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Genetics of Adenoviruses

  • Harold S. Ginsberg
  • C. S. H. Young
Part of the Comprehensive Virology book series (CV, volume 9)

Abstract

Since the initial discoveries of adenoviruses (Rowe et al., 1953; Hilleman and Werner, 1954), these agents have generated intense interest because of the varied clinical and cellular responses they induce. In vivo, adenoviruses produce infections which range from acute, febrile diseases to latent infections and induction of malignancy in unnatural hosts. Similarly, in cell cultures the reactions vary from acute cytopathic effects to cellular transformation. This array of host responses evolves from the nuclear infection which adenoviruses establish, and thus offers the opportunity to investigate intranuclear replication and transcription of an easily identified and manipulated species of DNA in eukaryotic cells. Since mammalian cells are so complex and contain on the order of 107 genes, it is a most difficult task to study directly the molecular reactions regulating cellular DNA synthesis, transcription of its complex genome, modification of its mRNAs, and translation of its messengers into functional gene products. Study of the smaller adenovirus genome, which contains a maximum of 50 genes and replicates in the nucleus of an eukaryotic cell, offers a simpler model which should yield evidence germane to the molecular biology of mammalian cells as well as to viral biosynthesis. Investigations with bacteriophages, however, pointed to the problem that biochemical techniques alone were insufficient to reveal the controls governing many intracellular reactions. Selected deletion and conditionally lethal mutants were essential to expose the balanced mechanisms regulating the biosynthesis and assembly of bacteriophage components.

Keywords

Simian Virus Complementation Group Adenovirus Type Restrictive Temperature Nonpermissive Temperature 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alberts, B., and Frey, L., 1970, T4 bacteriophage gene 32: A structural protein in the replication and recombination of DNA, Nature (London) 227: 1313.Google Scholar
  2. Anderson, C. W., Baum, P. R., and Gesteland, R. F., 1973, Processing of adenovirus 2-induced protein, J. Virol. 12: 241.PubMedGoogle Scholar
  3. Bartok, K., Garon, C. F., Berry, K. W., Fraser, M. J., and Rose, J. A., 1974, Specific fragmentation of adenovirus heteroduplex DNA molecules with single-strand specific nucleases from Neurospora crassa, J. Mo!. Biol. 87: 437.Google Scholar
  4. Bégin, M., and Weber, J., 1975, Genetic analysis of adenovirus type 2. I. Isolation and genetic characterization of temperature-sensitive mutants, J. Virol. 15: 1.PubMedGoogle Scholar
  5. Bellett, A. J. D., and Younghusband, H. B., 1972, Replication of the DNA of chick embryo lethal orphan virus, J. Mol. Biol. 72: 691.PubMedGoogle Scholar
  6. Bello, L. J., and Ginsberg, H. S., 1969, Relationship between deoxyribonucleic acid synthesis and inhibition of host protein synthesis in type 5 adenovirus-infected KB cells, J. Virol. 3: 106.PubMedGoogle Scholar
  7. Berget, S. M., Flint, S. J., Williams, J. F., and Sharp, P. A., 1976, Adenovirus transcription IV. Synthesis of viral-specific RNA in human cells infected with temperature-sensitive mutants of adenovirus 5, J. Virol. 19: 879–889.PubMedGoogle Scholar
  8. Boyer, G. S., Leuchtenberger, C., and Ginsberg, H. S., 1957, Cytological and cytochemical studies of HeLa cells infected with adenoviruses, J. Exp. Med. 105: 95.Google Scholar
  9. Boyer, G. S., Denny, F. W., Jr., and Ginsberg, H. S., 1959, The sequential cellular changes produced by types 5 and 7 adenoviruses in HeLa cells and in human amniotic cells: Cytological studies aided by fluorescein-labelled antibody, J. Exp. Med. 110: 827.PubMedGoogle Scholar
  10. Brockman, W. W., and Nathans, D., 1974, The isolation of simian virus 40 variants with specifically altered genomes, Proc. Natl. Acad. Sci. USA 71: 942.PubMedGoogle Scholar
  11. Brown, S. M., Ritchie, D. A., and Subak-Sharpe, J. H., 1973, Genetic studies with herpes simplex virus type 1: The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map, J. Gen. Virol. 18: 329.PubMedGoogle Scholar
  12. Brugge, J. S., and Butel, J. S., 1975, Role of simian virus 40 gene A function in maintenance of transformation, J. Virol. 15: 619.PubMedGoogle Scholar
  13. Burlingham, B. T., Brown, D. T., and Doerfler, W., 1974, Incomplete particles of adenovirus. I. Characteristics of the DNA associated with incomplete adenovirions of types 2 and 12, Virology 60: 419.PubMedGoogle Scholar
  14. Carter, T. H., and Ginsberg, H. S., 1976, Viral transcription in KB cells infected by temperature sensitive “early” mutants of adenovirus type 5, J. Virol. 18: 156.PubMedGoogle Scholar
  15. Chardonnet, Y., and Dales, S., 1970, Early events in the interaction of adenoviruses with HeLa cells. I. Penetration of type 5 and intracellular release of the DNA genome, Virology 40: 462.PubMedGoogle Scholar
  16. Chou, J. Y., and Martin, R. G., 1974, Complementation analysis of simian virus 40 mutants, J. Viro!. 13: 1101.Google Scholar
