immunity, Int. J. Cancer 14: 145.PubMedCrossRefGoogle Scholar
  155. Grodzicker, T., Williams, J., Sharp, P., and Sambrook, J., 1975, Physical mapping of temperature-sensitive mutations of adenoviruses, Cold Spring Harbor Symp. Quant. Biol. 39: 439.PubMedCrossRefGoogle Scholar
  156. Guntaka, R. V., Mahy, B. W. J., Bishop, J. M., and Varmus, H. E., 1975, Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus, Nature (London) 253: 507.CrossRefGoogle Scholar
  157. Haapala, D. K., and Fischinger, P. J., 1973, Molecular relatedness of mammalian RNA tumor viruses as determined by DNA-RNA hybridization, Science 180: 972.PubMedCrossRefGoogle Scholar
  158. Hakomori, S., Wyke, J. A., and Vogt, P. K., 1977, Glycolipids of chick embryo fibroblasts infected with temperature sensitive mutants of avian sarcoma viruses, Virology 76: 485.PubMedCrossRefGoogle Scholar
  159. Hall, W. T., Gazdar, A. F., Hobbs, B. A., and Chopra, H. C., 1974, Morphology of a “noninfectious” sarcoma virus, J. Natl. Cancer Inst. 52: 1337.PubMedGoogle Scholar
  160. Halpern, M. S., Wade, E., Rucker, E., Baxter-Gabbard, K. L., Levine, A. S., and Friis, R. R., 1973, A study of the relationship of reticuloendotheliosis virus to the avian leukosis-sarcoma complex of viruses, Virology 53: 287.PubMedCrossRefGoogle Scholar
  161. Halpern, M. S., Hunter, E., Alevy, M. C., Friis, R. R., and Vogt, P. K., 1974, Immunological studies with avian RNA tumor viruses, in: Advances in the Biosciences 12 ( G. Raspé, ed.), pp. 567–576, Pergamon Press, New York.Google Scholar
  162. Halpern, M. S., Bolognesi, D. P., Friis, R. R., and Mason, W. S., 1975, Expression of the major viral glycoprotein of avian tumor virus in cells of chf(+) chicken embryos, J. Virol. 15: 1131.PubMedGoogle Scholar
  163. Halpern, M. S., Bolognesi, D. P., and Friis, R. R., 1976, Viral glycoprotein synthesis studied in an established line of Japanese quail embryo cells infected with the Bryan high-titer strain of Rous sarcoma virus, J. Virol. 18: 504.PubMedGoogle Scholar
  164. Hanafusa, H., 1965, Analysis of the defectiveness of Rous sarcoma virus. III. Determining influence of a new helper virus on the host range and susceptibility to interference of RSV, Virology 25: 248.PubMedCrossRefGoogle Scholar
  165. Hanafusa, H., and Hanafusa, T., 1966, Determining factor in the capacity of Rous sarcoma virus to induce tumors in mammals, Proc. Natl. Acad. Sci. USA 55: 532.PubMedCrossRefGoogle Scholar
  166. Hanafusa, H., and Hanafusa, T., 1968, Further studies on RSV production from transformed cells, Virology 34: 630.PubMedCrossRefGoogle Scholar
  167. Hanafusa, H., and Hanafusa, T., 1971, Noninfectious RSV deficient in DNA polymerase, Virology 43: 313.PubMedCrossRefGoogle Scholar
  168. Hanafusa, H., Hanafusa, T., and Rubin, H., 1963, The defectiveness of Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 49: 572.PubMedCrossRefGoogle Scholar
  169. Hanafusa, H., Hanafusa, T., and Rubin, H., 1964a, Analysis of the defectiveness of Rous sarcoma virus. II. Specification of RSV antigenicity by helper virus, Proc. Natl. Acad. Sci. USA 51: 41.PubMedCrossRefGoogle Scholar
  170. Hanafusa, H., Hanafusa, T., and Rubin, H., 1964b, Analysis of the defectiveness of Rous sarcoma virus. I. Characterization of the helper virus, Virology 22: 591.PubMedCrossRefGoogle Scholar
  171. Hanafusa, H., Miyamoto, T., and Hanafusa, T., 1970, A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 66: 314.PubMedCrossRefGoogle Scholar
  172. Hanafusa, H., Baltimore, D., Smoler, D., Watson, K. F., Yaniv, A., and Spiegelman, S., 1972, Absence of polymerase protein on virions of alpha-type Rous sarcoma virus, Science 177: 1188.PubMedCrossRefGoogle Scholar
  173. Hanafusa, H., Aoki, T., Kawai, S., Miyamoto, T., and Wilsnack, R. E., 1973, Presence of antigen common to avian tumor viral envelope antigen in normal chick embryo cells, Virology 56: 22.PubMedCrossRefGoogle Scholar
  174. Hanafusa, T., and Hanafusa, H., 1973, Isolation of leukosis-type virus from pheasant embryo cells: Possible presence of viral genes in cells, Virology 51: 247.PubMedCrossRefGoogle Scholar
  175. Hanafusa, T., Miyamoto, T., and Hanafusa, H., 1970a, A type of chick embryo cell that fails to support formation of infectious RSV, Virology 40: 55.PubMedCrossRefGoogle Scholar
  176. Hanafusa, T., Hanafusa, H., and Miyamoto, T., 1970b, Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses, Proc. Natl. Acad. Sci. USA 67: 1797.PubMedCrossRefGoogle Scholar
  177. Hanafusa, T., Hanafusa, H., Metroka, C. E., Hayward, W. S., Rettenmier, C. W., Sawyer, R. C., Dougherty, R. M., and Di Stefano, H. S., 1976, Pheasant virus: A new class of ribodeoxyvirus, Proc. Natl. Acad. Sci. USA 73: 1333.PubMedCrossRefGoogle Scholar
  178. Hartley, J. W., and Rowe, W. P., 1966, Production of altered cell foci in tissue culture by defective Moloney sarcoma virus particles, Proc. Natl. Acad. Sci. USA 55: 780.PubMedCrossRefGoogle Scholar
  179. Hartley, J. W., and Rowe, W. P., 1976, Naturally occurring murine leukemia viruses in wild mice: Characterization of a new “amphotropic” class, J. Virol 19: 19.PubMedGoogle Scholar
  180. Hartley, J. W., Rowe, W. P., and Huebner, R. J., 1970, Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures, J. Virol. 5: 221.PubMedGoogle Scholar
  181. Harvey, J. J., 1964, An unidentified virus which causes the rapid production of tumours in mice, Nature (London) 204: 1104.CrossRefGoogle Scholar
  182. Harvey, J. J., and East, J., 1971, The murine sarcoma virus (MSV), Int. Rev. Exp. Pathol. 10: 265.PubMedGoogle Scholar
  183. Hatanaka, M., and Hanafusa, H., 1970, Analysis of a functional change in membrane in the process of cell transformation by Rous sarcoma virus; alteration in the characteristics of sugar transport, Virology 41: 647.PubMedCrossRefGoogle Scholar
  184. Hatanaka, M., Kakefuda, T., Gilden, R. V., and Callan, E. A. O., 1971, Cytoplasmic DNA synthesis induced by RNA tumor viruses, Proc. Natl. Acad. Sci. USA 68: 1844.PubMedCrossRefGoogle Scholar
  185. Hayman, M. J., and Vogt, P. K., 1976, Subgroup specific antigenic determinants of avian RNA tumor virus structural proteins: Analysis of virus recombinants, Virology 73: 372.PubMedCrossRefGoogle Scholar
  186. Hayward, W. S., and Hanafusa, H., 1975, Recombination between endogenous and exogenous RNA tumor virus genes as analyzed by nucleic acid hybridization, J. Virol. 15: 1367.PubMedGoogle Scholar
  187. Heine, U. I., Weber, G. H., Cottler-Fox, M., Layard, M. W., Stephenson, M. L., and Zamecnik, P. C., 1975, Analysis of oncornavirus RNA subunits by electron microscopy, Proc. Natl. Acad. Sci. USA 72: 3716.PubMedCrossRefGoogle Scholar
  188. Henderson, I. C., Lieber, M. M., and Todaro, G. J., 1974, Mink cell line MvILu (CCL 64). Focus formation and the generation of “nonproducer” transformed cell lines with murine and feline sarcoma viruses, Virology 60: 282.PubMedCrossRefGoogle Scholar
  189. Hill, M., and Hillova, J., 1972, Virus recovery in chicken cells treated with Rous sarcoma cell DNA, Nature (London) New Biol. 237: 35.Google Scholar
  190. Hill, M., and Hillova, J., 1974, RNA and DNA forms of the genetic material of C-type viruses and the integrated state of the DNA form in the cellular chromosome, Biochim. Biophys. Acta 355: 7.PubMedGoogle Scholar
  191. Hill, M., Hillova, J., Dantchev, D., Mariage, R., and Goubin, G., 1975, Infectious viral DNA in Rous sarcoma virus-transformed nonproducer and producer animal cells, Cold Spring Harbor Symp. Quant. Biol. 39: 1015.PubMedCrossRefGoogle Scholar
  192. Hillova, J., Dantchev, D., Mariage, R., Plichon, M.-P., and Hill, M., 1974, Sarcoma and transformation-defective viruses produced with infectious DNA(s) from Rous sarcoma virus (RSV)-transformed chicken cells, Virology 62: 197.PubMedCrossRefGoogle Scholar
  193. Hirst, G. K., 1962, Genetic recombination with Newcastle disease virus, polioviruses, and influenza, Cold Spring Harbor Symp. Quant. Biol. 27: 303.PubMedCrossRefGoogle Scholar
  194. Holtzer, H., Biehl, J., Yeoh, G., Meganathan, R., and Kaji, A., 1975, Effect of oncogenic virus on muscle differentiation, Proc. Natl. Acad. Sci. USA 72: 4051.PubMedCrossRefGoogle Scholar
  195. Huang, A. S., Besmer, P., Chu, L., and Baltimore, D., 1973, Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses, J. Virol. 12: 659.PubMedGoogle Scholar
  196. Huebner, R. J., Hartley, J. W., Rowe, W. P., Lane, W. T., and Capps, W. I., 1966, Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses, Proc. Natl. Acad. Sci. USA 56: 1164.PubMedCrossRefGoogle Scholar
