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Protein Chemistry in a General Hospital

  • Brenda Slavin

Abstract

All chemical pathology laboratories should be able to offer a measurement of total serum protein and albumin and when indicated an electrophoretic strip (serum is preferred to plasma for most protein studies). These three basic estimations yield valuable information and may indicate a need for further tests. Many laboratories will also offer quantitative analysis of specific protein, most commonly those of the immunoglobulins G, A, and M as well as qualitative protein investigation by immunoelectrophoresis. These techniques require some experience and for their correct interpretation clinical background and liaison with the clinicians is required.

Keywords

Free Light Chain Protein Chemistry Monoclonal Protein Radial Immunodiffusion Monoclonal Band 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    D. N. Baron, P. M. G. Broughton, M. Cohen, T. S. Lansley, S.M. Lewis, and N. K. Shinton, Ann. Clin. Biochem., 11, 194 (1974).PubMedGoogle Scholar
  2. 2.
    D. S. Rowe, S. G. Anderson, and B. Grab, Bull. W.H.O., 42, 535 (1970).PubMedGoogle Scholar
  3. 3.
    J. F. Stevens, Ann. Clin. Biochem., 10, 127 (1973).Google Scholar
  4. 4.
    J. F. Stevens Lancet, 2, 83 (1971).Google Scholar
  5. 5.
    R. I. N. Greaves, Cryobiology, 5, 76 (1968).PubMedGoogle Scholar
  6. 6.
    T. Kawai, Clinical Aspects of the Plasma Proteins (Igaku Shoin Ltd., Tokyo, and Springer, New York, 1973), p. 164.Google Scholar
  7. 7.
    Multipurpose Serological Surveys and WHO. Reference Banks, W.H.O. Tech. Rep. Ser., No. 454(1970).Google Scholar
  8. 8.
    B. T. Doumas, and H. G. Biggs, Stand. Methods Clin. Chem., 7, 175 (1972).Google Scholar
  9. 9.
    G. R. Kingsley, Stand. Methods Clin. Chem., 7, 199 (1972).Google Scholar
  10. 10.
    F. W. Sunderman, Jr., Crit. Rev. Clin. Lab. Sci., 1, 427 (1970).Google Scholar
  11. 11.
    W. T. Caraway, Amer. J. Clin. Pathol., 37, 445 (1962).Google Scholar
  12. 12.
    J. K. Fawcett and V. Wynn, J. Clin. Pathol., 13, 304 (1960).PubMedGoogle Scholar
  13. 13.
    T. Kawai, Clinical Aspects of the Plasma Proteins (Igaku Shoin Ltd., Tokyo, and Springer, New York, 1973), p. 182.Google Scholar
  14. 14.
    P. E. Hønger, Scand. J. Clin. Lab. Invest., 21, 3 (1968).PubMedGoogle Scholar
  15. 15.
    J. W. W. Studd, J. D. Blainey, and D. E. Bailey, J. Obstet. Gynaecol. Brit. Common., 77, 42 (1970).Google Scholar
  16. 16.
    H. McFarlane, Advan. Clin. Chem., 16, 153 (1973).Google Scholar
  17. 17.
    J. R. Hobbs, Brit. J. Hosp. Med., 3, 669 (1970).Google Scholar
  18. 18.
    B. Abrams, Clin. Sci., 40, 67 (1971).PubMedGoogle Scholar
  19. 19.
    M. Allansmith, B. H. McClellan, M. Butterworth, and J. R. Maloney, J. Pediat., 72, 276 (1968).PubMedGoogle Scholar
  20. 20.
    H. Geiger and P. Hoffmann, Z Kinderheilk, 109, 22 (1970).PubMedGoogle Scholar
  21. 21.
    J. R. Hobbs, Advan. Clin. Chem., 14, 259 (1971).Google Scholar
  22. 22.