  17. Chou, J. Y., and Martin, R. G., 1975, Products of complementation between temperature sensitive mutants of simian virus 40, J. Virol. 15: 127.PubMedGoogle Scholar
  18. Cleaver, J. E., and Weil, S., 1975, UV-induced reversion of a temperature-sensitive late mutant of simian virus 40 to a wild-type phenotype, J. Virol. 16: 214.PubMedGoogle Scholar
  19. Cornick, G., Sigler, P. B., and Ginsberg, H. S., 1973, Mass of protein in the asymmetric unit of hexon crystals —A new method, J. Mol. Biol. 73: 533.PubMedGoogle Scholar
  20. Craig, E. A., Zimmer, S., and Raskas, H. S., 1975, Analysis of early adenovirus 2 RNA using EcoR-R1 viral DNA fragments, J. Virol. 15: 1202.PubMedGoogle Scholar
  21. Crick, F. H. C., and Watson, J. D., 1956, Structure of small viruses, Nature (London) 177: 473.Google Scholar
  22. Dales, S., 1962, An electron microscope study of the early association between two mammalian viruses and their hosts, J. Cell Biol. 13: 303.PubMedGoogle Scholar
  23. Davis, B. D., 1948. Isolation of biochemically deficient mutants of bacteria by penicillin, J. Am. Chem. Soc. 70: 4267.PubMedGoogle Scholar
  24. Doerfler, W., and Kleinschmidt, A. K., 1970, Denaturation pattern of the DNA of adenovirus type 2 as determined by electron microscopy, J. Mol. Biol. 50: 579.PubMedGoogle Scholar
  25. Doerfler, W., Hellman, W., and Kleinschmidt, A. K., 1972, The DNA of adenovirus type 12 and its denaturation pattern, Virology 47: 507.PubMedGoogle Scholar
  26. Dorsett, P. H., and Ginsberg, H. S., 1975, Characterization of type 5 adenovirus fiber protein, J. Virol. 15: 208.PubMedGoogle Scholar
  27. Ellens, D. J., Sussenbach, J. S., and Jansz, H. S., 1974, Studies on the mechanism of replication of adenovirus DNA. III. Electron microscopy of replicating DNA, Virology 61: 427.PubMedGoogle Scholar
  28. Ensinger, M. J., and Ginsberg, H. S., 1972, Selection and preliminary characterization of temperature-sensitive mutants of type 5 adenovirus, J. Virol. 10: 328.PubMedGoogle Scholar
  29. Everett, S. F., and Ginsberg, H. S., 1958, A toxinlike material separable from type 5 adenovirus particles, Virology 6: 770.PubMedGoogle Scholar
  30. Everitt, E., Sundquist, B., and Philipson, L., 1971, Mechanism of the arginine require- ment for adenovirus synthesis. I. Synthesis of structural proteins, J. Virol. 8: 742.PubMedGoogle Scholar
  31. Everitt, E., Sundquist, B., Pettersson, U., and Philipson, L., 1973, Structural proteins of adenoviruses. X. Isolation and topography of low-molecular-weight antigens from the virion of adenovirus type 2, Virology 52: 130.PubMedGoogle Scholar
  32. Ezoe, H., and Mak, S., 1974, Comparative studies on functions of human adenovirus type 12 and its low oncogenic mutant virions, J. Virol. 14: 733.PubMedGoogle Scholar
  33. Fenner, F., 1969. Conditional lethal mutants of animal viruses, Curr. Top. Microbiol. Immunol. 48: 1.PubMedGoogle Scholar
  34. Fincham, J. R. S., 1966, Genetic Complementation, Benjamin, New York.Google Scholar
  35. Franklin, R. M., Pettersson, U., Akervall, K., Strandberg, B., and Philipson, L., 1971, Structural proteins of adenovirus. V. Size and structure of the adenovirus type 2 hexon, J. Mol. Biol. 57: 383.PubMedGoogle Scholar
  36. Fujinaga, K., and Green, M., 1970, Mechanism of viral carcinogenesis by DNA mammalian viruses. VII. Viral genes transcribed in adenovirus type 2 infected and transformed cells, Proc. Natl. Acad. Sci. USA 65: 375.PubMedGoogle Scholar
  37. Gallimore, P. H., Sharp, P. A., and Sambrook, J., 1974, Viral DNA in transformed cells. II. A study of the sequences of adenovirus 2 DNA in nine lines of transformed rat cells using specific fragments of the viral genome, J. Mol. Biol. 89: 49.PubMedGoogle Scholar
  38. Garon, C. F., Berry, K. W., and Rose, J. A., 1972, A unique form of terminal redundancy in adenovirus DNA molecules, Proc. Natl. Acad. Sci. USA 69: 2391.PubMedGoogle Scholar
  39. Garon, C. F., Berry, K. W., Hierholzer, J. C., and Rose, J. A., 1973, Mapping of base sequence heterologies between genomes from different adenovirus serotypes, Virology 54: 414.PubMedGoogle Scholar
  40. Gilead, Z., and Ginsberg, H. S., 1965, Characterization of a tumorlike antigen in type 12 and type 18 adenovirus-infected cells, J. Bacteriol. 90: 120.PubMedGoogle Scholar
  41. Gilead, Z., Arens, M. Q., Bhaduri, S., Shanmugam, G., and Green, M., 1975, Tumour antigen specificity of a DNA-binding protein from cells infected with adenovirus 2, Nature (London) 254: 533.Google Scholar
  42. Ginsberg, H. S., 1969, Biochemistry of adenovirus infection, in: The Biochemistry of Viruses ( H. B. Levy, ed.), pp. 329–359, Dekker, New York.Google Scholar
  43. Ginsberg, H. S., Pereira, H. G., Valentine, R. C., and Wilcox, W. C., 1966, A proposed terminology for the adenovirus antigens and virion morphological subunits, Virology 28: 782.PubMedGoogle Scholar
  44. Ginsberg, H. S., Bello, L. J., and Levine, A. J., 1967, Control of biosynthesis of host macromolecules in cells infected with adenoviruses, in: The Molecular Biology of Viruses ( J. S. Colter and W. Paranchych, eds.), pp. 547–572, Academic Press, New York.Google Scholar