  197. Humphries, E. H., and Temin, H. M., 1972, Cell cycle-dependent activation of Rous sarcoma virus-infected stationary chicken cells: Avian leukosis virus group-specific antigens and ribonucleic acid, J. Virol. 10: 82.PubMedGoogle Scholar
  198. Humphries, E. H., and Temin, H. M., 1974, Requirement for cell division for initiation of transcription of Rous sarcoma virus RNA, J. Virol. 14: 531.PubMedGoogle Scholar
  199. Hunter, E., and Vogt, P. K., 1976, Temperature-sensitive mutants of avian sarcoma viruses: Genetic recombination with wild type sarcoma virus and physiological analysis of multiple mutants, Virology 69: 23.PubMedCrossRefGoogle Scholar
  200. Hunter, E., Hayman, M. J., Rongey, R. W., and Vogt, P. K., 1976a, An avian sarcoma virus mutant which is temperature-sensitive for virion assembly, Virology 69: 35.PubMedCrossRefGoogle Scholar
  201. Hunter, E., Hayman, M. J., and Tereba, A., 1977, On the mechanism of genetic recombination among avian RNA tumor viruses, in preparation.Google Scholar
  202. Hynes, R. O., 1973, Alteration of cell-surface proteins by viral transformation and by proteolysis, Proc. Natl. Acad. Sci. USA 70: 3170.PubMedCrossRefGoogle Scholar
  203. Hynes, R. O., and Wyke, J. A., 1975, Alterations in surface proteins in chicken cells transformed by temperature-sensitive mutants of Rous sarcoma virus, Virology 64: 492.PubMedCrossRefGoogle Scholar
  204. Ikeda, H., Hardy, W., Tress, E., and Fleissher, E., 1975, Chromatographic separation and antigenic analysis of proteins of oncornaviruses. V. Identification of a new murine viral protein p15(E), J. Virol. 16: 53.PubMedGoogle Scholar
  205. Isaka, T., Yoshida, M., Owada, M., and Toyoshima, K., 1975, Alterations in membrane polypeptides of chick embryo fibroblasts induced by transformation with avian sarcoma viruses, Virology 65: 226.PubMedCrossRefGoogle Scholar
  206. Ishizaki, R., and Shimizu, T., 1970, Heterogeneity of strain R avian erythroblastosis virus, Cancer Res. 30: 2827.PubMedGoogle Scholar
  207. Ishizaki, R., Langlois, A. J., Chabot, J., and Beard, J. W., 1971, Component of strain MC29 avian leukosis virus with the property of defectiveness, J. Virol. 8: 821.PubMedGoogle Scholar
  208. Jacobson, A. B., and Bromley, P. A., 1975a, Molecular weight of RNA subunits of Rous sarcoma virus determined by electron microscopy, J. Virol. 15: 161.PubMedGoogle Scholar
  209. Jacobson, A. B., and Bromley, P. A., 1975b, Determination of the molecular weight of the RNA subunits of Rous sarcoma virus by electron microscopy, Cold Spring Harbor Symp. Quant. Biol. 39: 845.PubMedCrossRefGoogle Scholar
  210. Jacobson, M. F., and Baltimore, D., 1968, Polypeptide cleavages in the formation of poliovirus proteins, Proc. Natl. Acad. Sci. USA 61: 77.PubMedCrossRefGoogle Scholar
  211. Jacobson, M. F., Asso, J., and Baltimore, D., 1970, Further evidence on the formation of poliovirus proteins, J. Mol. Biol. 49: 657.PubMedCrossRefGoogle Scholar
  212. Joho, R. H., Billeter, M. A., and Weissmann, C., 1975, Mapping of biological functions of RNA of avian tumor viruses: Location of regions required for transformation and determination of host range, Proc. Natl. Acad. Sci. USA 72: 4772.PubMedCrossRefGoogle Scholar
  213. Jolicoeur, P., and Baltimore, D., 1975, Effect of the Fv-1 locus on the titration of murine leukemia viruses, J. Virol. 16: 1593.PubMedGoogle Scholar
  214. Jolicoeur, P., and Baltimore, D., 1976, Effect of Fv-1 gene product on synthesis of N-tropic and B-tropic murine leukemia viral RNA, Cell 7: 33.PubMedCrossRefGoogle Scholar
  215. Kacian, D. L., Watson, K. F., Burny, A., and Spiegelman, S., 1971, Purification of the DNA polymerase of avian myeloblastosis virus, Biochim. Biophys. Acta 246: 365.PubMedGoogle Scholar
  216. Kakefuda, T., and Bader, J. P., 1969, Electron microscopic observations on the ribonucleic acid of murine leukemia virus, J. Virol. 4: 460.PubMedGoogle Scholar
  217. Kang, C.-Y., and Temin, H. M., 1973, Lack of sequence homology among RNAs of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and chicken endogenous RNA-directed DNA polymerase activity, J. Virol. 12: 1314.PubMedGoogle Scholar
  218. Kang, C.-Y., and Temin, H. M., 1974, Reticuloendotheliosis virus nucleic acid sequences in cellular DNA, J. Virol. 14: 1179.PubMedGoogle Scholar
  219. Karpas, A., and Milstein, C., 1973, Recovery of the genome of murine sarcoma virus (MSV) after infection of cells with nuclear DNA from MSV transformed non-virus producing cells, Eur. J. Cancer 9: 295.PubMedGoogle Scholar
  220. Katz, E. and Vogt, P. K., 1971, Conditional lethal mutants of avian sarcoma viruses. II. Analysis of the lesion in is 75, Virology 46: 745.PubMedCrossRefGoogle Scholar
  221. Kawai, S., and Hanafusa, H., 1971, The effects of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant, Virology 46: 470.PubMedCrossRefGoogle Scholar
  222. Kawai, S., and Hanafusa, H., 1972a, Plaque assay for some strains of avian leukosis virus, Virology 48: 126.PubMedCrossRefGoogle Scholar
  223. Kawai, S., and Hanafusa, H., 19726, Genetic recombination with avian tumor virus, Virology 49: 37.Google Scholar
  224. Kawai, S., and Hanafusa, H., 1973, Isolation of defective mutant of avian sarcoma virus, Proc. Natl. Acad. Sci. USA 70: 3493.PubMedCrossRefGoogle Scholar
  225. Kawai, S., and Hanafusa, H., 1976, Recombination between temperature sensitive mutant and a deletion mutant of Rous sarcoma virus. J. Virol 19: 389.PubMedGoogle Scholar
  226. Kawai, S., and Yamamoto, T., 1970, Isolation of different kinds of non-virus producing chick cells transformed by Schmidt-Ruppin strain (subgroup A) of Rous sarcoma virus, Jap. J. Exp. Med. 40: 243.PubMedGoogle Scholar
  227. Kawai, S., Metroka, C. E., and Hanafusa, H., 1972, Complementation of functions required for cell transformation by double infection with RSV mutants, Virology 49: 302.PubMedCrossRefGoogle Scholar
  228. Keith, J., and Fraenkel-Conrat, H., 1975, Identification of the 5’ end of Rous sarcoma virus RNA, Proc. Natl. Acad. Sci. USA 72: 3347.PubMedCrossRefGoogle Scholar
  229. King, A. M. Q., 1976, High molecular weight RNAs from Rous sarcoma virus and Moloney murine leukemia virus contain two subunits, J. Biol. Chem. 251: 141.PubMedGoogle Scholar
  230. King, A. M. Q., and Wells, R. D., 1976, All intact subunit RNAs from Rous sarcoma virus contain poly(A), J. Biol. Chem. 251: 150.PubMedGoogle Scholar
  231. Kirsten, W. H., and Mayer, L. A., 1967, Morphologic responses to a murine erythroblastosis virus, J. Natl. Cancer Inst. 39: 311.PubMedGoogle Scholar
  232. Kleinschmidt, A. K., 1968, Monolayer techniques in electron microscopy of nucleic acid molecules, in: Methods in Enzymology: Nucleic Acids, Vol. 12 (L. Grossman and K. Moldave, eds.), Part B, pp. 361–377, Academic Press, New York.Google Scholar
  233. Klement, V., Hartley, J. W., Rowe, W. P., and Huebner, R. J., 1969, Recovery of a hamster-specific, focus-forming, and sarcomagenic virus from a “noninfectious” hamster tumor induced by the Kirsten mouse sarcoma virus, J. Natl. Cancer Inst. 43: 925.PubMedGoogle Scholar
  234. Klement, V., Nicolson, M. O., and Huebner, R. J., 1971, Rescue of the genome of focus forming virus from rat non-productive lines by 5’ -bromodeoxyuridine, Nature (London) New Biol. 234: 12.Google Scholar
  235. Kletzien, R. F., and Perdue, J. F., 1974, Sugar transport in chick embryo fibroblasts. II. Alterations in transport following transformation by a temperature-sensitive mutant of the Rous sarcoma virus, J. Biol. Chem. 249: 3375.PubMedGoogle Scholar
  236. Kletzien, R. F., and Perdue, J. F., 1975, Regulation of sugar transport in chick embryo fibroblasts infected with a temperature-sensitive mutant of RSV, Cell 6: 513.CrossRefGoogle Scholar
  237. Krontiris, T. G., Soeiro, R., and Fields, B. N., 1973, Host restriction of Friend leukemia virus: Role of the viral outer coat, Proc. Natl. Acad. Sci. USA 70: 2549.PubMedCrossRefGoogle Scholar
  238. Kung, H.-J., Bailey, J. M., Davidson, N., Nicolson, M. O., and McAllister, R. M., 1974, Structure and molecular length of the large subunits of RD-114 viral RNA, J. Virol. 14: 170.Google Scholar
  239. Kung, H.-J., Bailey, J. M., Davidson, N., Nicolson, M. O., and McAllister, R. M., 1975a, Structure, subunit composition, and molecular weight of RD-114 RNA, J. Virol. 16: 397.PubMedGoogle Scholar
  240. Kung, H. J., Bailey, J. M., Davidson, N., Vogt, P. K., Nicolson, M. O., and McAllister, R. M., 1975b, Electron microscope studies of tumor virus RNA, Cold Spring Harbor Symp. Quant. Biol. 39: 827.PubMedCrossRefGoogle Scholar
