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Jaundice pp 383–400Cite as

An Ultrastructural Look at Intrahepatic Cholestasis

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Part of the book series: Hepatology ((H,volume 2))

Abstract

Ultrastructural studies of the cholestatic liver in man and experimental animals have indicated that the subcellular changes are most frequently localized to the bile canaliculus and the immediately adjacent structures in the liver cell (1,2,5,22, 24,30). The mechanisms causing these localized hepatocellular changes have yet to be established but one of the experimental models most intensively studied in this regard has been the cholestasis induced by the monohydroxy bile acid, lithocholic acid (LCA) (4,10,11,12,14,29,31).

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References

  1. BIAYA CG: Studies on cholestasis. A re-evaluation of the fine structure of normal human bile canaliculi. Lab Invest 13: 840–864, 1964.

    Google Scholar 

  2. BIAVA CG: Studies on cholestasis. The fine structure and morphogenesis of hepatocellular and canalicular bile pigment. Lab Invest 13: 1099–1123, 1964.

    PubMed  CAS  Google Scholar 

  3. BOYER JL, KLATSKEN G: Canalicular bile flow and bile secretory pressure. Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver. Gastroenterology 59: 853–859, 1970.

    PubMed  CAS  Google Scholar 

  4. CAREY JB: Bile salts and hepatobiliary disease. In Diseases of the Liver. Edited by Schiff, L. Philadelphia and Toronto. JB Lippincott Co. 1969. pp. 103–146.

    Google Scholar 

  5. DESMET VJ: Morphologic and histochemical aspects of cholestasis. In Progress in Liver Diseases. Edited by Popper, H, Schaffner F. New York, Grune Stratton, 1972. vol 4: 97–132.

    Google Scholar 

  6. DEUTICKE B: Transformation and restoration of biconcave shape of human erythrocytes induced by amphipathic agents and changes of ionic environment. Biochim Biophys Acta 163: 494–500, 1968.

    Article  PubMed  CAS  Google Scholar 

  7. ERLINGER S: Physiology of bile flow. In Progress in Liver Diseases, vol. 4. Edited by Popper H, Schaffner F. New York, Grune Stratton, 1972. pp 63–82.

    Google Scholar 

  8. ERLINGER S, DHUMEAUX D: Mechanisms and control of secretion of bile water and electrolytes. Gastroenterology 66281–304, 1974.

    PubMed  CAS  Google Scholar 

  9. FISHER MM, MAGNUSSON R, MIYAI K: Bile acid metabolism in mammals. I. Bile acid induced intrahepatic cholestasis. Lab Invest 25: 88–91, 1971.

    PubMed  CAS  Google Scholar 

  10. HEATON KW: Bile salts in health and disease. Edinburgh and London, Churchill Livingstone, 1972. pp. 98–172.

    Google Scholar 

  11. HOLSTI P: Cirrhosis of the liver induced in rabbits by gastric instillation of 3-monohydroxy-cholanic acid. Nature (Lond) 186: 250, 1960.

    Article  Google Scholar 

  12. JAVITT NB, EMERMAN S: Effect of sodium taurolithocholate on bile flow and bile acid excretion. J. Clin Invest 47: 1002–1014, 1968.

    Article  PubMed  CAS  Google Scholar 

  13. KING JE, SCHOENFIELD LJ: Cholestasis induced by sodium taurolithocholate in isolated hamster liver. J Clin Invest 50: 2305–2312, 1971.

    Article  PubMed  CAS  Google Scholar 

  14. MIETTINEN TA: Clinical implications of bile acid metabolism in man. In The Bile Acids. Edited by Nair PN, and Kritchevsky D, New York, Plenum Press, 1973. vol. 2, pp 191–247.

    Google Scholar 

  15. MIYAI K, FISHER MM: Influence of bile acids on biliary secretion. (Abstract). In Proceedings 7th International Congress on Electron Microscopy. Edited by Favard P. Societe Francaise de Microscopie Electronique, Paris, 1970. Vol. 3, pp 495–496.

    Google Scholar 

  16. MEYAI K, MAYR W, RICHARDSON A: Freeze-fracture study of bile canalicular changes induced by lithocholic acid (abstract). Lab Invest 30: 16, 1974.

    Google Scholar 

  17. MIYAI K, MAYR WW, RICHARDSON A: Acute cholestasis induced by lithocholic acid in the rat: A freeze-fracture replica and thin section study. Lab Invest (in press)

    Google Scholar 

  18. MEYAI K, PRICE VM, FISHER MM: Bile acid metabolism in mammals. Ultrastructural studies on the intrahepatic cholestasis induced by lithocholic and chenodeoxycholic acids in the rat. Lab Invest 24: 292–302, 1971.