  45. Ginsberg, H. S., Ensinger, M. J., Kauffman, R. S., Mayer, A. J., and Lundholm, U., 1974a, Cell transformation: A study of regulation with types 5 and 12 adenovirus temperature sensitive mutants, Cold Spring Harbor Symp. Quant. Biol. 39: 419.Google Scholar
  46. Ginsberg, H. S., Ensinger, M. J., Rubenstein, F. E., and Kauffman, R. S., 1974b, Adenovirus genes and cancer, in: Viruses, Evolution and Cancer ( E. Kurstak and K. Maramorosch, eds.), pp. 167–181, Academic Press, New York.Google Scholar
  47. Graham, F. L., and van der Eb, A. J., 1973, A new technique for the assay of infectivity of human adenovirus 5 DNA, Virology 52: 456.PubMedGoogle Scholar
  48. Graham, F. L., van der Eb, A. J., and Heijneker, H. L., 1974, Size and location of the transforming region in human adenovirus type 5 DNA, Nature (London) 251: 687.Google Scholar
  49. Green, M., 1962, Studies on the biosynthesis of viral DNA. IV. Isolation, purification and chemical analysis of adenovirus, Cold Spring Harbor Symp. Quant. Biol. 27: 219.PubMedGoogle Scholar
  50. Green, M., 1970, Oncogenic viruses, Annu. Rev. Biochem. 39: 701.PubMedGoogle Scholar
  51. Green, M., Pina, M., Kimes, R., Wensink, P. C., MacHattie, L. A., and Thomas, C. A., Jr., 1967, Adenovirus DNA. I. Molecular weight and conformation, Proc. Natl. Acad. Sci. USA 57: 1302.PubMedGoogle Scholar
  52. Green, M., Parsons, J. T., Pina, M., Fujinaga, K., Caffier, H., and Landgraf-Leurs, I., 1970, Transcription of adenovirus genes in productively infected and in transformed cells, Cold Spring Harbor Symp. Quant. Biol. 35: 803.Google Scholar
  53. Grodzicker, T., Anderson, C., Sharp, P. A., and Sambrook, J., 1974a, Conditional lethal mutants of adenovirus 2-simian virus 40 hybrids. I. Host range mutants of Ad2+ND1, J. Virol. 13: 1237.PubMedGoogle Scholar
  54. Grodzicker, T., Williams, J., Sharp, P., and Sambrook, J., 1974b, Physical mapping of temperature-sensitive mutations of adenoviruses, Cold Spring Harbor Symp. Quant. Biol. 39: 439.Google Scholar
  55. Hedgpeth, J., Goodman, H. M., and Boyer, H. W., 1972, DNA nucleotide sequence restricted by the R1 endonuclease, Proc. Natl. Acad. Sci. USA 69: 3448.PubMedGoogle Scholar
  56. Hershey, A. D. (ed.), 1971, The Bacteriophage Lambda, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.Google Scholar
  57. Hilleman, M. R., and Werner, J. R., 1954, Recovery of new agent from patients with acute respiratory illness, Proc. Soc. Exp. Biol. Med. 85: 183.PubMedGoogle Scholar
  58. Horwitz, M. S., Brayton, C., and Brown, S. G., 1973, Synthesis of type 2 adenovirus DNA in the presence of cycloheximide, J. Virol. 11: 544.PubMedGoogle Scholar
  59. Huebner, R. J., Casey, M. J., Chanock, R. M., and Schell, K., 1965, Tumors induced in hamsters by a strain of adenovirus type 3: Sharing of tumor antigens and “neoantigens” with those produced by adenovirus type 7 tumors, Proc. Natl. Acad. Sci. USA 54: 381.PubMedGoogle Scholar
  60. Hyman, R. W., Brunovskis, I., and Summers, W. C., 1973, DNA base sequence homology between coliphages T7 and OII and between T3 and OII as determined by heteroduplex mapping in the electron microscope, J. Mol. Biol. 77: 189.PubMedGoogle Scholar
  61. Ishibashi, M., 1970, Retention of viral antigen in the cytoplasm of cells infected with temperature-sensitive mutants of an avian adenovirus, Proc. Natl. Acad. Sci. USA 65: 304.PubMedGoogle Scholar
  62. Ishibashi, M., 1971, Temperature-sensitive conditional lethal mutants of an avian adenovirus (CELO), Virology 45: 42.PubMedGoogle Scholar
  63. Ishibashi, M., and Maizel, J. V., Jr., 1974a, The polypeptides of adenovirus. V. Young virions, structural intermediates between top components and aged virions, Virology 57: 409.PubMedGoogle Scholar
  64. Ishibashi, M., and Maizel, J. V., Jr., 1974b, The polypeptides of adenovirus. VI. Early and late glycopolypeptides, Virology 58: 345.PubMedGoogle Scholar
  65. Ito, M., and Suzuki, E., 1970, Adeno-associated satellite virus growth supported by a temperature-sensitive mutant of human adenovirus, J. Gen. Virol. 9: 243.PubMedGoogle Scholar
  66. Jacobson, M. F., and Baltimore, D., 1968, Morphogenesis of poliovirus. I. Association of the viral RNA with boat protein, J. Mol. Biol. 33: 369.PubMedGoogle Scholar
  67. Kasel, J. A., Huber, M., Loda, F., Banks, P. A., and Knight, V., 1964, Immunization of volunteers with soluble antigens of adenovirus type 1, Proc. Soc. Exp. Biol. Med. 117: 186.PubMedGoogle Scholar
  68. Kathmann, P., Schick, J., Winnacker, E-L., and Doerfler, W. 1976. Isolation and Characterization of temperature-sensitive mutants of adenovirus type 2, J. Virol. 19: 43–53.PubMedGoogle Scholar
  69. Kauffman, R. S., and Ginsberg, H. S., 1976, Characterization of a temperature-sensitive, hexon transport mutant of type 5 adenovirus, J. Virol. 19: 643.PubMedGoogle Scholar
  70. Kellenberger, E., Eiserling, F. A., and Boy de la Tour, E., 1968, Studies on the morphogenesis of the head of phage T-even. III. The cores of head-related structures, J. Ultrastruct. Res. 21: 335.Google Scholar
