Contributions to the Substructure of Neuroendocrinology

  • John W. Everett
Part of the Perspectives in Neuroendocrine Research book series (PNR, volume 1)


At the 56th annual meeting of the American Association of Anatomists, two adjacent exhibits were the demonstration by F. L. Dey (1940) describing the follicular ovaries of guinea pigs resulting from anterior hypothalamic lesions and my demonstration (Everett, 1940a) concerned with spontaneous and light-induced persistent estrus in rats. I doubt that either of us recognized that we were concerned with closely interrelated phenomena.


Corpus Luteum Estrous Cycle Median Eminence Stainless Steel Electrode Medial Preoptic Area 
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  1. Barraclough, C. A., R. A. Gorski (1961). Evidence that the hypothalamus is responsible for androgen-induced sterility in the female rat. Endocrinology 68: 68.PubMedCrossRefGoogle Scholar
  2. Boling, J. L., R. J. Blandau, A. L. Soderwall, W. C. Young (1941a). Growth of the Graafian follicle and the time of ovulation in the albino rat. Anat. Rec. 79: 313.CrossRefGoogle Scholar
  3. Boling, J. L., R. J. Blandau, B. Rundlett, W. C. Young (1941 b). Factors underlying the failure of cyclic mating behavior in the albino rat. Anat. Rec. 80: 155.Google Scholar
  4. Browman, L. G. (1937). Light in its relation to activity and estrus rhythms in the albino rat. J. Exp. Zool. 75: 375.CrossRefGoogle Scholar
  5. Bunn, J. P., J. W. Everett (1957). Ovulation of persistent-estrous rats after electrical stimulation of the brain. Proc. Soc. Exp. Biol. Med. (N.Y.) 96: 369.Google Scholar
  6. Critchlow, B. V. (1957). Ovulation induced by hypothalamic stimulation in the rat. Anat. Rec. 127: 283.Google Scholar
  7. Critchlow, V. (1958). Ovulation induced by hypothalamic stimulation in the anesthetized rat. Am. J. Physiol. 195: 171.PubMedGoogle Scholar
  8. Dempsey, E. W., H. F. Searles (1943). Environmental modification of certain endocrine phenomena. Endocrinology 32: 119.CrossRefGoogle Scholar
  9. Desclin, L. (1950). Ä propos du mecanisme d’action des oestrogenes sur le lobe anterieur de l’hypophyse chez le Rat. Ann. Endocrinol. (Paris) 11: 656.Google Scholar
  10. Dey, F. L. (1940). Ovarian and uterine changes in guinea pigs with hypothalamic lesions. Anat. Rec. 76 (2) (Suppl.): 86.Google Scholar
  11. Everett, J. W. (1939). Spontaneous persistent estrus in a strain of albino rats. Endocrinology 25: 123.CrossRefGoogle Scholar
  12. Everett, J. W. (1940a). Persistent estrus, correlated with a failure of spontaneous ovulation, appearing in early life in a certain strain of rats. Anat. Rec. 76 (2) (Suppl.): 87.Google Scholar
  13. Everett, J. W. (1940b). The restoration of ovulatory cycles and corpus luteum formation in persistent-estrous rats by progesterone. Endocrinology 27: 681.CrossRefGoogle Scholar
  14. Everett, J. W. (1943). Further studies on the relationship of progesterone to ovulation and lu- teinization in the persistent-estrous rat. Endocrinology 32: 285.CrossRefGoogle Scholar
  15. Everett, J. W. (1944a). Evidence in the normal albino rat that progesterone facilitates ovulation and corpus-luteum formation. Endocrinology 34: 136.CrossRefGoogle Scholar
  16. Everett, J. W. (19446). Evidence suggesting a role of the lactogenic hormone in the estrous cycle of the albino rat. Endocrinology 35: 507.Google Scholar
  17. Everett, J. W. (1945). The microscopically demonstrable lipids of cyclic corpora lutea in the rat. Am. J. Anat. 77: 293.PubMedCrossRefGoogle Scholar
  18. Everett, J. W. (1947). Hormonal factors responsible for deposition of cholesterol in the corpus luteum of the rat. Endocrinology 41: 364.PubMedCrossRefGoogle Scholar
  19. Everett, J. W. (1948). Progesterone and estrogen in the experimental control of ovulation time and other features of the estrous cycle in the rat. Endocrinology 43: 389.PubMedCrossRefGoogle Scholar
  20. Everett, J. W. (1952). Presumptive hypothalamic control of spontaneous ovulation. Ciba Found. Colloq. Endocrinol. 4: 167.Google Scholar
  21. Everett, J. W. (1954). Luteotrophic function of autografts of the rat hypophysis. Endocrinology 54: 685.PubMedCrossRefGoogle Scholar
  22. Everett, J. W. (1956). Functional corpora lutea maintained for months by autografts of rat hypophyses. Endocrinology 58: 786.PubMedCrossRefGoogle Scholar
  23. Everett, J. W. (1961). The preoptic region of the brain and its relation to ovulation. Pages 101–112 in C. A. Villee, ed. Control of Ovulation. Pergamon Press, New York.Google Scholar
  24. Everett, J. W. (1964). Preoptic stimulative lesions and ovulation in the rat: Thresholds’ and LH-release time in late diestrus and proestrus. Pages 346–366 in E. Bajusz and G. Jasmin, eds. Major Problems in Neuroendocrinology. S. Karger, Basel/New York.Google Scholar
