Jaundice pp 367-382 | Cite as

Bile Canalicular Structure and Function

  • M. James Phillips
  • Masaya Oda
  • Ellen Mak
  • M. M. Fisher
Part of the Hepatology book series (H, volume 2)


Bile canaliculi from normal and cholestatic liver have been extensively studied using conventional electron microscopic techniques (1–8). Other studies have dealt with the relationships of the bile canaliculi to the sinusoids and the space of Disse (9–11). It is now well established that bile canaliculi are formed by two or three hepatocytes , are closed by junctional complexes, and are surrounded by an organelle-free ectoplasmic zone. It has been suggested that the pericanalicular ectoplasmic layer is composed of filamentous structures in human (1) and in calf liver (12), but the filamentous structures were not distinctly defined.


Junctional Complex Bile Canaliculus Filamentous Structure Heavy Meromyosin Cell BioI 


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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • M. James Phillips
    • 1
  • Masaya Oda
    • 1
  • Ellen Mak
    • 1
  • M. M. Fisher
    • 1
  1. 1.Banting InstituteUniversity of TorontoTorontoCanada

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