Genetics of Picornaviruses

  • Peter D. Cooper
Part of the Comprehensive Virology book series (CV, volume 9)


Picornaviruses have long seemed to have many genes. The size of the genome compared with the “average” gene product suggested about ten for poliovirus (Fenner, 1968), which causes at least a dozen synthetic and degenerative changes in the host cell. Many viral polypeptides are found, originally about 14 (Summers et al.,1965) and now more than 34 (Abraham and Cooper, 1975a). Other picornaviruses are very similar.


Encephalomyocarditis Virus Empty Capsid Host Protein Synthesis Poliovirus Strain vRNA Template 
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  1. Abraham, G., and Cooper, P. D., 1975a, Poliovirus polypeptides examined in more detail, J. Gen. Virol. 29: 199.PubMedGoogle Scholar
  2. Abraham, G., and Cooper, P. D., 1975b, Relations between poliovirus polypeptides as shown by tryptic peptide analysis, J. Gen. Virol. 29: 215.PubMedGoogle Scholar
  3. Agol, V. I., and Shirman, G. A., 1964, Interaction of guanidine-sensitive and guanidine-dependent variants of poliovirus in mixedly infected cells, Biochem. Biophys. Res. Commun. 17: 28.Google Scholar
  4. Agol, V. I., Romanova, L. I., Cumakov, I. M., Dunaevskaya, L. D., and Bogdanov, A. A., 1972, Circularisation and cross-linking in preparations of replicative form of EMC virus RNA, J. Mol. Biol. 72: 77.PubMedGoogle Scholar
  5. Amako, K., and Dales, S., 1967, Cytopathology of mengovirus. II. Proliferation of membranous cisternae, Virology 32: 201.PubMedGoogle Scholar
  6. Arlinghaus, R. B., and Polatnick, J., 1969, The isolation of two enzyme-RNA complexes involved in the synthesis of foot-and-mouth-disease virus RNA, Proc. Natl. Acad. Sci. USA 62: 822.Google Scholar
  7. Ascione, R., and Vande Woude, G. F., 1971, Ribosomal factors effecting the stimulation of cell-free protein synthesis in the presence of foot-and-mouth disease virus ribonucleic acid, Biochem. Biophys. Res. Commun. 45: 14.PubMedGoogle Scholar
  8. Bablanian, R., 1972, Mechanisms of virus cytopathic effect, in: Microbial Pathogenicity in Man and Animals (H. Smith and J. H. Pearce, eds.), Symp. Soc. Gen. Microbiol. 22: 359.Google Scholar
  9. Bablanian, R., and Russell, W. C., 1974, Adenovirus polypeptide synthesis in the presence of non-replicating poliovirus, J. Gen. Virol. 24: 261.PubMedGoogle Scholar
  10. Bachrach, H. L., Swaney, J. B., and Vande Woude, G. F., 1973, Isolation of the structural polypeptides of foot-and-mouth disease virus and analysis of their C-terminal sequences, Virology 52: 520.PubMedGoogle Scholar
  11. Baltimore, D., 1968, Inhibition of poliovirus replication by guanidine, in: Medical and Applied Virology ( M. Sanders and E. H. Lennette, eds.), Warren H. Green Inc., St. Louis. pp. 340–347.Google Scholar
  12. Baltimore, D., 1969, The replication of picornaviruses, in: The Biochemistry of Viruses ( H. B. Levy, ed.), pp. 101–176, Dekker, New York.Google Scholar
  13. Baltimore, D., Girard, M., and Darnell, J. E., 1966, Aspects of the synthesis of poliovirus RNA and the formation of virus particles, Virology 29: 179.PubMedGoogle Scholar
  14. Béchet, J. M., 1972, Isolement de la chaíne “moins” d’acide ribonucléique du virus de l’encephalomyocardite de la souris et étude de son infectivité, C. R. Acad. Sci. Ser. D 274: 1761.Google Scholar
  15. Bengtsson, S., 1968, Attempts to map the poliovirus genome by analysis of selected recombinants, Acta Pathol. Microbiol. Scand. 73: 592.PubMedGoogle Scholar
  16. Benzer, S., 1957, The elementary units of heredity, in: The Chemical Basis of Heredity ( W. D. McElroy and B. Glass, eds.), pp. 70–93, Johns Hopkins Press, Baltimore.Google Scholar
  17. Black, D. N., 1975, Proteins induced in BHK cells by infection with foot-and-mouth disease virus, J. Gen. Virol. 26: 109.PubMedGoogle Scholar
  18. Black, D., and Brown, F., 1976, A major difference in the strategy of the calici-and picornaviruses and its significance in classification. Intervirology 6: 57.Google Scholar
  19. Boime, I., and Leder, R., 1972, Protein synthesis directed by encephalomyocarditis virus mRNA. III. Discrete polypeptides translated from a monocistronic messenger in vitro, Arch. Biochem. Biophys. 153: 706.PubMedGoogle Scholar
  20. Boime, I., Aviv, H., and Leder, P., 1971, Protein synthesis directed by EMC virus RNA. II. The in vitro synthesis of high molecular weight proteins and elements of the viral capsid, Biochem. Biophys. Res. Commun. 45: 788.PubMedGoogle Scholar
  21. Bond, C. W., and Swim, H. E., 1975, Physiological characteristics of temperature-sensitive mutants of mengovirus, J. Virol. 15: 288.PubMedGoogle Scholar
  22. Brown, F., and Martin, S. J., 1965, A new model for virus RNA replication, Nature (London) 208: 861.Google Scholar
  23. Buck, C. A., Granger, G. A., Taylor, M. W., and Holland, J. J., 1967, Efficient, inefficient and abortive infection of different mammalian cells by small RNA viruses, Virology 33: 36.PubMedGoogle Scholar
  24. Burness, A. T. H., Pardoe, I. U., and Fox, S. M., 1973, Evidence for lack of a glycoprotein in the encephalomyocarditis virus particle, J. Gen. Virol. 18: 33.PubMedGoogle Scholar
  25. Burrell, C. J., and Cooper, P. D., 1973, N-Terminal aspartate, glycine and serine in poliovirus capsid protein, J. Gen. Virol. 21: 443.PubMedGoogle Scholar