  241. Kung, H.-J., Hu, S., Bender, W., Bailey, J. M., and Davidson, N., 1976, RD-114, Baboon and wooly monkey viral RNA’s compared in size and structure, Cell 7: 609.PubMedCrossRefGoogle Scholar
  242. Kurth, R., and Bauer, H., 1972a, Cell-surface antigens induced by avian RNA tumor viruses: Detection by a cytotoxic microassay, Virology 47: 426.PubMedCrossRefGoogle Scholar
  243. Kurth, R., and Bauer, H., 1972b, Common tumor-specific surface antigens on cells of different species transformed by avian RNA tumor viruses, Virology 49: 145.PubMedCrossRefGoogle Scholar
  244. Kurth, R., and Bauer, H., 1975, Avian RNA tumor viruses. A model for studying tumor associated cell surface alterations, Biochim. Biophys. Acta 417: 1.PubMedGoogle Scholar
  245. Kurth, R., Friis, R. R., Wyke, J. A., and Bauer, H., 1975, Expression of tumor-specific surface antigens on cells infected with temperature-sensitive mutants of avian sarcoma virus, Virology 64: 400.PubMedCrossRefGoogle Scholar
  246. Lai, C.-J., and Nathans, D., 1975, Mapping of the genes of simian virus 40, Cold Spring Harbor Symp. Quant. Biol. 39: 53.PubMedCrossRefGoogle Scholar
  247. Lai, M. M. C., and Duesberg, P. H., 1972, Adenylic acid-rich sequence in RNAs of Rous sarcoma virus and Rauscher mouse leukaemia virus, Nature (London) 235: 383.CrossRefGoogle Scholar
  248. Lai, M. M. C., Duesberg, P. H., Horst, J., and Vogt, P. K., 1973, Avian tumor virus RNA: A comparison of three sarcoma viruses and their transformation-defective derivatives by oligonucleotide fingerprinting and DNA-RNA hybridization, Proc. Natl. Acad. Sci. USA 70: 2266.PubMedCrossRefGoogle Scholar
  249. Langlois, A. J., and Beard, J. W., 1967, Converted-cell focus formation in culture by strain MC29 avian leukosis virus, Proc. Soc. Exp. Biol. Med. 126: 718.Google Scholar
  250. Langlois, A. J., Veprek, L., Beard, D., Fritz, R. B., and Beard, J. W., 1971, Isolation of a nonfocus forming agent from strain MC29 avian leukosis virus, Cancer Res. 31: 1010.PubMedGoogle Scholar
  251. Latarjet, R., and Chamaillard, L., 1962, Inactivation du virus de Friend par les rayons X et les ultraviolets, Bull. Cancer 49: 382.Google Scholar
  252. Leis, J., Schincariol, A., Ishizaki, R., and Hurwitz, J., 1975, RNA-dependent DNA polymerase activity of RNA tumor viruses. V. Rous sarcoma virus single-stranded RNA-DNA covalent hybrids in infected chicken embryo fibroblast cells, J. Virol. 15: 484.PubMedGoogle Scholar
  253. Leong, J.-A., Garapin, A.-C., Jackson, N., Fanshier, L., Levinson, W., and Bishop, J. M., 1972, Virus-specific ribonucleic acid in cells producing Rous sarcoma virus: Detection and characterization, J. Virol. 9: 891.PubMedGoogle Scholar
  254. Levin, J. G., and Rosenak, M. J., 1976, Synthesis of murine leukemia virus proteins associated with virions assembled in actinomycin D-treated cells: Evidence for the persistence of viral messenger RNA, Proc. Natl. Acad. Sci. USA 73: 1154.PubMedCrossRefGoogle Scholar
  255. Levinson, W., and Rubin, H., 1966, Radiation studies of avian tumor viruses and of Newcastle disease virus, Virology 28: 533.PubMedCrossRefGoogle Scholar
  256. Levy, J. A., 1971, Demonstration of differences in murine sarcoma virus foci formed in mouse and rat cells under a soft agar overlay, J. Natl. Cancer Inst. 46: 1001.PubMedGoogle Scholar
  257. Levy, J. A., 1973, Xenotropic viruses: Murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains, Science 182: 1151.PubMedCrossRefGoogle Scholar
  258. Levy, J. A., 1975, Host range of murine xenotropic virus: Replication in avian cells, Nature (London) 253: 140.CrossRefGoogle Scholar
  259. Levy, J. A., 1977, Murine xenotropic type C viruses. III. Phenotypic mixing with avian sarcoma viruses, Virology.Google Scholar
  260. Levy, J. A., Hartley, J. W., Rowe, W. P., and Huebner, R. J., 1973, Studies of FBJ osteosarcoma virus in tissue culture. I. Biologic characteristics of the “C”-type viruses, J. Natl. Cancer Inst. 51: 525.PubMedGoogle Scholar
  261. Levy, J. A., Kazan, P. A., and Varmus, H. E., 1974, The importance of DNA size for successful transfection of chicken embryo fibroblasts, Virology 61: 297.PubMedCrossRefGoogle Scholar
  262. Lieber, M. M., Sherr, C. J., Benveniste, R. E., and Todaro, G. J., 1975a, Biologic and immunologic properties of porcine type C viruses, Virology 66: 616.PubMedCrossRefGoogle Scholar
  263. Lieber, M. M., Sherr, C. J., Todaro, G. J., Benveniste, R. E., Callahan, R., and Coon, H. G., 1975b, Isolation from the Asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses, Proc. Natl. Acad. Sci. USA 72: 2315.PubMedCrossRefGoogle Scholar
  264. Lieber, M. M., Benveniste, R. E., Sherr, C. J., and Todaro, G. J., 1975c, Isolation of a type C virus (FS-1) from the European wildcat (Felis sylvestris), Virology 66: 117.PubMedCrossRefGoogle Scholar
  265. Lilly, F., 1967, Susceptibility to two strains of Friend leukemia virus in mice, Science 155: 461.PubMedCrossRefGoogle Scholar
  266. Lilly, F., and Pincus, T., 1973, Genetic control of murine viral leukemogenesis, in: Advances in Cancer Research, Vol. 17 ( G. Klein and S. Weinhouse, eds.), p. 231, Academic Press, New York.CrossRefGoogle Scholar
  267. Linial, M., and Mason, W. S., 1973, Characterization of two conditional early mutants of Rous sarcoma virus, Virology 53: 258.PubMedCrossRefGoogle Scholar
  268. Livingston, D. M., and Todaro, G. J., 1973, Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus, Virology 53: 142.PubMedCrossRefGoogle Scholar
  269. Lo, A. C. H., and Ball, J. K., 1974, Evidence for helper-independent murine sarcoma virus. II. Differences between the ribonucleic acids of clone-purified leukemia virus, helper-independent and helper-dependent sarcoma viruses, Virology 59: 545.PubMedCrossRefGoogle Scholar
  270. Love, D. N., and Weiss, R. A., 1974, Pseudotypes of vesicular stomatitis virus determined by exogenous and endogenous avian RNA tumor viruses, Virology 57: 271.PubMedCrossRefGoogle Scholar
  271. Lovinger, G. G., Ling, H. P., Klein, R. A., Gilden, R. V., and Hatanaka, M., 1974, Unintegrated murine leukemia viral DNA in newly infected cells, Virology 62: 280.PubMedCrossRefGoogle Scholar
  272. Lovinger, G. C., Ling, H. P., Gilden, R. V., and Hatanaka, M., 1975a, Effect of UV light on RNA-directed DNA polymerase activity of murine oncornaviruses, J. Virol. 15: 1273.PubMedGoogle Scholar
  273. Lovinger, G. G., Klein, R., Ling, H. P., Gilden, R. V., and Hatanaka, M., 1975b, Kinetics of murine type C virus-specifiec DNA synthesis in newly infected cells, J. Virol. 16: 824.PubMedGoogle Scholar
  274. Maisel, J., Klement, V., Lai, M. M.-C., Ostertag, W., and Duesberg, P., 1973, Ribonucleic acid components of murine sarcoma and leukemia viruses, Proc. Natl. Acad. Sci. USA 70: 3536.PubMedCrossRefGoogle Scholar
  275. Maisel, J., Scolnick, E. M., and Duesberg, P., 1975, Base sequence differences between the RNA components of Harvey sarcoma virus, J. Virol. 16: 749.PubMedGoogle Scholar
  276. Maldonado, R. L., and Bose, H. R., 1971, Separation of reticuloendotheliosis virus from avian tumor viruses, J. Virol. 8: 813.PubMedGoogle Scholar
  277. Maldonado, R. L., and Bose, H. R., 1973, Relationship of reticuloendotheliosis virus to the avian tumor viruses: Nucleic acid and polypeptide composition, J. Virol. 11: 741.PubMedGoogle Scholar
  278. Mangel, W. F., Delius, H., and Duesberg, P. H., 1974, Structure and molecular weight of the 60–70 S RNA and the 30–40 S RNA of the Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 71: 4541.PubMedCrossRefGoogle Scholar
  279. Martin, G. S., 1970, Rous sarcoma virus: A function required for the maintenance of the transformed state, Nature (London) 227: 1021.CrossRefGoogle Scholar
  280. Martin, G. S., 1971, Mutants of the Schmidt-Ruppin strain of Rous sarcoma virus, in: The Biology of Oncogenic Viruses ( L. G. Silvestri, ed.), pp. 320–325, North-Holland, Amsterdam.Google Scholar
  281. Martin, G. S., and Duesberg, P. H., 1972, The a subunit in the RNA of transforming avian tumor viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in nontransforming variants, Virology 47: 494.PubMedCrossRefGoogle Scholar
  282. Martin, G. S., Venuta, S., Weber, M., and Rubin, H., 1971, Temperature-dependent alterations in sugar transport in cells infected by a temperature-sensitive mutant of Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 68: 2739.PubMedCrossRefGoogle Scholar
