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Microsomal Enzymes Involved in the Metabolism of Ether-Linked Glycerolipids and Their Precursors in Mammals

  • Robert L. Wykle
  • Fred Snyder

Abstract

The pathway by which ether-linked glycerolipids are synthesized in animals remained obscure until 1968. Metabolic in vivo studies and structural analysis of alkyl-linked glycerolipids indicated that the alkyl chains were derived from fatty alcohols (Keenan et al., 1961; Friedberg and Greene, 1967; Ellingboe and Karnovsky, 1967; Snyder and Blank, 1969; Schmid and Takahashi, 1970) and that alk-1-enyl-linked glycerolipids (plasmalogens) were formed by desaturation of alkyl glycerolipids (Horrocks and Ansell, 1967; Bickerstaffe and Mead, 1968; Malins, 1968; Thompson, 1968; Wood and Snyder, 1969; Wood and Healy, 1970; Blank et al., 1970; Wood et al., 1970; Bell et al., 1971; Debuch et al., 1970, 1971; Paltauf, 1971a,b; Stoffel and LeKim, 1971). Thompson and Hanahan (1963) found that radioactivity from [6–14C]glucose was incorporated into ether lipids by bone marrow and that the label was almost exclusively in the sn-3 carbon of the glycerol moiety. Later Friedberg and Greene (1968) concluded from in vivo experiments with Tetrahymena and 14C., 3H-labeled glycerol that the glycerol portion of ether lipids is derived from a triose phosphate or some other carbohydrate instead of α-glycerophosphate.

Keywords

Fatty Alcohol Phosphatidic Acid Microsomal Enzyme Ether Lipid Glyceryl Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Robert L. Wykle
    • 1
  • Fred Snyder
    • 1
  1. 1.Medical and Health Sciences DivisionOak Ridge Associated UniversitiesOak RidgeUSA

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