    I. D. P. Wootton, Microanalysis in Medical Biochemistry (Churchill Livingstone, Edinburgh and London, 1974), Chap. 9.Google Scholar
  23. 23.
    D. C. Cannon, I. Olitzky, and J. Inkpen in (eds. R. J. Henry, D. C. Cannon, J. W. Winkelman), Clinical Chemistry, Principles and Technics (Harper and Row, London and New York, 1974), Chap. 16.Google Scholar
  24. 24.
    R. A. Phillips, D. D. Van Slyke, P. B. Hamilton, V. P. Dole, K. Emerson, and R. M. Archibald, J. Biol. Chem., 183, 305 (1950).Google Scholar
  25. 25.
    C. F. M. Rose, Lab. Pract., 20, 61 (1971).Google Scholar
  26. 26.
    O. H. Lowry and T. H. Hunter, J. Biol. Chem., 159, 465 (1945).Google Scholar
  27. 27.
    D. Webster, Clin. Chim. Acta, 53, 109 (1974).PubMedGoogle Scholar
  28. 28.
    D. Webster, A. H. C. Bignell, and E. C. Attwood., Clin. Chim. Acta, 53, 101 (1974).PubMedGoogle Scholar
  29. 29.
    R. J. Bartholomew and A. M. Delaney, Proc. Aust. Ass. Clin. Biochem., 1, 64 (1964).Google Scholar
  30. 30.
    J. Kohn and J. G. Feinberg, Shandon Instrument Applications, Monogr., 11 (1970).Google Scholar
  31. 31.
    R. I. Harris and J. Kohn, J. Clin. Path., 27, 986 (1974).PubMedGoogle Scholar
  32. 32.
    C. B. Laurell, Clin. Chem., 19, 99 (1973).PubMedGoogle Scholar
  33. 33.
    P. F. Kohler and R. S. Farr, Nature (London), 210, 1070 (1966).Google Scholar
  34. 34.
    G. Mancini, A. O. Caronara, and J. F. Heremans, Immunochemistry, 2, 235 (1965).PubMedGoogle Scholar
  35. 35.
    J. L. Fahey and E. M. McKelvey, J. Immunol, 94, 84 (1965).PubMedGoogle Scholar
  36. 36.
    M. W. Klaff, Clin. Biochem., 3, 91 (1970).Google Scholar
  37. 37.
    J. R. Hobbs, G. M. J. Slot, C. H. Campbell, G. P. Clein, J. T. Scott, D. Crowther, and H. T. Swan, Lancet, 2, 614 (1966).PubMedGoogle Scholar
  38. 38.
    J. R. Hobbs, Ass. Clin. Pathologists Broadsheet, No. 68 (1970).Google Scholar
  39. 39.
    M. L. Salkie and E. M. McNeil, Ann. Clin. Biochem., 11, 112 (1974).PubMedGoogle Scholar
  40. 40.
    B. Weeke (eds. N. H. Axelsen, J. Krøll, B. Weeke), A Manual of Quantitative Immunoelectrophoresis (Universitets Forlaget, Oslo, 1973), Chap. 2.Google Scholar
  41. 41.
    B. Weeke, Scand. J. Clin. Lab. Invest., 21, 341 (1968).Google Scholar
  42. 42.
    W. von Stephen and U. Frahm, Z. Klin. Chem., 9, 224 (1971).Google Scholar
  43. 43.
    L. Slater, Ann. Clin. Biochem., 12, 19 (1975).PubMedGoogle Scholar
  44. 44.
    N. Ressler, Clin. Chim. Acta, 5, 795 (1960).PubMedGoogle Scholar
  45. 45.
    C. B. Laurell, Anal. Biochem., 15, 45 (1966).PubMedGoogle Scholar
  46. 46.
    J. M. B. Versey, Ann. Clin. Biochem., 10, 100 (1973).Google Scholar
  47. 47.
    L. H. Killingsworth and J. Savory, Clin. Chem., 18, 335 (1972).PubMedGoogle Scholar
  48. 48.
