Jaundice pp 383-400 | Cite as

An Ultrastructural Look at Intrahepatic Cholestasis

  • K. Miyai
  • W. Mayr
  • A. Richardson
  • M. M. Fisher
Part of the Hepatology book series (H, volume 2)


Ultrastructural studies of the cholestatic liver in man and experimental animals have indicated that the subcellular changes are most frequently localized to the bile canaliculus and the immediately adjacent structures in the liver cell (1,2,5,22, 24,30). The mechanisms causing these localized hepatocellular changes have yet to be established but one of the experimental models most intensively studied in this regard has been the cholestasis induced by the monohydroxy bile acid, lithocholic acid (LCA) (4,10,11,12,14,29,31).


Bile Acid Intrahepatic Cholestasis Lithocholic Acid Canalicular Membrane Bile Acid Metabolism 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • K. Miyai
    • 1
    • 2
  • W. Mayr
    • 1
    • 2
  • A. Richardson
    • 1
    • 2
  • M. M. Fisher
    • 1
    • 2
  1. 1.University of California at San DiegoLa JollaUSA
  2. 2.University of TorontoTorontoCanada

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