  26. Burroughs, J. N., and Brown, F., 1974, Physico-chemical evidence for the reclassification of the caliciviruses, J. Gen. Virol. 22: 281.PubMedGoogle Scholar
  27. Butterworth, B. E., 1973, A comparison of the virus-specific polypeptides of encephalomyocarditis virus, human rhinovirus and poliovirus, Virology 56: 439.PubMedGoogle Scholar
  28. Butterworth, B. E., and Korant, B. D., 1974, Characterisation of the large picornaviral polypeptides produced in the presence of zinc ion, J. Virol. 14: 282.PubMedGoogle Scholar
  29. Butterworth, B. E., and Rueckert, R. R., 1972a, Kinetics of synthesis and cleavage of EMC virus-specific proteins, Virology 50: 535.PubMedGoogle Scholar
  30. Butterworth, B. E., and Rueckert, R. R., 1972b, Gene order of encephalomyocarditis virus as determined by studies with pactamycin, J. Virol. 9: 823.PubMedGoogle Scholar
  31. Butterworth, B. E., Hall, L., Stolzfus, C. M., and Rueckert, R. R., 1971, Virus-specific proteins synthesised in encephalomyocarditis (EMC) virus-infected HeLa cells, Proc. Natl. Acad. Sci. USA 68: 3083.PubMedGoogle Scholar
  32. Caliguiri, L. A., 1974, Analysis of RNA associated with the poliovirus RNA replication complexes, Virology 58: 526.PubMedGoogle Scholar
  33. Caliguiri, L. A., and Compans, R. W., 1973, Formation of poliovirus particles in association with the RNA replication complexes, J. Gen. Virol. 21: 99.PubMedGoogle Scholar
  34. Caliguiri, L. A., and Mosser, A. G., 1971, Proteins associated with the poliovirus RNA replication complex, Virology 46: 375.PubMedGoogle Scholar
  35. Caliguiri, L. A., and Tamm, I., 1968, Action of guanidine on the replication of poliovirus RNA, Virology 35: 408.PubMedGoogle Scholar
  36. Caliguiri, L. A., and Tamm, I., I970a, The role of cytoplasmic membranes in poliovirus biosynthesis, Virology 42: 100.Google Scholar
  37. Caliguiri, L. A., and Tamm, I., 1970b, Characterization of poliovirus-specific structures associated with cytoplasmic membranes, Virology 42: 112.PubMedGoogle Scholar
  38. Chatterjee, N. K., Koch, G., and Weissbach, H., 1973, Initiation of protein synthesis in vivo in poliovirus-infected cells, Arch. Biochem. Biophys. 154: 431.PubMedGoogle Scholar
  39. Choppin, P. W., and Holmes, K. V., 1967, Replication of SV5 and the effects of superinfection with poliovirus, Virology 33: 442.PubMedGoogle Scholar
  40. Cole, C. N., and Baltimore, D., 1973a, Defective interfering particles of poliovirus. II. Nature of the defect, J. Mol. Biol. 76: 325.PubMedGoogle Scholar
  41. Cole, C. N., and Baltimore, D., 1973b, Defective interfering particles of poliovirus. III. Interference and enrichment, J. Mol. Biol. 76: 345.PubMedGoogle Scholar
  42. Cole, C. N., Smoler, D., Wimmer, E., and Baltimore, D., 1971, Defective interfering particles of poliovirus. I. Isolation and physical properties, J. Virol. 7: 478.PubMedGoogle Scholar
  43. Collins, F. D., and Roberts, W. K., 1972, Mechanism of mengovirus-induced cell injury in L cells: Use of inhibitors of protein synthesis to dissociate virus-specific events, J. Virol. 10: 969.PubMedGoogle Scholar
  44. Cooper, P. D., 1964a, The mutation of poliovirus by 5-fluorouracil, Virology 22:186. Cooper, P. D., 1964b, Synchrony and the elimination of chance delays in the growth of poliovirus, J. Gen. Microbiol. 37: 259.Google Scholar
  45. Cooper, P. D., 1965, Rescue of one phenotype in mixed infections with heat-defective mutants of type 1 poliovirus, Virology 25: 431.PubMedGoogle Scholar
  46. Cooper, P. D., 1966, The inhibition of poliovirus growth by actinomycin D and the prevention of the inhibition by pretreatment of the cells with serum or insulin, Virology 28: 663.PubMedGoogle Scholar
  47. Cooper, P. D., 1968, A genetic map of poliovirus temperature-sensitive mutants, Virology 35: 584.PubMedGoogle Scholar
  48. Cooper, P. D., 1969, The genetic analysis of poliovirus, in: Biochemistry of Viruses ( H. B. Levy, ed.), pp. 177–218, Dekker, New York.Google Scholar
  49. Cooper, P. D., 1974, Towards a more profound basis for the classification of viruses, Intervirology 4: 317.PubMedGoogle Scholar
  50. Cooper, P. D., and Bellett, A. J. D., 1959, A transmissible interfering component of vesicular stomatitis virus preparations, J. Gen. Microbiol. 21: 485.PubMedGoogle Scholar
  51. Cooper, P. D., and Bennett, D. J., 1973, Genetic and structural implications of tryptic peptide analysis of poliovirus structural protein, J. Gen. Virol. 20: 151.PubMedGoogle Scholar
  52. Cooper, P. D., and Wyke, J. A., 1974, The genome of RNA tumor viruses: A functional requirement for a polyploid structure? Cold Spring Harbor Symp. Quant. Biol. 39: 997.Google Scholar
  53. Cooper, P. D., Johnson, R. T., and Garwes, D. J., 1966, Physiological characterization of heat-defective (temperature-sensitive) poliovirus mutants: Preliminary classification, Virology 30: 638.PubMedGoogle Scholar
  54. Cooper, P. D., Wentworth, B. B., and McCahon, D., 1970a, Guanidine inhibition of poliovirus: A dependence of viral RNA synthesis on the configuration of structural protein, Virology 40: 486.Google Scholar
  55. Cooper, P. D., Stank, D., and Summers, D. F., 1970b, Synthesis of double-stranded RNA by poliovirus temperature-sensitive mutants, Virology 40: 971.PubMedGoogle Scholar