  71. Kelly, T. J., Jr. and Lewis, A. M., Jr., 1973, Use of non-defective adenovirus-simian virus 40 hybrids for mapping the simian virus 40 genome, J. Virol. 12: 643.PubMedGoogle Scholar
  72. King, J., and Casjens, S., 1974, Catalytic head assemblying protein in virus morphogenesis, Nature (London) 251: 112.Google Scholar
  73. Kjellén, L., and Pereira, H. G., 1968, Role of adenovirus antigens in the induction of virus neutralizing antibody, J. Gen. Virol. 2: 177.PubMedGoogle Scholar
  74. Koczot, F. J., Carter, B. J., Garon, C. F., and Rose, J. A., 1973, Self-complementarity of terminal sequences within plus or minus strands of adenovirus-associated virus DNA, Proc. Natl. Acad. Sci. USA 70: 215.PubMedGoogle Scholar
  75. Lai, C.-J., and Nathans, D., 1974, Mapping temperature-sensitive mutants of simian virus 40: Rescue of mutants by fragments of viral DNA, Virology 60: 466.PubMedGoogle Scholar
  76. Lavelle, G., Patch, C., Khoury, G., and Rose, J., 1975, Isolation and partial characterization of single-stranded adenoviral DNA produced during synthesis of adenovirus type 2 DNA, J. Virol. 16: 775.PubMedGoogle Scholar
  77. Laver, W. G., 1970, Isolation of an arginine-rich protein from particles of adenovirus type 2, Virology 41: 488.PubMedGoogle Scholar
  78. Lawrence, W. C., and Ginsberg, H. S., 1967, Intracellular uncoating of type 5 adenovirus deoxyribonucleic acid, J. Virol. 1: 851.PubMedGoogle Scholar
  79. Ledinko, N., 1971, Inhibition by a-amanitin of adenovirus 12 replication in human embryo kidney cells of adenovirus transformation of hamster cells, Nature (London) New Biol. 233: 247.Google Scholar
  80. Ledinko, N., 1974, Temperature-sensitive mutants of adenovirus type 12 defective in viral DNA synthesis, J. Virol. 14: 457.PubMedGoogle Scholar
  81. Levine, A. J., and Ginsberg, H. S., 1967, Mechanism by which fiber antigen inhibits multiplication of type 5 adenovirus, J. Virol. 1: 747.PubMedGoogle Scholar
  82. Levine, A. J., van der Vliet, P. C., Rosenwirth, B., Rabek, J., Frenkel, G., and En-singer, M., 1974, Adenovirus-infected, cell-specific, DNA-binding proteins, Cold Spring Harbor Symp. Quant. Biol. 39: 559.Google Scholar
  83. Lewis, A. M., Jr., Levin, M. J., Wiese, W. H., Crumpacker, C. S., and Henry, P. H., 1969, A nondefective (component) adenovirus-SV40 hybrid isolated from the Ad.2SV40 hybrid population, Proc. Natl. Acad. Sci. USA 63: 1128.PubMedGoogle Scholar
  84. Lewis, J. B., Atkins, J. F., Anderson, C. W., Baum, P. R., and Gesteland, R. F., 1975, Mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments, Proc. Natl. Acad. Sci. USA 72: 1344.PubMedGoogle Scholar
  85. Lewis, J. B., Atkins, J. F., Baum, P. R., Solem, R., and Gesteland, R. F., 1976, Location and identification of the genes for adenovirus type 2 early polypeptides, Cell 7: 141–151.PubMedGoogle Scholar
  86. Lindberg, U., Persson, T., and Philipson, L., 1972, Isolation and Characterization of adenovirus messenger ribonucleic acid in productive infection, J. Virol. 10: 909.PubMedGoogle Scholar
  87. Lonberg-Holm, K., and Philipson, L., 1969, Early events of virus-cell interaction in an adenovirus system, J. Virol. 4: 323.PubMedGoogle Scholar
  88. Lucas, J. J., and Ginsberg, H. S., 1971, Synthesis of virus-specific ribonucleic acid in KB cells infected with type 2 adenovirus, J. Virol. 8: 203.PubMedGoogle Scholar
  89. Lucas, J. J., and Ginsberg, H. S., 1972, Transcription and transport of virus-specific ribonucleic acids in African green monkey kidney cells abortively infected with type 2 adenovirus, J. Virol. 10: 1109.PubMedGoogle Scholar
  90. Lundholm, U., and Doerfler, W., 1971, Temperature-sensitive mutants of human adenovirus type 12, Virology 45: 827.PubMedGoogle Scholar
  91. Maizel, J. F., Jr., Phillips, B. A., and Summers, D. F., 1967, Composition of artificially produced and naturally occurring empty capsids of poliovirus type 1, Virology 32: 692.PubMedGoogle Scholar
  92. Maizel, J. V., Jr., White, D. O., and Scharff, M. D., 1968a, The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12, Virology 36: 115.PubMedGoogle Scholar
  93. Maizel, J. V., Jr., White, D. O., and Scharff, M. D., 1968b, The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion, Virology 36: 126.PubMedGoogle Scholar
  94. Mak, S., 1971, Defective virions in human adenovirus type 12, J. Virol. 7: 426.PubMedGoogle Scholar
  95. Martin, R. G., and Chou, J. Y., 1975, Simian virus 40 functions required for the establishment and maintenance of malignant transformation, J. Virol. 15: 599.PubMedGoogle Scholar
  96. Mautner, V., Williams, J., Sambrook, J., Sharp, P. A., and Grodzicker, T., 1975, The location of the genes coding for hexon and fiber proteins in adenovirus DNA, Cell 5: 93.PubMedGoogle Scholar
  97. McGuire, P. M., Swart, C., and Hodge, L. D., 1972, Adenovirus messenger RNA in mammalian cells: Failure of polyribosome association in the absence of nuclear cleavage, Proc. Natl. Acad. Sci. USA 69: 1578.PubMedGoogle Scholar
