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Effects of Malnutrition on Brain Development

  • Myron Winick
  • Pedro Rosso

Abstract

During the past 15 years, it has become increasingly clear that severe malnutrition imposed during certain critical periods of development will affect brain growth and function. Because infantile malnutrition still constitutes one of the greatest health problems in the world, since even by conservative estimates 300 million people may have been afflicted by malnutrition in infancy, it would seem important to examine, critically, the evidence upon which this statement is based. The purpose of this chapter is to review normal brain growth, to examine the data leading up to the “critical periods” hypothesis, and to document the effects of undernutrition during these critical periods.

Keywords

Anorexia Nervosa Cellular Growth Myelin Sheath Total Lipid Content Cholesterol Sulfate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M. Enesco and C. P. Leblond, Increase in cell number as a factor in the growth of the organs and tissues of the young male rat, J. Embryol. Exptl. Morphol. 10:530–562, 1967.Google Scholar
  2. 2.
    L. W. Lapham, Tetraploid DNA content of Purkinje neurons of human cerebellar cortex, Science 159:310–312, 1968.CrossRefGoogle Scholar
  3. 3.
    M. Winick and A. Noble, Quantitative changes in DNA, RNA, and protein during prenatal and postnatal growth in the rat, Develop. Biol. 12:451–466, 1965.CrossRefGoogle Scholar
  4. 4.
    I. Fish and M. Winick, Cellular growth in various regions of the developing rat brain, Pediat. Res. 3:407–412, 1969.CrossRefGoogle Scholar
  5. 5.
    J. Altman and G. Das, Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in infant rats with special reference to postnatal neurogenesis in some brain regions, J.Comp. Neurol. 126:337–360, 1966.CrossRefGoogle Scholar
  6. 6.
    M. Winick, Changes in nucleic acid and protein content of the human brain during growth, Pediat. Res. 2:352–355, 1968.CrossRefGoogle Scholar
  7. 7.
    J. Dobbing and J. Sands, Timing of neuroblast multiplication in developing human brain, Nature 226:639–640, 1970.CrossRefGoogle Scholar
  8. 8.
    M. Winick, P. Rosso, and J. Waterlow, Cellular growth of cerebrum, cerebellum, and brain stem in normal and marasmic children, Exptl. Neurol. 26:393–400, 1970.CrossRefGoogle Scholar
  9. 9.
    S. Duckett and A. G. Pearse, The chemo-architectonic patterns of the cerebral cortex of the embryonic and fetal human brain, in “Proceedings of the Fifth International Congress of Neuropathology,” p. 738, Pub. Excerpta Medica Foundations International Congress Series, No. 100.Google Scholar
  10. 10.
    S. Duckett and A. G. Pearse, Monamine cells in the developing human cortex, Rev. Can. Biol. 26:173–174, 1967.Google Scholar
  11. 11.
    S. Duckett and A. G. Pearse, The cells of Cajal-Retzius in the developing human brain, J.Anat. 102:183–186, 1968.Google Scholar
  12. 12.
    S. Duckett and A. G. Pearse, The histoenzymology of the developing human spinal cord, Anat. Rec. 163:59–61, 1969.CrossRefGoogle Scholar
  13. 13.
    D. Nachmansohn, in “Modern Trends in Physiology and Biochemistry” (E. S. G. Barron, ed.), pp. 236–276, Academic Press, New York, 1952.Google Scholar
  14. 14.
    I. J. Holstein, W. A. Fish, and W. M. Stokes, Pathway of cholesterol biosynthesis in the brain of the neonatal rat, J.Lipid Res. 7:364–368, 1966.Google Scholar
  15. 15.
    D. Kritchevsky and W. L. Holmes, Occurrence of demosterol in developing rat brain, Biochem. Biophys. Res. Commun. 7:128–130, 1962.CrossRefGoogle Scholar
  16. 16.
    C. W. M. Adams and A. N. Davison, The occurrence of sterified cholesterol in the developing nervous system, J.Neurochem. 4:282–289, 1959.CrossRefGoogle Scholar
  17. 17.
    G. Rouser and A. Yamamoto, in “Handbook of Neurochemistry” (A. Lajtha, ed.), Vol. 1, p. 121, Plenum Press, New York, 1969.Google Scholar
  18. 18.
    L. Svennerholm, Distribution and fatty acid composition of phosphoglycerides in normal human brain, J.Lipid Res. 9:570–579, 1968.Google Scholar
  19. 19.
    H. Wiegardt, The subcellular localization of gangliosides in the brain, J.Neurochem. 14:671–674, 1967.CrossRefGoogle Scholar
  20. 20.
    F. Le Baron, in “Handbook of Neurochemistry” (A. Lajtha, ed.), Vol. 3, p. 561, Plenum Press, New York, 1970.Google Scholar
  21. 21.
    W. Sperry, in “Neurochemistry” (K. A. C. Elliott, I. H. Page, and J. H. Quastel, eds.), pp. 55–84, C. C. Thomas, Springfield, Ill., 1962.Google Scholar
  22. 22.
    A. N. Davison and J. Dobbing, in “Applied Neurochemistry” (A. N. Davison and J. Dobbing, eds.), pp. 253–286, Blackwell Scientific Publications, Oxford and Edinburgh, 1968.Google Scholar