    C. Larson, J. M. Gorman, and A. Becker, Automated Immuno Precipitin Reactions (Technicon Instruments Corp., New York, 1972), p. 21.Google Scholar
  49. 49.
    C. C. Hall, Clin. Chim. Acta, 46, 21 (1973).PubMedGoogle Scholar
  50. 50.
    K. Hellsing, Automated Immuno Precipitin Reactions (Technicon Instruments Corp., New York, 1972), p. 17.Google Scholar
  51. 51.
    H. Riccomi, P. L. Masson, and J. F. Heremans, Automated Immuno Precipitin Reactions (Technicon Instruments Corp., New York, 1972), p. 25.Google Scholar
  52. 52.
    A. Watson, P. Young, J. F. Davidson, and A. Fleck, Med. Lab. Technol, 31, 63 (1974).PubMedGoogle Scholar
  53. 53.
    K. J. Catt, H. D. Neal, and G. Tregear, Biochem. J., 100, 31C (1966).Google Scholar
  54. 54.
    J. Lieberman, C. Mittman, and A. S. Schneider, J. Amer. Med. Ass., 210, 2055 (1969).Google Scholar
  55. 55.
    H. A. Ravin, Lancet, 1, 726 (1956).Google Scholar
  56. 56.
    H. G. Van Eijk, C. van der Heul, W. F. Wiltink, and B. Leijnse, Scand. J. Clin. Lab. Invest., 29, Suppl. 126, 1.19 (1972).Google Scholar
  57. 57.
    W. N. M. Ramsay, Clin. Chim. Acta 2, 214 (1957).PubMedGoogle Scholar
  58. 58.
    K. Dixon, Ann. Clin. Biochem. 10, 127 (1973).Google Scholar
  59. 59.
    J. Kohn, J. Clin. Pathol., 23, 733 (1970).Google Scholar
  60. 60.
    O. Nørgaard, Brit. J. Cancer, 25, 417 (1971).PubMedGoogle Scholar
  61. 61.
    J. L. Bell and D. N. Baron, Proc. Ass. Clin. Biochem., 5, 63 (1968).Google Scholar
  62. 62.
    J. Clausen, Laboratory Techniques in Biochemistry and Molecular Biology, Part III (North Holland Publ. Co., Amsterdam and London, 1969), Chap. 5.Google Scholar
  63. 63.
    J. Kohn, in (ed., S. C. Dyke) Recent Advances in Clinical Pathology (Churchill Livingstone, Edinburgh and London, 1973), Chap. 20.Google Scholar
  64. 64.
    R. J. Wieme, Studies on Agar GEl Electrophoresis (Arcia Uitgaven N.V., Brussels; and Elsevier, Amsterdam, 1965).Google Scholar
  65. 65.
    C. B. Laurell, Scand. J. Clin. Invest., 29, Suppl. 124, 23 (1972).Google Scholar
  66. 66.
    J. R. Hobbs, A. A. Corbett, and H. McLaughlin, Scand. J. Clin. Lab. Invest., 29, Suppl. 126, 14(1972).Google Scholar
  67. 67.
    I. D. P. Wootton, Microanalysis in Medical Biochemistry (Churchill Livingstone, Edinburgh and London, 1974), p. 173.Google Scholar
  68. 68.
    J. Kohn, Nature (London), 183, 1055 (1958).Google Scholar
  69. 69.
    J. Clausen, Laboratory Techniques in Biochemistry and Molecular Biology, Part III (North Holland Publ. Co., Amsterdam and London, 1969), p. 510.Google Scholar
  70. 70.
    J. Radl, Immunology, 19, 137 (1970).PubMedGoogle Scholar
  71. 71.
    K. Bergstrom, Acta Med. Scand. (Suppl.), 445, 127 (1966).Google Scholar
  72. 72.