  56. Cooper, P. D., Summers, D. F., and Maizel, J. V., 1970c, Evidence for ambiguity in the posttranslational cleavage of poliovirus proteins, Virology 41: 408.PubMedGoogle Scholar
  57. Cooper, P. D., Geissler, E., Scotti, P. D., and Tannock, G. A., 1971, Further characterisation of the genetic map of poliovirus temperature-sensitive mutants, in: Strategy of the Viral Genome ( G. E. W. Wolstenholme and M. O’Connor, eds.), pp. 75–100, Churchill Livingstone, Edinburgh.Google Scholar
  58. Cooper, P. D., Steiner-Pryor, A., and Wright, P. J., 1973, A proposed regulator for poliovirus: The equestron, Intervirology 1: 1.PubMedGoogle Scholar
  59. Cooper, P. D., Steiner-Pryor, A., Scotti, P. D., and Delong, D., 1974, On the nature of poliovirus genetic recombinants, J. Gen. Virol. 23: 41.Google Scholar
  60. Cooper, P. D., Geissler, E., and Tannock, G. A., 1975, Attempts to extend the genetic map of poliovirus temperature-sensitive mutants, J. Gen. Virol. 29: 109.PubMedGoogle Scholar
  61. Cordell-Stewart, B., and Taylor, M. W., 1971, Effect of double-stranded viral RNA on mammalian cells in culture, Proc. Natl. Acad. Sci. USA 68: 1326.PubMedGoogle Scholar
  62. Cordell-Stewart, B., and Taylor, M. W., 1973a, Effect of viral double-stranded RNA on protein synthesis in intact cells, J. Virol. 11: 232.PubMedGoogle Scholar
  63. Cordell-Stewart, B., and Taylor, M. W., 19736, Effect of viral double-stranded RNA on mammalian cells in culture: Cytotoxicity under conditions preventing viral replication and protein synthesis, J. Virol. 12: 360.Google Scholar
  64. Cords, C. E., and Holland, J. J., 1964a, Interference between enteroviruses and conditions affecting its reversal, Virology 22: 226.PubMedGoogle Scholar
  65. Cords, C. E., and Holland, J. J., 1964b, Alteration of the species and tissue specificity of poliovirus by enclosure of its RNA within the protein capsid of Coxsackie BI virus, Virology 24: 492.PubMedGoogle Scholar
  66. Cords, C. E., and Holland, J. J., 1964c, Replication of poliovirus RNA induced by heterologous virus, Proc. Natl. Acad. Sci. USA 51: 1080.PubMedGoogle Scholar
  67. Cory, S., Adams, J. M., Spahr, P. F., and Rensing, U., 1972, Sequence of 51 nucleotides at the 3 end of R15 bacteriophage RNA, J. Mol. Biol. 63: 41.PubMedGoogle Scholar
  68. Cranston, J., Malathi, V. G., and Silber, R., 1973, Further studies on RNA ligase, Fed. Proc. Abst. 32: 498.Google Scholar
  69. Dales, S., and Silverberg, H., 1968, Controlled double infection with unrelated animal viruses, Virology 34: 531.PubMedGoogle Scholar
  70. Dales, S., Eggers, H. J., Tamm, I., and Palade, G. E., 1965, Electron-microscopic study of the formation of poliovirus, Virology 26: 379.PubMedGoogle Scholar
  71. Dobos, P., and Martin, E. M., 1972, Virus-specific polypeptides in ascites cells infected with encephalomyocarditis virus, J. Gen. Virol. 17: 197.PubMedGoogle Scholar
  72. Dobos, P., Kerr, I. M., and Martin, E. M., 1971, Synthesis of capsid and non-capsid viral proteins in response to encephalomyocarditis virus RNA in animal cell-free systems, J. Virol. 8: 491.PubMedGoogle Scholar
  73. Doyle, M., and Holland, J. J., 1972, Virus-induced interference in heterologously infected HeLa cells, J. Virol. 9: 22.PubMedGoogle Scholar
  74. Drake, J. W., 1958, Interference and multiplicity reactivation in poliovirus, Virology 6: 244.PubMedGoogle Scholar
  75. Drzeniek, R., and Billelo, P., 1974, Absence of glycoproteins in poliovirus particles, J. Gen. Virol. 25: 125.PubMedGoogle Scholar
  76. Dulbecco, R., 1961, Poliovirus mutations seen from the point of view of molecular biology, in: Poliomyelitis, pp. 21–24, Fifth International Poliomyelitis Conference, Lippincott, Philadelphia.Google Scholar
  77. Eggen, K. L., and Shatkin, A. S., 1972, In vitro translation of cardiovirus RNA by cell-free extracts, J. Virol. 9: 636.Google Scholar
  78. Eggers, H. J., and Tamm, I., 1966, Antiviral chemotherapy, Annu. Rev. Pharmacol. 6: 231.PubMedGoogle Scholar
  79. Ehrenfeld, E., and Hunt, T., 1971, Double-stranded poliovirus RNA inhibits initiation of protein synthesis by reticulocyte lysates, Proc. Natl. Acad. Sci. USA 68: 1075.PubMedGoogle Scholar
  80. Ehrenfeld, E., Maizel, J. V., and Summers, D. F., 1970, Soluble RNA polymerase complex from poliovirus-infected HeLa cells, Virology 40: 840.PubMedGoogle Scholar
  81. Ensminger, W. D., and Tamm, I., 1970, The step in cellular DNA synthesis blocked by Newcastle disease or mengovirus infection, Virology 40: 152.PubMedGoogle Scholar
  82. Esteban, M., and Kerr, I. M., 1974, The synthesis of encephalomyocarditis virus polypeptides in infected L cells and cell-free systems, Eur. J. Biochem. 45: 567.PubMedGoogle Scholar
  83. Fenner, F., 1968, The Biology of Animal Viruses, 1st ed., Academic Press, New York.Google Scholar
  84. Fenner, F., McAuslan, B. R., Mims, C. A., Sambrook, J., and White, D. O., 1974, The Biology of Animal Viruses, 2nd ed., Academic Press, New York.Google Scholar
  85. Fenner, F., Pereira, H. G., Porterfield, J. S., Joklik, W. K., and Downie, A. W., 1975, Family and generic names for viruses approved by the International Committee on Taxonomy of Viruses, June 1974, Intervirology 3: 193.Google Scholar