  283. Mason, W. S., Friis, R. R., Linial, M., and Vogt, P. K., 1974, Determination of the defective function in two mutants of Rous sarcoma virus, Virology 61: 559.PubMedCrossRefGoogle Scholar
  284. McAllister, R. M., Nicolson, M., Gardner, M. B., Rongey, R. W., Rasheed, S., Sarma, P. S., Huebner, R. J., Hatanaka, M., Oroszlan, S., Gilden, R. J., Kabigting, A., and Vernon, L., 1972, C-type virus released from cultured human rhabdomyosarcoma cells, Nature (London) New Biol. 235: 3.Google Scholar
  285. Meyers, P., Sigel, M. M., and Holden, H. T., 1972, Cross protection in vivo against avian sarcoma virus subgroups A, B, and C induced by Rous-associated viruses, J. Natl. Cancer Inst. 49: 173.PubMedGoogle Scholar
  286. Miyamoto, K., and Gilden, R. V., 1971, Electron microscopic studies of tumor viruses. I. Entry of murine leukemia virus into mouse embryo fibroblasts, J. Virol. 7: 395.PubMedGoogle Scholar
  287. Mizutani S., and Temin, H. M., 1973, Lack of serological relationship among DNA polymerases of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and chicken cells, J. Virol. 12: 440.PubMedGoogle Scholar
  288. Moelling, K., Gelderblom, H., Pauli, G., Friis, R., and Bauer, H., 1975, A comparative study of the avian reticuloendotheliosis virus: Relationship to murine leukemia virus and viruses of the avian sarcoma-leukosis complex, Virology 65: 546.PubMedCrossRefGoogle Scholar
  289. Montagnier, L., and Vigier, P., 1972, Un intermédiare ADN infectieux et transformant du virus du sarcome de Rous dans les cellules de Poule transformées par ce virus, C. R. Acad. Sci. Paris 274 (D): 1977.Google Scholar
  290. Montagnier, L., Goldé, A., and Vigier, P., 1969, A possible subunit structure of Rous sarcoma virus RNA, J. Gen. Virol. 4: 449.PubMedCrossRefGoogle Scholar
  291. Morgan, C., and Rose, H. M., 1968, Structure and development of viruses as observed in the electron microscope. VIII. Entry of influenza virus, J. Virol. 2: 925.PubMedGoogle Scholar
  292. Moscovici, C., 1967, A quantitative assay for avian myeloblastosis virus, Proc. Soc.Exp. Biol. Med. 125: 1213.PubMedGoogle Scholar
  293. Moscovici, C., 1975, Leukemic transformation with avian myeloblastosis virus: Present status, Curr. Top. Microbiol. Immunol. 71: 79.PubMedGoogle Scholar
  294. Moscovici, C., and Vogt, P. K., 1968, Effects of genetic cellular resistance on cell transformation and virus replication in chicken hematopoietic cell cultures infected with avian myeloblastosis virus, Virology 35: 487.PubMedCrossRefGoogle Scholar
  295. Moscovici, C., and Zanetti, M., 1970, Studies on single foci of hematopoietic cells transformed by avian myeloblastosis virus (BAI-A), Virology 35: 487.CrossRefGoogle Scholar
  296. Moscovici, C., Gazzolo, L., and Moscovici, M. G., 1975, Focus assay and defectiveness of avian myeloblastosis virus, Virology 68: 173.PubMedCrossRefGoogle Scholar
  297. Naso, R. B., Wang, C. S., Tsai, S., and Arlinghaus, R. B., 1973, Ribosomes from Rauscher leukemia virus-infected cells and their response to Rauscher viral RNA and polyuridylic acid, Biochim. Biophys. Acta 324: 346.Google Scholar
  298. Naso, R. B., Arcement, L. J., and Arlinghaus, R. B., 1975, Biosynthesis of Rauscher leukemia viral proteins, Cell 4: 31.PubMedCrossRefGoogle Scholar
  299. Nass, M. M. K., 1973, Temperature-dependent formation of dimers and oligomers of mitochondrial DNA in cells transformed by a thermosensitive mutant of Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 70: 3739.PubMedCrossRefGoogle Scholar
  300. Neiman, P. E., 1973, Measurement of endogenous leukosis virus nucleotide sequences in the DNA of normal avian embryos by RNA-DNA hybridization, Virology 53: 196.PubMedCrossRefGoogle Scholar
  301. Neiman, P. E., Wright, S. E., McMillin, C., and MacDonnell, D., 1974, Nucleotide sequence relationships of avian RNA tumor viruses: Measurement of the deletion in a transformation-defective mutant of Rous sarcoma virus, J. Virol. 13: 837.PubMedGoogle Scholar
  302. Nowinski, R. C., Watson, K. F., Yaniv, A., and Spiegelman, S., 1972, Serological analysis of the deoxyribonucleic acid polymerase of avian oncornaviruses. II. Comparison of avian deoxyribonucleic acid polymerases, J. Virol. 10: 959.PubMedGoogle Scholar
  303. Ogura, H., and Friis, R., 1975, Further evidence for the existence of a viral envelope protein defect in Bryan high-titer strain of Rous sarcoma virus, J. Virol. 16: 443.PubMedGoogle Scholar
  304. Oroszlan, S., Bova, D., Martin White, M. H., Toni, R., Foreman, C., and Gilden, R. V., 1972, Purification and immunological characterization of the major internal protein of the RD-114 virus, Proc. Natl. Acad. Sci. USA 69: 1211.PubMedCrossRefGoogle Scholar
  305. Ostertag, W., Cole, T., Crozier, T., Gaedicke, G., Kind, J., Kluge, N., Krieg, J. C., Roesler, G., Weimann, B. J., and Dube, S. K., 1975, Viral involvement in the differentiation of erythroleukemic mouse and human cells, in: Differentiation and Control of Malignancy ( Waro Nakahara ed.), Univ. of Tokyo Press, Tokyo.Google Scholar
  306. Otten, J., Bader, J., Johnson, G. S., and Pastan, I., 1972, A mutation in a Rous sarcoma virus gene that controls adenosine 3’,5’ -monophosphate levels and transformation, J. Biol. Chem. 247: 1632.PubMedGoogle Scholar
  307. Owada, M., and Toyoshima, K., 1973, Analysis on the reproducing and cell-transforming capacities of temperature sensitive mutant (ts334) of avian sarcoma virus B77, Virology 54: 170.PubMedCrossRefGoogle Scholar
  308. Owada, M., Ihara, S., Toyoshima, K., Kozai, Y., and Sugino, Y., 1976, Ultraviolet-inactivation of avian sarcoma viruses: Biological and biochemical analysis, Virology 69: 710.PubMedCrossRefGoogle Scholar
  309. Pal, B. K., and Roy-Burman, P., 1975, Phosphoproteins: Structural components of oncornaviruses, J. Virol. 15: 540.PubMedGoogle Scholar
  310. Pal, B. K., McAllister, R. M., Gardner, M. B., and Roy-Burman, P., 1975, Comparative studies on the structural phosphoproteins of mammalian type C viruses, J. Virol. 16: 123.PubMedGoogle Scholar
  311. Panet, A., Baltimore, D., and Hanafusa, T., 1975a, Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay, J. Virol. 16: 146.PubMedGoogle Scholar
  312. Panet, A., Haseltine, W., Baltimore, D., Peters, G., Harada, F., and Dahlberg, J. E., 1975b, Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase), Proc. Natl. Acad. Sci. USA 72: 2535.PubMedCrossRefGoogle Scholar
  313. Pani, P. K., 1975, Genetic control of resistance of chick embryo cultures to RSV(RAV 50), J. Gen. Virol. 27: 163.PubMedCrossRefGoogle Scholar
  314. Parkman, R., Levy, J. A., and Ting, R. C. 1970, Murine sarcoma virus: The question of defectiveness, Science 168: 387.PubMedCrossRefGoogle Scholar
  315. Payne, L. N., 1972, Interactions between host genome and avian RNA tumor viruses, in: RNA Viruses and Host Genome in Oncogenesis ( P. Emmelot and P. Bentvelzen, eds.), pp. 93–115, North-Holland, Amsterdam.Google Scholar
  316. Payne, L. N., and Biggs, P. M., 1964, Differences between highly inbred lines of chickens in the response to Rous sarcoma virus of the chorioallantoic membrane and of embryonic cells in tissue culture, Virology 24: 610.PubMedCrossRefGoogle Scholar
  317. Payne, L. N., and Biggs, P. M., 1970, Genetic resistance of fowl to MH2 reticuloendothelioma virus, J. Gen. Virol. 7: 177.PubMedCrossRefGoogle Scholar
  318. Payne, L. N., and Pani, P. K., 1971, Evidence for linkage between genetic loci controlling response of fowl to subgroup A and subgroup C sarcoma viruses, J. Gen. Virol. 13: 253.PubMedCrossRefGoogle Scholar
  319. Payne, L. N., Pani, P. K., and Weiss, R. A., 1971, A dominant epistatic gene which inhibits cellular susceptibility to RSV(RAV-O), J. Gen. Virol. 13: 455.PubMedCrossRefGoogle Scholar
  320. Payne, L. N., Crittenden, L. B., and Weiss, R. A., 1973, A brief definition of host genes which influence infection by avian RNA tumor viruses, in: Possible Episomes in Eukaryotes, Proceedings of the Fourth Lepetit Colloquium, 1972 ( L. Silvestri, ed.), pp. 94–97, North-Holland, Amsterdam.Google Scholar
  321. Peebles, P. T., Bassin, R. H., Haapala, D. K., Phillips, L. A., Nomura, S., and Fischinger, P. J., 1971, Rescue of murine sarcoma virus from a sarcoma-positive leukemia-negative cell line: Requirement for replicating leukemia virus, J. Virol. 8: 690.PubMedGoogle Scholar
  322. Peebles, P. T., Haapala, D. K., and Gazdar, A. F., 1972, Deficiency of viral ribonucleic acid-dependent deoxyribonucleic acid polymerase in noninfectious virus-like particles released from murine sarcoma virus-transformed hamster cells, J. Virol. 9: 488.PubMedGoogle Scholar
