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Reproduction of RNA Bacteriophages

  • L. Eoyang
  • J. T. August
Part of the Comprehensive Virology book series (CV, volume 2)

Abstract

Studies on virus replication have been greatly facilitated by the discovery in 1961 of a small RNA-containing bacteriophage (Loeb and Zinder, 1961). The RNA coliphage represents a biological system uniquely reduced to its simplest form. Unlike all other bacterial viruses, the RNA phage does not contain DNA, but rather RNA as its sole genetic material. As a consequence, the RNA must serve a dual function both as a template for nucleic acid synthesis and as a messenger for virus-specific protein synthesis. Due to the size of the genome and the limited number (three) of gene products, it has been possible to elucidate the biological processes of replication and translation as well as the mechanisms by which these events are controlled. Over the past several years, considerable progress has been made in this respect, and though by no means complete, our knowledge of the RNA bacteriophage has become quite extensive. We have attempted to summarize below some of the more recent contributions toward our understanding of the molecular biology of virus replication.

Keywords

Coat Protein Ribonucleic Acid Phage Particle Minus Strand Maturation Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • L. Eoyang
    • 1
  • J. T. August
    • 1
  1. 1.Department of Molecular Biology Division of Biological SciencesAlbert Einstein College of MedicineBronxUSA

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