    Google Scholar 

  19. MIYAI K, WAGNER RM, RICHARDSON AL: Preparation of liver for combined SEM and TEM study. Scanning Electron Microscopy/1974 (part 1). In Proceedings of 7th Annual Scanning Electron Microscopy Symposium. Edited by Johari O, IIT Research Institute, Chicago. pp 282–289.

    Google Scholar 

  20. OSEROF AR, ROBBINS FW, BURGER MM: The cell surface membrane: biochemical aspects and biophysical probes. Ann Rev Biochem 42: 647–682, 1973.

    Article  Google Scholar 

  21. POPPER H, SCHAFENER F: Pathophysiology of cholestasis. Hum Pathol 1: 1–24, 1970.

    Article  PubMed  CAS  Google Scholar 

  22. SCHAFENER F: Ultrastructure of liver in intrahepatic and extrahepatic cholestasis. In Ikterus, International Symposium. Edited by Beck K, Freiburg, Stuttgart, New York, Schattauer Verlag. pp. 143–149, 1968.

    Google Scholar 

  23. SCHAFENER F, JAVITT NB: Morphologic changes in hamster liver during intrahepatic cholestasis induced by taurolitho-cholate. Lab Invest 15: 1783–1792, 1966.

    Google Scholar 

  24. SCHAFENER F, POPPER H: Cholestasis is the result of hypo-active hypertrophic smooth endoplasmic reticulum in the hepatocyte. Lancet II: 355–359, 1969.

    Article  Google Scholar 

  25. SEEMAN P, ROTH S: General anesthetics expand cell membranes at surgical concentrations. Biochim Biophys Acta 225: 171–177, 1972.

    Google Scholar 

  26. SINGER SJ: The molecular organization of membranes. Ann Rev Biochem 43: 805–833, 1974.

    Article  PubMed  CAS  Google Scholar 

  27. SINGER SJ, NICOLSON GL: The fluid mosaic model of the structure of cell membranes. Cell membranes are viewed as two-dimensional solutions of oriented globular proteins and lipids. Science 175: 720–731, 1972.

    Article  PubMed  CAS  Google Scholar 

  28. SMALL DM: The physical chemistry of cholanic acids. In The Bile Acids, vol. 1. Edited by Nair PP, Kritchevsky D. New York, Plenum Press, 1971. pp. 249–356.

    Google Scholar 

  29. SPERBER I: Secretion of organic anions in the formation of urine and bile. Pharmacol Rev 11: 109–134, 1959.

    PubMed  CAS  Google Scholar 

  30. STEINER JR, JEZEQUEL AM, PHILLIPS MJ, et al: Some aspects of the ultrastructural pathology of the liver. In Progress in Liver Diseases. Edited by Popper H, Schaffner F. New York, Grne Stratton, 1965. vol 2. pp 303–372.

    Google Scholar 

  31. WHEELER HO: Secretion of bile acids by the liver and their role in the formation of hepatic bile. Arch Intern Med 130: 533–541, 1972.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. University of California at San Diego, La Jolla, California, 92037, USA

    K. Miyai, W. Mayr, A. Richardson & M. M. Fisher

  2. University of Toronto, Toronto, Ontario, Canada

    K. Miyai, W. Mayr, A. Richardson & M. M. Fisher

Authors
  1. K. Miyai
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  2. W. Mayr
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  3. A. Richardson
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  4. M. M. Fisher
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Editor information

Editors and Affiliations

  1. McGill University, Montreal, Quebec, Canada

    Carl A. Goresky M.D. (Professor of Medicine) (Professor of Medicine)

  2. University of Toronto, Toronto, Ontario, Canada

    Murray M. Fisher M.D. (Associate Professor of Medicine and Pathology) (Associate Professor of Medicine and Pathology)

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© 1975 Plenum Press, New York

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Miyai, K., Mayr, W., Richardson, A., Fisher, M.M. (1975). An Ultrastructural Look at Intrahepatic Cholestasis. In: Goresky, C.A., Fisher, M.M. (eds) Jaundice. Hepatology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2649-6_23

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  • DOI: https://doi.org/10.1007/978-1-4684-2649-6_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2651-9

  • Online ISBN: 978-1-4684-2649-6

  • eBook Packages: Springer Book Archive

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