Genetic Disorders of Brain Development: Animal Models

  • Norbert N. Herschkowitz


The normal functioning of the central nervous system depends on the integrated and coordinated action of an immense number of neurons. The integrated cellular pattern is the result of a sequence of developmental steps: proliferation of cells, migration to determined locations, differentiation to specific functions, and cell death. These processes depend on the genetically controlled selective synthesis and degradation of proteins at specific times during development. Genetic mutations or exogenous factors which affect genetic control can, therefore, interfere with normal brain development and may result in severe brain dysfunction.


Purkinje Cell Brain Development Neural Tube Neural Crest Neural Plate 


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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Norbert N. Herschkowitz
    • 1
  1. 1.Department of PediatricsUniversity of BerneBerneSwitzerland

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