  86. Fenwick, M. L., 1963, The influence of poliovirus infection on RNA synthesis in mammalian cells, Virology 19: 241.PubMedGoogle Scholar
  87. Fenwick, M. L., and Cooper, P. D., 1962, Early interactions between poliovirus and ERK cells: Some observations on the nature and significance of the rejected particles, Virology 18: 212.PubMedGoogle Scholar
  88. Fernandez-Thomas, C. B., and Baltimore, D., 1973, Morphogenesis of poliovirus. II. Demonstration of a new intermediate, the proviron, J. Virol. 12: 1122.Google Scholar
  89. Fincham, J. R. S., 1966, Genetic Complementation, W. A. Benjamin, New York.Google Scholar
  90. Fiszman, M. Y., Bucchini, D., Girard, M., and Lwoff, A., 1970, Inhibition of poliovirus RNA synthesis by supra-optimal temperatures, J. Gen. Virol. 6: 293.PubMedGoogle Scholar
  91. Freda, C. E., and Buck, C. A., 1971, System of double infection between vaccinia virus and mengovirus, J. Virol. 8: 293.PubMedGoogle Scholar
  92. Garfinkle, B. D., and Tershak, D. R., 1971, Effect of temperature on the cleavage of polypeptides during growth of LSc poliovirus, J. Mol. Biol. 59: 537.PubMedGoogle Scholar
  93. Garfinkle, B. D., and Tershak, D. R., 1972, Degradation of poliovirus polypeptides in vivo, Nature (London) New Biol. 238: 206.Google Scholar
  94. Garwes, D. J., Wright, P. J., and Cooper, P. D., 1975, Poliovirus temperature-sensitive mutants defective in cytopathic effects are also defective in synthesis of double-stranded RNA, J. Gen. Virol. 27: 45.PubMedGoogle Scholar
  95. Ghendon, Y. Z., 1972, Conditional-lethal mutants of animal viruses, Prog. Med. Virol. 14: 68.Google Scholar
  96. Ghendon, Y. Z., and Yakobson, G. A., 1971, Antigenic specificity of poliovirus related particles, J. Virol. 8: 589.PubMedGoogle Scholar
  97. Ghendon, Y. Z., Babushkina, L., Mikheeva, A., and Soloviev, G. Y., 1970, Synthesis of the virus-specific proteins of a conditionally lethal mutant of poliovirus under non-permissive conditions, Virology 40: 595.PubMedGoogle Scholar
  98. Ghendon, Y. Z., Babushkina, L., and Blagoveshienskaya, O., 1973a, Inhibition of poliovirus RNA synthesis in an in vitro system by antiserum against 14 S virus-specific structures, Arch. Ges. Virusforsch. 40: 47.PubMedGoogle Scholar
  99. Ghendon, Y. Z., Marchenko, A. T., Markushin, S. G., Chenkina, D. B., Mikheeva, A. V., and Rozian, E. E., 1973b, Correlation between is phenotype and pathogenicity of some animal viruses, Arch. Ges. Virusforsch. 42: 154.PubMedGoogle Scholar
  100. Ginevskaya, V. A., Scarlat, I. V., Kalinina, N. 0., and Agol, V. I., 1972, Synthesis and cleavage of virus-specific proteins in Krebs II carcinoma cells infected with encephalomyelitis virus, Arch. Ges. Virusforsch. 39: 98.Google Scholar
  101. Girard, M., Baltimore, D., and Darnell, J. E., 1967, The poliovirus replication complex: Site for synthesis of poliovirus RNA, J. Mol. Biol. 24: 59.Google Scholar
  102. Gordon, I., Ghenault, S. S., Stevenson, D., and Acton, J. D., 1966, Effect of interferon and polymerisation of single-stranded and double-stranded mengovirus RNA, J. Bacteriol. 91: 1230.PubMedGoogle Scholar
  103. Gorini, L., and Beckwith, J. R., 1966, Suppression, Annu. Rev. Microbiol. 20: 401.PubMedGoogle Scholar
  104. Granboulan, N., and Girard, M., 1969, Molecular weight of poliovirus ribonucleic acid, J. Virol. 4: 475.PubMedGoogle Scholar
  105. Haase, A. T., Baron, S., Levy, H. B., and Kasel, J. A., 1969, Mengovirus-induced cytopathic effect in L-cells: Protective effect of interferon, J. Virol. 4: 490.PubMedGoogle Scholar
  106. Hayes, W., 1968, The Genetics of Bacteria and Their Viruses, 2nd ed., Blackwell, Oxford.Google Scholar
  107. Hershko, A., and Fry, M., 1975, Posttranslational cleavage of polypeptide chains: Role in assembly, Annu. Rev. Biochem. 44: 775.PubMedGoogle Scholar
  108. Hirst, G. K., 1962, Genetic recombination with Newcastle disease virus, poliovirus and influenza, Cold Spring Harbor Symp. Quant. Biol. 27: 303.PubMedGoogle Scholar
  109. Ho, M., 1973, Animal virus and interferon formation, in: Interferon and Interferon Inducers ( N. B. Finter, ed.), p. 36, North-Holland, Amsterdam.Google Scholar
  110. Ho, M., and Enders, J. F., 1959, Further studies on an inhibition of viral activity appearing in infected cell cultures and its role in chronic viral infections, Virology 9: 446.PubMedGoogle Scholar
  111. Ho, P. P. K., and Washington, A. L., 1971, Evidence for a cellular RNA synthesis inhibitor from poliovirus infected HeLa cells, Biochemistry 10: 3646.PubMedGoogle Scholar
  112. Holland, J. J., 1963, Depression of host-controlled RNA synthesis in human cells during poliovirus infection, Proc. Natl. Acad. Sci. USA 49: 23.PubMedGoogle Scholar
  113. Holland, J. J., and Kiehn, E. D., 1968, Specific cleavage of viral proteins as steps in the synthesis and maturation of enteroviruses, Proc. Natl. Acad. Sci. USA 60: 1015.PubMedGoogle Scholar
  114. Holland, J. J., McLaren, L. C., Hoyer, B. H., and Syverton, J. T., 1960, Enteroviral ribonucleic acid. II. Biological, physical and chemical studies, J. Exp. Med. 112: 841.PubMedGoogle Scholar
  115. Holland, J. J., Doyle, M., Perrault, J., Kingsbury, D. T., and Etchison, J., 1972, Proteinase activity in purifying animal viruses, Biochem. Biophys. Res. Commun. 46: 634.PubMedGoogle Scholar