  98. Morgan, C., Godman, G. C., Breitenfeld, P. M., and Rose, H. M., 1960, A correlative study by electron and light microscopy of the development of type 5 adenovirus. I. Electron microscopy, J. Exp. Med. 112: 373.PubMedGoogle Scholar
  99. Morgan, C., Rosenkranz, H. S., and Mednis, B., 1969, Structure and development of viruses as observed in the electron microscope. X. Entry and uncoating of adenovirus, J. Virol. 4: 777.PubMedGoogle Scholar
  100. Mulder, C., Arrand, J. R., Delius, H., Keller, W., Pettersson, U., Roberts, R. J., and Sharp, P. A., I974a, Cleavage maps of DNA from adenovirus types 2 and 5 by restriction endonucleases Eco • R1 and Hpa1, Cold Spring Harbor Symp. Quant. Biol. 39: 397.Google Scholar
  101. Mulder, C., Sharp, P. A., Delius, H., and Pettersson, U., 1974b, Specific fragmentation of DNA of adenovirus serotypes 3, 5, 7 and 12 and adenosimian virus 40 hybrid virus Ad2+ND 1 by restriction endonuclease R • Eco R 1, J. Virol. 14: 68.PubMedGoogle Scholar
  102. Neurath, A. R., Rubin, B. A., and Stasny, J. T., 1968, Cleavage by formamide of intercapsomer bonds in adenovirus types 4 and 7 virions and hemagglutinins, J. Virol. 2: 1086.PubMedGoogle Scholar
  103. Norrby, E., 1968, Biological significance of structural adenovirus components, Curr. Top. Microbiol. Immunol. 43: 1.PubMedGoogle Scholar
  104. Norrby, E., 1969, The structural and functional diversity of adenovirus capsid components, J. Gen. Virol. 5: 221.PubMedGoogle Scholar
  105. Norrby, E., and Skaaret, P., 1967, The relationship between soluble antigens and the virion of adenovirus type 3. III. Immunological identification of fiber antigen and isolated vertex capsomer antigen, Virology 32: 489.PubMedGoogle Scholar
  106. Okubo, C. K., and Raskas, N. J., 1971, Thermosensitive events in the replication of adenovirus type 2 at 42°, Virology 46: 175.PubMedGoogle Scholar
  107. Osborn, M., and Weber, K., 1975, Simian virus 40 gene A function and maintenance of transformation, J. Virol. 15: 636.PubMedGoogle Scholar
  108. Ozer, H. L., 1972, Synthesis and assembly of simian virus 40. I. Differential synthesis of intact virions and empty shells, J. Virol. 9: 41.PubMedGoogle Scholar
  109. Ozer, H. L., and Tegtmeyer, P., 1972, Synthesis and assembly of simian virus 40. II. Synthesis of the major capsid protein and its incorporation into viral particles, J. Virol. 9: 52.PubMedGoogle Scholar
  110. Parsons, J. T., and Green, M., 1971, Biochemical studies on adenovirus multiplication. XVIII. Resolution of early virus-specific RNA species in Ad2 infected and transformed cells, Virology 45: 154.PubMedGoogle Scholar
  111. Pearson, G. D., and Hanawalt, P. C., 1971, Isolation of DNA replication complexes from uninfected and adenovirus-infected HeLa cells, J. Mol. Biol. 62: 65.PubMedGoogle Scholar
  112. Pereira, H. G., 1958, A protein factor responsible for the early cytopathic effect of adenoviruses, Virology 6: 601.PubMedGoogle Scholar
  113. Pereira, H. G., 1960, Antigenic structure of non-infectious adenovirus materials, Nature (London) 186: 571.Google Scholar
  114. Pettersson, U., 1973, Some unusual properties of replicating adenovirus type 2 DNA, J. Mol. Biol. 81: 521.PubMedGoogle Scholar
  115. Pettersson, U., and Höglund, S., 1969, Structural proteins of adenoviruses. III. Purifi- cation and characterization of the adenovirus type 2 penton antigen, Virology 39: 90.PubMedGoogle Scholar
  116. Pettersson, U., Mulder, C., Delius, H., and Sharp, P. A., 1973, Cleavage of adenovirus type 2 DNA into six unique fragments by endonuclease R-R I, Proc. Natl. Acad. Sci. USA 70: 200.PubMedGoogle Scholar
  117. Philipson, L., and Lindberg, U., 1974, Reproduction of adenoviruses, in: Comprehensive Virology, Vol. 3 ( H. Fraenkel-Conrat and R. R. Wagner, eds.), pp. 143–227, Plenum Press, New York.Google Scholar
  118. Philipson, L., and Pettersson, U., 1973, Structure and function of virion proteins of adenoviruses, Progr. Exp. Tumor Res. 18: 1.PubMedGoogle Scholar
  119. Philipson, L., Lonberg-Holm, K., and Pettersson, U., 1968, Virus-receptor interaction in an adenovirus system, J. Virol. 2: 1064.PubMedGoogle Scholar
  120. Philipson, L., Wall, R., Glickman, G., and Darnell, J. E., 1971, Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication, Proc. Natl. Acad. Sci. USA 68: 2806.PubMedGoogle Scholar
  121. Philipson, L., Lindberg, U., Persson, T., and Vennström, B., 1973, Transcription and processing of adenovirus RNA in productive infection, in: Advances in the Biosciences, Vol. 11 ( G. Raspé, ed.) pp. 167–183, Pergamon Press, Vieweg: Braunschweig.Google Scholar
  122. Phillips, B. A., Summers, D. F., and Maizel, J. V., Jr., 1968, In vitro assembly of poliovirus-related particles, Virology 35: 216.Google Scholar
  123. Pina, M., and Green, M., 1965, Biochemical studies on adenovirus multiplication. IX. Chemical and base composition analysis of 28 human adenoviruses, Proc. Natl. Acad. Sci. USA 54: 547.PubMedGoogle Scholar
  124. Pina, M., and Green, M., 1969, Biochemical studies on adenovirus multiplication. XIV. Macromolecule and enzyme synthesis in cells replicating oncogenic and nononcogenic human adenovirus, Virology 38: 573.PubMedGoogle Scholar