  23. 23.
    G. Brante, Studies on lipids in nervous system with special reference to quantitative chemical determination and topical distribution, Acta Physiol. Scand. 18:1–189, 1949 (Suppl. 63).CrossRefGoogle Scholar
  24. 24.
    A. H. Tingey, Human brain lipids at various ages in relation to myelination, J.Ment. Sci. (London) 102:429–435, 1956.Google Scholar
  25. 25.
    J. N. Cummings, H. Goodwin, E. M. Woodward, and G. Curzong, Lipids in the brain of infants and children, J.Neurochem. 2:289–294, 1958.CrossRefGoogle Scholar
  26. 26.
    E. Howard and D. M. Granoff, Effect of neonatal food restriction in mice on brain growth, DNA and cholesterol on adult delayed response learning, J.Nutrition 95:111–121, 1968.Google Scholar
  27. 27.
    J. Altman, in “Handbook of Neurochemistry” (A. Lajtha, ed.), Vol.2, p. 137, Plenum Press, New York, 1969.Google Scholar
  28. 28.
    R. P. Bunge, Glial cells and the central myelin sheath, Physiol. Rev. 48:197–243, 1968.Google Scholar
  29. 29.
    P. Rosso, J. Hormazbel, and M. Winick, Changes in brain weight, cholesterol, phospholipid and DNA content in marasmic children, Am. J. Clin. Nutrition 23:1275–1279, 1970.Google Scholar
  30. 30.
    M. Winick, Nutrition and nerve cell growth, Fed. Proc. 29:1510–1515, 1970.Google Scholar
  31. 31.
    E. M. Widdowson and R. A. McCance, Some effects of accelerating growth. I. General somatic development, Proc. Roy. Soc. London 152:88–206, 1960.CrossRefGoogle Scholar
  32. 32.
    J. W. T. Dickerson, J. Dobbing, and R. A. McCance, The effect of undernutrition on the postnatal development of the brain and cord in pigs, Proc. Roy. Soc. London 166:396–407, 1966–1967.CrossRefGoogle Scholar
  33. 33.
    C. M. Jackson and C. A. Steward, The effects of inanition in the young upon the ultimate size of the body and of the various organs in the albino rat, J.Exptl. Zool. 30:97–128, 1920.CrossRefGoogle Scholar
  34. 34.
    M. Winick and A. Noble, Cellular response in rats during malnutrition at various ages, J.Nutrition 89:300–306, 1966.Google Scholar
  35. 35.
    M. Winick and A. Noble, Cellular response with increased feeding in neonatal rats, J.Nutrition 91:179–182, 1967.Google Scholar
  36. 36.
    M. Winick, I. Fish, and P. Rosso, Cellular recovery in rat tissues after a brief period of neonatal malnutrition, J.Nutrition 95:623–626, 1968.Google Scholar
  37. 37.
    A. N. Davison and J. Dobbing, Myelination as a vulnerable period in brain development, Brit. Med. Bull. 22:40–44, 1966.Google Scholar
  38. 38.
    H. P. Chase, J. Dorsey, and G. M. McKhann, The effect of malnutrition on the synthesis of a myelin lipid, Pediatrics 40:551–559, 1967.Google Scholar
  39. 39.
    B. S. Platt, Proteins in nutrition, Proc. Roy. Soc. London 156:337–344, 1962.Google Scholar
  40. 40.
    B. S. Platt, C. R. C. Heard, and R. J. C. Steward, in “Mammalian Protein Metabolism” (A. N. Munro and J. B. Alison, eds.), Academic Press, New York, 1964.Google Scholar
  41. 41.
    F. S. Zeman and E. C. Stanbrough, Effect of maternal protein deficiency on cellular development in the fetal rat, J.Nutrition 99:274–281, 1969.Google Scholar
  42. 42.
    M. Winick and P. Rosso, The effect of severe early malnutrition on cellular growth of human brain, Pediat. Res. 3:181–184, 1969.CrossRefGoogle Scholar
  43. 43.
    M. Winick, in “Diagnosis and Treatment of Fetal Disorders” (K. Adamsons, ed.), Springer-Verlag, New York, 1968.Google Scholar
  44. 44.
    S. Zamenhof, E. Van Marthens, and F. L. Margolis, DNA (cell number) and protein in neonatal brain: Alteration by maternal dietary protein restriction, Science 160:322–330, 1968.CrossRefGoogle Scholar
  45. 45.
    M. Winick, Cellular changes during placental and fetal growth, Am. J. Obstet. Gynecol. 109:166–176, 1971.Google Scholar
  46. 46.
    M. Winick and E. Velasco, The effect of maternal protein restriction on cellular growth of the offspring, in “Proceedings of the Eighth International Congress of Nutrition,” Prague, 1969.Google Scholar
  47. 47.
    E. M. Widdowson, Malnutrition during pregnancy and early neonatal life, Presented at the Symposium on Fetal Malnutrition, New York, 1970.Google Scholar
  48. 48.
    M. Winick, Cellular growth of the human placenta. III. Intrauterine growth failure, J. Pediat. 71:390–395, 1967.CrossRefGoogle Scholar
  49. 49.
    C. A. Smith, Effects of maternal undernutrition upon the newborn infant in Holland, J. Pediat. 30:229–243, 1947.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Myron Winick
    • 1
  • Pedro Rosso
    • 1
  1. 1.Institute of Human Nutrition, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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