  25. Everett, J. W. (1965). Ovulation in rats from preoptic stimulation through platinum electrodes. Importance of duration and spread of stimulus. Endocrinology 76: 1195.PubMedCrossRefGoogle Scholar
  26. Everett, J. W. (1967). Provoked ovulation or long-delayed pseudopregnancy from coital stimuli in barbiturate-blocked rats. Endocrinology 80: 145.PubMedCrossRefGoogle Scholar
  27. Everett, J. W. (1970). Photoregulation of the ovarian cycle in the rat. Pages 387–403 in J. Benoit and I. Assenmacher, eds. La Photoregulation de la Reproduction chez les Oiseaux et les Mammifères. CNRS, Paris.Google Scholar
  28. Everett, J. W., H. M. Radford (1961). Irritative deposits from stainless steel electrodes in the preoptic rat brain causing release of pituitary gonadotropin. Proc. Soc. Exp. Biol. Med. (New York) 108: 604.Google Scholar
  29. Everett, J. W., R. L. Riley, C. D. Christian (1959). Ovulation after stimulating the rat hypothalamus late in diestrus. Proceedings of the Endocrine Society, 41st Annual Meeting.Google Scholar
  30. Everett, J. W., C. H. Sawyer (1949). A neural timing factor in the mechanism by which progesterone advances ovulation in the cyclic rat. Endocrinology 45: 581.PubMedCrossRefGoogle Scholar
  31. Everett, J. W., C. H. Sawyer (1950). A 24-hour periodicity in the “LH-release apparatus” of female rats, disclosed by barbiturate sedation. Endocrinology 47: 198.PubMedCrossRefGoogle Scholar
  32. Everett, J. W., C. H. Sawyer, J. E. Markee (1949). A neurogenic timing factor in control of the ovulatory discharge of luteinizing hormone in the cyclic rat. Endocrinology 44: 234.PubMedCrossRefGoogle Scholar
  33. Green, J. D., G. W. Harris (1947). The neurovascular link between the neurohypophysis and adenohypophysis. J. Endocrinol. 5: 136.PubMedCrossRefGoogle Scholar
  34. Haläsz, B. (1969). The endocrine effects of isolation of the hypothalamus from the rest of the brain. Pages 307–342 in W. F. Ganong and L. Martini, eds. Frontiers in Neuroendocrinology, Oxford Univ. Press, New York.Google Scholar
  35. Harris, G. W., D. Jacobsohn (1952). Functional grafts of the anterior pituitary gland. Proc. R. Soc. London Ser. B, 139: 263.CrossRefGoogle Scholar
  36. Hemmingsen, A. M., and N. B. Krarup (1937). Rhythmic diurnal variations in the oestrous phenomena of the rat and their susceptibility to light and dark. K. Dan. Vidensk. Selsk., Biol. Medd. 13 (7): 1.Google Scholar
  37. Hillarp, N.-Ä. (1949). Studies on the localization of hypothalamic centres controlling the gonadotrophic function of the hypophysis. Acta Endocrinol. 2: 11.PubMedGoogle Scholar
  38. Knobil, E. (1974). On the control of gonadotropin secretion in the rhesus monkey. Recent Prog. Horm. Res. 30: 1.PubMedGoogle Scholar
  39. Nikitovitch-Winer, M., J. W. Everett (1958). Functional restitution of pituitary grafts re- transplanted from kidney to median eminence. Endocrinology 63: 916.PubMedCrossRefGoogle Scholar
  40. Nikitovitch-Winer, M., J. W. Everett (1959). Histocytologic changes in grafts of rat pituitary on the kidney and upon re-transplantation under the diencephalon. Endocrinology 65: 357.PubMedCrossRefGoogle Scholar
  41. Phillips, W. A. (1937). The inhibition of oestrous cycles in the albino rat by progesterone. Am. J. Physiol. 119: 623.Google Scholar
  42. Redmond, W. C. (1968). Ovulatory response to brain stimulation or exogenous luteinizing hormone in progesterone-treated rats. Endocrinology 83: 1013.PubMedCrossRefGoogle Scholar
  43. Sawyer, C. H., J. W. Everett, J. E. Markee (1949). A neural factor in the mechanism by which estrogen induces the release of luteinizing hormone in the rat. Endocrinology 44: 218.PubMedCrossRefGoogle Scholar
  44. Sawyer, C. H., J. E. Markee, W. H. Hollinshead (1947). The inhibition of ovulation in the rabbit by the adrenergic blocking agent Dibenamine. Endocrinology 41: 395.PubMedCrossRefGoogle Scholar
  45. Sawyer, C. H., J. E. Markee, B. F. Townsend (1949). Cholinergic and adrenergic components in the neurohumoral control of the release of LH in the rabbit. Endocrinology 44: 18.PubMedCrossRefGoogle Scholar
  46. Terasawa, E., C. H. Sawyer (1969). Electrical and electrochemical stimulation of the hypothalamo-hypophysial system with stainless steel electrodes. Endocrinology 84: 918.PubMedCrossRefGoogle Scholar
  47. Westman, A., D. Jacobsohn (1938). Endokrinologische Untersuchungen an Ratten mit durchtrennten Hypophysenstiel. VI. Production und Abgabe der Gonadotropen Hormone. Acta Pathol. Microbiol. Scand. 15: 445.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • John W. Everett
    • 1
  1. 1.Department of AnatomyDuck University School of MedicineDurhamUSA

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