    P. M. Carter and J. R. Hobbs, Brit. Med. J., 1, 260 (1971).Google Scholar
  73. 73.
    W. F. Barth and A. Solomon, J. Amer. Med. Ass., 192, 120 (1965).Google Scholar
  74. 74.
    D. J. Wright and D. E. Jenkins, Jr., Blood, 36, 516 (1970).PubMedGoogle Scholar
  75. 75.
    D. J. Wright and D. E. Jenkins, Jr. Lancet, 1, 359 (1973).Google Scholar
  76. 76.
    R. F. Ritchie, Automated Immuno Precipitin Reactions (Technicon Instruments Corp., New York, 1972), p. 25.Google Scholar
  77. 77.
    M. Werner, S. H. Brooks, and G. Cohen, Clin. Chem., 18, 116 (1972).PubMedGoogle Scholar
  78. 78.
    D. A. Montgomery, D. W. Neill, and E. B. D. Dowdle, Clin. Sci., 22, 141 (1962).PubMedGoogle Scholar
  79. 79.
    L. Melartin and B. S. Blumberg, Clin. Res., 14, 482 (1966).Google Scholar
  80. 80.
    C. B. Laurell and S. Ericksonn, Scand. J. Clin. Lab. Invest., 15, 132 (1963).Google Scholar
  81. 81.
    F. S. Rosen and C. A. Janeway, New England J. Med., 275, 709, 769 (1966).Google Scholar
  82. 82.
    M. Seligmann, H. H. Fundenberg, and R. A. Good, Amer. J. Med., 45, 817 (1968).PubMedGoogle Scholar
  83. 83.
    Medical Research Council Working Party, Lancet, 1, 163 (1969).Google Scholar
  84. 84.
    M. E. Miller and R. M. Schieken, Amer. J. Med. Sci., 253, 741 (1967).PubMedGoogle Scholar
  85. 85.
    J. R. Hobbs, Lancet, 1, 110, (1968).PubMedGoogle Scholar
  86. 86.
    R. Bachman, Scand. J. Clin. Lab. Invest., 17, 316 (1965).Google Scholar
  87. 87.
    Lancet, 144(1971).Google Scholar
  88. 88.
    C. D. West, R. Hong, and N. H. Holland, J. Clin. Invest., 41, 2054 (1962).PubMedGoogle Scholar
  89. 89.
    A. J. Ammann and R. Hong, J. Lab. Clin. Med., 74, 846 (1969).Google Scholar
  90. 90.
    M. A. Blajchman, J. V. Dacie, J. R. Hobbs, and J. E. Pettit, Lancet, 2, 340 (1969).PubMedGoogle Scholar
  91. 91.
    G. Meshaka, P. Burtin, F. Danon, B. Delpech, and M. Seligmann, Protides Biol. Fluids, Proc. Colloq., 14, 715 (1966).Google Scholar
  92. 92.
    J. R. Hobbs, Advan. Clin. Chem., 14, 241 (1971).Google Scholar
  93. 93.
    C. Y. Yeung and J. R. Hobbs, Lancet, 1, 1167 (1968).PubMedGoogle Scholar
  94. 94.
    J. R. Hobbs, Brit. J. Hosp. Med., 3, 669 (1970).Google Scholar
  95. 95.
    H. McFarlane, Advan. Clin. Chem., 15, 191 (1973).Google Scholar
  96. 96.
    S. G. O. Johansson, T. Mellbin, and B. D. Vahlquist, Lancet, 1, 1119 (1968).Google Scholar
  97. 97.
    J. Hallen, Acta Med. Scand., Suppl. 462, 1 (1966).Google Scholar
  98. 98.
    J. R. Hobbs, Brit. Med. J., 2, 67 (1971).Google Scholar
  99. 99.
    E. F. Osserman, N.Y. Acad. Sci. Conf. Immunoglobulins, New York, March 8–10, (1971), p. 507.Google Scholar
  100. 100.