  323. Peebles, P. T., Fischinger, P. J., Bassin, R. H., and Papageorge, A. G., 1973, Isolation of human amnion cells transformed by rescuable murine sarcoma virus, Nature (London) New Biol. 242: 98.CrossRefGoogle Scholar
  324. Phillips, L. A., Hollis, V. W., Jr., Bassin, R. H., and Fischinger, P. J., 1973, Characterization of RNA from noninfectious virions produced by sarcoma positive leukemia-negative transformed 3T3 cells, Proc. Natl. Acad. Sci. USA 70: 3002.PubMedCrossRefGoogle Scholar
  325. Pincus, T., Hartley, J. W., and Rowe, W. P., 1971a, A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses, J. Exp. Med. 133: 1219.PubMedCrossRefGoogle Scholar
  326. Pincus, T., Rowe, W. P., and Lilly, F., 1971b, A Major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to Friend murine leukemia virus, J. Exp. Med. 133: 1234.PubMedCrossRefGoogle Scholar
  327. Pincus, T., Hartley, J. W., and Rowe, W. P., 1975, A major genetic locus affecting resistance to infection with murine leukemia viruses. IV. Dose-response relationships in Fv-1 sensitive and resistant cell cultures, Virology 65: 333.PubMedCrossRefGoogle Scholar
  328. Piraino, F., 1967, The mechanism of genetic resistance of chick embryo cells to infection by Rous sarcoma virus-Bryan strain (BS-RSV), Virology 32: 700.PubMedCrossRefGoogle Scholar
  329. Purchase, H. G., and Okazaki, W., 1964, Morphology of foci produced by standard preparation of Rous sarcoma virus, J. Natl. Cancer Inst. 32: 579.PubMedGoogle Scholar
  330. Quade, K., Smith, R. E., and Nichols, J. L., 1974a, Evidence for common nucleotide sequences in the RNA subunits comprising Rous sarcoma virus 70 S RNA, Virology 61: 287.PubMedCrossRefGoogle Scholar
  331. Quade, K., Smith, R. E., and Nichols, J. L., 1974b, Poly(riboadenylic acid) and adjacent nucleotides in Rous sarcoma virus RNA, Virology 62: 60.PubMedCrossRefGoogle Scholar
  332. Quigley, J. P., Rifkin, D. B., and Reich, E., 1972, Lipid studies of Rous sarcoma virus and host cell membranes, Virology 50: 550.PubMedCrossRefGoogle Scholar
  333. Quintrell, N., Varmus, H. E., Bishop, J. M., Nicholson, M. O., and McAllister, R. M., 1974, Homologies among the nucleotide sequences of the genomes of C-type viruses, Virology 58: 568.PubMedCrossRefGoogle Scholar
  334. Rao, P. R., Bonar, R. A., and Beard, J. W., 1966, Lipids of the BAI strain A avian tumor virus and of the myeloblast host cell, Exp. Mol. Pathol. 5: 374.PubMedCrossRefGoogle Scholar
  335. Rasheed, S., Gardner, M. B., and Chan, E., 1976, Amphotropic host range of naturally occurring wild mouse leukemia viruses, J. Virol. 19: 13.PubMedGoogle Scholar
  336. Rho, H. M., and Green, M., 1974, The homopolyadenylate and adjacent nucleotides at the 3’-terminus of 30–40 S RNA subunits in the genome of murine sarcoma-leukemia virus, Proc. Natl. Acad. Sci. USA 71: 2386.PubMedCrossRefGoogle Scholar
  337. Richert, N. J., and Hare, J. D., 1972, Distinctive effects of inhibitors of mitochondria) function on Rous sarcoma virus replication and malignant transformation, Biochem. Biophys. Res. Commun. 46: 5.PubMedCrossRefGoogle Scholar
  338. Riggin, C. H., Bondurant, M., and Mitchell, W. M., 1975, Physical properties of Moloney murine leukemia virus high-molecular-weight RNA: A two subunit structure, J. Virol. 16: 1528.PubMedGoogle Scholar
  339. Roa, R. C., and Bose, S. K., 1974, Inhibition by ethidium bromide of the establishment of infection by murine sarcoma virus. J. Gen. Virol. 25: 197.PubMedCrossRefGoogle Scholar
  340. Robbins, P. W., Wickus, G. G., Branton, P. E., Gaffney, B. J., Hirschberg, C. B., Fuchs, P., and Blumberg, P. M., 1975, The chick fibroblast cell surface after transformation by Rous sarcoma virus, Cold Spring Harbor Symp. Quant. Biol. 39: 1173.PubMedCrossRefGoogle Scholar
  341. Robinson, H. L., 1967, Isolation of noninfectious particles containing Rous sarcoma virus RNA from the medium of Rous sarcoma virus-transformed nonproducer cells, Proc. Natl. Acad. Sci. USA 57: 1655.PubMedCrossRefGoogle Scholar
  342. Robinson, W. S., and Robinson, H. L., 1971, DNA polymerase in defective Rous sarcoma virus, Virology 44: 457.PubMedCrossRefGoogle Scholar
  343. Robinson, W. S., Pitkanen, A., and Rubin, H., 1965, The nucleic acid of the Bryan strain of Rous sarcoma virus: Purification of the virus and isolation of the nucleic acid, Proc. Natl. Acad. Sci. USA 54: 137.PubMedCrossRefGoogle Scholar
  344. Robinson, W. S., Robinson, H. L., and Duesberg, P. H., 1967, Tumor virus RNA’s, Proc. Natl. Acad. Sci. USA 58: 825.PubMedCrossRefGoogle Scholar
  345. Rohrschneider, L. R., Kurth, R., and Bauer, H., 1975, Biochemical characterization of tumor-specific cell surface antigens on avian oncornavirus transformed cells, Virology 66: 481.PubMedCrossRefGoogle Scholar
  346. Rosenberg, N., Baltimore, D., and Scher, C. D., 1975, In vitro transformation of lymphoid cells by Abelson murine leukemia virus, Proc. Natl. Acad. Sci. USA 72: 1932.Google Scholar
  347. Rowe, W. P., 1971, The kinetics of rescue of the murine sarcoma virus genome from a nonproducer line of transformed mouse cells, Virology 46: 369.PubMedCrossRefGoogle Scholar
  348. Rowson, K. E. K., and Parr, I. B., 1970, A new virus of minimal pathogenicity associated with Friend virus. I. Isolation by end-point dilution, Int. J. Cancer 5: 96.PubMedCrossRefGoogle Scholar
  349. Roy-Burman, P., and Klement, V., 1975, Derivation of mouse sarcoma virus (Kirsten) by acquisition of genes from heterologous host, J. Gen. Virol. 28: 193.PubMedCrossRefGoogle Scholar
  350. Rubin, H., 1960, Growth of rous sarcoma virus in chick embryo cells following irradiation of host cells or free virus, Virology 11: 28.PubMedCrossRefGoogle Scholar
  351. Rubin, H., 1965, Genetic control of cellular susceptibility of pseudotypes of Rous sarcoma virus, Virology 26: 270.PubMedCrossRefGoogle Scholar
  352. Rubin, H., and Temin, H. M., 1959, A radiological study of cell-virus interaction in the Rous sarcoma, Virology 7: 75.PubMedCrossRefGoogle Scholar
  353. Rymo, L., Parsons, J. T., Coffin, J. M., and Weissmann, C., 1974, In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase, Proc. Natl. Acad. Sci. USA 71:2782.Google Scholar
  354. Sarma, P. S., Log, T., and Huebner, R. J., 1970, Trans-species rescue of defective genomes of murine sarcoma virus from hamster tumor cells with helper feline leukemia virus, Proc. Natl. Acad. Sci. USA 65: 81.PubMedCrossRefGoogle Scholar
  355. Sarma, P. S., Baskar, J. F., Gilden, R. V., Gardner, M. B., and Huebner, R. J., 1971, In vitro isolation and characterization of the GA strain of feline sarcoma virus, Proc. Soc. Exp. Biol. Med. 137: 1333.Google Scholar
  356. Sarma, P. S., Tseng, J., Lee, Y. K., and Gilden, R. V., 1973, Virus similar to RD114 virus in cat cells, Nature (London) New Biol. 244: 56.Google Scholar
  357. Scheele, C. M., and Hanafusa, H., 1971, Proteins of helper-dependent RSV, Virology 45: 401.PubMedCrossRefGoogle Scholar
  358. Scher, C. D., and Siegler, R., 1975, Direct transformation of 3T3 cells by Abelson murine leukaemia virus, Nature (London) 253: 729.CrossRefGoogle Scholar
  359. Schincariol, A. L., and Joklik, W. K., 1973, Early synthesis of virus-specific RNA and DNA in cells rapidly transformed with Rous sarcoma virus, Virology 56: 532.PubMedCrossRefGoogle Scholar
  360. Scolnick, E. M., and Parks, W. P., 1973, Isolation and characterization of a primate sarcoma virus: Mechanism of rescue, Int. J. Cancer 12: 138.PubMedCrossRefGoogle Scholar
  361. Scolnick, E. M., and Parks, W. P., 1974, Harvey sarcoma virus: A second murinc type C sarcoma virus with rat genetic information, J. Virol. 13: 1211.PubMedGoogle Scholar
  362. Scolnick, E. M., Parks, W. P., Todaro, G. J., and Aaronson, S. A., 1972a, Immunological characterization of primate C-type virus reverse transcriptases, Nature New Biol. 235: 35.PubMedGoogle Scholar
  363. Scolnick, E. M., Stephenson, J. R., and Aaronson, S. A., 19726, Isolation of temperature-sensitive mutants of murine sarcoma virus, J. Virol. 10: 653.Google Scholar
  364. Scolnick, E. M., Rands, E., Williams, D., and Parks, W. P., 1973, Studies on the nucleic acid sequences of Kirsten sarcoma virus: A model for formation of a mammalian RNA-containing sarcoma virus, J. Virol. 12: 458.PubMedGoogle Scholar
  365. Scolnick, E. M., Parks, W., Kawakami, T., Kohne, D., Okabe, H., Gilden, R., and Hatanaka, M., 1974, Primate and murine type-C viral nucleic acid association kinetics: analysis of model systems and natural tissues, J. Virol. 13: 363.PubMedGoogle Scholar