  125. Pope, J. H., and Rowe, W. P., 1964, Immunofluorescent studies of adenovirus 12 tumors and of cells transformed or infected by adenoviruses, J. Exp. Med. 120:577.PubMedGoogle Scholar
  126. Prage, L., and Pettersson, U., 1971, Structural proteins of adenoviruses. VII. Purification and properties of an arginine-rich core protein from adenovirus type 2 and type 3, Virology 45: 364.PubMedGoogle Scholar
  127. Price, R., and Penman, S., 1972, Transcription of the adenovirus genome by an aamanitin-sensitive ribonucleic acid polymerase in HeLa cells, J. Virol. 9: 621.PubMedGoogle Scholar
  128. Robb, J. A., and Martin, R. G., 1972, Genetic analysis of simian virus 40. III. Characterization of a temperature-sensitive mutant blocked at an early stage of productive infection in monkey cells, J. Virol. 9: 956.PubMedGoogle Scholar
  129. Robinson, A. J., Younghusband, H. B., and Bellett, A. J. D., 1973, A circular DNA-protein complex from adenoviruses, Virology 56: 54.PubMedGoogle Scholar
  130. Rose, J. A., 1974, Parvovirus reproduction, in: Comprehensive Virology, Vol. 3 ( H. Fraenkel-Conrat and R. R. Wagner, eds.) pp. 1–61, Plenum Press, New York.Google Scholar
  131. Rosen, L., 1960, A hemagglutination-inhibition technique for typing adenoviruses, Am. J. Hyg. 71: 120.PubMedGoogle Scholar
  132. Rosenwirth, B., Shiroki, K., Levine, A. J., and Shimojo, H., 1975, Isolation and characterization of adenovirus type 12 DNA binding proteins, Virology 67: 14.PubMedGoogle Scholar
  133. Rouse, H. C., and Schlesinger, R. W., 1972, The effects of arginine starvation on macromolecular synthesis in infection with type 2 adenovirus. I. Synthesis and utilization of structural proteins, Virology 48: 463.PubMedGoogle Scholar
  134. Rowe, W. P., Huebner, R. J., Gilmore, L. K., Parrott, R. H., and Ward, T. G., 1953, Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture, Proc. Soc. Exp. Biol. Med. 84: 570.PubMedGoogle Scholar
  135. Rubenstein, F. E., and Ginsberg, H. S., 1974, Transformation characteristics of temperature-sensitive mutants of type 12 adenovirus, Intervirology 3: 170.PubMedGoogle Scholar
  136. Russell, W. C., and Knight, B. E., 1967, Evidence for a new antigen within the adenovirus capsid, J. Gen. Virol. 1: 523.PubMedGoogle Scholar
  137. Russell, W. C., McIntosh, K., and Skehel, J. J., 1971, The preparation and properties of adenovirus cores, J. Gen. Virol. 11: 35.PubMedGoogle Scholar
  138. Russell, W. C., Newman, C., and Williams, J. F., 1972a, Characterization of temperature-sensitive mutants of adenovirus type 5—Serology, J. Gen. Virol. 17: 265.Google Scholar
  139. Russell, W. C., Skehel, J. J., Machado, R., and Pereira, H. G., 19726, Phosphorylated polypeptides in adenovirus-infected cells, Virology 50: 931.Google Scholar
  140. Russell, W. C., Skehel, J. J., and Williams, J. F., 1974, Characterization of temperature-sensitive mutants of adenovirus type 5: Synthesis of polypeptides in infected cells, J. Gen. Virol. 24: 247.PubMedGoogle Scholar
  141. Sambrook, J., Botchan, M., Gallimore, P., Ozanne, B., Pettersson, U., Williams, J., and Sharp, P. A., 1974, Viral DNA sequences in cells transformed by simian virus 40, adenovirus type 2 and adenovirus type 5, Cold Spring Harbor Symp. Quant. Biol. 39: 615.Google Scholar
  142. Sambrook, J., Williams, J., Sharp, P. A., and Grodzicker, T., 1975, Physical mapping of temperature-sensitive mutations of adenoviruses, J. Mol. Biol. 97: 369–390.PubMedGoogle Scholar
  143. Schlesinger, R. W., 1969, Adenoviruses: The nature of the virion and of controlling factors in productive or abortive infection and tumorigenesis, Adv. Virus Res. 14: 1.PubMedGoogle Scholar
  144. Sharp, P. A., and Flint, S. J., 1976, Adenovirus transcription, Curr. Top. Microbiol. Immunol. 74: 137–166.PubMedGoogle Scholar
  145. Shenk, T. E., Rhodes, C., Rigby, P. W. J., and Berg, P., 1975, Biochemical method for mapping mutational alterations in DNA with S1 nuclease: The location of deletions and temperature-sensitive mutations in simian virus 40, Proc. Natl. Acad. Sci. USA 72: 989.PubMedGoogle Scholar
  146. Shiroki, K., and Shimojo, H., 1974, Analysis of adenovirus 12 temperature-sensitive mutants defective in viral DNA replication, Virology 61: 474.PubMedGoogle Scholar
  147. Shiroki, K., Irisawa, J., and Shimojo, H., 1972, Isolation and preliminary characterization of temperature sensitive mutants of adenovirus 12, Virology 49: 1.PubMedGoogle Scholar
  148. Shiroki, K., Shimojo, H., and Yamaguchi, K., 1974, The viral DNA replication complex of adenovirus 12, Virology 60: 192.PubMedGoogle Scholar
  149. Simon, L., 1972, Infection of Escherichia coli by T2 and T4 bacteriophages as seen in the electron microscope: T4 head morphogenesis, Proc. Natl. Acad. Sci. USA 69: 907.PubMedGoogle Scholar
  150. Steenbergh, P. H., Sussenbach, J. S., Roberts, R. J., and Jansz, H. S., 1975, The 3’-terminal nucleotide sequences of adenovirus types 2 and 5 DNA, J. Virol. 15: 268.PubMedGoogle Scholar
  151. Stinski, M. F., and Ginsberg, H. S., 1975, Hexon peptides of types 2, 3 and 5 adenoviruses and their relationship to hexon structure, J. Virol. 15: 898.PubMedGoogle Scholar
