Disorders of Glucose Metabolism in Brain Dysfunction

  • William Sacks


The brain is unique among the organs of the body in that it consumes about 50 ml of oxygen per minute (a value representing almost 20% of the resting human’s total requirements) and in that it “extracts” from blood about 70 mg of glucose per minute. Furthermore, experiments have demonstrated the brain’s utter dependence on oxygen and glucose, with irreparable damage resulting from deprivation of either or both for only short periods of time. A causal relationship between altered glucose metabolism and mental disturbances is implied. In this chapter, the association of both systemic and cerebral disorders of glucose metabolism with brain dysfunction will be discussed, with emphasis on in vivo investigations with human subjects and animals.


Cerebral Blood Flow Brain Dysfunction Cerebral Metabolism Mental Patient Glucose Curve 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • William Sacks
    • 1
  1. 1.Research CenterRockland State HospitalOrangeburgUSA

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