  116. Hoskins, J. M., 1959, Host-controlled variation in animal viruses, in: Virus Growth and Variation (A. Isaacs and B. W. Lacey, eds.), Symp. Soc. Gen. Microbiol. 9: 122.Google Scholar
  117. Hotchkiss, R. D., 1971, Towards a general theory of recombination in DNA, Adv. Genet. 16: 325.PubMedGoogle Scholar
  118. Hsiung, G. D., 1960, Studies in variation in coxsackie A9 virus, J. Immunol. 84: 285.PubMedGoogle Scholar
  119. Ito, Y., Okazaki, H., and Ishida, N., 1968, Growth inhibition of Newcastle disease virus upon superinfection with poliovirus in the presence of guanidine, J. Virol. 2: 645.PubMedGoogle Scholar
  120. Jacobson, M. F., and Baltimore, D., 1968a, Morphogenesis of poliovirus. I. Association of the viral RNA with protein, J. Mol. Biol. 33: 369.PubMedGoogle Scholar
  121. Jacobson, M. F., and Baltimore, D., 1968b, Polypeptide cleavage in the formation of poliovirus proteins, Proc. Natl. Acad. Sci. USA 61: 77.PubMedGoogle Scholar
  122. Jacobson, M. F., Asso, J., and Baltimore, D., 1970, Further evidence on the formation of poliovirus proteins, J. Mol. Biol. 49: 657.PubMedGoogle Scholar
  123. Joklik, W. K., and Merigan, T. C., 1966, Concerning the mechanism of action of interferon, Proc. Natl. Acad Sci. USA 56: 558.PubMedGoogle Scholar
  124. Kerr, I. M., Martin, E. M., Hamilton, M. G., and Work, T. S., 1962, The initiation of virus protein synthesis in Krebs ascites tumor cells infected with EMC virus, Cold Spring Harbor Symp. Quant. Biol. 27: 259.PubMedGoogle Scholar
  125. Kerr, I. M., Brown, R. E., and Tovell, D. R., 1972, Characterization of the polypeptides formed in response to encephalomyocarditis virus RNA in a cell-free system from mouse ascites tumor cells, J. Virol. 10: 73.PubMedGoogle Scholar
  126. Kiehn, E. D., and Holland, J. J., 1970, Synthesis and cleavage of enterovirus polypeptides in mammalian cells, J. Virol. 5: 358.PubMedGoogle Scholar
  127. Koch, A. S., Eremenko, T., Benedetto, A., and Volpe, P., 1974, A guanidine-sensitive step of the poliovirus RNA replication cycle, Intervirology 4: 221.PubMedGoogle Scholar
  128. Korant, B. D., 1972, Cleavage of viral precurser proteins in vivo and in vitro, J. Virol. 10: 751.PubMedGoogle Scholar
  129. Korant, B. D., 1973, Cleavage of poliovirus-specific polypeptide aggregates, J. Virol. 12: 556.PubMedGoogle Scholar
  130. Kornberg, A., 1974, DNA Synthesis, Freeman, San Francisco.Google Scholar
  131. Bonnardière, C., 1971, Application de la technique de Cooper a l’isolement de mutants thermosensibles du virus de la fièvre aphteuse, Ann. Rech. Vet. 2: 231.Google Scholar
  132. Lake, J. R., and MacKenzie, J. S., 1973, Improved technique for the isolation of temperature-sensitive mutants of foot-and-mouth disease virus, J. Virol. 12: 665.PubMedGoogle Scholar
  133. Lake, J. R., Priston, R. A. J., and Slade, W. R., 1975, A genetic recombination map of foot-and-mouth disease virus, J. Gen. Virol. 27: 355.PubMedGoogle Scholar
  134. Laporte, J., 1969, The structure of foot-and-mouth disease virus protein, J. Gen. Virol. 4: 631.PubMedGoogle Scholar
  135. Ledinko, N., 1963a, An analysis of interference between active poliovirus types 1 and 2 in HeLa cells, Virology 20: 29.PubMedGoogle Scholar
  136. Ledinko, N., 1963b, Genetic recombination with poliovirus type 1: Studies of crosses between a normal horse-serum resistant mutant and several guanidine resistant mutants of the same strain, Virology 20: 107.PubMedGoogle Scholar
  137. Ledinko, N., and Hirst, G. K., 1961, Mixed infection of HeLa cells with polioviruses types 1 and 2, Virology 14: 207.PubMedGoogle Scholar
  138. Leibowitz, R., and Penman, S., 1971, Regulation of protein synthesis in HeLa cells. III. Inhibition during poliovirus infection, J. Virol. 8: 661.PubMedGoogle Scholar
  139. Levy, H. B., 1964, Studies on the mechanism of interferon action. II. The effect of interferon on some early events in mengovirus infection in L-cells, Virology 22: 575.PubMedGoogle Scholar
  140. Levy, H. B., and Carter, W. A., 1968, Molecular basis of the action of interferon, J.Mol. Biol. 31: 501.Google Scholar
  141. Lonberg-Holm, K., Gosser, L. B., and Kauer, J. C., 1975, Early alteration of poliovirus in infected cells and its specific inhibition, J. Gen. Virol. 27: 329.PubMedGoogle Scholar
  142. Lucas-Lenard, J., 1975, Cleavage of mengovirus polyprotein in vivo, J. Virol. 14: 261.Google Scholar
  143. Lundquist, R. E., Ehrenfeld, E., and Maizel, J. V., 1974, Isolation of a viral polypeptide associated with poliovirus RNA polymerase, Proc. Natl. Acad. Sci. USA 71: 4773.PubMedGoogle Scholar
  144. Lwoff, A., and Lwoff, M., 1963, L’action de la guanidine sur le développement du poliovirus, C. R. Acad. Sci. 256: 5001.Google Scholar
  145. MacKenzie, J. S., 1975, Virulence of temperature-sensitive mutants of foot-and-mouth disease virus, Arch. Virol. 48: 1.PubMedGoogle Scholar
  146. MacKenzie, J. S., and Slade, W. R., 1975, Evidence for recombination between two different immunological types of foot-and-mouth disease virus, Aust. J. Exp. Biol. Med. Sci. 53: 251.PubMedGoogle Scholar
  147. MacKenzie, J. S., Slade, W. R., Lake, J., Priston, R. A. J., Bisby, J., Laing, S., and Newman, J., 1975, Temperature-sensitive mutants of foot-and-mouth disease virus: The isolation of mutants and observations on their properties and genetic recombination, J. Gen. Virol. 27: 61.PubMedGoogle Scholar