  152. Straus, S. E., Ginsberg, H. S., and Rose, J. A., 1975, DNA minus temperature-sensitive mutants of adenovirus type 5 help adenovirus-associated virus replication, J. Virol. 17: 140.PubMedGoogle Scholar
  153. Sundquist, B., Everitt, E., Philipson, L., and Höglund, S., 1973a, Assembly of adenoviruses, J. Virol. 11: 449.PubMedGoogle Scholar
  154. Sundquist, B., Pettersson, U., Thelander, L., and Philipson, L., 1973b, Structural proteins of adenoviruses. IX. Molecular weight and subunit composition of adenovirus type 2 fiber, Virology 51: 252.Google Scholar
  155. Sussenbach, J. S., 1967, Early events in the infection process of adenovirus type 5 in HeLa cells, Virology 33: 567.PubMedGoogle Scholar
  156. Sussenbach, J. S., van der Vliet, P. C., Ellens, D. J., and Jansz, H. S., 1972, Linear intermediates in the replication of adenovirus DNA, Nature (London) New Biol. 239: 47.Google Scholar
  157. Sussenbach, J. S., Ellens, D. J., and Jansz, H. S., 1973, Studies on the mechanism of replication of adenovirus DNA. II. The nature of single-stranded DNA in replicative intermediates, J. Virol. 12: 1131.PubMedGoogle Scholar
  158. Suzuki, E., and Shimojo, H., 1971, A temperature-sensitive mutant of adenovirus 31, defective in viral deoxyribonucleic acid replication, Virology 43: 488.PubMedGoogle Scholar
  159. Suzuki, E., and Shimojo, H., 1974, Temperature-sensitive formation of the DNA replication complex in adenovirus 31-infected cells, J. Virol. 13: 538.PubMedGoogle Scholar
  160. Suzuki, E., Shimojo, H., and Moritsugu, Y., 1972, Isolation and a preliminary characterization of temperature sensitive mutants of adenovirus 31, Virology 49: 426.PubMedGoogle Scholar
  161. Takahashi, M., 1972, Isolation of conditional lethal mutants (temperature sensitive and host dependent mutants) of adenovirus type 5, Virology 49: 815.PubMedGoogle Scholar
  162. Takahashi, M., Minekawa, U., and Yamanishi, K., 1974, Transformation of a hamster embryo cell line (Nil) with a host-dependent mutant of adenovirus type 5, Virology 57: 300.PubMedGoogle Scholar
  163. Takemori, N., 1972, Genetic studies with tumorigenic adenoviruses. III. Recombination in adenovirus type 12, Virology 47: 157.PubMedGoogle Scholar
  164. Takemori, N., Riggs, J. L., and Aldrich, C., 1968, Genetic studies with tumorigenic adenoviruses. I. Isolation of cytocidal (cyt) mutants of adenovirus type 12, Virology 36: 575.PubMedGoogle Scholar
  165. Takemori, N., Riggs, J. L., and Aldrich, C. D., 1969, Genetic studies with tumorigenic adenoviruses. II. Heterogeneity of cyt mutants of adenovirus type 12, Virology 38: 8.PubMedGoogle Scholar
  166. Tegtmeyer, P., 1975, Function of simian virus 40 gene A in transforming infection, J. Virol. 15: 613.PubMedGoogle Scholar
  167. Thomas, D. C., and Green, M., 1966, Biochemical studies on adenovirus multiplication. XI. Evidence of a cytoplasmic site for the synthesis of viral coded proteins, Proc. Natl. Acad. Sci. USA 56: 243.PubMedGoogle Scholar
  168. Thomas, D. C., and Green, M., 1969, Biochemical studies on adenovirus multiplication. XV. Transcription of the adenovirus type 2 genome during productive infection, Virology 39: 205.PubMedGoogle Scholar
  169. Tibbetts, C., and Pettersson, U., 1974, Complementary strand-specific sequences from unique fragments of adenovirus type 2 DNA for hybridization-mapping experiments, J. Mol. Biol. 88: 767.PubMedGoogle Scholar
  170. Tibbetts, C., Pettersson, U., Johansson, K., and Philipson, L., 1974, Relationship of mRNA from productively infected cells to the complementary strands of adenovirus type 2 DNA, J. Virol. 13: 370.PubMedGoogle Scholar
  171. Timbury, M. C., 1971, Temperature-sensitive mutants of herpes simplex virus type 2, J. Gen. Virol. 13: 373.PubMedGoogle Scholar
  172. Tooze, J. (ed.), 1973, The Molecular Biology of Tumour Viruses, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.Google Scholar
  173. Ustacelebi, S., 1973, Induction of interferon in chick embryo cells infected by adenovirus type 5 and polyoma virus, Ph.D. thesis, University of Glasgow.Google Scholar
  174. Ustacelebi, S., and Williams, J. F., 1972, Temperature-sensitive mutants of adenovirus defective in interferon induction at non-permissive temperature, Nature (London) 235: 52.Google Scholar
  175. Valentine, R. C., and Pereira, H. G., 1965, Antigens and structure of the adenovirus, J. Mol. Biol. 13: 13.PubMedGoogle Scholar
  176. van der Eb, A. J., 1973, Intermediates in type 5 adenovirus DNA replication, Virology 51: 11.PubMedGoogle Scholar
  177. van der Eb, A. J., van Kesteren, L. W., and van Bruggen, E. F. G., 1969, Structural properties of adenovirus DNA’s, Biochim. Biophys. Acta 182: 530.PubMedGoogle Scholar
  178. van der Vliet, P. C., and Levine, A. J., 1973, DNA-binding proteins specific for cells infected by adenovirus, Nature (London) New Biol. 246: 170.Google Scholar
  179. van der Vliet, P. C., and Sussenbach, J. S., 1972, The mechanism of adenovirus-DNA synthesis in isolated nuclei, Eur. J. Biochem. 30: 584.PubMedGoogle Scholar
