Disorders of Cerebrospinal Fluid and Brain Extracellular Fluid

  • Leon D. Prockop


The chemical composition of the extracellular fluid (ECF) of the brain is similar to that of cerebrospinal fluid (CSF). Brain ECF is inaccessible for studies in humans, and serial determinations are difficult in animals. On the other hand, CSF can be sampled serially, in vivo, without altering physical or chemical parameters. Therefore, the CSF’s dynamic alterations are used to define dysfunction within the CSF compartment, as a direct index of dysfunction of brain ECF, and as an indirect index of cerebrocellular metabolism and dysfunction.


Multiple Sclerosis Cerebrospinal Fluid Extracellular Fluid Choroid Plexus Tuberculous Meningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Leon D. Prockop
    • 1
  1. 1.Department of Neurology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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