    W. Pruzanski, Med. Clin. N. Amer., 56, 371 (1972).PubMedGoogle Scholar
  101. 101.
    D. A. G. Galton, Brit. Med. J., 1, 323 (1971).Google Scholar
  102. 102.
    J. R. Hobbs, Brit. J. Haematol., 16, 607 (1969).Google Scholar
  103. 103.
    S. O. Berlin, H. Odeberg, and L. Weingart, Acta Med. Scand., 183, 347 (1968).PubMedGoogle Scholar
  104. 104.
    E. W. Houston, S. E. Ritzmann, and W. C. Levin, Blood, 29, 214 (1967).PubMedGoogle Scholar
  105. 105.
    A. G. Cooper and J. R. Hobbs, Brit. J. Haematol, 19, 383 (1970).Google Scholar
  106. 106.
    D. M. Parr, W. Pruzanski, J. G. Scott, and D. M. Mills, Blood, 37, 473 (1971).PubMedGoogle Scholar
  107. 107.
    T. Isobe and E. F. Osserman, Ann. N.Y. Acad. Sci., 507 (1972).Google Scholar
  108. 108.
    Soothill, J. F., J. Lab. Clin. Med., 59, 859 (1962).PubMedGoogle Scholar
  109. 109.
    J. S. Cameron and G. Blandford, Lancet, 2, 242 (1966).PubMedGoogle Scholar
  110. 110.
    R. Beetham, R. J. Mills, D. N. Raine, and R. H. R. White, Ann. Clin. Biochem., 11, 59 (1974).Google Scholar
  111. 111.
    C. S. Ogg, J. S. Cameron, and R. H. R. White, Lancet, 2, 78 (1968).Google Scholar
  112. 112.
    R. J. Henry, D. C. Cannon, and J. W. Winkelman, in Clinical Chemistry, Principles and Technics (Harper and Row, London and New York), p. 422.Google Scholar
  113. 113.
    T. Hartley, D. Merrill, and H. Claman, Arch. Neurol., 15, 472 (1966).PubMedGoogle Scholar
  114. 114.
    D. Riddoch and R. A. Thompson, Brit. Med. J., 1, 396 (1970).PubMedGoogle Scholar
  115. 115.
    K. Ganrot and C. B. Laurell, Clin. Chem., 20, 571 (1974).PubMedGoogle Scholar
  116. 116.
    A. S. Tavill, J. Clin. Pathol., 24, Suppl. (Roy. Coll. Path.) 5, 45 (1971).Google Scholar
  117. 117.
    J. R. Hobbs and C. W. Hepner, Lancet, 1, 217 (1968).Google Scholar
  118. 118.
    R. A. Crabbé and J. F. Heremans, Amer. J. Med., 42, 319 (1967).PubMedGoogle Scholar
  119. 119.
    P. Asquith, R. A. Thompson, and W. T. Cooke, Lancet, 2, 129 (1969).PubMedGoogle Scholar
  120. 120.
    B. Weeke and S. Jarnum, Gut, 12, 297 (1971).PubMedGoogle Scholar
  121. 121.
    M. Seligmann and J. C. Rambaud, Isr. J. Med. Sci., 5, 151 (1969).PubMedGoogle Scholar
  122. 122.
    W. F. Doe, J. R. Hobbs, K Henry, and R. H. Dowling, Quart. J. Med., 39, 619 (1970).Google Scholar
  123. 123.
    J. G. Walker, Ann. Clin. Biochem., 7, 93 (1970).Google Scholar
  124. 124.
    J. Behbassat, L. Keren, and A. Ziotnic, Brit. Med. J., 4, 762 (1973).Google Scholar
  125. 125.
    G. A. LoGrippo, K. Anselm, and H. Hayashi, Amer. J. Gastroenterol., 56, 357 (1971).Google Scholar
  126. 126.
    T. Feizi, Gut, 9, 193 (1968).PubMedGoogle Scholar
  127. 127.