  180. van der Vliet, P. C., Levine, A. J., Ensinger, M. J., and Ginsberg, H. S., 1975, Thermolabile DNA binding proteins from cells infected with a temperature-sensitive mutant of adenovirus defective in viral DNA synthesis, J. Virol. 15: 348.Google Scholar
  181. Velicer, L., and Ginsberg, H. S., 1968, Cytoplasmic synthesis of type 5 adenovirus capsid proteins, Proc. Natl. Acad. Sci. USA 61: 1264.PubMedGoogle Scholar
  182. Velicer, L. F., and Ginsberg, H. S., 1970, Synthesis, transport, and morphogenesis of type 5 adenovirus capsid proteins, J. Virol. 5: 338.PubMedGoogle Scholar
  183. Wall, R., Philipson, L., and Darnell, J. E., 1972, Processing of adenovirus specific nuclear RNA during virus replication, Virology 50: 27.PubMedGoogle Scholar
  184. Weber, J., 1976, Genetic analysis of adenovirus type 2. III. Temperature sensitivity of processing of viral proteins. J. Virol. 17: 462–471.PubMedGoogle Scholar
  185. Weber, J., Bégin, M., and Khittoo, G., 1975, Genetic analysis of adenovirus type 2. II. Preliminary phenotypic characterization of temperature-sensitive mutants, J. Virol. 15: 1049.PubMedGoogle Scholar
  186. White, D. O., Scharff, M. D., and Maizel, J. V., Jr., 1969, The polypeptides of adenovirus. III. Synthesis in infected cells, Virology 38: 395.PubMedGoogle Scholar
  187. Wilcox, W. C., and Ginsberg, H. S., 1961, Purification and immunological characterization of types 4 and 5 adenovirus-soluble antigens, Proc. Natl. Acad. Sci. USA 47: 512.PubMedGoogle Scholar
  188. Wilcox, W. C., and Ginsberg, H. S., 1963a, Production of specific neutralizing anti- body with soluble antigens of type 5 adenovirus, Proc. Soc. Exp. Biol. Med. 114: 37.PubMedGoogle Scholar
  189. Wilcox, W. C., and Ginsberg, H. S., 1963b, Protein synthesis in type 5 adenovirusinfected cells: Effect of p-fluorophenylalanine of synthesis of protein, nucleic acids, and infectious virus, Virology 20: 269.PubMedGoogle Scholar
  190. Wilcox, W. C., and Ginsberg, H. S., 1963c, Structure of type 5 adenovirus. I. Antigenic relationship of virus-structural proteins to virus-specific soluble antigens from infected cells, J. Exp. Med. 118: 295.PubMedGoogle Scholar
  191. Wilcox, W. C., Ginsberg, H. S., and Anderson, T. F., 1963, Structure of type 5 adenovirus. II. Fine structure of virus subunits. Morphologic relationship of structural subunits to virus-specific soluble antigens from infected cells, J. Exp. Med. 118: 307.PubMedGoogle Scholar
  192. Wilhelm, J. M., and Ginsberg, H. S., 1972, Synthesis in vitro of type 5 adenovirus capsid proteins, J. Virol. 9: 973.PubMedGoogle Scholar
  193. Wilkie, N. M., Ustacelebi, S., and Williams,-J. F., 1973, Characterization of temperature-sensitive mutants of adenovirus type 5: Nucleic acid synthesis, Virology 51: 499.Google Scholar
  194. Williams, J. F., 1973, Oncogenic transformation of hamster embryo cells in vitro by adenovirus type 5, Nature (London) 243:162.Google Scholar
  195. Williams, J. F., and Ustacelebi, S., 1971a, Complementation and recombination with temperature-sensitive mutants of adenovirus type 5, J. Gen. Virol. 13: 345.PubMedGoogle Scholar
  196. Williams, J. F., and Ustacelebi, S., 1971b, Temperature-restricted mutants of human adenovirus type 5, in: Strategy of the Viral Genome ( G. E. W. Wolstenholme and M. O’Connor, eds.), Ciba Foundation Symposium, Churchill Livingstone, London.Google Scholar
  197. Williams, J. F., Gharpure, M., Ustacelebi, S., and McDonald, S., 1971, Isolation of temperature-sensitive mutants of adenovirus type 5, J. Gen. Virol. 11: 95.PubMedGoogle Scholar
  198. Williams, J. F., Young, C. S. H., and Austin, P. E., 1974, Genetic analysis of human adenovirus type 5 in permissive and nonpermissive cells, Cold Spring Harbor Symp. Quant. Biol. 39: 427.Google Scholar
  199. Williams, J. F., Grodzicker, T., Sharp, P., and Sambrook, J., 1975a, Adenovirus recombination: Physical mapping of crossover events, Cell 4: 113.PubMedGoogle Scholar
  200. Williams, J. F., Young, H., and Austin, P., 1975b, Complementation of human adenovirus type 5 is mutants by human adenovirus type 12, J. Virol. 15: 675.PubMedGoogle Scholar
  201. Wolfson, J., and Dressler, D., 1972, Adenovirus-2 DNA contains an inverted terminal repetition, Proc. Natl. Acad. Sci. USA 69: 3054.PubMedGoogle Scholar
  202. Yamashita, T., and Green, M., 1974, Adenovirus DNA replication. I. Requirement for protein synthesis and isolation of nuclear membrane fractions containing newly synthesized viral DNA and proteins, J. Virol. 14: 412.PubMedGoogle Scholar
  203. Yoshimori, R. N., 1971, A genetic and biochemical analysis of the restriction and modification of DNA by resistance transfer factors, Ph.D. thesis, University of California, San Francisco Medical Center.Google Scholar
  204. Young, C. S. H., and Williams, J. F., 1975, Heat-stable variant of human adenovirus type 5: Characterization and use in three-factor crosses, J. Virol. 15: 1168.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Harold S. Ginsberg
    • 1
  • C. S. H. Young
    • 1
  1. 1.Department of Microbiology College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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