  148. Manor, D., Barzilai, R., and Goldblum, N., 1974, Dependence of RNA replication on continuous protein synthesis in a temperature-sensitive mutant of foot-and-mouth disease virus, J. Gen. Virol. 25: 157.PubMedGoogle Scholar
  149. Marcus, P. I., and Carver, D. H., 1967, Intrinsic interference: A new type of viral interference, J. Virol. 1: 334.PubMedGoogle Scholar
  150. Margalith, M., Margalith, E., and Goldblum, N., 1969, Genetic characteristics of echovirus type 9 strains: association of mouse virulence with other genetic markers, J. Gen. Virol. 4: 379.PubMedGoogle Scholar
  151. McBride, W. D., 1962, Biological significance of poliovirus mutants of altered cystine requirement, Virology 18: 118.Google Scholar
  152. McCahon, D., and Cooper, P. D., 1970, Identification of poliovirus temperature-sensitive mutants having defects in virus structural protein, J. Gen. Virol. 6: 51.PubMedGoogle Scholar
  153. McClean, C., and Rueckert, R. R., 1973, Picornaviral gene order: Comparison of a rhinovirus with a cardiovirus, J. Virol. 11: 341.Google Scholar
  154. McCormick, W., and Penman, S., 1968, Replication of mengovirus in HeLa cells preinfected with non-replicating poliovirus, J. Virol. 2: 859.PubMedGoogle Scholar
  155. Medvedkina, O. A., Scarlat, I. V., Kalinina, N. O., and Agol, V. I., 1974, Virus-specific proteins associated with ribosomes of Krebs II cells infected with EMC virus, FEBS Lett. 39: 4.PubMedGoogle Scholar
  156. Melnick, J. L., Agol, V. I., Bachrach, H. L., Brown, F., Cooper, P. D., Fiers, W., Gard, S., Gear, J. H. S., Ghendon, Y., Kasza, L., Placa, M., Mandel, B., McGregor, S., Mohanty, S. B., Plummer, G., Ruecket, R. R., Schaffer, F. L., Tagaya, I., Tyrrell, D. A. J., Voroshilova, M., and Wenner, H. A., 1974, Picornaviridae, Intervirology 4: 303.PubMedGoogle Scholar
  157. Mikhejeva, A., Yakobson, E., and Soloviev, G. Y., 1970, Characterization of some poliovirus temperature-sensitive mutants and poliovirus-related particle formation under non-permissive conditions, J. Virol. 6: 188.PubMedGoogle Scholar
  158. Mikhejeva, A., Yakobson, E., and Ghendon, Y. Z., 1973, Studies on temperature sensitive events in synthesis of poliovirus temperature sensitive mutants, Arch. Ges. Virusforsch. 43: 352.PubMedGoogle Scholar
  159. Miner, N., Ray, W. J., and Simon, E. H., 1966, Effect of interferon on the production and action of viral RNA polymerase, Biochem. Biophys. Res. Commun. 24: 264.PubMedGoogle Scholar
  160. Moss, B., 1968, Inhibition of HeLa cell protein synthesis by the vaccinia virion, J.Virol. 2: 1028.PubMedGoogle Scholar
  161. Mosser, A. G., Caliguiri, L. A., Scheid, A. S., and Tamm, I., 1972a, Chemical and enzymatic characteristics of cytoplasmic membranes in poliovirus-infected HeLa cells, Virology 47: 30.PubMedGoogle Scholar
  162. Mosser, A. G., Caliguiri, L. A., and Tamm, I., 19726, Incorporation of lipid precursors into cytoplasmic membranes of poliovirus infected HeLa cells, Virology 47: 39.Google Scholar
  163. Newman, J. F. E., Rowlands, D. J., and Brown, F., 1973, A physico-chemical sub-grouping of the mammalian picornaviruses, J. Gen. Virol. 18: 171.PubMedGoogle Scholar
  164. Norman, A., 1960, Ultra-violet inactivation of poliovirus ribonucleic acid, Virology 10: 384.PubMedGoogle Scholar
  165. Öberg, B., and Philipson, L., 1971, Replicative structures of poliovirus RNA in vivo, J. Mol. Biol. 58: 725.PubMedGoogle Scholar
  166. Öberg, B. F., and Shatkin, A. J., 1972, Initiation of picornavirus protein synthesis in ascites cell extracts, Proc. Natl. Acad. Sci. USA 69: 3589.PubMedGoogle Scholar
  167. Oberg, B. F., and Shatkin, A. J., 1974, Translation of mengovirus RNA in Ehrlich ascites cell extracts, Biochem. Biophys. Res. Commun. 57: 1186.PubMedGoogle Scholar
  168. Ohlbaum, A., Figueroa, F., Grado, C., and Contreras, G., 1970, Target molecular weight of foot-and-mouth disease virus and poliovirus, J. Gen. Virol. 6: 429.PubMedGoogle Scholar
  169. Paucha, E., Seehafer, J., and Colter, J. S., 1974, Synthesis of viral-specific polypeptides in mengovirus infected L-cells: Evidence for asymmetric translation of the genome, Virology 61: 315.PubMedGoogle Scholar
  170. Penman, S., 1965, Stimulation of the incorporation of choline in poliovirus-infected cells, Virology 25: 148.Google Scholar
  171. Penman, S., and Summers, D. F., 1965, Effects on host cell metabolism following synchronous infection with poliovirus, Virology 27: 614.PubMedGoogle Scholar
  172. Penman, S., Becker, Y., and Darnell, J. E., 1964, A cytoplasmic structure involved in the synthesis and assembly of poliovirus components, J. Mol. Biol. 8: 541.PubMedGoogle Scholar
  173. Pérez-Bercoff, R., Carrara, G., Dolei, A., Conciatori, G., and Rita, G., 1974a, In vitro binding of a cellular a-amanitin sensitive RNA polymerase to infectious mengovirusinduced double-stranded RNA, Biochem. Biophys. Res. Commun. 56: 876.Google Scholar
  174. Pérez-Bercoff, R., Coié, L., Meo, P., Carrara, G., Mechali, M., Falcoff, E,., and Rita, G., 1974b, Infectivity of mengovirus replicative form: Relationship to cellular transcription, J. Gen. Virol. 25: 53.Google Scholar
