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Functional Specialization of Membrane-Bound Ribosomes in Eukaryotic Cells

  • David D. Sabatini
  • Gert Kreibich

Abstract

Ultrastructural studies have revealed a very high degree of macromolecular organization in eukaryotic cells. The plasma membrane, the nuclear envelope, and the membranes of cytoplasmic organelles create subcellular compartments with specific functions and macromolecular composition. The limiting membranes of these compartments and the structures within them rely for their function on the precise spatial organization of specific protein constituents. There is therefore considerable interest in understanding the processes which coordinate the biogenesis of membrane components with their assembly into cellular membranes. This requires an elucidation of the mechanisms which ensure that newly synthesized proteins and phospholipids are transferred to their sites of function. For many proteins this entails transfer between several compartments and for some, extensive structural modifications. For secretory proteins and for some proteins in the outer face of plasma membranes discharge towards the extracellular environment eventually occurs.

Keywords

Large Subunit Ribosomal Subunit Ribosome Binding Site Microsomal Membrane Nascent Polypeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • David D. Sabatini
    • 1
  • Gert Kreibich
    • 1
  1. 1.Department of Cell BiologyNew York University School of MedicineNew YorkUSA

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