    J. R. Hobbs, Proc. Roy. Soc. Med., 60, 1250 (1967).PubMedGoogle Scholar
  128. 128.
    N. G. Frazer, H. M. Dick, and W. B. Crichton, Brit. J. Dermatol., 81, 89 (1969).Google Scholar
  129. 129.
    R. Norberg, Acta Med. Scand., 181, 497 (1967).PubMedGoogle Scholar
  130. 130.
    L. Juhlin, S. G. O. Johansson, H. Bennich, C. Hogman, and N. Thyresson, Arch. Dermatol, 100, 12 (1969).PubMedGoogle Scholar
  131. 131.
    K. James, H. Fudenberg, W. L. Epstein, and J. Shuster, Clin. Exp. Immunol., 2, 153 (1967).PubMedGoogle Scholar
  132. 132.
    J. J. Cream, Brit. J. Dermatol, 84, 223 (1971).Google Scholar
  133. 133.
    A. E. Schoenfeld, A. Rubinstein, and U. Raviv, Isr. J. Med. Sci., 4, 815 (1968).PubMedGoogle Scholar
  134. 134.
    J. R. Hobbs, R. G. Sommerville, and D. A. McSwiggan, Lancet, 1, 1108 (1967).Google Scholar
  135. 135.
    B. Abrams, Clin. Sci., 40, 67 (1971).PubMedGoogle Scholar
  136. 136.
    H. Geiger and P. Hoffman, Z. Kinderheilk, 109, 22 (1970).PubMedGoogle Scholar
  137. 137.
    S. G. O. Johansson, Int. Arch. Allergy Appl. Immunol, 34, 1 (1968).PubMedGoogle Scholar
  138. 138.
    T. Berg, and S. G. O. Johansson, Acta Paediat. Scand., 58, 513 (1969).PubMedGoogle Scholar
  139. 139.
    T. Berg, and S. G. O. Johansson, Lancet, 1, 1041 (1973).Google Scholar
  140. 140.
    J. R. Hobbs and J. A. Davis, Lancet, 1, 757 (1967).PubMedGoogle Scholar
  141. 141.
    C. Y. Yeung and J. R. Hobbs, Lancet, 1, 1167, (1968).PubMedGoogle Scholar
  142. 142.
    B. Taylor, A. P. Norman, H. A. Orgel, C. R. Stokes, M. W. Turner, and J. F. Soothill, Lancet, 2, 111 (1973).PubMedGoogle Scholar
  143. 143.
    C. A. Porter, A. P. Mowat, P. J. L. Cook, D. W. G. Haynes, K. B. Shilkin, and R. Williams, Brit. Med. J., 3, 435 (1972).PubMedGoogle Scholar
  144. 144.
    H. McFarlane, M. I. Ogbeide, S. Reddy, K. J. Adcock, H. Adeshina, J. M. Gurney, A. Cooke, G. O. Taylor, and J. A. Moraie, Lancet, 1, 392 (1969).PubMedGoogle Scholar
  145. 145.
    M. A. Hyvarinen, P. Zeltzer, W. Oh, and E. R. Stiehm, J. Pediat., 82, 430 (1973).PubMedGoogle Scholar
  146. 146.
    P. M. Zeltzer, R. C. Neerhout, E. W. Fonkalsrud, and E. R. Stiehm, Lancet, 1, 373 (1974).PubMedGoogle Scholar
  147. 147.
    D. J. H. Brock and R. G. Sltcliffe, Lancet, 2, 197 (1972).PubMedGoogle Scholar
  148. 148.
    D. J. H. Brock, A. E. Bolton, and J. M. Monaghen, Lancet, 2, 923 (1973).PubMedGoogle Scholar
  149. 149.
    M. J. Seller, J. D. Singer, T. M. Coltart, and S. Campbell, Lancet, 1, 428 (1974).Google Scholar
  150. 150.