  175. Perlin, M., and Phillips, B. A., 1973, In vitro assembly of poliovirus. III. Assembly of 14S particles into empty capsids by poliovirus infected HeLa cell membranes, Virology 53: 107.Google Scholar
  176. Pérol-Vauchez, Y., Tournier, P., and Lwoff, M., 1962, Atténuation de la virulence du virus de l’encéphalomyelite de la souris par culture a basse température: Influence de l’hypo-et de l’hyperthermie sur l’évolution de la maladie expérimentale, C. R. Acad. Sci. 253: 2164.Google Scholar
  177. Phillips, B. A., 1969, In vitro assembly of poliovirus. I. Kinetics of the assembly of empty capsids and the role of extracts from infected cells, Virology 39:811.Google Scholar
  178. Phillips, B. A., 1971, In vitro assembly of polioviruses. II. Evidence for the selfassembly of 14 S particles into empty capsids, Virology 44:307.Google Scholar
  179. Phillips, B. A., and Fennell, R., 1973, Polypeptide composition of poliovirions, naturally occurring empty capsids and 14S precursor particles, J. Virol. 12: 291.PubMedGoogle Scholar
  180. Phillips, B. A., Summers, D. F., and Maizel, J. V., 1968, In vitro assembly of poliovirus-related particles, Virology 35:216.Google Scholar
  181. Pine, M. J., 1972, Turnover of intra-cellular proteins, Annu. Rev. Microbiol. 26: 103.PubMedGoogle Scholar
  182. Pohjanpelto, P., 1958, Stabilization of poliovirus by cystine, Virology 6: 472.PubMedGoogle Scholar
  183. Pohjanpelto, P., and Cooper, P. D., 1965, Interference between polioviruses induced by strains that cannot multiply, Virology 25: 350.PubMedGoogle Scholar
  184. Pringle, C. R., 1968, Recombination between conditional lethal mutants of foot-and-mouth disease virus, J. Gen. Virol. 2: 199.PubMedGoogle Scholar
  185. Pringle, C. R., 1969, Electrophoretic properties of foot-and-mouth disease virus strains and the selection of intra-strain mutants, J. Gen. Virol. 4: 541.PubMedGoogle Scholar
  186. Pringle, C. R., and Slade, W. R., 1968, The origin of hybrid variants of sub-type strains of foot-and-mouth disease virus, J. Gen. Virol. 2: 319.PubMedGoogle Scholar
  187. Pringle, C. R., Slade, W. R., Elsworthy, P., and O’Sullivan, M., 1970, Properties of temperature-sensitive mutants of the Kenya 3/57 strain of foot-and-mouth disease virus, J. Gen. Virol. 6: 213.PubMedGoogle Scholar
  188. Rekosh, D. M., 1972, The gene order of poliovirus capsid proteins, J. Virol. 9: 479.PubMedGoogle Scholar
  189. Rekosh, D. M., Lodish, H. F., and Baltimore, D., 1970, Protein synthesis in E. coli extracts programmed by poliovirus RNA, J. Mol. Biol. 54: 327.PubMedGoogle Scholar
  190. Rosenberg, H., Diskin, B., Oron, L., and Traub, A., 1972, Isolation and subunit structure of polycytidylate-dependent RNA polymerase of encephalomyocarditis virus, Proc. Natl. Acad. Sci. USA 69: 3815.PubMedGoogle Scholar
  191. Roumiantzeff, M., Summers, D. F., and Maizel, J. V., 1971, In vitro protein synthetic activity of membrane-bound poliovirus polyribosomes, Virology 44: 249.Google Scholar
  192. Rueckert, R. R., 1971, Picornaviral architecture, in: Comparative Virology ( K. Maramarosch and E. Kurstar, eds.), pp. 255–306, Academic Press, New York.Google Scholar
  193. Sabin, A. B., and Lwoff, A., 1959, Relation between reproductive capacity of poliovirus at different temperatures in tissue culture and neurovirulence, Science 129: 1287.Google Scholar
  194. Saborio, J. L., Pong, S. S., and Koch, G., 1974, Selective and reversible inhibition of initiation of protein-synthesis in mammalian cells, J. Mol. Biol. 85: 195.PubMedGoogle Scholar
  195. Saxton, R. E., and Stevens, J. G., 1972, Restriction of herpes simplex virus replication by poliovirus: A selective inhibition of viral translation, Virology 48: 207.PubMedGoogle Scholar
  196. Schaffer, F. L., and Gordon, M., 1966, Differential inhibitory effects of actinomycin D among strains of poliovirus, J. Bacteriol. 91: 2309.PubMedGoogle Scholar
  197. Schaffer, F. L., and Schwerdt, C. G., 1965, Chemistry of the RNA viruses, in: Viral and Rickettsia Infections of Man 4th ed. ( F. L. Horsfall and I. Tamm, eds.) p. 94, Lippincott, Pennsylvania.Google Scholar
  198. Scharff, M. D., Maizel, J. V., and Levintow, L., 1964, Physical and immunological properties of a soluble precursor of the poliovirus capsid, Proc. Natl. Acad. Sci. USA 51: 329.PubMedGoogle Scholar
  199. Sergiescu, D., and Aubert-Combiescu, A., 1969, Differential sensitivity to gliotoxin of virulent and attenuated poliovirus and its possible use as a genetic marker, Arch. Ges. Virusforsch. 27: 268.PubMedGoogle Scholar
  200. Sergiescu, D., Aubert-Combiescu, A., and Crainic, R., 1969, Recombination between guanidine-resistant and dextran sulphate-resistant mutants of type 1 poliovirus, J. Virol. 3: 326.PubMedGoogle Scholar
  201. Sergiescu, D., Horodniceanu, F., and Aubert-Combiescu, A., 1972, The use of inhibitors in the study of picornavirus genetics, Prog. Med. Virol. 14: 123.PubMedGoogle Scholar
  202. Shirman, G. A., Maslova, S. V., Gavrilovskaya, I. N., and Agol, V. I., 1973, Stimulation of restricted reproduction of EMC virus in HeLa cells by non-replicating poliovirus, Virology 51: 1.PubMedGoogle Scholar
  203. Silber, R., Malathi, V. G., and Hurwitz, J., 1972, Purification and properties of bacteriophage T4-induced RNA ligase, Proc. Natl. Acad. Sci. USA 69: 3009.PubMedGoogle Scholar
