Jaundice pp 159-174 | Cite as

The Hepatic Uptake Process: Its Implications for Bilirubin Transport

  • Carl A. Goresky
Part of the Hepatology book series (H, volume 2)


One of the fundamental aims of this symposium is to provide a framework upon which information concerning the handling of bilirubin can be knitted together, a framework which will prove useful both to the investigator concerned with fundamental phenomena and the clinician concerned with the care of a patient with jaundice. My task, within this framework, is to provide some insight into the kinetic processes involved in the uptake by the liver of substances like bilirubin. In order to attain this end I will present to you a general examination of the process of uptake at the hepatic cell surface. From this background, I will develop ideas concerning the manner in which the processes of biliary secretion or intracellular metabolic sequestration create steady state concentration gradients in the parenchymal cells distributed along the length of the sinusoids within each liver lobule. Finally, I will deal with the manner in which the lobular gradient phenomenon may account for the increase in the Tm for the biliary secretion of bilirubin which accompanies bile salt induced increments in bile flow.


Bile Flow Hepatic Uptake Biliary Secretion Sequestration Coefficient Hepatic Parenchymal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    GORESKY CA: A linear method for determining liver sinusoidal and extravascular volumes. Am J Physiol 204: 626–640, 1963.PubMedGoogle Scholar
  2. 2.
    GORESKY CA, NADEAU BE: Uptake of materials by the intact liver: the exchange of glucose across the cell membrane. J Clin Invest 53: 634–646, 1974.PubMedCrossRefGoogle Scholar
  3. 3.
    GORESKY CA: The lobular design of the liver: its effect on uptake processes, in Regulation of Hepatic Metabolism, edited by LUNDQUIST F, TYGSTRUP N, Copenhagen, Munksgaard, 1974, p 808–822.Google Scholar
  4. 4.
    GORESKY CA, BACH GG: On the uptake of materials by the intact liver: the concentrative transport of rubidium-86. J Clin Invest 52: 975–990, 1973.PubMedCrossRefGoogle Scholar
  5. 5.
    CAHILL GF, Jr, ASHMORE J, EARLE AS, ZOTTU S: Glucose penetration into liver. Am J Physiol 192: 491–496, 1958.PubMedGoogle Scholar
  6. 6.
    TYGSTRUP N, WINKLER K: Kinetics of galactose elimination. Acta Physiol Scand 32: 354–362, 1954.PubMedCrossRefGoogle Scholar
  7. 7.
    GORESKY CA, BACH GG, NADEAU BE: On the uptake of materials by the intact liver: the transport and net removal of galactose. J Clin Invest 52:991–1009, 1973.PubMedCrossRefGoogle Scholar
  8. 8.
    GORESKY CA: Initial distribution and rate of uptake of sulfo-bromophthalein inthe liver. Am J Physiol 207: 13–26, 1964.PubMedGoogle Scholar
  9. 9.
    LEVI AJ, GAITMAITAN Z, ARIAS IM: Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other organic anions. J Clin Invest 48: 2156–2167, 1969.PubMedCrossRefGoogle Scholar
  10. 10.
    WHEELER HO, EPSTEIN RM, ROBINSON RR et al: Hepatic storage and excretion of sulfobromophthalein sodium in the dog. J Clin Invest 39: 236–247, 1960.PubMedCrossRefGoogle Scholar
  11. 11.
    GORESKY CA, BACH GG, NADEAU BE: Red cell carriage of label: its limiting effect on the exchange of materials in the liver. Circ Res. In Press.Google Scholar
  12. 12.
    BARNHART JL, CLARENBERG R: Binding of bilirubin to erythrocytes. Ptoc Soc Biol Med 142: 1101–1103, 1973.Google Scholar
  13. 13.
    O’MAILLE ERL, RICHARDS TG, SHORT AH: Factors determining the maximal rate of organic anion secretion by the liver and further evidence of the hepatic site of action of the hormone secretin. J Physiol 186: 424–438, 1966.PubMedGoogle Scholar
  14. 14.
    GORESKY CA, HADDAD HH, KLUGER WS et al: The enhancement of maximal bilirubin excretion with taurocholate-induced increments in bile flow. Can J Physiol Pharmacol 52: 389–403, 1974.PubMedCrossRefGoogle Scholar
  15. 15.
    BARNHART J, RITT D, WARE A et al: A comparison of the effects of taurocholate and theophylline on BSP excretion in dogs, in The Liver -Quantitative Aspects of Structure and Function, edited by PAUMGARTNER G, PREISIG R, Basel, S. Karger, 1973, p 315–325.Google Scholar
  16. 16.
    ERLINGER S, DUMONT M: Influence of canalicular bile flow on sulfobromophthalein transport maximum in bile in the dog, in The Liver -Quantitative Aspects of Structure andFunction, edited by PAUMGARTNER G, PREISIG R, Basel, S. Karger, 1973, p306–314.Google Scholar
  17. 17.
    VERSCHURE JCM, MIJNLIEFF PF: The dominating macromolecular complex of human bile. Clin China Acta 1: 154–166, 1956.CrossRefGoogle Scholar
  18. 18.
    JUNIPER K: Physicochemical characteristics of bile and their relation to gallstone formation. Am J Med 39:98–107, 1965.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Carl A. Goresky
    • 1
  1. 1.The McGill University Medical ClinicMontreal General HospitalMontrealCanada

Personalised recommendations