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Abstract

Haptoglobin (Hp) is an α-2 globulin with several unusual properties. For example, it has the unique capability of combining with the globin moiety of hemoglobin (which accounts for its name), thereby providing the major determinant of the renal threshold for hemoglobin. Also, it is the chief component of the “acute phase” proteins, its concentration increasing up to several-fold during inflammatory reactions. Finally, Hp is not a single structural entity; the genetic polymorphism of one of its polypeptide chains represents a very important form of molecular evolution. These properties have made Hp the subject of a large variety of laboratory and clinical investigations which can be only partially covered in this chapter. Other reviews1–7 may be consulted for more complete details.

Keywords

Polypeptide Chain Pernicious Anemia Electrophoretic Pattern Reductive Cleavage Electron Magnetic Resonance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Company Ltd 1974

Authors and Affiliations

  • E. Giblett
    • 1
  1. 1.King County Central Blood BankSeattleUSA

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