    S. B. Smith and C. Arkin, Amer. J. Clin. Pathol., 58, 524 (1972).Google Scholar
  151. 151.
    E. A. Rachmilewitz, M. I. Sacks, and A. Zlothick, Isr. J. Med. Sci., 6, 32 (1970).PubMedGoogle Scholar
  152. 152.
    H. M. Grey and P. F. Kohler, Semin. Hematol., 10(2), 87 (1973).PubMedGoogle Scholar
  153. 153.
    E. C. Gordon-Smith, R. J. Harrison, and J. R. Hobbs, Froc. Roy. Soc. Med., 61, 1112 (1968).Google Scholar
  154. 154.
    M. L. Peterman and K. R. Hogness, Cancer (Philadelphia), 1, 100 (1948).Google Scholar
  155. 155.
    F. Martel, Scand. J. Clin. Lab. Invest., 29, Suppl. 126, 133 (1972).Google Scholar
  156. 156.
    B. M. Slavin, G. Chisholm, and B. Lewis (in press).Google Scholar
  157. 157.
    R. J. Ablin, Lancet, 2, 874 (1972).PubMedGoogle Scholar
  158. 158.
    S. Sugma and Z. Tamura, Cancer Res., 32, 426 (1972).Google Scholar
  159. 159.
    P. McPhedran, S. C. Finch, Y. R. Nemerson, and M. G. Barnes, Ann. Intern. Med., 76, 439 (1972).PubMedGoogle Scholar
  160. 160.
    G. J. Douma and A. van Dalen, Klin. Chem. Klin. Biochem., 12, 474 (1974).Google Scholar
  161. 161.
    W. Dobryzseka, J. Osada and J. Gerber, Scand. J. Clin. Lab. Invest., 29, Suppl. 126, 128 (1972).Google Scholar
  162. 162.
    A. H. Glasgow, R. B Nimberg, J. O. Menzoian, B. A. Sapotoschetz, S. R. Cooperband, K. Schmid, and J. A. Mannick. New England J. Med., 291, 1263 (1974).Google Scholar
  163. 163.
    L. R. Purves, E. Van der Merwe, and I. Bersohn, Lancet, 2, 464 (1970).PubMedGoogle Scholar
  164. 164.
    J. A. Smith, T. I. Francis, G. M. Edington, and A. O. Williams. Brit. J. Cancer, 25, 343 (1971).PubMedGoogle Scholar
  165. 165.
    A. Foli, S. Sherlock, and M. Adinolfi, Lancet, 2, 1267 (1969).Google Scholar
  166. 166.
    G. T. O’Conor, Y. S. Tatarinov, G. I. Abelev, and J. Uriel, Cancer, 25, 1091 (1970).PubMedGoogle Scholar
  167. 167.
    L. R. Purves and E. W. Geddes, Lancet, 1, 47 (1972).PubMedGoogle Scholar
  168. 168.
    C. Bourgeaux, F. Martin, and F. Cabanne, Presse Med., 36, 1585 (1971).Google Scholar
  169. 169.
    S. Akai and K. Kato, Gann Monogr. Cancer Res., 14, 149 (1973).Google Scholar
  170. 170.
    E. Ruoslahti, M. Salaspuro, H. Pihko, L. Andersson, and M. Seppala, Brit. Med. J., 2, 2(1974).Google Scholar
  171. 171.
    H. K. B. Silver, P. Gold, J. Shuster, N. B. Javitt, S. O. Freedman, and N. D. C. Finlayson, New England J. Med., 291, 506 (1974).Google Scholar
  172. 172.
    S. L. Kamholz, Amer. J. Gastroenterol., 59(3), 233 (1973).Google Scholar
  173. 173.
    O. Banwo, J. Versey, and J. R. Hobbs, Lancet, 1, 643 (1974).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Brenda Slavin
    • 1
  1. 1.Department of Chemical PathologyCentral Middlesex HospitalLondonUK

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