  366. Scolnick, E. M., Goldberg, R. J., and Parks, W. P., 1975a, A biochemical and genetic analysis of mammalian RNA-containing sarcoma viruses, Cold Spring Harbor Symp. Quant. Biol. 39: 885.CrossRefGoogle Scholar
  367. Scolnick, E. M., Howk, R. S., Anisowicz, A., Peebles, P. T., Scher, C. D., Parks, W. P., 19756, Separation of sarcoma virus-specific and leukemia virus-specific genetic sequences of Moloney sarcoma virus, Proc. Natl. Acad. Sci. USA 72: 4650.Google Scholar
  368. Shanmugam, G., Bhaduri, S., and Green, M., 1974, The virus-specific RNA species in free and membrane-bound polyribosomes of transformed cells replicating murine sarcoma-leukemia viruses, Biochem. Biophys. Res. Commun. 56: 697.PubMedCrossRefGoogle Scholar
  369. Shenk, T. E., Rhodes, C., Rigby, P. W. J., and Berg, P., 1975, Mapping of mutational alterations in DNA with S, nuclease: The location of deletions, insertions and temperature-sensitive mutations in SV40, Cold Spring Harbor Symp. Quant. Biol. 39: 61.PubMedCrossRefGoogle Scholar
  370. Sherr, C. J., and Todaro, G. J., 1974, Radioimmunoassay of the major group specific protein of endogenous baboon type C viruses: Relation to RD-114/CCC group and detection of antigen in normal baboon tissue, Virology 61: 168.PubMedCrossRefGoogle Scholar
  371. Sherr, C. J., Lieber, M. M., Benveniste, R. E., and Todaro, G. J., 1974, Endogenous baboon type C virus (M7): Biochemical and immunologic characterization, Virology 58: 492.PubMedCrossRefGoogle Scholar
  372. Sherr, C. J., Fedele, L. A., Benveniste, R. E., and Todaro, G. J., 1975, Interspecies antigenic determinants of the reverse transcriptases and p30 proteins of mammalian type C viruses, J. Virol. 15: 1440.PubMedGoogle Scholar
  373. Shoyab, M., Markham, P. D., and Baluda, M. A., 1975, Host induced alteration of avian sarcoma virus B-77 genome, Proc. Natl. Acad. Sci. USA 72: 1031.PubMedCrossRefGoogle Scholar
  374. Siegert, W., Konings, R. N. H., Bauer, H., and Hofschneider, P. H., 1972, Translation of avian myeloblastosis virus RNA in a cell-free lysate of Escherichia coli, Proc. Natl. Acad. Sci. USA 69: 888.CrossRefGoogle Scholar
  375. Sklar, M. D., White, B. J., and Rowe, W. P., 1974, Initiation of oncogenic transformation of mouse lymphocytes in vitro by Abelson leukemia virus, Proc. Natl. Acad. Sci. USA 71: 4077.PubMedCrossRefGoogle Scholar
  376. Smith, J. D., Barnett, L., Brenner, S., and Russell, R. L., 1970, More mutant tyrosine transfer ribonucleic acids, J. Mol. Biol. 54: 1.PubMedCrossRefGoogle Scholar
  377. Smotkin, D., Gianni, A. M., Rozenblatt, S., and Weinberg, R. A., 1975, Infectious viral DNA of murine leukemia virus, Proc. Natl. Acad. Sci. USA 72: 4910.PubMedCrossRefGoogle Scholar
  378. Somers, K., and Kit, S., 1973, Temperature-dependent expression of transformation by a cold-sensitive mutant of murine sarcoma virus, Proc. Natl. Acad. Sci. USA 70: 2206.PubMedCrossRefGoogle Scholar
  379. Somers, K. D., May, J. T., and Kit, S., 1973, Control of gene expression in rat cells transformed by a cold-sensitive murine sarcoma virus (MSV) mutant, Intervirology 1: 176.PubMedCrossRefGoogle Scholar
  380. Steeves, R. A., Eckner, R. J., Bennett, M., Mirand, E. A., and Trudel, P. J., 1971, Isolation and characterization of a lymphatic leukemia virus in the Friend virus cornplex, J. Natl. Cancer Inst. 46: 1209.PubMedGoogle Scholar
  381. Stehelin, D., Guntaka, R. V., Varmus, H. E., and Bishop, J. M., 1976a, Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses, J. Mol. Biol. 101: 349.PubMedCrossRefGoogle Scholar
  382. Stehelin, D., Varmus, H. E., Bishop, J. M., and Vogt, P. K., 19766, DNA related to the transforming genes of avian sarcoma viruses is present in normal avian NDA, Nature (London) 260: 170.Google Scholar
  383. Steiner, S. M., Melnick, J. L., Kit, S., and Somers, K. D., 1974, Fucosyl-glycolipids in cells transformed by a temperature-sensitive mutant of murine sarcoma virus, Nature (London) 248: 682.CrossRefGoogle Scholar
  384. Stephenson, J. R., and Aaronson, S. A., 1971, Murine sarcoma and leukemia viruses: Genetic differences determined by RNA-DNA hybridization, Virology 46: 480.PubMedCrossRefGoogle Scholar
  385. Stephenson, J. R., and Aaronson, S. A., 1973, Characterization of temperature-sensitive mutants of murine leukemia virus, Virology 54: 53.PubMedCrossRefGoogle Scholar
  386. Stephenson, J. R., and Aaronson, S. A., 1974, Temperature-sensitive mutants of murine leukemia virus. III. Mutants defective in helper functions for sarcoma virus fixation, Virology 58: 294.PubMedCrossRefGoogle Scholar
  387. Stephenson, J. R., Reynolds, R. K., and Aaronson, S. A., 1972, Isolation of temperature-sensitive mutants of murine leukemia virus, Virology 48: 749.PubMedCrossRefGoogle Scholar
  388. Stephenson, J. R., Anderson, G. R., Tronick, S. R., and Aaronson, S. A., 1974a, Evidence for genetic recombination between endogenous and exogenous mouse RNA type C viruses, Cell 2: 87.PubMedCrossRefGoogle Scholar
  389. Stephenson, J. R., Tronick, S. R., and Aaronson, S. A., 1974b, Temperature-sensitive mutants of murine leukemia virus. IV. Further physiological characterization and evidence for genetic recombination, J. Virol. 14: 918.PubMedGoogle Scholar
  390. Stephenson, J. R., Tronick, S. R., and Aaronson, S. A., 1975, Murine leukemia virus mutants with temperature-sensitive defects in precursor polypeptide cleavage, Cell 6: 543.CrossRefGoogle Scholar
  391. Stoltzfus, C. M., and Snyder, P. N., 1975, Structure of B77 sarcoma virus RNA: Stabilization of RNA after packaging, J. Virol. 16: 1161.PubMedGoogle Scholar
  392. Stone, K. R., Smith, R. E., and Joklik, W. K., 1974, Changes in membrane polypeptides that occur when chick embryo fibroblasts and NRK cells are transformed with avian sarcoma viruses, Virology 58: 86.PubMedCrossRefGoogle Scholar
  393. Stone, M. P., Smith, R. E., and Joklik, W. K., 1975, 35S a and b RNA subunits of avian RNA tumor virus strains cloned and passaged in chick and duck cells, Cold Spring Harbor Symp. Quant. Biol. 39: 859.Google Scholar
  394. Sveda, M. M., Fields, B. N., and Soeiro, R., 1974, Host restriction of Friend leukemia virus; fate of input virion RNA, Cell 2: 271.PubMedCrossRefGoogle Scholar
  395. Taber, R., Rekosh, D., and Baltimore, D., 1971, Effect of pactamycin on synthesis of poliovirus proteins: A method for genetic mapping, J. Virol. 8: 395.PubMedGoogle Scholar
  396. Takano, T., and Hatanaka, M., 1975, Fate of viral RNA of murine leukemia virus after infection, Proc. Natl. Acad. Sci. USA 72: 343.PubMedCrossRefGoogle Scholar
  397. Taylor, J. M., and Illmensee, R., 1975, Site on the RNA of an avian sarcoma virus at which primer is bound, J. Virol. 16: 553.PubMedGoogle Scholar
  398. Taylor, J. M., Varmus, H. E., Faras, A. J., Levinson, W. E., and Bishop, J. M., 1974, Evidence for non-repetitive subunits in the genome of Rous sarcoma virus, J. Mol. Biol. 84: 217.PubMedCrossRefGoogle Scholar
  399. Taylor, J. M., Cordell-Stewart, B., Rohde, W., Goodman, H. M., and Bishop, J. M., 1975, Reassociation of 4 S and 5 S RNA’s with the genome of avian sarcoma virus, Virology 65: 248.PubMedCrossRefGoogle Scholar
  400. Temin, H., 1960, The control of cellular morphology in embryonic cells infected with Rous sarcoma virus in vitro, Virology 10: 182.CrossRefGoogle Scholar
  401. Temin, H. M., 1961, Mixed infection with two types of Rous sarcoma virus, Virology 13: 158.PubMedCrossRefGoogle Scholar
  402. Temin, H. M., 1962, Separation of morphological conversion and virus production in Rous sarcoma virus infection, Cold Spring Harbor Symp. Quant. Biol. 27: 407.PubMedCrossRefGoogle Scholar
  403. Temin, H. M., 1963, Further evidence for a converted, non-virus-producing state of Rous sarcoma virus-infected cells, Virology 20: 235.PubMedCrossRefGoogle Scholar
  404. Temin, H. M., 1971, The role of the DNA provirus in carcinogenesis by RNA tumor viruses, in: The Biology of Oncogenic Viruses ( L. Silvestri, ed.), pp. 176–187, North-Holland, Amsterdam.Google Scholar
  405. Temin, H., and Baltimore, D., 1972, RNA-directed DNA synthesis and RNA tumor viruses, in: Advances in Virus Research, Vol. 17 ( K. Smith, M. Lauffer, and F. Bang, eds.), pp. 129–185, Academic Press, New York.CrossRefGoogle Scholar
  406. Temin, H. M., and Mizutani, S., 1970, RNA-dependent DNA polymerase in virions of Rous sarcoma virus, Nature (London) 226: 1211.CrossRefGoogle Scholar
  407. Tennant, R. W., Myer, F. E., and McGrath, L., 1974a, Effect of the Fv-1 gene on leukemia virus in mouse cell heterokaryons, Int. J. Cancer 14: 504.PubMedCrossRefGoogle Scholar
