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Structure and Function of Plasma Proteins pp 195–222Cite as

Complement

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Abstract

It was almost a century ago that the ability of fresh serum to destroy certain bacteria was noted. This bactericidal capacity was soon resolved into a heat-stable substance, bactericidin, bacteriolysin, or, in modern terms, specific antibody, and a heat-labile substance called alexin by Büchner and complement by Bordet. At the turn of this century, Ehrlich and Morgenroth found similar requirements for the immune lysis of sheep red cells. Since the release of hemoglobin could be quantitated, the sheep cell (E), amboceptor or antibody (A), and complement (C) model system provided a powerful tool for the further study of complement and its actions. It was rapidly established that antibody could combine with the sheep cell in the absence of complement but complement could not exert its lytic action in the absence of antibody.

The original observations cited in this chapter were aided by U.S. Public Health Service Grants AM 13855 and AM 16392.

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Author information

Authors and Affiliations

  1. Centre for Blood Research, 800 Huntington Avenue, Boston, Massachusetts, 02115, USA

    Chester A. Alper

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  1. Chester A. Alper
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Editors and Affiliations

  1. Clinical Research Centre, Watford Road, Harrow, Middlesex, UK

    A. C. Allison

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© 1974 Plenum Publishing Company Ltd

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Alper, C.A. (1974). Complement. In: Allison, A.C. (eds) Structure and Function of Plasma Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2676-2_7

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  • DOI: https://doi.org/10.1007/978-1-4684-2676-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2678-6

  • Online ISBN: 978-1-4684-2676-2

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