  204. Smith, A. E., 1973, The initiation of protein synthesis directed by the RNA from encephalomyocarditis virus, Eur. J. Biochem. 33: 301.PubMedGoogle Scholar
  205. Smith, A. E., Marcker, K. A., and Mathews, M. B., 1970, Translation of RNA from EMC virus in a mammalian cell-free system, Nature (London) 225: 184.Google Scholar
  206. Spector, D. H., and Baltimore, D., 1974, Requirement of 3’ terminal poly (adenylic acid) for infectivity of poliovirus RNA, Proc. Natl. Acad. Sci. USA 71: 2983.PubMedGoogle Scholar
  207. Steiner-Pryor, A., and Cooper, P. D., 1973, Temperature-sensitive poliovirus mutants defective in repression of host protein synthesis are also defective in structural protein, J. Gen. Virol. 21: 215.PubMedGoogle Scholar
  208. Sturman, L. S., and Tamm, I., 1966, Host dependence of GD VII virus: Complete or abortive multiplication in various cell types, J. Immunol. 97: 885.PubMedGoogle Scholar
  209. Sturman, L. S., and Tamm, I., 1969, Formation of viral RNA and virus in cells that are permissive or nonpermissive for murine encephalomyletis virus (GD VII), J. Virol. 3: 8.PubMedGoogle Scholar
  210. Summers, D. F., and Maizel, J. V., 1968, Evidence for large precurser proteins in poliovirus synthesis, Proc. Natl. Acad. Sci. USA 59: 966.PubMedGoogle Scholar
  211. Summers, D. F., and Maizel, J. V., 1971, Determination of the gene sequence of poliovirus with pactamycin, Proc. Natl. Acad. Sci. USA 68: 2852.PubMedGoogle Scholar
  212. Summers, D. F., Maizel, J. V., and Darnell, J. E., 1965, Evidence for virus specific non-capsid proteins in poliovirus infected HeLa cells, Proc. Natl. Acad. Sci. USA 54: 505.PubMedGoogle Scholar
  213. Summers, D. F., Shaw, E. N., Stewart, M. C., and Maizel, J. V., 1972, Inhibition of cleavage of large poliovirus-specific precurser proteins in infected HeLa cells by inhibition of proteolytic enzymes, J. Virol. 10: 880.PubMedGoogle Scholar
  214. Taber, R., Rekosh, D., and Baltimore, D., 1971, Effect of pactamycin on synthesis of poliovirus proteins: A method for genetic mapping, J. Virol. 8: 395.PubMedGoogle Scholar
  215. Tannock, G. A., Gibbs, A. J., and Cooper, P. D., 1970, A re-examination of the molecular weight of poliovirus RNA, Biochem. Biophys. Res. Commun. 38: 298.PubMedGoogle Scholar
  216. Todd, D., and Martin, S. J., 1975, Determination of the molecular weight of bovine enterovirus RNA by nuclease digestion, J. Gen. Virol. 26: 121.PubMedGoogle Scholar
  217. Vanden Berghe, D., and Boeyé, A., 1972, New polypeptides in poliovirus, Virology 48: 604.Google Scholar
  218. Vesco, C., and Penman, S., 1969, Insensitivity of mitochondria) RNA synthesis to mengovirus infections in CHO cells, Nature (London) 224: 1021.Google Scholar
  219. Villa-Komaroff, L., Baltimore, D., and Lodish, H. F., 1973, Translation of poliovirus messenger RNA in mammalian cell-free systems, Fed. Proc. Abst. 33: 531.Google Scholar
  220. Wall, R., and Taylor, M. W., 1969, Host-dependent restriction of mengovirus replication, J. Virol. 4: 681.PubMedGoogle Scholar
  221. Wall, R., and Taylor, M. W., 1970, Mengovirus RNA synthesis in productive and restrictive cell lines, Virology 42: 78.PubMedGoogle Scholar
  222. Wecker, E., and Lederhilger, G., 1964a, Curtailment of the latent period by double-infection with polioviruses, Proc. Natl. Acad. Sci. USA 52: 246.PubMedGoogle Scholar
  223. Wecker, E., and Lederhilger, G., 1964b, Genomic masking produced by double-infection of HeLa cells with heterotypic polioviruses, Proc. Natl. Acad. Sci. USA 52: 705.Google Scholar
  224. Wentworth, B. B., McCahon, D., and Cooper, P. D., 1968, Production of infectious RNA and serum-blocking antigen by poliovirus temperature-sensitive mutants, J.Gen. Virol. 2: 297.PubMedGoogle Scholar
  225. Wetlaufer, D. B., and Ristow, S., 1973, Acquisition of 3-dimensional structure of proteins, Annu. Rev. Biochem. 42: 135.PubMedGoogle Scholar
  226. Wildy, P., 1971, Classification and Nomenclature of Viruses, First Report of the International Committee on Nomenclature of Viruses, Monographs in Virology, Vol. 5, Karger, Basel.Google Scholar
  227. Wright, P. J., and Cooper, P. D., 1974a, Poliovirus proteins associated with ribosomal structures in infected cells, Virology 59: 1.PubMedGoogle Scholar
  228. Wright, P. J., and Cooper, P. D., 1974b, Isolation of cold-sensitive mutants of poliovirus, Intervirology 2: 20.PubMedGoogle Scholar
  229. Wright, P. J., and Cooper, P. D., 1976, Poliovirus proteins associated with the replication complex in infected cells, J. Gen. Virol. 30: 63.PubMedGoogle Scholar
  230. Yogo, Y., and Wimmer, E., 1973, Poly(A) and poly(U) in poliovirus double-stranded RNA, Nature (London) New Biol. 242: 171.Google Scholar
  231. Zdvadovd, Z., 1971, Host cell repair of vaccinia virus and of double-stranded RNA of encephalomyocarditis virus, Nature (London) New Biol. 233: 123.Google Scholar
  232. Zimmerman, E. F., Heeter, M., and Darnell, J. E., 1963, RNA synthesis in poliovirusinfected cells, Virology 19: 400.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Peter D. Cooper
    • 1
  1. 1.Department of Microbiology John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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