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Albumin Synthesis and Degradation

  • M. A. Rothschild
  • M. Oratz

Abstract

Serum albumin is the major protein produced in the liver, comprising as much as 50% of the productive effort at any one moment. The concentration of this protein in the plasma has long been used as an indicator of health and disease. Yet it must be remembered that the serum albumin level is only the complex end result of synthesis, degradation, and distribution. The basic properties of albumin were recognized as early as 1837 by Ancell,1 who noted that “albumen” was needed for transport functions, for maintaining fluidity of the vascular system, and for the prevention of edema, and who recorded values for protein levels in different age groups and species, and in males and females. These fine early observations have not been proved wrong during the past 140 years.

Keywords

Albumin Level Serum Albumin Level Amino Acid Pool Albumin Synthesis Albumin Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. A. Rothschild
    • 1
    • 2
  • M. Oratz
    • 1
    • 3
  1. 1.Department of Nuclear MedicineVeterans Administration HospitalNew YorkUSA
  2. 2.Department of MedicineNew York University School of MedicineNew YorkUSA
  3. 3.Department of BiochemistryNew York University College of DentistryNew YorkUSA

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