  408. Tennant, R. W., Schulter, B., Yang, W.-K., and Brown, A., 1974b, Reciprocal inhibition of mouse leukemia virus infection by Fv-1 allele cell extracts, Proc. Natl. Acad. Sci. USA 71: 4241.PubMedCrossRefGoogle Scholar
  409. Tereba, A., Skoog, L., and Vogt, P. K., 1975, RNA tumor virus specific sequences in nuclear DNA of several avian species, Virology 65: 524.PubMedCrossRefGoogle Scholar
  410. Theilen, G. H., Zeigel, R. F., and Twiehaus, M. J., 1966, Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail, J. Natl. Cancer Inst. 37: 731.PubMedGoogle Scholar
  411. Todaro, G. J., Benveniste, R. E., Lieber, M. M., and Sherr, C. J., 1974, Characterization of a C type virus released from the porcine cell line PK(15), Virology 58: 65.PubMedCrossRefGoogle Scholar
  412. Todaro, G. J., Benveniste, R. E., Callahan, R., Lieber, M. M., and Sherr, C. J., 1975, Endogenous primate and feline type C viruses, Cold Spring Harbor Symp. Quant. Biol. 39: 1159.PubMedCrossRefGoogle Scholar
  413. Tooze, J., 1973, RNA tumour viruses: Morphology, composition and classification, in: The Molecular Biology of Tumour Viruses ( J. Tooze, ed.), pp. 502–584, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.Google Scholar
  414. Toyoshima, K., and Vogt, P. K., 1969, Temperature-sensitive mutants of an avian sarcoma virus, Virology 39: 930.PubMedCrossRefGoogle Scholar
  415. Toyoshima, K., Friis, R. R., and Vogt, P. K., 1970; The reproductive and cell-transforming capacities of avian sarcoma virus B77: Inactivation with UV light, Virology 42: 163.PubMedCrossRefGoogle Scholar
  416. Toyoshima, K., Owada, M., and Kozai, Y., 1973, Tumor producing capacity of temperature sensitive mutants of avian sarcoma viruses in chicks, Biken J. 16: 103.PubMedGoogle Scholar
  417. Toyoshima, K., Nomaguchi, H., Owada, M., Ihara, S., and Yoshida, M., 1975, Hereditary modification of avian sarcoma viruses by quail cell passage, in: VIIth International Symposium on Comparative Leukemia Research Program and Abstracts, p. 139.Google Scholar
  418. Trâvnicek, M., 1968, RNA with amino acid-acceptor activity isolated from an oncogenic virus, Biochim. Biophys. Acta 166: 757.PubMedGoogle Scholar
  419. Tronick, S. R., Stephenson, J. R., Verma, I. M., and Aaronson, S. A., 1975, Thermolabile reverse transcriptase of a mammalian leukemia virus mutant temperature sensitive in its replication and sarcoma virus helper functions, J. Virol. 16: 1476.PubMedGoogle Scholar
  420. Tsuchida, N., Robin, M. S., and Green, M., 1972, Viral RNA subunits in cells transformed by RNA tumor viruses, Science 176: 1418.Google Scholar
  421. Tsuchida, N., Long, C., and Hatanaka, M., 1974, Viral RNA of murine sarcoma virus produced by a hamster-mouse somatic cell hybrid, Virology 60, 200.PubMedCrossRefGoogle Scholar
  422. Twardzik, D., Simonds, J., Oskarsson, M., and Portugal, F., 1973, Translation of AKR-murine leukemia viral RNA in an E. coli cell-free system, Biochem. Biophys. Res. Commun. 52: 1108.Google Scholar
  423. Unkeless, J. C., Tobia, A., Ossowski, L., Quigley, J. P., Rifkin, D. B., and Reich, E., 1973, An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses, J. Exp. Med. 137: 85.PubMedCrossRefGoogle Scholar
  424. Vaheri, A., and Ruoslahti, E., 1974, Disappearance of a major cell-type specific surface glycoprotein antigen (SF) after transformation of fibroblasts by Rous sarcoma virus, Int. J. Cancer 13: 579.PubMedCrossRefGoogle Scholar
  425. van Zaane, D., Gielkens, A. L. J., Dekker-Michielsen, M. J. A., and Bloemers, H. P. J., 1975, Virus-specific precursor polypeptides in cells infected with Rauscher leukemia virus, Virology 67: 544.Google Scholar
  426. Varmus, H. E., and Shank, P. R., 1976, Unintegrated viral DNA is synthesized in the cytoplasm of avian sarcoma virus-transformed duck cells by viral DNA polymerase, J. Virol. 18: 567.PubMedGoogle Scholar
  427. Varmus, H. E., Weiss, R. A., Friis, R. R., Levinson, W., and Bishop, J. M., 1972, Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs, Proc. Natl. Acad. Sci. USA 69: 20.PubMedCrossRefGoogle Scholar
  428. Varmus, H. E., Bishop, J. M., and Vogt, P. K., 1973a, Synthesis and integration of Rous sarcoma virus-specific DNA in permissive and non-permissive hosts, in: Virus Research, Proceedings of the Second ICN-UCLA Symposium on Molecular Biology ( C. Fox and W. Robinson, eds.), pp. 373–383, Academic Press, New York.Google Scholar
  429. Varmus, H. E., Vogt, P. K., and Bishop, J. M., 1973b, Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts, Proc. Natl. Acad. Sci. USA 70: 3067.PubMedCrossRefGoogle Scholar
  430. Varmus, H. E., Guntaka, R. V., Fan, W. J. W., Heasley, S., and Bishop, J. M., 1974, Synthesis of viral DNA in the cytoplasm of duck embryo fibroblasts and in enucleated cells after infection by avian sarcoma virus, Proc. Natl. Acad. Sci. USA 71: 3874.PubMedCrossRefGoogle Scholar
  431. Varmus, H. E., Guntaka, R. V., Deng, C.-T., and Bishop, J. M., 1975a, Synthesis, structure and function of avian sarcoma virus-specific DNA in permissive and non-permissive host cells, Cold Spring Harbor Symp. Quant. Biol. 39: 987.PubMedCrossRefGoogle Scholar
  432. Varmus, H. E., Guntaka, R. V., Deng, C.-T., Domenik, C., and Bishop, J. M., 1975b, Synthesis and function of avian sarcoma virus-specific DNA in permissive and non-permissive host cells, in: Proceedings XI International Cancer Congress, Florence, Italy, 1974 ( P. Bucalossi, U. Veronesi, and N. Casinelli, eds.), pp. 272–276, American Elsevier, New York.Google Scholar
  433. Venuta, S., and Rubin, H., 1973, Sugar transport in normal and Rous sarcoma virus-transformed chick-embryo fibroblasts, Proc. Natl. Acad. Sci. USA 70: 653.PubMedCrossRefGoogle Scholar
  434. Verma, I. M., 1975, Studies on reverse transcriptase of RNA tumor viruses. I. Localization of thermolabile DNA polymerase and RNase H activities on one polypeptide, J. Virol. 15: 121.PubMedGoogle Scholar
  435. Verma, I. M., and Gibson, W., 1975, Role of reverse transcriptase in the life cycle of RNA tumor viruses, in: DNA Synthesis and its Regulation, Proceedings of the Fifth ICN-UCLA Symposium on Molecular and Cell Biology ( M. Gullian, P. Hanowalt, and C. Fox, eds.), pp. 730–752, W. A. Benjamin, Menlo Park, Calif.Google Scholar
  436. Verma, I. M., Mason, W. S., Drost, S. D., and Baltimore, D., 1974, DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile, Nature (London) 251: 27.CrossRefGoogle Scholar
  437. Verma, I. M., Varmus, H., and Hunter, E., 1976, Characterization of early temperature-sensitive mutants of avian sarcoma viruses—Biological properties and thermal lability of the reverse transcriptase in vitro and synthesis of viral DNA in infected cells, Virology, 74: 16.PubMedCrossRefGoogle Scholar
  438. Vogt, P. K., 1965, A heterogeneity of Rous sarcoma virus revealed by selectively resistant chick embryo cells, Virology 25: 237.PubMedCrossRefGoogle Scholar
  439. Vogt, P. K., 1967a, A virus released by “nonproducing” Rous sarcoma cells, Proc. Natl. Acad. Sci. USA 58: 801.PubMedCrossRefGoogle Scholar
  440. Vogt, P. K., 1967b, Phenotypic mixing in the avian tumor virus group, Virology 32: 708.PubMedCrossRefGoogle Scholar
  441. Vogt, P. K., 1967c, Virus-directed host response in the avian leukosis and sarcoma complex, in: Perspectives in Virology, Vol. 5 ( M. Pollard, ed.), pp. 199–228, Academic Press, New York.Google Scholar
  442. Vogt, P. K., 1970, Envelope classification of avian RNA tumor viruses, in: Comparative Leukemia Research 1969 (Bibl. Haematol., No. 36) ( R. M. Dutcher, ed.), pp. 153–167, Karger, New York.Google Scholar
  443. Vogt, P. K., 1971a, Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses, Virology 46: 939.PubMedCrossRefGoogle Scholar
  444. Vogt, P. K., 1971b, Genetically stable reassortment of markers during mixed infection with avian tumor viruses, Virology 46: 947.PubMedCrossRefGoogle Scholar
  445. Vogt, P. K., 1973, The genome of avian RNA tumor viruses: A discussion of four models, in: Possible Episomes in Eukaryotes, Proceedings of the Fourth Lepetit Colloquium, 1972 ( L. Silvestri, ed.), pp. 35–41, North-Holland, Amsterdam.Google Scholar
  446. Vogt, P. K., 1976, The oncovirinae—A definition of the group, in: WHO Centre for Collection and Evaluation of Data on Comparative Virology (P. Thein, ed.), pp. 327–339, Munich, 1976.Google Scholar
  447. Vogt, P. K., and Duesberg, P. H., 1973, On the mechanism of recombination between avian RNA tumor viruses, in: Virus Research, Proceedings of the Second ICNUCLA Symposium on Molecular Biology (C. Fox and W. Robinson, eds.), pp. 505–511, Academic Press, New York.Google Scholar
