Advertisement

Ned Opes Ned Vires Sed Artis Aceptra Permanent

  • Hans Heller
Part of the Perspectives in Neuroendocrine Research book series (PNR, volume 1)

Abstract

At the beginning of 1928, Professor E. P. Pick, head of the Institute of Pharmacology of the University of Vienna, was looking for a research assistant with a degree in organic chemistry. I had obtained such a degree the previous year by studies which included a year of research in the field of organic arsenic compounds. This had led me to the work of Paul Ehrlich, whose hypotheses on the selective binding of dyes and dyelike arsenic compounds made a deep impression on me. Pharmacology seemed therefore to be the right subject for me: I applied for the post and obtained it. At that time Pick was interested in the findings of several workers that extracts of duodenal mucosa produce a hypoglycemic effect and that they do so even when given by mouth. The latter statement was of special interest to him because a friend of his, Msgr. Ignaz Seipel, formerly a professor of theology in the University of Vienna and thus a colleague of his, and later Federal Chancellor of the Republic of Austria, was a diabetic and had complained to him about the discomfort caused by the injection, several times daily, of soluble insulin, the only preparation then available. I was able to confirm that extract of the upper third of the small intestine lowered the blood sugar of rabbits when given parenterally and that the dried extract when given in very much larger doses was also orally active.

Keywords

Neurosecretory System Soluble Insulin Neural Lobe Neurohypophyseal Hormone Arginine Vasotocin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dixon, W. E., F. H. A. Marshall (1924). The influence of the ovary on pituitary secretion; a probable factor in parturition. J. Physiol. 49: 276.Google Scholar
  2. Elliott, T. R. (1904). On the action of adrenalin. J. Physiol. 31: 20 P.Google Scholar
  3. Ferguson, D. R. (1969). The genetic distribution of vasopressins in the peccary (Tayassu angulatus) and warthog (Phaecochoerus aethiopieus). Gen. Comp. Endocrinol. 12: 609.Google Scholar
  4. Ferguson, D. R., H. Heller (1965). Distribution of neurohypophysial hormones in vertebrates. J. Physiol. 180: 846.PubMedGoogle Scholar
  5. Fröhlich, A. (1901). Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie. Wien. Klin. Rundschau 15: 883, 906.Google Scholar
  6. Gaddum, J. H. (1965). In Polypeptides which Stimulate Plain Muscle. Livingstone, Edinburgh and London.Google Scholar
  7. Ginsburg, M., H. Heller (1953). The clearance of injected vasopressin from the circulation and its fate in the body. J. Endocrinol. 9: 283.PubMedCrossRefGoogle Scholar
  8. Gunn, J. A. (1932). Obituary for Walter Ernest Dixon. J. Pharmacol. Exp. Ther. 44: 3.Google Scholar
  9. Heller, H. (1930ö). Über die Einwirkung von Hypophysenhinterlappenextrakten auf den Wasserhaushalt des Frosches. Arch. Exp. Pathol. Pharmakol. 157: 298.Google Scholar
  10. Heller, H. (19306). Über die Wirkung der getrennten Hypophysenhinterlappenhormone auf die Wasseraufnahme beim Frosch. Arch. Exp. Pathol. Pharmakol. 157: 323.Google Scholar
  11. Heller, H. (1931). Über das blutzuckersenkende Hormon der Darmschleimhaut (Duodenin). Wien. Klin. Wochenschr. 44: 476.Google Scholar
  12. Heller, H. (1941). Differentiation of an (amphibian) water balance principle from the antidiuretic principle of the posterior pituitary gland. J. Physiol. 100: 125.PubMedGoogle Scholar
  13. Heller, H. (1944). The renal function of newborn infants. J. Physiol. 102: 429.PubMedGoogle Scholar
  14. Heller, H. (1951). The water metabolism of newborn infants and animals. Arch. Dis. Child. 26: 195.PubMedCrossRefGoogle Scholar
  15. Heller, H. (1958). Die Hypophysenhinterlappen- und Nebennierenrindenhormone wahrend der ersten Lebenszeit im Zusammenhang mit der Regulation des Wasserhaushaltes. Monatsschr. Kinderheilk. 106: 81.Google Scholar
  16. Heller, H. (1961). Occurrence, storage and metabolism of oxytocin. Page 3 in R. Caldeyro-Barcia and H. Heller, eds. Oxytocin. Pergamon Press, Oxford.Google Scholar
  17. Heller, H. (1974). Molecular aspects in comparative endocrinology. Gen. Comp. Endocrinol. 22: 315.PubMedCrossRefGoogle Scholar
  18. Heller, H., G. Kusunoki (1933). Die zentrale Blutdruckwirkung des neurohypophysären Kreislaufhormons (Vasopressin). Arch. Exp. Pathol. Pharmakol. 173: 301.CrossRefGoogle Scholar
  19. Heller, H., K. Lederis (1962). Characteristics of isolated neurosecretory vesicles from mammalian neural lobes. In H. Heller and R. B. Clark, eds. Neurosecretion. Mem. Soc. Endocrinol. 12: 35.Google Scholar
  20. Heller, H., B. T. Pickering (1960). Identification of a new neurohypophysial hormone. J. Physiol. 152: 56 P.Google Scholar
  21. Heller, H., B. T. Pickering (1961). Neurohypophysial hormones of nonmammalian vertebrates. J. Physiol. 155: 98.PubMedGoogle Scholar
  22. Heller, H., F. H. Smirk (1932). Studies concerning the alimentary absorption of water and tissue hydration in relation to diuresis. Part III. The influence of posterior pituitary hormone on the absorption and distribution of water. J. Physiol. 76: 283.PubMedGoogle Scholar
  23. Heller, H., F. F. Urban (1935). The fate of the antidiuretic principle of postpituitary extracts in vivo and in vitro. J. Physiol. 85: 502.PubMedGoogle Scholar
  24. Henderson, I. W., N. A. M. Wales (1974). Renal diuresis and anti-diuresis after injection of arginine vasotocin in the freshwater eel (Anguilla anguilla L.). J. Endocrinol. 61: 487.PubMedCrossRefGoogle Scholar
  25. Janssen, S. (1928). Über zentrale Wasserregulation und Hypophysenantidiurese. Arch. Exp. Pathol. Pharmakol. 135: 1.CrossRefGoogle Scholar
  26. Loewi, O. (1960). An autobiographical sketch. Perspect. Biol. Med. 4: 3.Google Scholar
  27. Pfeiffer, E., S. Raptis, and R. Fussg’anger (1973). Gastrointestinal hormones and islet function. Page 259 in Handbook of Experimental Pharmacology, vol. 34. Springer, Berlin/Heidelberg/New York.Google Scholar
  28. Pickering, B. T., H. Heller (1959). Chromatographic and biological characteristics of fish and frog neurohypophysial extracts. Nature 184: 1463.PubMedCrossRefGoogle Scholar
  29. Skadhauge, E. (1964). Effects of unilateral infusion of arginine vasotocin into the portal circulation of the avian kidney. Acta Endocrinol. (Kbh.) 41: 321.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Hans Heller

There are no affiliations available

Personalised recommendations