  448. Vogt, P. K., and Ishizaki, R., 1965, Reciprocal patterns of genetic resistance to avian tumor viruses in two lines of chickens, Virology 26: 664.PubMedCrossRefGoogle Scholar
  449. Vogt, P. K., Weiss, R. A., and Hanafusa, H., 1974, Proposal for numbering mutants of avian leukosis and sarcoma viruses, J. Virol. 13: 551.PubMedGoogle Scholar
  450. Vogt, P. K., Hunter, E., Hayman, M., and Duesberg, P. H., 1977, A new nonconditional replication defective mutant of Rous sarcoma virus, in preparation.Google Scholar
  451. Vogt, V. M., and Eisenman, R., 1973, Identification of a large polypeptide precursor to avian’oncornavirus proteins, Proc. Natl. Acad. Sci. USA 70: 1734.PubMedCrossRefGoogle Scholar
  452. Vogt, V. M., Eisenman, R., and Diggelmann, H., 1975, Generation of avian myeloblastosis virus structural proteins by proteolytic cleavage of a precursor polypeptide, J. Mol. Biol. 96: 471.PubMedCrossRefGoogle Scholar
  453. Von der Helm, K., and Duesberg, P. H., 1975, Translation of Rous sarcoma virus RNA in a cell-free system from ascites Krebs II cells, Proc. Natl. Acad. Sci. USA 72: 614.PubMedCrossRefGoogle Scholar
  454. Walker, T. A., Pace, N. R., Erikson, R. L., Erikson, E., and Behr, F., 1974, The 7 S RNA common to oncornaviruses and normal cells is associated with polyribosomes, Proc. Natl. Acad. Sci. USA 71: 3390.PubMedCrossRefGoogle Scholar
  455. Wang, L.-H., and Duesberg, P., 1974, Properties and location of poly(A) in Rous sarcoma virus RNA, J. Virol. 14: 1515.PubMedGoogle Scholar
  456. Wang, L.-H., Duesberg, P., Beemon, K., and Vogt, P. K., 1975, Mapping RNase T,-resistant oligonucleotides of avian tumor virus RNAs: Sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end, J. Virol. 16: 1051.PubMedGoogle Scholar
  457. Wang, L.-H., Duesberg, P. H., Kawai, S., and Hanafusa, H., I976a, The location of envelope-specific and sarcoma-specific oligonucleotides on the RNA of SchmidtRuppin Rous sarcoma virus, Proc. Natl. Acad. Sci. USA 73: 447.Google Scholar
  458. Wang, L.-H., Duesberg, P. H., Mellon, P., and Vogt, P. K., 1976b, Distribution of envelope specific and sarcoma specific nucleotide sequences from different parents in the RNAs of avian tumor virus recombinants, Proc. Natl. Acad. Sci. USA 73: 1073.PubMedCrossRefGoogle Scholar
  459. Warren, L., Critchley, D., and MacPherson, I., 1972, Surface glycoproteins and glycolipids of chicken embryo cells transformed by a temperature-sensitive mutant of Rous sarcoma virus, Nature (London) 235: 275.CrossRefGoogle Scholar
  460. Waters, L. C., Mullin, B. C., Bailiff, E. G., and Popp, R. A., 1975, tRNA’s associated with the 70 S RNA of avian myeloblastosis virus, J. Virol. 16: 1608.Google Scholar
  461. Weber, G. H., Heine, U., Cottler-Fox, M., Garon, C. F., and Beaudreau, G. S., 1975, Nucleic acids of RNA tumor viruses: Identification and ultrastructure, Virology 64: 205.PubMedCrossRefGoogle Scholar
  462. Weber, M. J., 1973, Hexose transport in normal and in Rous sarcoma virus-transformed cells, J. Biol. Chem. 248: 2978.PubMedGoogle Scholar
  463. Weiss, R., 1967, Spontaneous virus production from “non-virus producing” Rous sarcoma cells, Virology 32: 719.PubMedCrossRefGoogle Scholar
  464. Weiss, R. A., 1969a, The host range of Bryan strain Rous sarcoma virus synthesized in the absence of helper virus, J. Gen. Virol. 5: 511.CrossRefGoogle Scholar
  465. Weiss, R. A., 1969b, Interference and neutralization studies with Bryan strain Rous sarcoma virus synthesized in the absence of helper virus, J. Gen. Virol. 5: 529.CrossRefGoogle Scholar
  466. Weiss, R. A., 1972, Helper viruses and helper cells, in: RNA Viruses and Host Genome in Oncogenesis ( P. Emmelot and P. Bentvelzen, eds.), pp. 117–135, North-Holland, Amsterdam.Google Scholar
  467. Weiss, R. A., 1973, Transmission of cellular genetic elements by RNA tumor viruses, in: Possible Episomes in Eukaryotes ( L. Silvestri, ed.), pp. 130–141, North-Holland, Amsterdam.Google Scholar
  468. Weiss, R. A., Friis, R. R., Katz, E., and Vogt, P. K., 1971, Induction of avian tumor viruses in normal cells by physical and chemical carcinogens, Virology 46: 920.PubMedCrossRefGoogle Scholar
  469. Weiss, R. A., Mason, W. S., and Vogt, P. K., 1973, Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses, Virology 52: 535.PubMedCrossRefGoogle Scholar
  470. Weiss, R. A., Boettiger, D., and Love, D. N., 1975, Phenotypic mixing between vesicular stomatitis virus and avian RNA tumor viruses, Cold Spring Harbor Symp. Quant. Biol. 39: 913.PubMedCrossRefGoogle Scholar
  471. Weiss, R. A., and Wong, A. L., 1977, Phenotypic mixing between avian and mammalian RNA tumor viruses: Envelope pseudotypes of Rous sarcoma virus, Virology.Google Scholar
  472. Weissmann, C., Parsons, J. T., Coffin, J. W., Rymo, L., Billeter, M. A., and Hofstet-ter, H., 1975, Studies on the structure and synthesis of Rous sarcoma virus RNA, Cold Spring Harbor Symp. Quant. Biol. 39: 1043.CrossRefGoogle Scholar
  473. Wickus, G. G., and Robbins, P. W., 1973, Plasma membrane proteins of normal and Rous sarcoma virus-transformed chick-embryo fibroblasts, Nature (London) New Biol. 245: 65.CrossRefGoogle Scholar
  474. Wong, P. K. Y., and McCarter, J. A., 1973, Genetic studies of temperature-sensitive mutants of Moloney-murine leukemia virus, Virology 53: 319.PubMedCrossRefGoogle Scholar
  475. Wong, P. K. Y., and McCarter, J. A., 1974, Studies of two temperature-sensitive mutants of Moloney murine leukemia virus, Virology 58: 396.PubMedCrossRefGoogle Scholar
  476. Wong, P. K. Y., and MacLeod, R., 1975, Studies on the budding process of a temperature sensitive mutant of murine leukemia virus with a scanning-electron microscope, J. Virol. 16: 434.PubMedGoogle Scholar
  477. Wong, P. K. Y., Russ, L. J., McCarter, J. A., 1973, Rapid, selective procedure for isolation of spontaneous temperature-sensitive mutants of Moloney leukemia virus, Virology 51: 424.PubMedCrossRefGoogle Scholar
  478. Wright, S. E., and Neiman, P. E., 1974, Base-sequence relationships between avian ribonucleic acid endogenous and sarcoma viruses assayed by competitive ribonucleic acid—deoxyribonucleic acid hybridization, Biochemistry 13: 1549.PubMedCrossRefGoogle Scholar
  479. Wyke, J. A., 1973a, The selective isolation of temperature-sensitive mutants of Rous sarcoma virus, Virology 52: 587.PubMedCrossRefGoogle Scholar
  480. Wyke, J. A., 19736, Complementation of transforming functions by temperature-sensitive mutants of avian sarcoma virus, Virology 54: 28.Google Scholar
  481. Wyke, J. A., 1974, The genetics of C-type RNA tumor viruses, Int. Rev. of Cytology 38: 67.CrossRefGoogle Scholar
  482. Wyke, J. A., 1975, Temperature sensitive mutants of avian sarcoma viruses, Biochim. Biophys. Acta 417: 91.Google Scholar
  483. Wyke, J. A., and Linial, M., 1973, Temperature-sensitive avian sarcoma viruses: A physiological comparison of twenty mutants, Virology 53: 152.PubMedCrossRefGoogle Scholar
  484. Wyke, J. A., Bell, J. G., and Beamand, J. A., 1975, Genetic recombination among temperature-sensitive mutants of Rous sarcoma virus, Cold Spring Harbor Symp. Quant. Biol. 39: 897.CrossRefGoogle Scholar
  485. Yamada, K. M., Yamada, S. S., and Pastan, I., 1975, The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin, Proc. Natl. Acad. Sci. USA 72: 3158.PubMedCrossRefGoogle Scholar
  486. Yoshida, M., Owada, M., and Toyoshima, K., 1975, Strain specificity of changes in adenylate cyclase activity in cells transformed by avian sarcoma viruses, Virology 63: 68.PubMedCrossRefGoogle Scholar
  487. Yoshii, S., and Vogt, P. K., 1970, A mutant of Rous sarcoma virus (type O) causing fusiform cell transformation, Proc. Soc. Exp. Biol. Med. 135: 297.PubMedGoogle Scholar
  488. Yoshikura, H., 1973a, Ultraviolet inactivation of murine leukemia virus and its assay in permissive and non-permissive cells, Int. J. Cancer 11: 739.PubMedCrossRefGoogle Scholar
  489. Yoskikura, H., 1973b, Host range conversion of murine sarcoma-leukaemia complex, J. Gen. Virol. 19: 321.CrossRefGoogle Scholar
  490. Zâvada, J., 1972, Pseudotypes of vesicular stomatitis virus with the coat of murine leukaemia and of avian myeloblastosis viruses, J. Gen. Virol. 15: 183.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Peter K. Vogt
    • 1
  1. 1.Department of MicrobiologyUniversity of Southern California School of MedicineLos AngelesUSA

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